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Visualization of Cellular Metabolism using O-17 Oxygen MRI

Research Project

Project/Area Number 17H04254
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionHokkaido University

Principal Investigator

Kudo Kohsuke  北海道大学, 医学研究院, 教授 (10374232)

Co-Investigator(Kenkyū-buntansha) 小牧 裕司  公益財団法人実験動物中央研究所, ライブイメージングセンター, 室長代理 (10548499)
阿保 大介  北海道大学, 大学病院, 准教授 (30399844)
加藤 扶美  北海道大学, 大学病院, 講師 (80399865)
外山 穏香 (菊池穏香)  北海道大学, 医学研究院, 特任助教 (80783539)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords酸素代謝 / グルコース代謝 / 水動態 / MRI / O-17 / 核磁気共鳴画像(MRI) / 水動態解析 / 核磁気共鳴画像(MRI)
Outline of Final Research Achievements

Theoretical equation that converts MRI signal to O-17 concentration was successfully derived from the phantom acquisition (containing different concentration of O-17 water) and signal simulation of MRI. MRI experiments of culture cells in vitro were performed, and significant signal changes were observed after administration of O-17 gas or O-17 glucose, which were then converted into O-17 water. These results suggested that oxygen and glucose metabolisms could be measured by MRI using O-17. Intrathecal administration of O-17 water in rats were also conducted and dynamic signal changes of MRI in cerebrospinal fluid spaces were visualized. Quantitative water kinetics could be analyzed using human MRI data of intrathecal administration of O-17 water.

Academic Significance and Societal Importance of the Research Achievements

O-17酸素ガスの吸入によるMRI酸素代謝イメージングや、O-17グルコース分子によるMRI糖代謝イメージングの実現により、様々な中枢神経疾患の鑑別診断や重症度診断、治療効果判定などを非侵襲的かつ安全に行うことが可能となる。また、将来的には脳以外の臓器にも応用可能であり、全身の酸素代謝イメージングや糖代謝イメージングに発展するポテンシャルがある。さらに、O-17水分子での血流イメージングや水動態イメージングと組み合わせることで、組織の血流・水動態・酸素代謝・エネルギー代謝をMRIで総括的に評価することが可能となる。

Report

(4 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (101 results)

All 2021 2020 2019 2018 2017

All Journal Article (35 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 35 results,  Open Access: 8 results) Presentation (65 results) (of which Int'l Joint Research: 9 results,  Invited: 59 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Reinterpretation of magnetic resonance imaging findings with magnetoencephalography can improve the accuracy of detecting epileptogenic cortical lesions2021

    • Author(s)
      Otsuka Kosuke、Egawa Kiyoshi、Fujima Noriyuki、Kudo Kohsuke、Terae Satoshi、Nakajima Midori、Ito Tomoshiro、Yagyu Kazuyori、Shiraishi Hideaki
    • Journal Title

      Epilepsy & Behavior

      Volume: 114 Pages: 107516-107516

    • DOI

      10.1016/j.yebeh.2020.107516

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary study of AI-assisted diagnosis using FDG-PET/CT for axillary lymph node metastasis in patients with breast cancer2021

    • Author(s)
      Li Zongyao、Kitajima Kazuhiro、Hirata Kenji、Togo Ren、Takenaka Junki、Miyoshi Yasuo、Kudo Kohsuke、Ogawa Takahiro、Haseyama Miki
    • Journal Title

      EJNMMI Research

      Volume: 11 Issue: 1 Pages: 10-10

    • DOI

      10.1186/s13550-021-00751-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of a diffusion-weighted arterial spin labeling (DW-ASL) technique for evaluating the progression of brain white matter lesions2020

    • Author(s)
      Fujima Noriyuki、Kameda Hiroyuki、Shimizu Yukie、Harada Taisuke、Tha Khin Khin、Yoneyama Masami、Kudo Kohsuke
    • Journal Title

      Magnetic Resonance Imaging

      Volume: 69 Pages: 81-87

    • DOI

      10.1016/j.mri.2020.03.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microstructural Alterations in Bipolar and Major Depressive Disorders: A Diffusion Kurtosis Imaging Study2020

    • Author(s)
      Sawamura Daisuke、Narita Hisashi、Hashimoto Naoki、Nakagawa Shin、Hamaguchi Hiroyuki、Fujima Noriyuki、Kudo Kohsuke、Shirato Hiroki、Tha Khin K.
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: 52 Issue: 4 Pages: 1187-1196

    • DOI

      10.1002/jmri.27174

    • NAID

      120007160304

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of image quality on low-dose dynamic myocardial perfusion computed tomography with a novel 4-dimensional similarity filter2020

    • Author(s)
      Tsuneta Satonori、Oyama-Manabe Noriko、Kameda Hiroyuki、Harada Taisuke、Kato Fumi、Smit Ewoud J.、Prokop Mathias、Kudo Kohsuke
    • Journal Title

      Medicine

      Volume: 99 Issue: 26 Pages: e20804-e20804

    • DOI

      10.1097/md.0000000000020804

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Consensus survey on pre-procedural safety practices in radiological examinations: a multicenter study in seven Asian regions2020

    • Author(s)
      Lee Yuan-Hao、Quek Swee Tian、Khong Pek-Lan、Lee Cindy S.、Wu Jim S.、Zhang Lei、Ng Kwan-Hoong、Yang Seoung-Oh、Kudo Kohsuke、Do Kyung-Hyun、Kim Seung Hyup、Chen Dillon C.、Cheng Amy、Leung Joseph Hang、Chang Yeun-Chung、Hsu Hsian-He、Chan Wing P.
    • Journal Title

      The British Journal of Radiology

      Volume: 93 Issue: 1113 Pages: 20200082-20200082

    • DOI

      10.1259/bjr.20200082

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Halo artifacts of indwelling urinary catheter by inaccurate scatter correction in 18F-FDG PET/CT imaging: incidence, mechanism, and solutions2020

    • Author(s)
      Magota Keiichi、Numata Naoto、Shinyama Daiki、Katahata Junya、Munakata Yamato、Maniawski Piotr J.、Kobayashi Kentaro、Manabe Osamu、Hirata Kenji、Tateishi Ukihide、Kudo Kohsuke、Shiga Tohru
    • Journal Title

      EJNMMI Physics

      Volume: 7 Issue: 1 Pages: 66-66

    • DOI

      10.1186/s40658-020-00333-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Magnetic resonance imaging T1 and T2 mapping provide complementary information on the bone mineral density regarding cancellous bone strength in the femoral head of postmenopausal women with osteoarthritis2019

    • Author(s)
      Endo Kaori、Takahata Masahiko、Sugimori Hiroyuki、Yamada Satoshi、Tadano Shigeru、Wang Jeffrey、Todoh Masahiro、Ito Yoichi M.、Takahashi Daisuke、Kudo Kohsuke、Iwasaki Norimasa
    • Journal Title

      Clinical Biomechanics

      Volume: 65 Pages: 13-18

    • DOI

      10.1016/j.clinbiomech.2019.03.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Machine-Learning-Based Prediction of Treatment Outcomes Using MR Imaging-Derived Quantitative Tumor Information in Patients with Sinonasal Squamous Cell Carcinomas: A Preliminary Study.2019

    • Author(s)
      Fujima N, Shimizu Y, Yoshida D, Kano S, Mizumachi T, Homma A, Yasuda K, Onimaru R, Sakai O, Kudo K, Shirato H
    • Journal Title

      Cancers

      Volume: 11 Issue: 6 Pages: 800-800

    • DOI

      10.3390/cancers11060800

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of oxygen extraction fraction in systemic lupus erythematosus patients using quantitative susceptibility mapping2019

    • Author(s)
      Miyata Mari、Kakeda Shingo、Kudo Kohsuke、Iwata Shigeru、Tanaka Yoshiya、Wang Yi、Korogi Yukunori
    • Journal Title

      Journal of Cerebral Blood Flow & Metabolism

      Volume: 39 Issue: 8 Pages: 1648-1658

    • DOI

      10.1177/0271678x18764829

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Predicting metastasis in clinically negative axillary lymph nodes with minimum apparent diffusion coefficient value in luminal A-like breast cancer.2019

    • Author(s)
      Kato F, Kudo K, Yamashita H, Baba M, Shimizu A, Oyama-Manabe N, Kinoshita R, Li R, Shirato H
    • Journal Title

      Breast Cancer

      Volume: 印刷中 Issue: 5 Pages: 628-636

    • DOI

      10.1007/s12282-019-00969-0

    • NAID

      120006882079

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Percutaneous insertion of hepatic fiducial true-spherical markers for real-time adaptive radiotherapy2019

    • Author(s)
      Morita Ryo、Abo Daisuke、Sakuhara Yusuke、Soyama Takeshi、Katoh Norio、Miyamoto Naoki、Uchinami Yuusuke、Shimizu Shinichi、Shirato Hiroki、Kudo Kohsuke
    • Journal Title

      Minimally Invasive Therapy & Allied Technologies

      Volume: 29 Issue: 6 Pages: 334-343

    • DOI

      10.1080/13645706.2019.1663217

    • NAID

      120006885159

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of Hypoxia in Brain Tumors Using a Multivariate Model Built from MR Imaging and <sup>18</sup>F-Fluorodeoxyglucose Accumulation Data2019

    • Author(s)
      Shimizu Yukie、Kudo Kohsuke、Kameda Hiroyuki、Harada Taisuke、Fujima Noriyuki、Toyonaga Takuya、Tha Khin Khin、Shirato Hiroki
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: Epub ahead of print Issue: 3 Pages: 227-234

    • DOI

      10.2463/mrms.mp.2019-0049

    • NAID

      130007884315

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of the scan time point when assessing hypoxia in 18F-fluoromisonidazole PET: 2 vs. 4h2019

    • Author(s)
      Kobayashi Kentaro、Manabe Osamu、Hirata Kenji、Yamaguchi Shigeru、Kobayashi Hiroyuki、Terasaka Shunsuke、Toyonaga Takuya、Furuya Sho、Magota Keiichi、Kuge Yuji、Kudo Kohsuke、Shiga Tohru、Tamaki Nagara
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 47 Issue: 8 Pages: 1833-1842

    • DOI

      10.1007/s00259-019-04626-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of non-Gaussian model-based diffusion-weighted imaging in oral squamous cell carcinoma: comparison with tumour functional information derived from positron-emission tomography.2019

    • Author(s)
      Shima T, Fujima N, Yamano S, Kudo K, Hirata K, Minowa K.
    • Journal Title

      Clinical Radiology

      Volume: 75 Issue: 5 Pages: 15-21

    • DOI

      10.1016/j.crad.2019.12.018

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of microbleeds associated with sentinel headache using MRI quantitative susceptibility mapping: pilot study2019

    • Author(s)
      Nakagawa Daichi、Kudo Kohsuke、Awe Olatilewa、Zanaty Mario、Nagahama Yasunori、Cushing Cameron、Magnotta Vincent、Hayakawa Minako、Allan Lauren、Greenlee Jeremy、Awad Issam A.、Carroll Timothy、Torner James、Raghavan Madhavan L.、Hasan David M.
    • Journal Title

      Journal of Neurosurgery

      Volume: 130 Issue: 4 Pages: 1391-1397

    • DOI

      10.3171/2018.2.jns1884

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T: Comparison with <sup>15</sup>O-labeled Water Positron Emission Tomography2019

    • Author(s)
      Kikuchi Yasuka、Naya Masanao、Oyama-Manabe Noriko、Manabe Osamu、Sugimori Hiroyuki、Kudo Kohsuke、Kato Fumi、Aikawa Tadao、Tsutsui Hiroyuki、Tamaki Nagara、Shirato Hiroki
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 18 Issue: 2 Pages: 134-141

    • DOI

      10.2463/mrms.mp.2018-0003

    • NAID

      130007630070

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Three-dimensional Pseudo-continuous Arterial Spin-labeling Using Turbo-spin Echo with Pseudo-steady State Readout: A Comparison with Other Major Readout Methods2019

    • Author(s)
      Aoike Suzuko、Sugimori Hiroyuki、Fujima Noriyuki、Suzuki Yuriko、Shimizu Yukie、Suwa Akira、Ishizaka Kinya、Kudo Kohsuke
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 18 Issue: 2 Pages: 170-177

    • DOI

      10.2463/mrms.tn.2018-0031

    • NAID

      130007630074

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of the repeatability of parallel transmission at 7T using interleaved acquisition in the calibration scan2018

    • Author(s)
      Kameda Hiroyuki、Kudo Kohsuke、Matsuda Tsuyoshi、Harada Taisuke、Iwadate Yuji、Uwano Ikuko、Yamashita Fumio、Yoshioka Kunihiro、Sasaki Makoto、Shirato Hiroki
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: 48 Issue: 1 Pages: 94-101

    • DOI

      10.1002/jmri.25903

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrating quantitative morphological and intratumoural textural characteristics in FDG-PET for the prediction of prognosis in pharynx squamous cell carcinoma patients2018

    • Author(s)
      Fujima N.、Hirata K.、Shiga T.、Li R.、Yasuda K.、Onimaru R.、Tsuchiya K.、Kano S.、Mizumachi T.、Homma A.、Kudo K.、Shirato H.
    • Journal Title

      Clinical Radiology

      Volume: 73 Issue: 12 Pages: 1059.e1-1059.e8

    • DOI

      10.1016/j.crad.2018.08.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Semi-quantitative analysis of pre-treatment morphological and intratumoral characteristics using 18F-fluorodeoxyglucose positron-emission tomography as predictors of treatment outcome in nasal and paranasal squamous cell carcinoma2018

    • Author(s)
      Fujima Noriyuki、Hirata Kenji、Shiga Tohru、Yasuda Koichi、Onimaru Rikiya、Tsuchiya Kazuhiko、Kano Satoshi、Mizumachi Takatsugu、Homma Akihiro、Kudo Kohsuke、Shirato Hiroki
    • Journal Title

      Quantitative Imaging in Medicine and Surgery

      Volume: 8 Issue: 8 Pages: 788-795

    • DOI

      10.21037/qims.2018.09.09

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of a Hybrid IVIM-DKI Model to Predict the Development of Distant Metastasis in Head and Neck Squamous Cell Carcinoma Patients2018

    • Author(s)
      Fujima N, Sakashita T, Homma A, Yoshida D, Kudo K, Shirato H.
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 17 Issue: 1 Pages: 21-27

    • DOI

      10.2463/mrms.mp.2016-0136

    • NAID

      130006306824

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple modification of arm position improves B1+ and signal homogeneity in the thoracolumbar spine at 3T.2018

    • Author(s)
      Ishizaka K, Kudo K, Harada K, Shirai T, Fujiwara T, Aoike S, Takamori S, Shirato H.
    • Journal Title

      J Magn Reson Imaging

      Volume: 47 Issue: 1 Pages: 123-130

    • DOI

      10.1002/jmri.25767

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noninvasive electrical conductivity measurement by MRI: a test of its validity and the electrical conductivity characteristics of glioma.2018

    • Author(s)
      Tha KK, Katscher U, Yamaguchi S, Stehning C, Terasaka S, Fujima N, Kudo K, Kazumata K, Yamamoto T, Van Cauteren M, Shirato H.
    • Journal Title

      Eur Radiol

      Volume: 28 Issue: 1 Pages: 348-355

    • DOI

      10.1007/s00330-017-4942-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indirect Proton MR Imaging and Kinetic Analysis of <sup>17</sup>O-Labeled Water Tracer in the Brain2018

    • Author(s)
      Kudo K, Harada T, Kameda H, Uwano I, Yamashita F, Higuchi S, Yoshioka K, Sasaki M
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 17 Issue: 3 Pages: 223-230

    • DOI

      10.2463/mrms.mp.2017-0094

    • NAID

      130007403768

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity of longitudinal and circumferential contraction in relation to late gadolinium enhancement in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction2018

    • Author(s)
      Sakamoto K, Oyama-Manabe N, Manabe O, Aikawa T, Kikuchi Y, Sasai-Masuko H, Naya M, Kudo K, Kato F, Tamaki N, Shirato H
    • Journal Title

      Jpn J Radiol

      Volume: 36 Issue: 2 Pages: 103-112

    • DOI

      10.1007/s11604-017-0700-5

    • NAID

      210000186047

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accelerating Cell Therapy for Stroke in Japan: Regulatory Framework and Guidelines on Development of Cell-Based Products2018

    • Author(s)
      Houkin K, Shichinohe H, Abe K, Arato T, Dezawa M, Honmou O, Horie N, Katayama Y, Kudo K, Kuroda S, Matsuyama T, Miyai I, Nagata I, Niizuma K, Sakushima K, Sasaki M, Sato N, Sawanobori K, Suda S, Taguchi A, Tominaga T, Yamamoto H, Yamashita T, Yoshimine T.
    • Journal Title

      Stroke

      Volume: 49 Issue: 4

    • DOI

      10.1161/strokeaha.117.019216

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Different Post-Processing Algorithms for Dynamic Susceptibility Contrast Perfusion Imaging of Cerebral Gliomas2017

    • Author(s)
      Kudo K, Uwano I, Hirai T, Murakami R, Nakamura H, Fujima N, Yamashita F, Goodwin J, Higuchi S, Sasaki M
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 16 Issue: 2 Pages: 129-136

    • DOI

      10.2463/mrms.mp.2016-0036

    • NAID

      130005589294

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Delayed contrast-enhanced computed tomography in patients with known or suspected cardiac sarcoidosis: A feasibility study.2017

    • Author(s)
      Aikawa T, Oyama-Manabe N, Naya M, Ohira H, Sugimoto A, Tsujino I, Obara M, Manabe O, Kudo K, Tsutsui H, Tamaki N.
    • Journal Title

      Eur Radiol

      Volume: 27 Issue: 10 Pages: 4054-4063

    • DOI

      10.1007/s00330-017-4824-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-invasive prediction of the tumor growth rate using advanced diffusion models in head and neck squamous cell carcinoma patients.2017

    • Author(s)
      Fujima N, Sakashita T, Homma A, Harada T, Shimizu Y, Tha KK, Kudo K, Shirato H.
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 20 Pages: 33631-33643

    • DOI

      10.18632/oncotarget.16851

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Noninvasive Assessment of Oxygen Extraction Fraction in Chronic Ischemia Using Quantitative Susceptibility Mapping at 7 Tesla2017

    • Author(s)
      Uwano I, Kudo K, Sato R, Ogasawara K, Kameda H, Nomura JI, Mori F, Yamashita F, Ito K, Yoshioka K, Sasaki M
    • Journal Title

      Stroke

      Volume: 48 Issue: 8 Pages: 2136-2141

    • DOI

      10.1161/strokeaha.117.017166

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative Cerebral Oxygen Extraction Fraction Imaging Generated from 7T MR Quantitative Susceptibility Mapping Predicts Development of Cerebral Hyperperfusion following Carotid Endarterectomy.2017

    • Author(s)
      Nomura JI, Uwano I, Sasaki M, Kudo K, Yamashita F, Ito K, Fujiwara S, Kobayashi M, Ogasawara K.
    • Journal Title

      AJNR Am J Neuroradiol.

      Volume: 38(12) Issue: 12 Pages: 499-505

    • DOI

      10.3174/ajnr.a5390

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fast acceleration of ASL-based time-resolved magnetic resonance angiography by acquisition of control and labeled images in the same shot (fast ACTRESS): An optimization study2017

    • Author(s)
      Sugimori H, Fujima N, Suzuki Y, Hamaguchi H, Ishizaka K, Kudo K.
    • Journal Title

      Magn Reson Imaging

      Volume: 43 Pages: 136-143

    • DOI

      10.1016/j.mri.2017.07.026

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indirect MRI of 17o-labeled water using steady-state sequences: Signal simulation and preclinical experiment2017

    • Author(s)
      Kudo K, Harada T, Kameda H, Uwano I, Yamashita F, Higuchi S, Yoshioka K, Sasaki M
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: 47 Issue: 5 Pages: 1373-1379

    • DOI

      10.1002/jmri.25848

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Residual tumour detection in post-treatment granulation tissue by using advanced diffusion models in head and neck squamous cell carcinoma patients.2017

    • Author(s)
      Fujima N, Yoshida D, Sakashita T, Homma A, Kudo K, Shirato H
    • Journal Title

      Eur J Radiol

      Volume: 90 Pages: 14-19

    • DOI

      10.1016/j.ejrad.2017.02.025

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 17O 標識水による水動態イメージング2021

    • Author(s)
      工藤與亮
    • Organizer
      第22回日本正常圧水頭症学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] CT/MRIによる脳梗塞診断と画像診断の最近の話題2021

    • Author(s)
      工藤與亮
    • Organizer
      王子総合病院医療講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] CT・MRIを用いた血流解析:脳から心臓まで2021

    • Author(s)
      工藤與亮
    • Organizer
      北海道心臓核医学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 酸素の安定同位体O17による脳血流・代謝イメージング2021

    • Author(s)
      工藤與亮
    • Organizer
      第46回日本脳卒中学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 北海道における医療AI研究・教育の展望2021

    • Author(s)
      工藤與亮
    • Organizer
      第2回JAMI北海道支部会オンライン学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] QSMとO-17水によるアルツハイマー病早期診断MRI2020

    • Author(s)
      工藤與亮
    • Organizer
      第24回岐阜放射線医学セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 造影ダイナミックCT・MR灌流画像の変遷と最新情報2020

    • Author(s)
      工藤與亮
    • Organizer
      宮崎MRI研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 造影ダイナミックCT・MR灌流画像の歴史と最新の話題2020

    • Author(s)
      工藤與亮
    • Organizer
      第87回北海道MRI画像研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 画像診断の最近の話題2020

    • Author(s)
      工藤與亮
    • Organizer
      北見赤十字病院セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] MR Imaging Features of Primary CNS Lymphoma2020

    • Author(s)
      工藤與亮
    • Organizer
      ベレキシブルWebライブセミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 灌流画像自動解析ソフトPMAの現状と将来展望2020

    • Author(s)
      工藤與亮
    • Organizer
      第45回日本脳卒中学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] PCNSLの特徴的画像所見2020

    • Author(s)
      工藤與亮
    • Organizer
      ベレキシブルWebセミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] MRI定量的磁化率マッピング法(QSM)によるアルツハイマー病の早期診断2020

    • Author(s)
      工藤與亮
    • Organizer
      第61回日本神経学会学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 造影MRI Perfusionの最近の話題2020

    • Author(s)
      工藤與亮
    • Organizer
      第48回日本磁気共鳴医学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 定量的磁化率マッピング(QSM)による臨床応用と将来展望2020

    • Author(s)
      工藤與亮
    • Organizer
      第48回日本磁気共鳴医学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] AIの臨床応用へ:アルツハイマー病の定量的MR画像診断指標の導出2020

    • Author(s)
      工藤與亮
    • Organizer
      第48回日本磁気共鳴医学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 救急の脳CT/MRIと画像診断の最近の話題2020

    • Author(s)
      工藤與亮
    • Organizer
      第1回画像セミナーin十勝
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 水で脳を診る2020

    • Author(s)
      工藤與亮
    • Organizer
      第324回関西NR勉強会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脳卒中診断のピットフォール2020

    • Author(s)
      工藤與亮
    • Organizer
      第56回日本医学放射線学会秋季大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 中枢神経系原発悪性リンパ腫の画像診断2020

    • Author(s)
      工藤與亮
    • Organizer
      ベレキシブルWebセミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 急性期脳梗塞診断の最新情報2020

    • Author(s)
      工藤與亮
    • Organizer
      第34回ミッドウィンターセミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] MR Imaging Features of Primary CNS Lymphoma2020

    • Author(s)
      Kudo K
    • Organizer
      国際Webシンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clinical Applications and Future Perspectives of Quantitative Susceptibility Mapping (QSM)2020

    • Author(s)
      Kudo K
    • Organizer
      ISMRM
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical Applications and Future Perspectives of Quantitative Susceptibility Mapping (QSM)2020

    • Author(s)
      Kudo K
    • Organizer
      MSK MRI Workshop Series
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Imaging Strategies in Acute Stroke: Current Status in Japan2020

    • Author(s)
      Kudo K
    • Organizer
      ASFNR Perfusion Imaging Webinar
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 急性期脳梗塞・脳腫瘍における造影CT/MR灌流画像2019

    • Author(s)
      工藤與亮
    • Organizer
      第78回日本医学放射線学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] QSM解析によるアルツハイマー病早期診断と肝硬変への応用2019

    • Author(s)
      工藤與亮
    • Organizer
      第78回日本医学放射線学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] CT/MR灌流画像による虚血ペナンブラの体積自動計測2019

    • Author(s)
      工藤與亮
    • Organizer
      Hokkaido Neuroendovascular Conference
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] QSMによる神経変性疾患の MRI2019

    • Author(s)
      工藤與亮
    • Organizer
      第17回Radiology Seminar Izumo
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] MR検査の基礎:中枢神経・脊椎領域2019

    • Author(s)
      工藤與亮
    • Organizer
      第20回MR入門講座
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 急性期脳梗塞におけるCT・MR灌流画像の最前線2019

    • Author(s)
      工藤與亮
    • Organizer
      市立札幌病院講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 定量的磁化率マッピングによる認知症診断:脳表解析による診断精度向上2019

    • Author(s)
      工藤與亮
    • Organizer
      題47回日本磁気共鳴医学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] MRI-QSM画像での鉄沈着解析による認知症早期診断2019

    • Author(s)
      工藤與亮
    • Organizer
      第9回日本認知症予防学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 救急の脳CT/MRI2019

    • Author(s)
      工藤與亮
    • Organizer
      釧路市立病院講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] MRI-QSMによるアルツハイマー病診断2019

    • Author(s)
      工藤與亮
    • Organizer
      第38回日本認知症学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] O17標識水による水動態MRI2019

    • Author(s)
      工藤與亮
    • Organizer
      第27回鹿児島画像診断カンファレンス
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 中枢神経・画像診断の3つのポイント2019

    • Author(s)
      工藤與亮
    • Organizer
      Japanese Seminar in RSNA 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脳と体幹部のQSM解析2019

    • Author(s)
      工藤與亮
    • Organizer
      GE Healthcare Seminar
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] CT・MR灌流画像による虚血ペナンブライメージング2019

    • Author(s)
      工藤與亮
    • Organizer
      第22回低侵襲画像診断・治療研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] A Multicenter Study of the Correlation between the Quantitative Susceptibility Mapping (QSM) of Magnetic Resonance Imaging (MRI) and Amyloid Positron Emission Tomography (PET)2019

    • Author(s)
      Kudo K, Sato R, Yamaguchi A, Udo N, Matsushima M, Yabe I, Sasaki M, Harada M, Matsukawa N, Shirai T, Kawata Y, Ochi H, Bito Y
    • Organizer
      AAIC
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oxygen Extraction Fraction (OEF) using QSM in Patients2019

    • Author(s)
      Kudo K
    • Organizer
      5thInternational Workshop on MRI Phase Contrast & Quantitative Susceptibility Mapping
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] QSM Analysis for the Early Diagnosis of Alzheimer’s Disease2019

    • Author(s)
      Kudo K
    • Organizer
      ASFNR
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] O-17 Imaging to Open the Next Door of Neuroscience2019

    • Author(s)
      Kudo K
    • Organizer
      4thISMRM Japan Chapter
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] QSM解析で広がる新しい診断の世界2019

    • Author(s)
      工藤與亮
    • Organizer
      Hi advanced MRI セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] O-17 MRIによる脳血流・水動態解析2019

    • Author(s)
      工藤與亮
    • Organizer
      先端総合イメージングセミナー2019
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] MRI-QSMによるAD早期診断2019

    • Author(s)
      工藤與亮
    • Organizer
      AD研究会画像診断サブコミッティ2019
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] パーキンソニズムの多角的MRI診断2019

    • Author(s)
      工藤與亮
    • Organizer
      第48回日本神経放射線学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] QSMによる脳・体幹部診断2019

    • Author(s)
      工藤與亮
    • Organizer
      第19階桜山イメージングセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] QSMによる認知症のMRI早期診断2019

    • Author(s)
      工藤與亮
    • Organizer
      第42回日本脳神経CI学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] MR灌流画像の最新解析技術2019

    • Author(s)
      工藤與亮
    • Organizer
      第38回日本画像医学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 放射線科医の立場から~加算をとっていない立場~2018

    • Author(s)
      工藤與亮
    • Organizer
      第77回日本医学放射線学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 本邦におけるCT/MR灌流画像の在り方について考える2018

    • Author(s)
      工藤與亮
    • Organizer
      第4回FASTカンファレンス
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 主訴に沿う:俯瞰し収束する画像診断の目「パーキンソン症状」2018

    • Author(s)
      工藤與亮
    • Organizer
      第59回日本神経学会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] アルツハイマー病のMRI: アミロイド病理・鉄沈着を反映するQSM画像2018

    • Author(s)
      工藤與亮
    • Organizer
      第59回日本神経学会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] MR検査の基礎:中枢神経・脊椎領域2018

    • Author(s)
      工藤與亮
    • Organizer
      第19回MR入門講座
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 頭部救急画像診断のABC2018

    • Author(s)
      工藤與亮
    • Organizer
      MIL画像診断セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] PMA最新情報2018

    • Author(s)
      工藤與亮
    • Organizer
      脳血管内治療ブラッシュアップセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] パーキンソニズムのMRI診断2018

    • Author(s)
      工藤與亮
    • Organizer
      第47回断層映像研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脳血管障害の画像診断ABC2018

    • Author(s)
      工藤與亮
    • Organizer
      第18回網走放射線画像勉強会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] QSM (Quantitative Susceptibility Mapping)2018

    • Author(s)
      工藤與亮
    • Organizer
      第22回MR実践講座
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] MR Diagnosis of Alzheimer’s Disease using Quantitative Susceptibility Mapping2018

    • Author(s)
      工藤與亮
    • Organizer
      第58回日本核医学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 酸素の安定同位体O-17によるMRIイメージング2017

    • Author(s)
      工藤與亮
    • Organizer
      第2回北海道カムイカンファレンス
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Current Topics of Cerebral Perfusion and Oxygen Metabolism Imaging2017

    • Author(s)
      工藤與亮
    • Organizer
      第45回日本磁気共鳴医学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 酸素の安定同位体O-17を用いたMRI撮像2017

    • Author(s)
      工藤與亮
    • Organizer
      第33回Brain Function Imaging Conference
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Current Updates of QSM Sequence and Analysis: Alzheimer's Disease2017

    • Author(s)
      工藤與亮
    • Organizer
      JKT neuroradiology workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Patent(Industrial Property Rights)] 画像処理装置、画像処理方法、画像処理プログラム及び磁気共鳴イメージング装置2018

    • Inventor(s)
      佐藤良太、工藤與亮、白猪亨、河田康雄
    • Industrial Property Rights Holder
      佐藤良太、工藤與亮、白猪亨、河田康雄
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-160616
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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