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Development of newly almina^based adsorbent with excellent spatial structure which promotes domestic production of 99Mo/99mTc

Research Project

Project/Area Number 17H04256
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKobe University (2018-2019)
University of Tsukuba (2017)

Principal Investigator

Fukumitsu Nobuyoshi  神戸大学, 医学研究科, 客員准教授 (40277075)

Co-Investigator(Kenkyū-buntansha) 土谷 邦彦  国立研究開発法人日本原子力研究開発機構, 高速炉・新型炉研究開発部門 大洗研究所 環境技術開発センター 材料試験炉部, 課長 (50343926)
松本 孔貴  筑波大学, 医学医療系, 助教 (70510395)
藤田 善貴 (鈴木 喜貴)  国立研究開発法人日本原子力研究開発機構, 高速炉・新型炉研究開発部門 大洗研究所 環境技術開発センター 材料試験炉部, 研究職 (70766857)
Malgras Victor  国立研究開発法人物質・材料研究機構, 若手国際研究センター, ICYS研究員 (70773927)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywordsモリブデン / テクネチウム / 国産化 / アルミナ / 吸着材 / メソポーラス / メソポーラス加工 / 99Mo / 99mTc
Outline of Final Research Achievements

In the first synthesized mesoporous alumina, many pores were confirmed on the surface, and alumina particles with a large surface area were completed, but the structure was fragile. In the mesoporous alumina-silica composite, the defect of structural brittleness was improved. Mo adsorption capacity was the highest at 16.8 mg Mo · g-1 under the conditions of aluminum / silica molecular ratio of 0.6, calcination temperature of 750 ° C and pH = 3. Finally, the synthesis using the solvothermal method was tried as a method without using a template. As a result of gradually changing the production conditions by the solvothermal method, the Mo adsorption capacity was the highest at 56.2 mg Mo · g-1 under the conditions of firing time of 24 hours and calcination temperature of 700 ° C.

Academic Significance and Societal Importance of the Research Achievements

医用材料として用いられているアルミナ粒子の空間構造を変えることで表面積の大きさが変化し、Mo吸着能に直接影響を与えることを明らかにしたことが一番の学術的意義である。また、複数の方法で合成法を試みることで、どのような条件がアルミナ粒子の構造の強固さ、作業の簡便性、表面積の大きさに影響を与えるのか明らかにできた。99Mo/99mTc 国産化は、緊急に対処すべき課題であり、諸外国の事情に左右されない「安定的な医療の実現」に直接貢献できるための道筋を作っている。患者、医療者、医療産業いずれの側面でも社会的意義が大きい研究である。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (11 results)

All 2020 2019 2018 2017

All Journal Article (6 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (5 results)

  • [Journal Article] Self-sacrificial templated synthesis of a three-dimensional hierarchical macroporous honeycomb-like ZnO/ZnCo2O4 hybrid for carbon monoxide sensing2019

    • Author(s)
      Kaneti Yusuf Valentino、Wulan Septiani Ni Luh、Saptiama Indra、Jiang Xuchuan、Yuliarto Brian、Shiddiky Muhammad J. A.、Fukumitsu Nobuyoshi、Kang Yong-Mook、Golberg Dmitri、Yamauchi Yusuke
    • Journal Title

      Journal of Materials Chemistry A

      Volume: 7 Issue: 7 Pages: 3415-3425

    • DOI

      10.1039/c8ta11380g

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biomolecule‐Assisted Synthesis of Hierarchical Multilayered Boehmite and Alumina Nanosheets for Enhanced Molybdenum Adsorption2019

    • Author(s)
      Saptiama Indra、Kaneti Yusuf Valentino、Yuliarto Brian、Kumada Hiroaki、Tsuchiya Kunihiko、Fujita Yoshitaka、Malgras Victor、Fukumitsu Nobuyoshi、Sakae Takeji、Hatano Kentaro、Ariga Katsuhiko、Sugahara Yoshiyuki、Yamauchi Yusuke
    • Journal Title

      Chemistry A European Journal

      Volume: 25 Issue: 18 Pages: 4843-4855

    • DOI

      10.1002/chem.201900177

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molybdenum Adsorption Properties of Alumina-Embedded Mesoporous Silica for Medical Radioisotope Production2018

    • Author(s)
      Saptiama Indra、Kaneti Yusuf Valentino、Oveisi Hamid、Suzuki Yoshitaka、Tsuchiya Kunihiko、Takai Kimiko、Sakae Takeji、Pradhan Subrata、Hossain Md. Shahriar A.、Fukumitsu Nobuyoshi、Ariga Katsuhiko、Yamauchi Yusuke
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 91 Issue: 2 Pages: 195-200

    • DOI

      10.1246/bcsj.20170295

    • NAID

      130006350313

    • ISSN
      0009-2673, 1348-0634
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Template-free fabrication of mesoporous alumina nanospheres using post-synthesis water-ethanol treatment of monodispersed aluminium glycerate nanospheres for molybdenum adsorption2018

    • Author(s)
      Saptiama I, Kaneti YV, Suzuki Y, Tsuchiya K, Fukumitsu N, Sakae T, Kim J, Kang YM, Ariga K, Yamauchi Y
    • Journal Title

      Small

      Volume: - Issue: 21 Pages: 1800474-1800474

    • DOI

      10.1002/smll.201800474

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 45.メソポーラス加工を応用した新規アルミナ吸着剤の開発2018

    • Author(s)
      福光延吉, 山内悠輔, Indra Saptima, 有賀克彦, 籏野健太郎, 熊田博明, 藤田善貴, 土谷邦彦
    • Journal Title

      Isotopenews

      Volume: 760 Pages: 15-18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mesoporous Alumina as an Effective Adsorbent for Molybdenum (Mo) toward Instant Production of Radioisotope for Medical Use2017

    • Author(s)
      Saptiama Indra、Kaneti Yusuf Valentino、Suzuki Yumi、Suzuki Yoshitaka、Tsuchiya Kunihiko、Sakae Takeji、Takai Kimiko、Fukumitsu Nobuyoshi、Alothman Zeid Abdullah、Hossain Md. Shahriar A.、Ariga Katsuhiko、Yamauchi Yusuke
    • Journal Title

      Bulletin of the chemical society of Japan

      Volume: 90 Issue: 10 Pages: 1174-1179

    • DOI

      10.1246/bcsj.20170184

    • NAID

      130006770675

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 高性能Mo吸着材の開発2020

    • Author(s)
      305.福光延吉、山内悠輔、Indra Saptim、有賀克彦、籏野健太郎、熊田博明、藤田善孝、土谷邦彦
    • Organizer
      第92回日本核医学会関東甲信越地方会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 99mTc 国産化に向けてのMo吸着剤の開発2019

    • Author(s)
      296.福光延吉, 山内悠輔, Indra Saptima, 有賀克彦, 籏野健太郎, 熊田博明, 藤田善孝, 土谷邦彦
    • Organizer
      第322回日本医学放射線学会関西地方会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高性能Mo吸着剤2019

    • Author(s)
      300.福光延吉、山内悠輔、Indra Saptim、有賀克彦、籏野健太郎、熊田博明、藤田善孝、土谷邦彦
    • Organizer
      第59回日本核医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高性能Mo吸着剤の開発2018

    • Author(s)
      福光延吉, 山内悠輔, Indra Saptima, 有賀克彦, 籏野健太郎, 熊田博明, 藤田善孝, 土谷邦彦
    • Organizer
      第89回日本核医学会関東甲信越地方会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of effective adsorbent for Molybdenum2018

    • Author(s)
      Nobuyoshi Fukumitsu, Yusuke Yamauchi, Indra Saptiama, Katsuhiko Ariga, Kentaro Hatano, Hiroaki Kumada, Yoshitaka Suzuki, Kunihiko Tsuchiya
    • Organizer
      第58回日本核医学会
    • Related Report
      2018 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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