| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Outline of Final Research Achievements |
The applicants (1) identified the mechanical stress response factor TSP1 and (2) proved its causal relationship with aortic aneurysm using a mouse model. From the analysis of human aortic aneurysm samples, we found that (3) TSP1 was significantly elevated in human thoracic aorta. These results have led to numerous publications and conference presentations. The importance of TSP1 was also found not only in aortic aneurysms but also in vascular remodeling by shunting (joint research with Emory University, USA). The relationship between vascular biomechanics and aortic aneurysms was also developed into an international collaborative study using 10 different mouse models, including 4 universities in the U.S., and we were able to achieve results beyond our expectations. For this reason, we submitted an application one year ahead.
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