Development of Innovative Gene-Virus Therapy for Tumor Lysis, Immunity Induction, and Cancer Stem Cell Suppression in Bone and Soft Tissue Sarcoma.
| Project/Area Number |
17H04315
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
近藤 亨 北海道大学, 遺伝子病制御研究所, 教授 (30270573)
三井 薫 鹿児島大学, 医歯学域医学系, 准教授 (40324975)
永野 聡 鹿児島大学, 医歯学域医学系, 教授 (50373139)
伊地知 暢広 鹿児島大学, 医歯学域医学系, 助教 (80380624)
入江 理恵 鹿児島大学, 医歯学域医学系, 助教 (90381178)
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
|
|---|
| Keywords | 癌 / ウイルス / 遺伝子 / 免疫学 |
|---|
| Outline of Final Research Achievements |
We generated novel Surv.m-CRA expressing various therapeutic genes and analyzed their in vitro expression and various functions (tumor lysis, systemic anti-tumor immunity induction, etc.). These experiments first confirmed the expression and function of the therapeutic genes in each of the novel Surv. m-CRA and then largely confirmed their therapeutic properties. In addition, we conducted treatment experiments on several novel Surv. m-CRA in in vivo animal models to confirm their therapeutic efficacy. Thus, therapeutic properties of each new Surv. m-CRA-1 as well as experimental data on its usefulness, have been obtained from time to time.
|
| Academic Significance and Societal Importance of the Research Achievements |
学術的意義は、独自開発のm-CRA癌治療薬に、自身らが同定した治療遺伝子と発現システムを組み込む技術自体が、研究代表者のみ可能という優位性を持つ。さらに、腫瘍溶解性ウイルスに複数の遺伝子や制御ユニットなどの仕組みを導入し、革新的治療作用で劇的相乗的な癌治療薬効果を誘導する点で、科学的独創先駆性も持つ。
社会的意義は、独自技術開発が乏しい本邦で遅れている本分野の科学研究の発展に貢献する。医師主導治験までの実績を持つ基盤からの発展研究のため、目標の骨軟部肉腫の革新的な医薬開発の研究成果が期待できる。長期的には「本邦発の革新医薬の創出」により国民福祉や経済の向上という大きな波及効果も期待できる。
|
Report
(4 results)
Research Products
(40 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Phase I Study of Potentially "Best-in-Class" Survivin-Responsive Conditionally Replicating Adenovirus for Advanced Sarcoma Actually Demonstrates Potent and Long-Term Efficacy and High Safety2018
Author(s)
Ken-ichiro Kosai, Satoshi Nagano, Toshitaka Futagawa, Eriko Sumi, Nobuhiro Ijichi, Munekazu Yamaguchi, Masanori Nakajo, Teruto Hashiguchi, Yasuo Takeda, Takashi Yoshiura, Akira Shimizu, Muneo Takatani, Setsuro Komiya
Organizer
AMERICAN SOCIETY of GENE & CELL THERAPY(21stAnnual Meething ASGCT )
Related Report
Int'l Joint Research
-
[Presentation] Phase I Study of Potentially "Best-in-Class" Survivin-Responsive Conditionally Replicating Adenovirus for Advanced Sarcoma Actually Demonstrates Potent and Long-Term Efficacy and High Safety2018
Author(s)
S.Nagano, T.Futagawa, E.Sumi, N.Ijichi, M.Yamaguchi, M.Nakajo, T.hashiguchi, Y.Takeda, T.Yoshiura, A.Shimizu, M.Takatani, S.Komiya, K-i.Kosai
Organizer
American Association for Cancer Research(AACR Annual Meeting)
Related Report
Int'l Joint Research
-
-
[Presentation] Development of next-generation oncolytic viro-immuno-therapy and investigator-initiated first-in-human clinical trial2018
Author(s)
Ken-ichiro Kosai, Satoshi Nagano, Nobuhiro Ijichi, Toshitaka Futagawa, Eriko Sumi, Munekazu Yamaguchi, Masanori Nakajo, Teruto Hashiguchi, Yasuo Takeda, Takashi Yoshiura, Akira Shimizu, Muneo Takatani, Setsuro Komiya
Organizer
第77回日本癌学会学術総会
Related Report
-
-
-
-
[Presentation] Phase I Study of Potentially "Best-in-Class" Survivin-Responsive Conditionally Replicating Adenovirus for Advanced Sarcoma Actually Demonstrates Potent and Long-Term Efficacy and High Safety．2018
Author(s)
Ken-ichiro Kosai, Satoshi Nagano, Toshitaka Futagawa, Eriko Sumi, Nobuhiro Ijichi, Munekazu Yamaguchi, Masanori Nakajo, Teruto Hashiguchi, Yasuo Takeda, Takashi Yoshiura, Akira Shimizu, Muneo Takatani, Setsuro Komiya
Organizer
AMERICAN SOCIETY of GENE & CELL THERAPY
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
