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Development of analgesic strategy with anti-tumor effect

Research Project

Project/Area Number 17H04322
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology
Research InstitutionWakayama Medical University

Principal Investigator

Kawamata Tomoyuki  和歌山県立医科大学, 医学部, 教授 (80336388)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2017: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Keywordsがん疼痛 / 局所麻酔薬 / 電化 / QX-314 / がん性痛 / がん増殖 / TRPA1 / TRPV1 / がん / 痛み / 受容体 / 脳神経
Outline of Final Research Achievements

Our previous study has showed that TRPV1-positive afferents are involved in both cancer growth and cancer-induced pain. QX-314, a quaternary lidocaine derivative, has a permanent positive charge that theoretically impairs its ability to cross neuronal membranes. However, When TRPV1 was activated, extracellular QX-314 could produce a local anesthetic effect through entering the pore of TRPV1. Our results of this study revealed that systemic QX-314 decreases both cancer pain and cancer growth due to inhibition of activated TRPV1-positive afferents.

Academic Significance and Societal Importance of the Research Achievements

これまで、鎮痛治療と抗がん治療は別に考えられてきた。したがって、痛み神経とがんの生育を結びつけた本研究は学術的な意義は非常に大きい。本研究は、正に電化した局所麻酔薬QX-314を使用して、痛みと軸索反射をブロックする。痛みの伝達と腫瘍増殖に関与している活性化TRPV1(+)神経のみを選択的に抑制でき、活性化していないTRPV1(+)神経やTRPV1(-)神経、および中枢神経には作用しないことから、副作用が非常に少ない治療が期待できる。したがって、本研究結果が臨床応用されることにより副作用の少ない痛み治療・がん治療が可能となることが予想され、その臨床的意義は大きい。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (26 results)

All 2020 2019 2018 2017

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 4 results) Presentation (12 results) (of which Int'l Joint Research: 9 results,  Invited: 3 results) Book (3 results)

  • [Journal Article] Validation of noninvasive continuous arterial pressure measurement by ClearSight System during induction of anesthesia for cardiovascular surgery2020

    • Author(s)
      Tanioku Tadashi、Yoshida Akari、Aratani Yuichi、Fujii Keisuke、Kawamata Tomoyuki
    • Journal Title

      BMC Anesthesiology

      Volume: 20 Issue: 1 Pages: 176-183

    • DOI

      10.1186/s12871-020-01091-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phospholipase Cβ3 Expressed in Mouse DRGs is Involved in Inflammatory and Postoperative Pain2020

    • Author(s)
      Ide Susumu、Kawamata Tomoyuki、Ishida Kumiko、Fuseya Satoshi、Ishida Takashi、Sugiyama Yuki、Kawamata Mikito、Tanaka Satoshi
    • Journal Title

      Journal of Pain Research

      Volume: Volume 13 Pages: 3371-3384

    • DOI

      10.2147/jpr.s280565

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Opioid free anesthesia/analgesia2020

    • Author(s)
      川股知之、小川舜也
    • Journal Title

      臨床麻酔

      Volume: 44 Pages: 1542-1549

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 手術麻酔中の疼痛評価2020

    • Author(s)
      川股知之、若林美帆
    • Journal Title

      ペインクリニック

      Volume: 41 Pages: 22-30

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptionalnfactor Sp4 is required for hyperalgesic state persistence2019

    • Author(s)
      Sheehan K, Kawamata T, et al
    • Journal Title

      PLOS One

      Volume: 14

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Optimal Timing of Removal of Epidural and Urethral Catheters to Avoid Postoperative Urinary Retention Undergoing Abdominal Surgery.2019

    • Author(s)
      Hayami S, Ueno M, Kawai M, Kuriyama T, Kawamata T, Yamaue H.
    • Journal Title

      Dig Surg.

      Volume: 36 Issue: 3 Pages: 261-265

    • DOI

      10.1159/000490199

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of catheter-over-needle and catheter-through-needle on leakage from the catheter insertion site during continuous femoral nerve block.2018

    • Author(s)
      Nogawa R, Maruyama T, Kimoto Y, Yamazaki A, Kawamata T
    • Journal Title

      J Anesth

      Volume: 32 Issue: 3 Pages: 439-442

    • DOI

      10.1007/s00540-018-2479-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perinatal outcome of vaginal delivery with epidural analgesia initiated at the early or late phase of labor period: A retrospective cohort study in the Japanese population2018

    • Author(s)
      Michihisa Shiro, Katsutoshi Nakahata, Sawako Minami, Tomoyuki Kawamata, Kazuhiko Ino
    • Journal Title

      The Journal of Obstetrics and Gynaecology Research

      Volume: in press Issue: 8 Pages: 1415-1423

    • DOI

      10.1111/jog.13671

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of perinatal blood pressure on maternal brain functional connectivity2018

    • Author(s)
      Kurosaki Hiromichi、Nakahata Katsutoshi、Donishi Tomohiro、Shiro Michihisa、Ino Kazuhiko、Terada Masaki、Kawamata Tomoyuki、Kaneoke Yoshiki
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 8 Pages: e0203067-e0203067

    • DOI

      10.1371/journal.pone.0203067

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of Acute Arterial Occlusion During Artery Bypass Surgery for a Lower Extremity by Monitoring Regional Saturation of Oxygen of the Sole of the Foot2017

    • Author(s)
      Kurosaki H, Higuchi M, Nogawa R, Kawamata T
    • Journal Title

      J Cardiothorac Vasc Anesth

      Volume: 6 Issue: 6 Pages: 2167-9

    • DOI

      10.1053/j.jvca.2017.03.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腹部大動脈瘤ステントグラフト内挿術に対する末梢神経ブロックによる麻酔管理2017

    • Author(s)
      2.正木美帆、山﨑亮典、大森亜紀、川股知之
    • Journal Title

      麻酔

      Volume: 66 Pages: 761-764

    • NAID

      40021257708

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Long-term observation of changes in functional connectivity in patients with postherpetic neuralgia2020

    • Author(s)
      Kurosaki H, Hirai A, Ogawa S, Yamasaki K, Kawamata T
    • Organizer
      Annual Meeting of the American Society of Anesthesiologists
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Does temperature measured by Temple Touch Pro TM over the radial artery reflector temperature?2020

    • Author(s)
      Nishibata M, Yoshida A, Maruyama T, Kobai K, Kawamata T
    • Organizer
      Annual Meeting of the American Society of Anesthesiologists
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Validation of estimated continuous cardiac output in patients undergoing laparoscopic surgery.2020

    • Author(s)
      Maruyama T, Tanioku T, Aratani Y, Kanda Y, Kawamata T
    • Organizer
      Annual Meeting of the American Society of Anesthesiologists
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A case in which ultrasound was useful for repeated evaluation of pneumothorax during laparoscopic surgery2019

    • Author(s)
      Ogawa S, Tsujimoto M, Kawmata T
    • Organizer
      Annual meeting of the American society of Anesthesiologists
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRPV1 is involved in both tumor growth and cancer-induced pain2019

    • Author(s)
      Yoshida Q, Tanioku T, Aratani Y, Maruyama T, Tsujimoto M,vbKawamat T
    • Organizer
      Annual meeting of the American society of Anesthesiologists
    • Related Report
      2019 Annual Research Report
  • [Presentation] NSAIDs2018

    • Author(s)
      川股知之
    • Organizer
      日本麻酔科学会第65回大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 統合型臨床情報システムDWHが切り開く周術期データ検索とその可能性2018

    • Author(s)
      川股知之
    • Organizer
      日本麻酔科学会第65回大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Altered spontaneous brain activity in chronic PHN patients2018

    • Author(s)
      Kurosaki H, Tazoe M, Ogawa S, Kawamata T
    • Organizer
      Annual meeting of the American Society of Anesthesiologists
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRPA1 is involved in cancer-induced spontaneous pain but not mechanical and thermal hyperalgesia2018

    • Author(s)
      Yoshida A, Ogawa S, Tazoe M, Kawamata T
    • Organizer
      Annual meeting of the American Society of Anesthesiologists
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Altered resting-state functional connectivity of pain-related brain regions in patients with postherpetic neuralgia2017

    • Author(s)
      Kurosaki H, Kan S, Nakata R, Yamazaki A, Kuriyama T, Mizumoto K, Shibata M, Kawamata T
    • Organizer
      Annual Meeting of the American Society of Anesthesiologists
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Validation of ClearSight System during anesthetic induction in patients undergoing cardiovascular surgery2017

    • Author(s)
      Tanioku T, Higashi S, Deguchi K, Boki K, Nishibata M, Kawamata T
    • Organizer
      Annual Meeting of the American Society of Anesthesiologists
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Current status and future development of cancer pain management2017

    • Author(s)
      Kawamata T
    • Organizer
      25th Chinese Society of Anesthesiologists
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] LiSA別冊秋号 頭痛と鎮痛2018

    • Author(s)
      川股知之
    • Total Pages
      187
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Related Report
      2018 Annual Research Report
  • [Book] 麻酔科研修ノート改訂第三版2018

    • Author(s)
      吉田朱里、川股知之
    • Total Pages
      764
    • Publisher
      診断と治療社
    • ISBN
      9784787824011
    • Related Report
      2018 Annual Research Report
  • [Book] 日めくり麻酔科エビデンスアップデート22018

    • Author(s)
      吉田朱里、川股知之
    • Total Pages
      239
    • Publisher
      克誠堂
    • ISBN
      9784771905085
    • Related Report
      2018 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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