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Reconstruction of cerebrospinal pathway using iPS cells

Research Project

Project/Area Number 17H04302
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurosurgery
Research InstitutionKyoto University

Principal Investigator

TAKAHASHI Jun  京都大学, iPS細胞研究所, 教授 (10270779)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywords神経再生 / 再生医学
Outline of Final Research Achievements

We succeeded to induce cerebral organoids from human ES/iPS cells, and reported the results (Sakaguchi et al. Stem Cell Rep 2019). Next we transplanted the cerebral organoids into murine brain and found that early-stage organoids survive better and extend more axons along cerebrospinal tract, and that they showed neural overgrowth due to proliferating progenitors. The results are now under submission to an international journal.

Academic Significance and Societal Importance of the Research Achievements

脳血管疾患の患者数は100万人を超え、その後遺症による運動麻痺は要介護原因の1位を占める。その他、頭部外傷や筋萎縮性側索後遺症(ALS)など皮質脊髄路を形成する大脳運動ニューロンの障害のために非可逆的な運動機能低下に陥る患者は多く、患者福祉はもちろん医療経済的にもその治療法開発は急務である。本研究では、細胞移植と遺伝子治療の相乗効果により皮質脊髄路を再構築し、運動機能低下に対する再生医療技術の確立を目指す。
この成果は脳血管障害患者の症状改善だけでなく、全ての脳機能障害患者の症状改善に対する本質的かつ革新的治療アプローチとなる可能性を含んでいる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (18 results)

All 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (13 results) (of which Int'l Joint Research: 6 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] University of Oxford(英国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Self-organized synchronous calcium transients in a cultured human neural network derived from cerebral organoids.2019

    • Author(s)
      Sakaguchi H, Ozaki Y, Ashida T, Matsubara T, Oishi N, Kihara S, Takahashi J.
    • Journal Title

      Stem Cell Rep.

      Volume: 13 Issue: 3 Pages: 458-473

    • DOI

      10.1016/j.stemcr.2019.05.029

    • NAID

      120006888502

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Ethics of Cerebral Organoid Research: Being Conscious of Consciousness2019

    • Author(s)
      Sawai Tsutomu、Sakaguchi Hideya、Thomas Elizabeth、Takahashi Jun、Fujita Misao
    • Journal Title

      Stem Cell Reports

      Volume: 13 Issue: 3 Pages: 440-447

    • DOI

      10.1016/j.stemcr.2019.08.003

    • NAID

      120006734877

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Therapeutic effects of combined cell transplantation and locomotor training in rats with brain injury.2019

    • Author(s)
      Shimogawa T, Sakaguchi H, Kikuchi T, Tsuchimochi R, Sano N, Torikoshi S, Ito A, Aoyama T, Iihara K, Takahashi J.
    • Journal Title

      NPJ Regen Med.

      Volume: 4 Issue: 1 Pages: 13-13

    • DOI

      10.1038/s41536-019-0075-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 細胞の自己組織化能によって形成されるヒト多能性幹細胞由来の海馬、 大脳皮質、および脊髄、大脳皮質組織とその神経活動へのアプローチ2019

    • Author(s)
      坂口 秀哉
    • Organizer
      奈良先端科学技術大学院大学  研究科セミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] ENRICHMENT OF MOUSE SUBCEREBRAL PROJECTION NEURONS USING L1CAM2018

    • Author(s)
      Bumpei Samata
    • Organizer
      ISSCR Annual Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SELF-ORGANIZED SYNCHRONIZATION IN HUMAN NEURONAL NETWORK ACTIVITY DERIVED FROM CEREBRAL ORGANOID2018

    • Author(s)
      Hideya Sakaguchi
    • Organizer
      ISSCR Annual Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細胞の自己組織化能によって掲載されるヒト多能性幹細胞由来の大脳オルガノイド~イメージングによる多面的評価と新しいアプローチ~2018

    • Author(s)
      坂口 秀哉
    • Organizer
      第1回イノベーションフォーラム・ジャパン大阪-再生医療研究を'治療'に繋げる最先端技術
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細胞の自己組織化能によって形成されるヒト多能性幹細胞由来の海馬、大脳皮質、および脊髄組織2018

    • Author(s)
      坂口 秀哉
    • Organizer
      金沢大学(河崎洋志研究室)セミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] Self-organized human neuronal network activity derived from cerebral organoids2018

    • Author(s)
      Hideya Sakaguchi
    • Organizer
      Neuroscience 2018 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Purification of Mouse Cortical Neurons2017

    • Author(s)
      Bumpei Samata
    • Organizer
      ISSCR 2017 Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Three-dimensional Evaluation of Human Embryonic Stem Cell-derived Cerebral Organoid2017

    • Author(s)
      Hideya Sakaguchi
    • Organizer
      ISSCR 2017 Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒト胚性幹細胞由来の背内側終脳領域からの機能的な海馬神経細胞の生成2017

    • Author(s)
      坂口 秀哉
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A possible cell surface marker to enrich cortical motor neurons2017

    • Author(s)
      Bumpei Samata
    • Organizer
      14th International Symposium on Neural Transplantation & Repair
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細胞の自己組織化能によって形成されるヒト多能性幹細胞由来の3次元大脳組織2017

    • Author(s)
      坂口 秀哉
    • Organizer
      Japan Spotfire User Group Meeting (Spotfire総会 2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 細胞の自己組織化能によって形成されるヒト多能性幹細胞由来の海馬および大脳組織2017

    • Author(s)
      坂口 秀哉
    • Organizer
      平成29年度ライフサイエンスイノベーション推進機構セミナー
    • Related Report
      2017 Annual Research Report
  • [Presentation] Generation of cortical motor neurons from iPS cells2017

    • Author(s)
      高橋 淳
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 大脳皮質細胞からのL1CAM陽性細胞の取得およびその細胞製剤としての使用2018

    • Inventor(s)
      高橋 淳、佐俣 文平、佐野 徳隆
    • Industrial Property Rights Holder
      高橋 淳、佐俣 文平、佐野 徳隆
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-247960
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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