Visualization of Cellular Metabolism using O-17 Oxygen MRI
| Project/Area Number |
17H04254
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Kudo Kohsuke 北海道大学, 医学研究院, 教授 (10374232)
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| Co-Investigator(Kenkyū-buntansha) |
小牧 裕司 公益財団法人実験動物中央研究所, ライブイメージングセンター, 室長代理 (10548499)
阿保 大介 北海道大学, 大学病院, 准教授 (30399844)
加藤 扶美 北海道大学, 大学病院, 講師 (80399865)
外山 穏香 (菊池穏香) 北海道大学, 医学研究院, 特任助教 (80783539)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 酸素代謝 / グルコース代謝 / 水動態 / MRI / O-17 / 核磁気共鳴画像（MRI） / 水動態解析 / 核磁気共鳴画像（ＭＲＩ） |
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| Outline of Final Research Achievements |
Theoretical equation that converts MRI signal to O-17 concentration was successfully derived from the phantom acquisition (containing different concentration of O-17 water) and signal simulation of MRI. MRI experiments of culture cells in vitro were performed, and significant signal changes were observed after administration of O-17 gas or O-17 glucose, which were then converted into O-17 water. These results suggested that oxygen and glucose metabolisms could be measured by MRI using O-17. Intrathecal administration of O-17 water in rats were also conducted and dynamic signal changes of MRI in cerebrospinal fluid spaces were visualized. Quantitative water kinetics could be analyzed using human MRI data of intrathecal administration of O-17 water.
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| Academic Significance and Societal Importance of the Research Achievements |
O-17酸素ガスの吸入によるMRI酸素代謝イメージングや、O-17グルコース分子によるMRI糖代謝イメージングの実現により、様々な中枢神経疾患の鑑別診断や重症度診断、治療効果判定などを非侵襲的かつ安全に行うことが可能となる。また、将来的には脳以外の臓器にも応用可能であり、全身の酸素代謝イメージングや糖代謝イメージングに発展するポテンシャルがある。さらに、O-17水分子での血流イメージングや水動態イメージングと組み合わせることで、組織の血流・水動態・酸素代謝・エネルギー代謝をMRIで総括的に評価することが可能となる。
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Report
(4 results)
Research Products
(101 results)
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[Journal Article] Machine-Learning-Based Prediction of Treatment Outcomes Using MR Imaging-Derived Quantitative Tumor Information in Patients with Sinonasal Squamous Cell Carcinomas: A Preliminary Study.2019
Author(s)
Fujima N, Shimizu Y, Yoshida D, Kano S, Mizumachi T, Homma A, Yasuda K, Onimaru R, Sakai O, Kudo K, Shirato H
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Journal Title
Cancers
Volume: 11
Issue: 6
Pages: 800-800
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Noninvasive electrical conductivity measurement by MRI: a test of its validity and the electrical conductivity characteristics of glioma.2018
Author(s)
Tha KK, Katscher U, Yamaguchi S, Stehning C, Terasaka S, Fujima N, Kudo K, Kazumata K, Yamamoto T, Van Cauteren M, Shirato H.
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Journal Title
Eur Radiol
Volume: 28
Issue: 1
Pages: 348-355
DOI
Related Report
Peer Reviewed
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[Journal Article] Heterogeneity of longitudinal and circumferential contraction in relation to late gadolinium enhancement in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction2018
Author(s)
Sakamoto K, Oyama-Manabe N, Manabe O, Aikawa T, Kikuchi Y, Sasai-Masuko H, Naya M, Kudo K, Kato F, Tamaki N, Shirato H
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Journal Title
Jpn J Radiol
Volume: 36
Issue: 2
Pages: 103-112
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Accelerating Cell Therapy for Stroke in Japan: Regulatory Framework and Guidelines on Development of Cell-Based Products2018
Author(s)
Houkin K, Shichinohe H, Abe K, Arato T, Dezawa M, Honmou O, Horie N, Katayama Y, Kudo K, Kuroda S, Matsuyama T, Miyai I, Nagata I, Niizuma K, Sakushima K, Sasaki M, Sato N, Sawanobori K, Suda S, Taguchi A, Tominaga T, Yamamoto H, Yamashita T, Yoshimine T.
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Journal Title
Stroke
Volume: 49
Issue: 4
DOI
Related Report
Peer Reviewed
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[Journal Article] Comparison of Different Post-Processing Algorithms for Dynamic Susceptibility Contrast Perfusion Imaging of Cerebral Gliomas2017
Author(s)
Kudo K, Uwano I, Hirai T, Murakami R, Nakamura H, Fujima N, Yamashita F, Goodwin J, Higuchi S, Sasaki M
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Journal Title
Magnetic Resonance in Medical Sciences
Volume: 16
Issue: 2
Pages: 129-136
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Delayed contrast-enhanced computed tomography in patients with known or suspected cardiac sarcoidosis: A feasibility study.2017
Author(s)
Aikawa T, Oyama-Manabe N, Naya M, Ohira H, Sugimoto A, Tsujino I, Obara M, Manabe O, Kudo K, Tsutsui H, Tamaki N.
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Journal Title
Eur Radiol
Volume: 27
Issue: 10
Pages: 4054-4063
DOI
Related Report
Peer Reviewed
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[Journal Article] Noninvasive Assessment of Oxygen Extraction Fraction in Chronic Ischemia Using Quantitative Susceptibility Mapping at 7 Tesla2017
Author(s)
Uwano I, Kudo K, Sato R, Ogasawara K, Kameda H, Nomura JI, Mori F, Yamashita F, Ito K, Yoshioka K, Sasaki M
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Journal Title
Stroke
Volume: 48
Issue: 8
Pages: 2136-2141
DOI
Related Report
Peer Reviewed
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[Presentation] A Multicenter Study of the Correlation between the Quantitative Susceptibility Mapping (QSM) of Magnetic Resonance Imaging (MRI) and Amyloid Positron Emission Tomography (PET)2019
Author(s)
Kudo K, Sato R, Yamaguchi A, Udo N, Matsushima M, Yabe I, Sasaki M, Harada M, Matsukawa N, Shirai T, Kawata Y, Ochi H, Bito Y
Organizer
AAIC
Related Report
Int'l Joint Research
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