Genetic mechanisms underlying vulnerability to adverse side effects of opioids

• Project/Area Number: 17H04324
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: IKEDA Kazuaka 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 分野長 (60281656)
• Co-Investigator(Kenkyū-buntansha): 西澤 大輔 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (80450584) ; 森野 良蔵 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 研究員 (80366351)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2019: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000); Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
• Keywords: 薬物反応性 / ゲノム / 薬理学 / 脳・神経 / 医療福祉 / 薬剤反応性

Outline of Final Research Achievements

Opioids have serious adverse side effects, although they are useful analgesics. To find genetic factors for individual differences in the adverse side effects of opioids, we collected genome DNA and clinical and demographic data from 2020 patients who underwent surgery under the systemic anesthesia, and conducted a genome wide association study (GWAS). We found that several genetic polymorphisms such as polymorphisms in the PAR2 gene were associated with adverse side effects of opioids, although they were not associated at GWAS level. Furthermore, we found that the PAR2 genetic polymorphism was also associated with chronic pain by investigating our database of GWAS for opioid sensitivity and pain vulnerability.

Academic Significance and Societal Importance of the Research Achievements

オピオイド性鎮痛薬は有用であるが、副作用に注意が必要である。米国ではオピオイド過量服薬による呼吸抑制死が年間4万人を超えている。しかもこのような副作用の出現は患者ごとに大きく異なる。今回オピオイド副作用脆弱性関連遺伝子多型が見出されたことは、疼痛および鎮痛薬感受性の遺伝子メカニズムの解明に繋がるとともに、患者個々人の遺伝子に合わせて過量服薬死を防ぎつつ適切に疼痛治療を行うテーラーメイド疼痛治療に繋がるものである。

Research Products

• [Int'l Joint Research] カルガリー大学(カナダ)
• [Int'l Joint Research] スプリト大学(クロアチア)
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• [Journal Article] Polygenetic risk scores for major psychiatric disorders among schizophrenia patients, their first-degree relatives, and healthy participants. (2020)
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• [Journal Article] Possible role of amyloidogenic evolvability in dementia with Lewy bodies: insights from transgenic mice expressing P123H beta-synuclein. (2020)
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• [Journal Article] A Single Medical Marker for Diagnosis of Methamphetamine Addiction - DNA Methylation of SHATI/NAT8L Promoter Sites from Patient Blood (2020)
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• [Journal Article] Clinical study of GIRK channel inhibitors as candidate medicines for drug dependence (2020)
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• [Journal Article] 第6回アジア神経精神薬理学会. (2020)
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  • Journal Title: 現代化学 Volume: 587 Pages: 56-61
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• [Journal Article] Cognitive impairment that is induced by (R)-ketamine is abolished in NMDA GluN2D receptor subunit knockout mice. (2019)
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• [Journal Article] Study of effects of ifenprodil in patients with methamphetamine dependence: Protocol for an exploratory, randomized, double-blind, placebo-controlled trial. (2019)
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• [Journal Article] Three-dimensional alteration of neurites in schizophrenia. (2019)
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• [Journal Article] Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero. (2019)
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• [Journal Article] Opioid and non-dopamine reward circuitry and state-dependent mechanisms. (2018)
  • Author(s): Fujita M, Ide S, Ikeda K
  • Journal Title: Ann NY Acad Sci Volume: 印刷中 Issue: 1 Pages: 29-41
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• [Journal Article] Resistin is a novel marker for postoperative pain intensity. (2018)
  • Author(s): Hozumi J, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Abe H, Kato R, Kusakabe Y, Yamada Y, Japanese TR-Cancer Pain research Group
  • Journal Title: Anesth Analg Volume: 印刷中 Issue: 3 Pages: 563-568
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• [Journal Article] Brain hyperserotonemia causes autism-relevant social deficits in mice. (2018)
  • Author(s): Tanaka M, Sato A, Kasai S, Hagino Y, Kotajima-Murakami H, Kashii H, Takamatsu Y, Nishito Y, Inagaki M, Mizuguchi M, Hall FS, Uhl GR, Murphy D, Sora I, Ikeda K.
  • Journal Title: Mol Autism Volume: 9 Issue: 1 Pages: 60-60
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  • NAID: 120006543336
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• [Journal Article] Gamma-aminobutyric acid transaminase genetic polymorphism is a candidate locus for responsiveness to opioid analgesics in patients with cancer pain: an exploratory study (2018)
  • Author(s): Yokoshima Y, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Kato R, Hozumi J, Abe H, Azuma K, Tsuchida R, Yamada Y, Japanese TR-Cancer Pain research Group
  • Journal Title: Neuropsychopharmacol Rep Volume: 38(4) Issue: 4 Pages: 175-181
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• [Journal Article] Reward-enhancing effect of methylphenidate is abolished in dopamine transporter knockout mice: A model of attention-deficit/hyperactivity disorder (2018)
  • Author(s): Ide Soichiro、Ikekubo Yuiko、Hua Jennifer、Takamatsu Yukio、Uhl George R.、Sora Ichiro、Ikeda Kazutaka
  • Journal Title: Neuropsychopharmacology Reports Volume: 38 Issue: 3 Pages: 149-153
  • DOI: 10.1002/npr2.12020
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• [Journal Article] Initial severity of major depression and efficacy of new generation antidepressants: Individual-participant data meta-analysis (2018)
  • Author(s): Furukawa TA, Maruo K, Noma H, Tanaka S, Imai H, Shinohara K, Ikeda K, Yamawaki S, Levine SZ, Goldberg Y, Leucht S & Cipriani A
  • Journal Title: Acta Psychiatrica Scandinavica Volume: epub Issue: 6 Pages: 1-8
  • DOI: 10.1111/acps.12886
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• [Journal Article] Early manifestation of depressive-like behavior in transgenic mice that express dementia with Lewy bodies-linked mutant beta-synuclein. (2018)
  • Author(s): Fujita M, Hagino Y, Takamatsu Y, Shimizu Y, Takamatsu Y, Ikeda K, Hashimoto M
  • Journal Title: Neuropsychopharmacology Rep Volume: 印刷中 Issue: 2 Pages: 95-97
  • DOI: 10.1002/npr2.12009
  • Peer Reviewed / Open Access
• [Journal Article] Association between the rs7583431 single-nucleotide polymorphism close to the activating transcription factor 2 (ATF2) gene and the analgesic effect of fentanyl in the cold pain test. (2018)
  • Author(s): Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Journal Title: Neuropsychopharmacology Rep Volume: 印刷中 Issue: 2 Pages: 86-91
  • DOI: 10.1002/npr2.12012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between rs2275913 single-nucleotide polymorphism of the interleukin-17A gene and perioperative analgesic use in cosmetic orthognathic surgery (2018)
  • Author(s): Ohka Seii、Nishizawa Daisuke、Hasegawa Junko、Takahashi Kaori、Nakayama Kyoko、Ebata Yuko、Fukuda Ken-ichi、Ikeda Kazutaka
  • Journal Title: Neuropsychopharmacology Reports Volume: e12010 Issue: 2 Pages: 67-74
  • DOI: 10.1002/npr2.12010
  • Peer Reviewed / Open Access
• [Journal Article] Association between N-methyl-D-aspartate receptor subunit 2B gene polymorphisms and personality traits in a young Japanese population. (2018)
  • Author(s): Narita S, Onozawa Y, Yoshihara E, Nishizawa D, Numajiri M, Ikeda K, Iwahashi K
  • Journal Title: East Asian Arch Psychiatry Volume: 28 Pages: 45-52
  • DOI: 10.12809/eaap181712
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• [Journal Article] Brain tissue fingerprints of schizophrenia and control individuals. (2018)
  • Author(s): Mizutani R, Saiga R, Takeuchi A, Uesugi K, Terada Y, Suzuki Y, Andrade VD, Carlo FD, Takekoshi S, Inomoto C, Nakamura N, Kushima I, Iritani S, Ozaki N, Ide S, Ikeda K, Oshima K, Itokawa M, Arai M
  • Journal Title: Neurons and Cognition (q-bio.NC); Biological Physics (physics.bio-ph) Volume: arXiv
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• [Journal Article] Mechanisms of the Antidepressant Effects of Ketamine Enantiomers and Their Metabolites (2018)
  • Author(s): Ide Soichiro、Ikeda Kazutaka
  • Journal Title: Biological Psychiatry Volume: 84 Issue: 8 Pages: 551-552
  • DOI: 10.1016/j.biopsych.2018.07.018
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• [Journal Article] 薬物依存 (2018)
  • Author(s): 井手聡一郎, 池田和隆
  • Journal Title: Clinical Neuroscience Volume: 36 Pages: 732-735
• [Journal Article] Association between N-methyl-D-aspartate receptor 2B subunit gene polymorphisms and personality traits in a young Japanese population. (2018)
  • Author(s): Narita S, Yoshihara E, Nishizawa D, Numajiri M, Onozawa Y, Ikeda K, Iwahashi K
  • Journal Title: East Asian Arch Psychiatry Volume: 印刷中
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• [Journal Article] A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence. (2018)
  • Author(s): *Sugaya, N., *Ogai, Y.(*equal contribution), Aikawa, Y., Yumoto, Y., Takamaha, M., Tanaka, M., Haraguchi, A., Umeno, M., Ikeda, K.
  • Journal Title: Neuropsychopharmacology Reports. Volume: 38(1) Issue: 1 Pages: 9-17
  • DOI: 10.1002/npr2.12001
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• [Journal Article] Genome-wide association study identifies polymorphisms associated with the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test (2018)
  • Author(s): Takahashi K, Nishizawa D, Kasai S, Koukita Y, Fukuda K, Ichinohe T, Ikeda K
  • Journal Title: J Pharmacol Sci Volume: 136(3) Issue: 3 Pages: 107-113
  • DOI: 10.1016/j.jphs.2018.02.002
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• [Journal Article] Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy. (2018)
  • Author(s): 2.Nishizawa D, Mieda T, Tsujita M, Nakagawa H, Yamaguchi S, Kasai S, Hasegawa J, Fukuda KI, Kitamura A, Hayashida M, Ikeda K.
  • Journal Title: Pharmacogenomics Volume: 19 Issue: 2 Pages: 113-127
  • DOI: 10.2217/pgs-2017-0109
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• [Journal Article] Association between polymorphisms in the purinergic P2Y12 receptor gene and severity of both cancer pain and postoperative pain (2018)
  • Author(s): Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Abe H, Kato R, Ueda H, Yamada Y
  • Journal Title: Pain Med Volume: 19(2) Issue: 2 Pages: 348-354
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• [Journal Article] A pharmacogenetics approach to pain management. (2018)
  • Author(s): Yoshida K, Nishizawa D, Ide S, Ichinohe T, Fukuda K, Ikeda K
  • Journal Title: Neuropsychopharmacology Rep Volume: 38 Issue: 1 Pages: 2-8
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• [Journal Article] 創薬開発に向けた産官学連携―Public Private Partnerships, PPPs―. (2018)
  • Author(s): 池田和隆, 小居秀紀, 菊地哲朗, 森尾保徳, 川上善之, 須原哲也, 中込和幸, 山脇成人
  • Journal Title: 臨床精神医学 Volume: 47 Pages: 315-319
• [Journal Article] 薬剤選択に寄与する研究環境の整備. (2018)
  • Author(s): 中込和幸, 森尾保徳, 小居秀紀, 池田和隆, 山脇成人
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• [Journal Article] 依存の神経・分子メカニズム解析のための動物モデル. (2018)
  • Author(s): 井手聡一郎, 池田和隆
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• [Journal Article] Association between N-methyl-D-aspartate receptor subunit 2B gene polymorphisms and alcohol dependence in a Japanese population. (2017)
  • Author(s): Narita S, Yoshihara E, Nishizawa D, Kawai A, Ikeda K, Iwahashi K
  • Journal Title: 日本アルコール薬物医学会雑誌 Volume: 52(5) Pages: 156-167
  • NAID: 40021423809
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• [Journal Article] Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine. (2017)
  • Author(s): Ide S, Ikekubo Y, Mishina M, Hashimoto K, Ikeda K
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• [Journal Article] Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese (2017)
  • Author(s): Tanabe Y, Shimizu C, Hamada A, Hashimoto K, Ikeda K, Nishizawa D, Hasegawa J, Shimomura A, Ozaki Y, Tamura N, Yamamoto H, Yunokawa M, Yonemori K, Takano T, Kawabata H, Tamura K, Fujiwara Y
  • Journal Title: Cancer Chemother Pharmacol Volume: 79(6) Issue: 6 Pages: 1179-1186
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• [Journal Article] Light/dark phase-dependent spontaneous activity is maintained in dopamine-deficient mice. (2017)
  • Author(s): 3.Fujita M, Hagino Y, Takeda T, Kasai S, Tanaka M, Takamatsu Y, Kobayashi K, Ikeda K.
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• [Journal Article] No association between the polymorphism rs6943555 in the AUTS2 gene and personality traits in Japanese university students (2017)
  • Author(s): Narita S, Ikeda K, Nishizawa D, Yoshihara E, Numajiri M, Onozawa Y, Ohtani N, Iwahashi K
  • Journal Title: Psychiatry Investigation Volume: 14(5) Issue: 5 Pages: 681-686
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• [Journal Article] Opioid dose and neuropathic pain before and after electroconvulsive therapy (2017)
  • Author(s): Iwata K, Kobayashi Y, Mera H, Doi N, Suwa H, Ikeda K
  • Journal Title: Journal of Japan Society of Pain Clinicians Volume: 24 Issue: 2 Pages: 116-120
  • DOI: 10.11321/jjspc.16-0024
  • NAID: 130006832066
  • ISSN: 1340-4903, 1884-1791
  • Peer Reviewed / Open Access
• [Journal Article] ゲノムワイド関連解析を利用したオピオイドのテーラーメイド医療への試み. (2017)
  • Author(s): 三枝勉, 西澤大輔, 福田謙一, 池田和隆, 北村晶, 林田眞和
  • Journal Title: 麻酔・集中治療とテクノロジー2017 Volume: - Pages: 16-21
  • Open Access
• [Journal Article] JSNP Excellent Presentation Award for CINP2016: Association between autism susceptibility candidate 2 haplotypes and alcohol dependence in a Japanese population. (2017)
  • Author(s): Narita S, Iwahashi K, Yoshihara E, Kawai A, Nishizawa D, Ikeda K
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 37(3) Pages: 97-98
• [Journal Article] JSNP Excellent Presentation Award for CINP2016: 注意欠如/ 多動性障害モデルマウスにおけるメチルフェニデートの報酬効果の変化. (2017)
  • Author(s): 井手聡一郎, 高松幸雄, 池窪結子, Takeda TC, Nagasawa S, Hua J, Uhl GR, 曽良一郎, 池田和隆
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 37(2) Pages: 49-50
  • Int'l Joint Research
• [Journal Article] JSNP Excellent Presentation Award for CINP2016: ゲノムワイド関連解析 (GWAS) による腹腔鏡補助下大腸切除術後フェンタニル必要量に影響する遺伝子多型の同定. (2017)
  • Author(s): 西澤大輔, 三枝勉, 辻田美紀, 天野功二郎, 田代浄, 石井利昌, 山口茂樹, 笠井慎也, 長谷川準子, 池田和隆, 北村晶, 林田眞和
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 37(2) Pages: 53-54
• [Journal Article] 遺伝子多型に基づいた個別鎮痛法の開発. (2017)
  • Author(s): 西澤大輔, 福田謙一, 林田眞和, 池田和隆
  • Journal Title: ペインクリニック Volume: 38
• [Journal Article] ペインクリニックにおける精密医療. (2017)
  • Author(s): 池田和隆
  • Journal Title: ペインクリニック Volume: 38 Pages: 557-558
  • Peer Reviewed
• [Presentation] 日本人におけるoxytocin receptor遺伝子多型とアルコール依存症との関連研究. (2020)
  • Author(s): 宮本真起子, 鈴木玖実, 戸上樹音, 曽川一幸 , 吉原英児, 西澤大輔, 川合厚子, 池田和隆, 岩橋和彦
  • Organizer: 第39回アルコール医学生物学研究会学術集会
• [Presentation] Usefulness of intracranial self-stimulation method in drug dependence research. (2019)
  • Author(s): Ide S, Ikeda K
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research / Invited
• [Presentation] The role of NMDA receptor GluN2D subunit in the effects of ketamine and its enantiomers. (2019)
  • Author(s): Ide S, Ikeda K
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research / Invited
• [Presentation] 様々な依存性物質の感受性に共通して寄与する遺伝子多型. (2019)
  • Author(s): 西澤大輔, 池田和隆
  • Organizer: 2019年度アルコール・薬物依存関連学会合同学術総会
  • Invited
• [Presentation] 拡大するアディクション問題へアカデミアはどう取り組む. (2019)
  • Author(s): 池田和隆
  • Organizer: 2019年度アルコール・薬物依存関連学会合同学術総会
  • Invited
• [Presentation] Personalized opioid use for controlling pain and drug abuse. (2019)
  • Author(s): Ikeda K, Nishizawa D, Hayashida M, Fukuda K
  • Organizer: The 10th IBRO World Congress of Neuroscience (IBRO2019)
  • Int'l Joint Research / Invited
• [Presentation] 臨床につながる遺伝子研究アップデート. (2019)
  • Author(s): 池田和隆, 西澤大輔, 井関雅子, 林田眞和, 福田謙一
  • Organizer: 第39回鎮痛薬・オピオイドペプチドシンポジウム
  • Invited
• [Presentation] 自閉スペクトラム障害の動物モデル作成と解析. (2019)
  • Author(s): 池田和隆, 古田島浩子, 田中美歩, 柏井洋文, 佐藤敦志
  • Organizer: 第140回日本薬理学会関東部会
  • Invited
• [Presentation] 快・不快情動と疼痛制御に関わる分子群. (2019)
  • Author(s): 池田和隆
  • Organizer: 第41回日本生物学的精神医学会
  • Invited
• [Presentation] Involvement of NMDA receptor GluN2D subunit in ketamine effects. (2019)
  • Author(s): Ikeda K, Ide S
  • Organizer: 14th World Congress of Biological Psychiatry (WFSBP Congress 2019)
  • Int'l Joint Research / Invited
• [Presentation] 依存症に対する緩和医療薬学. (2019)
  • Author(s): 池田和隆
  • Organizer: 第13回日本緩和医療薬学会年会
  • Invited
• [Presentation] ドーパミン欠乏マウスは中枢神経抑制薬投与によって逆説関興奮を示す. (2019)
  • Author(s): 藤田雅代, 落合郁紀, 萩野洋子, 江藤圭, 鍋倉淳一, 池田和隆
  • Organizer: 次世代脳プロジェクト 冬のシンポジウム
• [Presentation] ゲノムワイド関連解析(GWAS)による慢性痛及び帯状疱疹後神経痛感受性遺伝子の同定. (2019)
  • Author(s): 西澤大輔, 有田英子, 花岡一雄, 矢島直, 井関雅子, 加藤実, 小川節郎, 平沼彩子, 笠井慎也, 長谷川準子, 江畑裕子, 中山京子, 林田眞和, 池田和隆
  • Organizer: 日本人類遺伝学会第64回大会
• [Presentation] Genome-wide association study identifies genetic polymorphisms and genes possibly associated with chronic pain and postherpetic neuralgia. (2019)
  • Author(s): Nishizawa D, Arita H, Hanaoka K, Yajima C, Iseki M, Kato J, Ogawa S, Hiranuma A, Kasai S, Hasegawa J, Ebata Y, Nakayama K, Hayashida M, Ikeda K
  • Organizer: The 69th Annual Meeting of the American Society of Human Genetics (ASHG2019)
  • Int'l Joint Research
• [Presentation] TMiMS addictive substance project. (2019)
  • Author(s): Ikeda K
  • Organizer: 21st TMIMS International Simposium on Overcoming Neuropsychopharmacology Crisis
• [Presentation] Behavioural characterisation of the GluN2DR knock-out mouse model in response to S-ketamine and R-ketamine. (2019)
  • Author(s): Du X, Ikeda K, Sundram S, Hill RA
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research
• [Presentation] Study of ifenprodil effects on patients with methamphetamine dependence: study protocol for an exploratory randomized double-blind placebo-controlled trial. (2019)
  • Author(s): Matsumoto T, Kotajima-Murakami H, Takano A, Ogai Y, Funada D, Tanibuchi Y, Tachimori H, Maruo K, Ikeda K
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research
• [Presentation] Behavioral sensitization and relapse in mu-, delta- and kappa-opioid receptor knockout mice. (2019)
  • Author(s): Moriya Y, Hall SF, Kasahara Y, Hagino Y, Kieffer BL, Uhl GR, Sora I, Ikeda K
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research
• [Presentation] Association between the rs11726196 Single-Nucleotide Polymorphism within the Transient Receptor Subfamily C Member 3 (TRPC3) Gene and Chronic Pain. (2019)
  • Author(s): Aoki Y, Nishizawa D, Yoshida K, Arita H, Hanaoka K, Yajima C, Iseki M, Kato J, Ogawa S, Hiranuma A, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research
• [Presentation] Genome-wide association studies on chronic pain and effects of drugs for the treatment of pain. (2019)
  • Author(s): Nishizawa D, Arita H, Hanaoka K, Yajima C, Iseki M, Kato J, Ogawa S, Hiranuma A, Kasai S, Hasegawa J, Ebata Y, Nakayama K, Hayashida M, Ikeda K
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research
• [Presentation] rs6738544 SNP of STAT4 and rs2298170 SNP of STAT6 are associated with nicotine dependence. (2019)
  • Author(s): Ohka S, Nishizawa D, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Ikeda K
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research
• [Presentation] 報酬行動の分子基盤 ～ICSSを用いた報酬メカニズムの解析～. (2019)
  • Author(s): 井手聡一郎, 池田和隆
  • Organizer: 第49回日本神経精神薬理学会
• [Presentation] Association between a protease-activated receptor 2 gene polymorphism and cold water immersion-induced pain sensitivity. (2019)
  • Author(s): Soeda M, Ohka S, Nishizawa D, Suno M, Fukuda K, Ichinohe T, Ikeda K
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research
• [Presentation] Association of a candidate locus for human opioid sensitivity identified in a genome-wide association study in patients undergoing laparoscopic-assisted colectomy with postoperative opioid requirements in patients undergoing painful cosmetic surgery. (2019)
  • Author(s): Inoue R, Nishizawa D, Hasegawa J, Nakayama K, Fukuda K, Sumikura H, Hayashida M, Ikeda
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research
• [Presentation] Associations between genetic polymorphisms on chromosome 14q32 and effects of opioid analgesics and chronic pain. (2019)
  • Author(s): Kosaki Y, Nishizawa D, Arita H, Hanaoka K, Yajima C, Iseki M, Kato J, Ogawa S, Hiranuma A, Kasai S, Hasegawa J, Nakayama K, Ebata Y, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research
• [Presentation] Analysis of the effects of serotonin related drugs on hyperlocomotion in dopamine-deficient mice. (2019)
  • Author(s): Ochiai Y, Fujita M, Hagino Y, Kobayashi K, Okiyama R, Ikeda K
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research
• [Presentation] Hippocampal neuronal excitability in dopamine deficient mice during hyperlocomotor activity caused by novel environment exposure. (2019)
  • Author(s): Fujita M, Ochiai Y, Takeda TC, Hagino Y, Kobayashi K, Ikeda K
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research
• [Presentation] mTOR signaling pathway plays a key role in non-syndromic autism spectrum disorder. (2019)
  • Author(s): Kotajima H, Kobayashi T, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu Y, Uchino S, Ikeda K
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research
• [Presentation] Effects of rapamycin treatment on impaired social interaction and gene expression in mice treated prenatally with valproic acid. (2019)
  • Author(s): Kotajima H, Kobayashi T, Kashii H, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu Y, Uchino S, Ikeda K
  • Organizer: The 10th IBRO World Congress of Neuroscience (IBRO2019)
  • Int'l Joint Research
• [Presentation] Effects of serotonergic drugs on dopamine-deficient mice. (2019)
  • Author(s): Ochiai Y, Fujita M, Hagino Y, Kobayashi K, Okiyama R, Ikeda K
  • Organizer: The 10th IBRO World Congress of Neuroscience (IBRO2019)
  • Int'l Joint Research
• [Presentation] Opioid system is involved in modulating the development of behavioral sensitization to METH. (2019)
  • Author(s): Moriya Y, Hall FS, Kasahara Y, Hagino Y, Kieffer BL, Uhl GR, Sora I, Ikeda K
  • Organizer: The International Narcotics Research Conference (INRC) 2019
  • Int'l Joint Research
• [Presentation] Role of opioid receptors in behavioral sensitization to methamphetamine. (2019)
  • Author(s): Moriya Y, Hall FS, Kasahara Y, Hagino Y, Kieffer BL, Uhl GR, Sora I, Ikeda K
  • Organizer: IBNS (The International Behavioral Neuroscience Society) 28th Annual Meeting
  • Int'l Joint Research
• [Presentation] プロテアーゼ活性化受容体PAR2の遺伝子多型と冷水刺激誘発性疼痛感受性の関連. (2019)
  • Author(s): 添田萌, 大岡静衣, 西澤大輔, 須野学, 福田謙一, 一戸達也, 池田和隆
  • Organizer: 第13回日本緩和医療薬学会年会
• [Presentation] GIRK channels and NMDA receptor GluN2D subunit in signal pathways from addictive substances. (2019)
  • Author(s): Ikeda K
  • Organizer: FAOPS2019
  • Int'l Joint Research / Invited
• [Presentation] Personalized opioid use for overcoming opioid overdose problems. (2019)
  • Author(s): Ikeda K
  • Organizer: AsCNP-ASEAN2019
  • Int'l Joint Research / Invited
• [Presentation] Clinical study of GIRK channel inhibitors as candidate medicines for drug dependence. (2019)
  • Author(s): Ikeda K
  • Organizer: 第92回日本薬理学会年会
• [Presentation] Analysis of neuronal activity in hyperlocomotive dopamine-deficient mice. (2019)
  • Author(s): Ochiai Y, Fujita M, Takeda TC, Hagino Y, Kobayashi K, Ikeda K
  • Organizer: AsCNP-ASEAN2019
  • Int'l Joint Research
• [Presentation] Investigation of dopamine-deficient mice showing hyperactivity. (2019)
  • Author(s): Ochiai Y, Fujita M, Ikeda K
  • Organizer: AsCNP-ASEAN2019
  • Int'l Joint Research
• [Presentation] Transcriptome analyses in rodent models and postmortem human brains. (2019)
  • Author(s): Kasai S, Ikeda K
  • Organizer: AsCNP-ASEAN2019
  • Int'l Joint Research
• [Presentation] Associations between polymorphisms of the inflammation-related genes and analgesia or sensitivity to analgesics. (2019)
  • Author(s): Ohka S, Nishizawa D, Fukuda K, Ikeda K
  • Organizer: AsCNP-ASEAN2019
  • Int'l Joint Research
• [Presentation] Identification of genetic variations associated with human sensitivity to addictive substances and its clinical application. (2019)
  • Author(s): Nishizawa D, Ikeda K
  • Organizer: AsCNP-ASEAN2019
  • Int'l Joint Research
• [Presentation] 中枢薬の作用機序解明、開発、適正使用のための研究基盤：JSNPの活動を踏まえた今後の方向性 (2018)
  • Author(s): 池田和隆
  • Organizer: 第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会
  • Invited
• [Presentation] Tailor-made opioid analgesia based on genome-wide association study. (2018)
  • Author(s): Ikeda K
  • Organizer: 第15回国際歯科麻酔学会議（IFDAS2018）
  • Int'l Joint Research / Invited
• [Presentation] GIRK channels as common effectors in some pathways of alcohol and other addictive substances. (2018)
  • Author(s): Ikeda K
  • Organizer: 19th Congress of International Society for Biomedical Research on Alcoholism (ISBRA2018)
  • Int'l Joint Research / Invited
• [Presentation] 発達障害とモノアミン (2018)
  • Author(s): 池田和隆
  • Organizer: 第33回日本大脳基底核研究会
  • Invited
• [Presentation] 遺伝子多型からみたテーラーメード医療 (2018)
  • Author(s): 池田和隆, 西澤大輔, 林田眞和, 福田謙一
  • Organizer: 日本ペインクリニック学会 第52回大会
  • Invited
• [Presentation] Neuropsychiatric phenotypes in dopamine-deficient mice and dopamine transporter knockout mice. (2018)
  • Author(s): Ikeda K
  • Organizer: 31st CINP World Congress
  • Int'l Joint Research / Invited
• [Presentation] NMDA receptor channel GluN2D subunit as a new target molecule for medicines for mental disorders. (2018)
  • Author(s): Ikeda K, Ide S
  • Organizer: 24th International Union of Biochemistry and Molecular Biology (IUBMB) Congress and 15th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Congress
  • Int'l Joint Research / Invited
• [Presentation] 遺伝子配列でわかる鎮痛薬感受性個人差 (2018)
  • Author(s): 池田和隆
  • Organizer: 第12回日本緩和医療薬学会年会
  • Invited
• [Presentation] 疼痛感受性と鎮痛薬感受性の遺伝要因解明とその臨床応用 (2018)
  • Author(s): 池田和隆
  • Organizer: 第61回日本糖尿病学会年次学術集会
  • Invited
• [Presentation] 腹腔鏡補助下大腸結腸切除術後鎮痛薬感受性ゲノムワイド網羅的多型解析で上位候補となった一塩基多型に関する外科的顎矯正術後鎮痛薬感受性との関連 (2018)
  • Author(s): 井上理恵, 西澤大輔, 長谷川準子, 中山京子, 福田謙一, 林田眞和, 池田和隆
  • Organizer: 第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会
• [Presentation] STAT4遺伝子の一塩基多型rs6738544およびSTAT6遺伝子の一塩基多型rs2298170はニコチン依存と統計的に有意に関連する (2018)
  • Author(s): 大岡静衣, 西澤大輔, 長谷川準子, 佐藤直美, 山田英孝, 谷岡書彦, 椙村春彦, 池田和隆
  • Organizer: 第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会
• [Presentation] NMDA受容体GluN2Dサブユニット欠損マウスにおける(R)-ケタミンの持続的抗うつ効果ならびに認知機能阻害効果の消失 (2018)
  • Author(s): 井手聡一郎, 池窪結子, 橋本謙二, 三品昌美, 池田和隆
  • Organizer: 第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会
• [Presentation] ドーパミン欠乏マウスを用いた各種自発行動のおけるドーパミン依存症の解析 (2018)
  • Author(s): 藤田雅代, 萩野洋子, 武田大志, 笠井慎也, 高松幸雄, 池田和隆
  • Organizer: 第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会
• [Presentation] ゲノムワイド関連解析(GWAS)による冷水誘発疼痛試験におけるフェンタニルの鎮痛効果と関連する遺伝子多型の同定 (2018)
  • Author(s): 西澤大輔, 髙橋香央里, 吉田香織, 笠井慎也, 長谷川準子, 中山京子, 江畑裕子, 高北義彦, 福田謙一, 一戸達也, 池田和隆
  • Organizer: 第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会
• [Presentation] 覚せい剤依存症患者者におけるイフェンプロジルの効果検討とfMRIを基点としたバイオマーカーの開発：二重盲検無作為化比較試験(研究プロトコル) (2018)
  • Author(s): 古田島浩子, 高野歩, 大谷保和, 塚本正太郎, 村上真紀, 船田大輔, 谷渕由布子, 立森久照, 丸尾和司, 佐々木剛, 高橋英彦, 川人光男, 花川隆, 松本俊彦, 池田和隆
  • Organizer: 第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会
• [Presentation] プロポフォール投与後の効果部位濃度におけるCYP2B6の遺伝子多型の影響 (2018)
  • Author(s): 髙橋香央里, 西澤大輔, 山田芳嗣, 笠井慎也, 須野学, 高北義彦, 一戸達也, 福田謙一, 池田和隆
  • Organizer: 第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会
• [Presentation] mTOR阻害剤を使用中の結節性硬化症患者における自閉症症状の変化 (2018)
  • Author(s): 佐藤敦志, 池田和隆, 水口雅
  • Organizer: 第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会
• [Presentation] Autistic-like behavioral deficits are severer in Tsc2 than Tsc1 haploinsufficiency in mouse models of TSC. (2018)
  • Author(s): Sato A, Tanaka M, Kashii H, Kotajima-Murakami H, Kasai S, Hagino Y, Kobayashi T, Hino O, Mizuguchi M, Ikeda K
  • Organizer: 国際TSCリサーチカンファレンス2018 (ITSCRC2018)
  • Int'l Joint Research
• [Presentation] How social deprivation differentially affects alcohol intake behavior among male and female mice?. (2018)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Ikeda K, Uhl GR, Sora I
  • Organizer: 19th Congress of International Society for Biomedical Research on Alcoholism (ISBRA2018)
  • Int'l Joint Research
• [Presentation] Psychological or physiological stress-induced alcohol consumption in mice lacking opioid receptors. (2018)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Ikeda K, Uhl GR, Sora I
  • Organizer: 19th Congress of International Society for Biomedical Research on Alcoholism (ISBRA2018)
  • Int'l Joint Research
• [Presentation] Identification of genetic polymorphisms associated with human sensitivity to addictive substances and its clinical application. (2018)
  • Author(s): Nishizawa D, Ikeda K
  • Organizer: 19th Congress of International Society for Biomedical Research on Alcoholism (ISBRA2018)
  • Int'l Joint Research
• [Presentation] Role of NMDA receptor GluN2D subunit in the antidepressant effects and the cognitive impairment effects on enantiomers of ketamine. (2018)
  • Author(s): Ide S, Ikekubo Y, Mishina M, Hashimoto K, Ikeda K
  • Organizer: 18th World Congress of Basic and Clinical Pharmacology (WCP2018)
  • Int'l Joint Research
• [Presentation] The role of the serotonin 1B receptor system in the development of methamphetamine-induced sensitization. (2018)
  • Author(s): Moriya Y, Kasahara Y, Hagino Y, Hall FS, Hen R, Ikeda K, Uhl GR, Sora I
  • Organizer: IBNS 27th Annual Meeting
  • Int'l Joint Research
• [Presentation] Genome-wide association study identifies genetic polymorphisms associated with the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test. (2018)
  • Author(s): Nishizawa D, Takahashi K, Yoshida K, Kasai S, Hasegawa J, Nakayama K, Ebata Y, Koukita Y, Fukuda K, Ichinohe T, Ikeda K
  • Organizer: 31st CINP World Congress
  • Int'l Joint Research
• [Presentation] The long-lasting antidepressant effects and the cognitive impairment effects of (R)-ketamine are abolished in NMDA receptor GluN2D subunit knockout mice. (2018)
  • Author(s): Ide S, Ikekubo Y, Mishina M, Hashimoto K, Ikeda K
  • Organizer: 31st CINP World Congress
  • Int'l Joint Research
• [Presentation] Rapamycin ameliorates impairment of social interaction in the mice exposed in utero to valproic acid. (2018)
  • Author(s): Murakami H, Kobayashi T, Kashii H, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu Y, Uchino S, Ikeda K
  • Organizer: 31st CINP World Congress
  • Int'l Joint Research
• [Presentation] Gene expression profile of dopamine-deficient mouse brain for underlying molecular pathology in psychiatric disorders. (2018)
  • Author(s): Kasai S, Hagino Y, Fujita M, Kobayashi K, Ikeda K
  • Organizer: 31st CINP World Congress
  • Int'l Joint Research
• [Presentation] rs6738544 SNP of STAT4 and rs2298170 SNP of STAT6 associate with nicotine dependence. (2018)
  • Author(s): Ohka S, Nishizawa D, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Ikeda K
  • Organizer: 31st CINP World Congress
  • Int'l Joint Research
• [Presentation] The orexin (hypocretin) receptor 2 gene polymorphism Val308Ile associated with nicotine dependence. (2018)
  • Author(s): Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Ujike H, Hashimoto R, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu M, Tanaka M, Hayashida M, Sugimura H, Ikeda K
  • Organizer: 2018 NIDA International Forum
  • Int'l Joint Research
• [Presentation] Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence found in genome-wide and subsequent association studies. (2018)
  • Author(s): Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Ujike H, Hashimoto R, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu M, Tanaka M, Hayashida M, Sugimura H, Ikeda K
  • Organizer: CPDD 80th Annual Scientific Meeting
  • Int'l Joint Research
• [Presentation] 結節性硬化症モデルマウスの自閉症様行動に関わる遺伝子発現変化の解析 (2018)
  • Author(s): 柏井洋文, 佐藤敦志, 笠井慎也, 萩野洋子, 古田島浩子, 田中美歩, 小林敏之, 樋野興夫, 池田和隆, 岡明, 水口雅
  • Organizer: 第60回日本小児神経学会学術集会
• [Presentation] セロトニントランスポーター欠損マウスの自閉症様行動はトリプトファン欠乏食によって改善する (2018)
  • Author(s): 佐藤敦志, 田中美歩, 笠井慎也, 萩野洋子, 古田島浩子, 柏井洋文, 西藤泰昌, 稲垣真澄, 曽良一郎, 水口雅, 池田和隆
  • Organizer: 第60回日本小児神経学会学術集会
• [Presentation] Ketamine and NMDA receptor channels. (2018)
  • Author(s): Ikeda K
  • Organizer: TSBPN 2018 Spring Meeting
  • Int'l Joint Research / Invited
• [Presentation] Rapamycin treatment ameliorates impairment of social interaction in the mice treated prenatally with valproic acid. (2018)
  • Author(s): Kotajima H, Kobayashi T, Kashii H, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu Y, Uchino S, Ikeda K
  • Organizer: 第8回 新潟大学脳研究所共同研究拠点国際シンポジウム
• [Presentation] Gene expression profile corresponding to autism-like behaviors in mouse models of tuberous sclerosis complex. (2018)
  • Author(s): Kashii H, Kasai S, Hagino Y, Sato A, Kotajima H, Tanaka M, Kobayashi T, Hino O, Oka A, Mizuguchi M, Ikeda K
  • Organizer: 第8回 新潟大学脳研究所共同研究拠点国際シンポジウム
• [Presentation] 次世代型薬物依存研究：神経ペプチド神経系の理解. (2017)
  • Author(s): 池田和隆
  • Organizer: 第52回日本アルコール・アディクション医学会学術総会
  • Invited
• [Presentation] Transcriptome profiling of dopamine-deficient mouse brain. (2017)
  • Author(s): Kasai S, Hagino Y, Fujita M, Kobayashi K, Ikeda K
  • Organizer: 第60回日本神経化学会大会
  • Invited
• [Presentation] 鎮痛薬適量予測式の構築と臨床応用技術の開発. (2017)
  • Author(s): 池田和隆
  • Organizer: 第４回包括的緩和医療科学学術研究会/第５回Tokyo疼痛緩和次世代研究会 合同研究会
  • Invited
• [Presentation] 疼痛緩和における“テーラーメイド治療”の実現に向けて. (2017)
  • Author(s): 井手聡一郎, 髙橋香央里, 西澤大輔, 福田謙一, 池田和隆
  • Organizer: 第11回日本緩和医療薬学会年会
  • Invited
• [Presentation] Molecular mechanisms underlying individual differences in pain and analgesic sensitivity. (2017)
  • Author(s): Kasai S, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research / Invited
• [Presentation] The involvement of acetylcholine system in hyperactivity in dopamine-deficient (DD) mice. (2017)
  • Author(s): Ikeda K, Fujita M, Hagino Y, Kobayashi K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research / Invited
• [Presentation] NMDA receptor channel subunit GluN2D: A dark horse molecule in Neuropsychopharmacology. (2017)
  • Author(s): Ikeda K, Hagino Y, Ide S
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research / Invited
• [Presentation] mTOR阻害剤投与による胎生期バルプロ酸曝露マウスの自閉症様行動への影響. (2017)
  • Author(s): 村上浩子, 小林敏之, 柏井洋文, 佐藤敦志, 萩野洋子, 田中美歩, 西藤泰昌, 高松幸雄, 内野茂夫, 池田和隆
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] Circadian rhythm is maintained in dopamine-deficient mice. (2017)
  • Author(s): Fujita M, Hagino Y, Takeda TC, Kasai S, Tanaka M, Takamatsu Y, Kobayashi K, Ikeda K
  • Organizer: The 56th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 56th Annual Meeting)
  • Int'l Joint Research
• [Presentation] ゲノムワイド関連解析（GWAS）による慢性疼痛感受性遺伝子多型の同定. (2017)
  • Author(s): 西澤大輔, 有田英子, 花岡一雄, 矢島直, 井関雅子, 加藤実, 小川節郎, 森山彩子, 笠井慎也, 長谷川準子, 林田眞和, 池田和隆
  • Organizer: 日本人類遺伝学会 第62回大会
• [Presentation] Sex differences in drinking behavior following stress in mu-opioid receptor knockout mice. (2017)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Hagino Y, Uhl GR, Ikeda K, Sora I
  • Organizer: Society for Neuroscience 2017
  • Int'l Joint Research
• [Presentation] TANDに対するmTOR阻害剤の自覚的改善効果. (2017)
  • Author(s): 佐藤敦志, 池田和隆, 水口雅
  • Organizer: 第5回日本結節性硬化症学会学術総会
• [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil requirements during laparoscopic-assisted celectomy. (2017)
  • Author(s): Nishizawa D, Mieda T, Tsujita M, Nakagawa H, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K
  • Organizer: ASHG2017 第67回米国人類遺伝学会
  • Int'l Joint Research
• [Presentation] 結節性硬化症モデルマウスにおける幼若期NMDA投与による点頭様発作の解析. (2017)
  • Author(s): 柏井洋文, 笠井慎也, 萩野洋子, 佐藤敦志, 古田島浩子, 田中美歩, 小林敏之, 樋野興夫, 岡明, 水口雅, 池田和隆
  • Organizer: 第51回日本てんかん学会年次学術集会
• [Presentation] インターロイキン-17A の一塩基多型と痛み関連表現型との関連解析. (2017)
  • Author(s): 大岡静衣, 西澤大輔, 長谷川準子, 高橋香央里, 中山京子, 江畑裕子, 福田謙一, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] ケタミンの抗うつ作用と認知機能障害におけるNMDA受容体GluN2Dサブユニットの役割. (2017)
  • Author(s): 井手聡一郎, 池窪結子, 橋本謙二, 三品昌美, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] muオピオイド受容体欠損マウスにおけるストレスとアルコール嗜好性に対する雌雄差の解析. (2017)
  • Author(s): 森屋由紀, 笠原好之, 萩野洋子, 池田和隆, 曽良一郎
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] 日本人における N-methyl-D-aspartate receptor 2B subunit 遺伝子多型とアルコール依存症との関連研究. (2017)
  • Author(s): 成田心, 吉原英児, 西澤大輔, 川合厚子, 池田和隆, 岩橋和彦
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] ゲノムワイド関連解析（GWAS）による腹腔鏡補助下大腸切除術中レミフェンタニル投与速度に影響する遺伝子多型の同定. (2017)
  • Author(s): 西澤大輔, 三枝勉, 辻田美紀, 山口茂樹, 笠井慎也, 長谷川準子, 福田謙一, 北村晶, 林田眞和, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] 胎生期バルプロ酸曝露マウスの社会性行動障害のラパマイシン投与による改善. (2017)
  • Author(s): 古田島（村上）浩子, 小林敏之, 柏井洋文, 佐藤敦志, 萩野洋子, 田中美歩, 西藤泰昌, 高松幸雄, 内野茂夫, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] Weaver変異型マウスにおける methamphetamineの報酬効果消失. (2017)
  • Author(s): 池窪結子, 井手聡一郎, 高松幸雄, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] Tsc2 ヘテロ欠損マウスの自閉症様行動に対するrapamycinの継続投与の効果とその副作用の検討. (2017)
  • Author(s): 柏井洋文, 笠井慎也, 萩野洋子, 佐藤敦志, 古田島浩子, 田中美歩, 小林敏之, 樋野興夫, 水口雅, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] セロトニントランスポーターノックアウトおよびヘテロ欠損マウスにおける自閉症様行動とトリプトファン欠乏食による改善効果. (2017)
  • Author(s): 田中美歩, 佐藤敦志, 笠井慎也, 萩野洋子, 古田島浩子, 柏井洋文, 西藤泰昌, 稲垣真澄, 曽良一郎, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] 各種自発行動におけるドーパミン依存性の解析. (2017)
  • Author(s): 藤田雅代, 萩野洋子, Takeda T, 笠井慎也, 高松幸雄, 池田和隆
  • Organizer: 第52回日本アルコール・アディクション医学会学術総会
• [Presentation] 外側視床下部脳内自己刺激におけるオピオイド神経系とドパミン神経系の役割. (2017)
  • Author(s): 井手聡一郎, 高橋雄大, 高松幸雄, Uhl GR, 曽良一郎, 池田和隆
  • Organizer: 第37回鎮痛薬・オピオイドペプチドシンポジウム
• [Presentation] Association study of a candidate genetic variant with the development of taxane-induced peripheral neuropathy. (2017)
  • Author(s): Tanabe Y, Nishizawa D, Hasegawa J, Ikeda K, Shimomura A, Takano T, Shimizu C
  • Organizer: 第15回日本臨床腫瘍学会学術集会
• [Presentation] The effects of chronic stress on alcohol consumption in mu-opioid receptor knockout mice. (2017)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Uhl GR, Ikeda K, Sora I
  • Organizer: International Narcotics Research Conference 2017 (INRC2017)
  • Int'l Joint Research
• [Presentation] Stress-induced alcohol drinking in mice lacking mu-opioid receptors. (2017)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Uhl GR, Ikeda K, Sora I
  • Organizer: 26th Annual Meeting of the International Behavioral Neuroscience Society (IBNS2017)
  • Int'l Joint Research
• [Presentation] 遺伝子多型と疼痛感受性・オピオイド感受性. (2017)
  • Author(s): 林田眞和, 福田謙一, 西澤大輔, 池田和隆
  • Organizer: 日本麻酔科学会第64回学術集会
• [Presentation] Inhibition of mTOR improves autism-like behaviors in mice in utero exposed to valproic acid. (2017)
  • Author(s): Kotajima-Murakami H, Kobayashi T, Kashii H, Sato A, Hagino Y, Nishito Y, Takamatsu Y, Uchino S, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Rapamycin treatment of impaired social behavior in adolescent Tsc2+/－mice. (2017)
  • Author(s): Kashii H, Hagino Y, Kasai S, Kotajima H, Sato A, Kobayashi T, Hino O, Mizuguchi M, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Association between genetic polymorphisms in Cav2.3 (R-type) Ca2+ channels and fentanyl sensitivity in patients undergoing painful cosmetic surgery. (2017)
  • Author(s): Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Associations between polymorphisms close to the cAMP responsive element binding protein 1 (CREB1) gene and the activating transcription factor 2 (ATF2) gene and fentanyl sensitivity. (2017)
  • Author(s): Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Single nucleotide polymorphisms in the 5’flanking region of interleukin-17A gene significantly associate with pain sensitivity. (2017)
  • Author(s): Ohka S, Nishizawa D, Hasegawa J, Takahashi K, Nakayama K, Ebata Y, Fukuda K, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Genetic polymorphisms in the orexin system (focusing on a polymorphism associated with nicotine dependence). (2017)
  • Author(s): Nishizawa D, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Association of Proopioimeranocortin gene polymorphism with vulnerability to alcohol dependence in Japanese. (2017)
  • Author(s): Kasai S, Nishizawa D, Higuchi S, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil infusion rate in patients undergoing laparoscopic-assisted colectomy. (2017)
  • Author(s): Nishizawa D, Mieda T, Tsujita M, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] The relationship between stress and alcohol consumption in female mice. (2017)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Uhl GR, Ikeda K, Sora I
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Book] Ketamine (2020)
  • Author(s): Hashimoto K, Ide S, Ikeda K
  • Total Pages: 189
  • Publisher: Springer Singapore
• [Book] アディクションサイエンス－依存・嗜癖の科学－ (2019)
  • Author(s): 宮田久嗣, 高田孝二, 池田和隆, 廣中直行
  • Total Pages: 304
  • Publisher: 朝倉書店
  • ISBN: 9784254520255
• [Remarks] 公益財団法人東京都医学総合研究所ホームページ
  • URL: http://www.igakuken.or.jp/
• [Remarks] 依存性薬物プロジェクトホームページ
  • URL: http://www.igakuken.or.jp/abuse/