Roles of dendritic cells in early detection of graft rejection and their dynamic influences on AKI biomarkers
| Project/Area Number |
17H04333
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
Takuya Ueno 東京医科大学, 医学部, 兼任講師 (00296469)
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| Co-Investigator(Kenkyū-buntansha) |
岩本 整 東京医科大学, 医学部, 准教授 (00338831)
竹内 裕紀 東京薬科大学, 薬学部, 准教授 (20439912)
高原 史郎 大阪大学, 医学系研究科, 招へい教授 (70179547)
新見 正則 帝京大学, 医学部, 准教授 (80198415)
中村 有紀 東京医科大学, 医学部, 講師 (50349487)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2019: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 拒絶反応 / イメージング / 急性腎障害 / バイオマーカー / 樹状細胞 / 腎移植 / 臓器移植 / AKI |
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| Outline of Final Research Achievements |
Due to the lack donor pool, to detect graft rejection in earlier time points should be mandatory and also high accuracy is preferable. Therefore, we aimed to investigate to develop a new therapeutic system to detect it with using measurements of acute kidney injury (AKI) biomarkers such as NGAL and L-FABP In the current study. Additionally, we determined a new role of Dendritic cells as a therapeutic target in transplantation instead of T cell targeted therapy, which would allow us to lead to prolong graft survival in a safety manner. These work have been already reported in both several international congress (i.e. American Transplant Congress, E-ISFA) and papers (Curr Protein Pept Sci. 2019、Transplant Proc 2018, 2016、Artif Organs. 2017, 2017、Front Immunol. 2016、Transpl Int. 2016、Cytokine. 2016).
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| Academic Significance and Societal Importance of the Research Achievements |
本研究課題はこれまでの治療対象であったT cell主体の治療に加え、抗原提示細胞の１つである樹状細胞への変遷を予期させる革新的な研究成果となった。移植臓器の提供が少ない環境下で、安全に移植医療を提供をし得たことは十分な成果であり、同時に新たな治療戦略の可能性を示唆させる結果に繋がったのは、今後の移植医療における更なる可能性を予測させるものある。
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Report
(4 results)
Research Products
(15 results)
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[Presentation] The current status of Acute Blood Purification in Sepsis - what we know, what we don’ -2020
Author(s)
Takuya Ueno, Toshiaki Ikeda, Yu Ueno, Masaaki Okihara, Isao Akashi, Yu Kihara, Osamu Konno, Yuki Nakamura, Hitoshi Iwamoto, Anil Chandraker
Organizer
3rd Congress of the European Group International Society for Apheresis
Related Report
Int'l Joint Research
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