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Roles of dendritic cells in early detection of graft rejection and their dynamic influences on AKI biomarkers

Research Project

Project/Area Number 17H04333
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionTokyo Medical University

Principal Investigator

Takuya Ueno  東京医科大学, 医学部, 兼任講師 (00296469)

Co-Investigator(Kenkyū-buntansha) 岩本 整  東京医科大学, 医学部, 准教授 (00338831)
竹内 裕紀  東京薬科大学, 薬学部, 准教授 (20439912)
高原 史郎  大阪大学, 医学系研究科, 招へい教授 (70179547)
新見 正則  帝京大学, 医学部, 准教授 (80198415)
中村 有紀  東京医科大学, 医学部, 講師 (50349487)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2019: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords拒絶反応 / イメージング / 急性腎障害 / バイオマーカー / 樹状細胞 / 腎移植 / 臓器移植 / AKI
Outline of Final Research Achievements

Due to the lack donor pool, to detect graft rejection in earlier time points should be mandatory and also high accuracy is preferable. Therefore, we aimed to investigate to develop a new therapeutic system to detect it with using measurements of acute kidney injury (AKI) biomarkers such as NGAL and L-FABP In the current study. Additionally, we determined a new role of Dendritic cells as a therapeutic target in transplantation instead of T cell targeted therapy, which would allow us to lead to prolong graft survival in a safety manner. These work have been already reported in both several international congress (i.e. American Transplant Congress, E-ISFA) and papers (Curr Protein Pept Sci. 2019、Transplant Proc 2018, 2016、Artif Organs. 2017, 2017、Front Immunol. 2016、Transpl Int. 2016、Cytokine. 2016).

Academic Significance and Societal Importance of the Research Achievements

本研究課題はこれまでの治療対象であったT cell主体の治療に加え、抗原提示細胞の1つである樹状細胞への変遷を予期させる革新的な研究成果となった。移植臓器の提供が少ない環境下で、安全に移植医療を提供をし得たことは十分な成果であり、同時に新たな治療戦略の可能性を示唆させる結果に繋がったのは、今後の移植医療における更なる可能性を予測させるものある。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (15 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results) Presentation (5 results) (of which Int'l Joint Research: 4 results) Remarks (3 results)

  • [Int'l Joint Research] Massachusetts General Hospital/Brigham and Women's Hospital/Harvard Medical School(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Brigham and Women's Hospital(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Potential Roles of Siglecs in the Regulation of Allo-Immune Reaction2019

    • Author(s)
      Cai Songjie、Zhao Jing、Ueno Takuya、Chandraker Anil
    • Journal Title

      Current Protein Peptide Science

      Volume: 20 Issue: 8 Pages: 823-828

    • DOI

      10.2174/1389203720666190507095759

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] An Examination of Pregnancy Cases After Kidney Transplantation: Single-Center Experience2018

    • Author(s)
      Kihara Y, Konno O, Yokoyama T, Nakamura Y, Ueno T, Iwamoto H
    • Journal Title

      Transplantation Proceedings

      Volume: 50(8) Issue: 8 Pages: 2531-2534

    • DOI

      10.1016/j.transproceed.2018.03.081

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early Outcomes of Living-Donor Kidney Transplantation With Immunosuppression Therapy Induction With Tacrolimus Extended-Release: A Comparison With Cyclosporine.2018

    • Author(s)
      Konno O, Yokoyama T, Kihara Y, Nakamura Y, Ueno T, Takeuchi H, Iwamoto H
    • Journal Title

      Transplantation Proceedings

      Volume: 50(8) Issue: 8 Pages: 2457-2460

    • DOI

      10.1016/j.transproceed.2018.04.023

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thomas E. Starzl, MD, PhD: Father of Transplantation-March 11, 1926-March 4, 2017.2017

    • Author(s)
      Ueno T
    • Journal Title

      Artif Organs

      Volume: 41 Issue: 7 Pages: 601-602

    • DOI

      10.1111/aor.12988

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Roles of Continuous Renal Replacement Therapy in Septic Acute Kidney Injury.2017

    • Author(s)
      Ueno T
    • Journal Title

      Artif Organs

      Volume: 417 Issue: 7 Pages: 667-672

    • DOI

      10.1111/aor.12941

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] The current status of Acute Blood Purification in Sepsis - what we know, what we don’ -2020

    • Author(s)
      Takuya Ueno, Toshiaki Ikeda, Yu Ueno, Masaaki Okihara, Isao Akashi, Yu Kihara, Osamu Konno, Yuki Nakamura, Hitoshi Iwamoto, Anil Chandraker
    • Organizer
      3rd Congress of the European Group International Society for Apheresis
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diagnosis of Acute Renal Rejection Using Saliva Metabolome Analysis2018

    • Author(s)
      H. Iwamoto, M. Sugimoto, O. Konnno, Y. Kihara, T. Yokoyama, Y. Nakamura, M. Sunamura, T. Ueno
    • Organizer
      2018 American Transplant Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cytokine modulation in abdominal septic shock following acute care surgery2018

    • Author(s)
      Ueno T, Ikeda T, Yokoyama T, et al.
    • Organizer
      The 2nd Congress of E-ISFA,the European Group of International Society for Apheresis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Imaging cell biology in transplantation2017

    • Author(s)
      Ueno T, et al.
    • Organizer
      2017 American Transplant Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Live images of donor dendritic cells trafficking via CX3CR1 pathway2017

    • Author(s)
      上野琢哉、Seok-Hyun Yun, Martina McGrath、他
    • Organizer
      第117回日本外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Remarks] Transplant Ctr, Brigham and Women's Hospital (BWH)

    • URL

      http://transplantresearch.bwh.harvard.edu/who-we-are/takuya-ueno-md-phd-faha/

    • Related Report
      2018 Annual Research Report
  • [Remarks] BWH, Harvard Medical School

    • URL

      http://researchfaculty.brighamandwomens.org/BRIProfile.aspx?id=6265

    • Related Report
      2018 Annual Research Report
  • [Remarks] Harvard Catalyst Profile

    • URL

      https://connects.catalyst.harvard.edu/Profiles/display/Person/59300

    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2023-01-30  

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