| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
We succeeded to induce cerebral organoids from human ES/iPS cells, and reported the results (Sakaguchi et al. Stem Cell Rep 2019). Next we transplanted the cerebral organoids into murine brain and found that early-stage organoids survive better and extend more axons along cerebrospinal tract, and that they showed neural overgrowth due to proliferating progenitors. The results are now under submission to an international journal.
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