Analysis of neoantigen-specific anti-tumor immune responses and its clinical application for personalized cancer immunotherapy
| Project/Area Number |
17H04278
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kanagawa Cancer Center Research Institute |
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Principal Investigator |
Sasada Tetsuro 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), がんワクチン・免疫センター, 部長 (70293967)
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| Co-Investigator(Kenkyū-buntansha) |
岸 裕幸 富山大学, 学術研究部医学系, 教授 (60186210)
東 公一 久留米大学, 医学部, 講師 (00368896)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | ネオアンチゲン / 腫瘍免疫 / 遺伝子変異 / 免疫反応 / 個別化治療 / ゼノグラフト / 抗腫瘍効果 / 細胞表面マーカー / 免疫療法 |
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| Outline of Final Research Achievements |
The aim of this study was to develop the methods to efficiently identify tumor-specific T cells recognizing neoantigens in cancer patients. This study demonstrated that T cells positive for multiple T cell markers, such as immune checkpoints and co-stimulatory molecules, can recognize and respond to tumor cells, suggesting that assessment of multiple T cell markers might be useful for efficient identification of tumor-specific T cells recognizing neoantigens. These findings could establish the basic knowledge and technology to facilitate clinical application of personalized cancer immunotherapy.
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| Academic Significance and Societal Importance of the Research Achievements |
がん免疫療法を今後さらに発展させるためには、がん特異的なＴ細胞を選択的に活性化させる特異的がん免疫療法の開発が不可欠である。ネオアンチゲンは高い免疫原性が期待できるうえに自己免疫反応を惹起する心配も少ないため、特異的がん免疫療法の格好の標的と思われる。本研究によりネオアンチゲンを認識すると思われる腫瘍反応性Ｔ細胞を効率的に同定できる手法が開発されたことから、本研究の成果は“個別化がん免疫治療”の臨床応用を加速するための知的・技術的基盤の確立に寄与するものと期待される。
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Distribution of Regulatory T-Cells and Other Phenotypes of T-Cells in Tumors and Regional Lymph Nodes of Colorectal Cancer Patients.2020
Author(s)
Kazama K, Otake J, Satoyoshi T, Shiozawa M, Sugano N, Sato S, Atsumi Y, Kano K, Murakawa M, Maezawa Y, Hashimoto I, Numata M, Oshima T, Yukawa N, Rino Y, Sasada T, Masuda M.
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Journal Title
In Vivo.
Volume: 34
Issue: 2
Pages: 849-856
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer.2020
Author(s)
Ohkuma R, Yada E, Ishikawa S, Komura D, Ishizaki H, Tamada K, Kubota Y, Hamada K, Ishida H, Hirasawa Y, Ariizumi H, Satoh E, Shida M, Watanabe M, Onoue R, Ando K, Tsurutani J, Yoshimura K, Yokobori T, Sasada T, Aoki T, Murakami M, Norose T, Ohike N, Takimoto M, Izumizaki M, Kobayashi S, Tsunoda T, Wada S.
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Journal Title
PLoS One
Volume: 10
Issue: 1
Pages: e0226707-e0226707
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Association between soluble immune mediators and tumor responses in patients with nonsmall cell lung cancer treated with anti-PD-1 inhibitor.2019
Author(s)
Matsuo N, Azuma K, Hattori S, Ohtake J, Kawahara A, Ishii H, Tokito T, Yamada K, Shibata Y, Shimokawaji T, Kondo T, Kato T, Saito H, Yamada K, Sasada T, Hoshino T.
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Journal Title
Int J Cancer.
Volume: 144
Issue: 5
Pages: 1170-1179
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A randomized, double-blind, phase III trial of personalized peptide vaccination for recurrent glioblastoma.2018
Author(s)
Narita Y, Arakawa Y, Yamasaki F, Nishikawa R, Aoki T, Kanamori M, Nagane M, Kumabe T, Hirose Y, Ichikawa T, Kobayashi H, Fujimaki T, Goto H, Takeshima H, Ueba T, Abe H, Tamiya T, Sonoda Y, Natsume A, Kakuma T, Sugita Y, Komatsu N, Yamada A, Sasada T, Matsueda S, Shichijo S, Itoh K, Terasaki M.
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Journal Title
Neuro Oncol.
Volume: 21
Issue: 3
Pages: 348-359
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic stratification of patients with nasopharyngeal carcinoma based on tumor immune microenvironment.2018
Author(s)
Ono T, Azuma K, Kawahara A, Sasada T, Matsuo N, Kakuma T, Kamimura H, Maeda R, Hattori C, On K, Nagata K, Sato F, Chitose SI, Shin B, Aso T, Akiba J, Umeno H.
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Journal Title
Head Neck.
Volume: 40
Issue: 9
Pages: 2007-2019
DOI
Related Report
Peer Reviewed
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[Journal Article] Personalized peptide vaccination as second-line treatment for metastatic upper tract urothelial carcinoma.2017
Author(s)
Suekane S, Ueda K, Nishihara K, Sasada T, Yamashita T, Koga N, Yutani S, Shichijo S, Itoh K, Igawa T, Noguchi M.
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Journal Title
Cancer Sci.
Volume: 108
Issue: 12
Pages: 2430-2437
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] High expression of Olfactomedin-4 correlates with chemoresistance and poor prognosis for pancreatic cancer.2019
Author(s)
Ryotaro Ohkuma, Erica Yada, Yutaro Kubota, Kazuyuki Hamada, Hiroo Ishida, Yuya Hirasawa, Hirotsugu Ariizumi, Etsuko Satoh, Junji Tsurutani, Kiyoshi Yoshimura, Tetsuro Sasada, Takeshi Aoki, Masahiko Murakami, Tomoko Norose, Nobuyuki Ohike, Masafumi Takimoto, Takuya Tsunoda, Satoshi Wada.
Organizer
AACR Annual Meeting 2019
Related Report
Int'l Joint Research
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[Presentation] Early changes in plasma CXCL2 and MMP2 levels predicts the response to anti-PD-1 therapy in non-small-cell lung cancer.2019
Author(s)
Matsuo N, Azuma K, Murotani K, Ishii H, Tokito T, Yamada K,Shibata Y, Shimokawaji T, Nakahara Y, Kondo T, Kato T, Saito H, Yamada K, Sasada T, Hoshino T.
Organizer
2019 World Conference on Lung Cancer
Related Report
Int'l Joint Research
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[Presentation] Proteogenomics-based identifying neoantigens in refractory cancers using xenograft mice.2019
Author(s)
Yuko Nakamura, Susumu Iizumi, Hiroki Ueda, Shogo Yamamoto, Kenji Tatsuno, Aya Nakayama, Kazuki Yamamoto, Taku Koro, Kyoko Hasegawa, Norihiro Nakamura, Hiroyuki Aburatani, Tetsuro Sasada, Takeshi Kawamura.
Organizer
18th Human Proteome Organization World Congress
Related Report
Int'l Joint Research
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[Presentation] Tumor responses and early onset cytokine release syndrome in synovial sarcoma patients treated with a novel affinity-enhanced NY-ESO-1-targeting TCR-redirected T cell transfer.2019
Author(s)
Ishihara M, Kitano S, Hattori H, Miyahara Y, Kato H, Mishima H, Yamamoto N, Funakoshi T, Kojima T, Sasada T, Sato E, Okamoto S, Tomura D, Chono H, Nukaya I, Mineno J, Ikeda H, Watanabe T, Kageyama S, Shiku H.
Organizer
ASCO Annual Meeting 2019
Related Report
Int'l Joint Research
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[Presentation] A novel affinity-enhanced NY-ESO-1-targeting TCR-redirected T cell transfer exhibited early-onset cytokine release syndrome and subsequent tumor responses in synovial sarcoma patients.2019
Author(s)
Hattori H, Ishihara M, Kitano S, Miyahara Y, Kato H, Mishima H, Yamamoto N, Funakoshi T, Kojima T, Sasada T, Sato E, Okamoto S, Tomura D, Chono H, Nukaya I, Mineno J, Ikeda H, Watanabe T, Kageyama S, Shiku H.
Organizer
ESMO 2019 Congress
Related Report
Int'l Joint Research
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[Presentation] Changes in plasma CXCL2 and MMP2 levels reflect response to anti-PD-1 therapy in non-small-cell lung cancer patients.2019
Author(s)
Norikazu Matsuo, Koichi Azuma, Kenta Murotani, Yoshiko Naito, Hidenobu Ishii, Takaaki Tokito, Tadasuke Shimokawaji, Yoshiro Nakahara, Tetsuro Kondo, Terufumi Kato Haruhiro Saito, Kouzo Yamada, Tetsuro Sasada, Tomoaki Hoshino.
Organizer
第17回日本臨床腫瘍学会学術集会
Related Report
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[Presentation] Changes of BCR repertoire are predictive biomarker for the efficacy of immune checkpoint inhibitor in NSCLC.2019
Author(s)
Yoshiro Nakahara, Norikazu Matsuo, Koichi Azuma, Yoshiko Naito, Hidenobu Ishii, Takaaki Tokito, Yuka Igarashi, Taku Kouro, Ryo Usui, Tadasuke Shimokawaji, Tetsuro Kondo, Terufumi Kato, Haruhiro Saito, KouzoYamada, Tomoaki Hoshino, Tetsuro Sasada.
Organizer
第17回日本臨床腫瘍学会学術集会
Related Report
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