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The effect of Microbiota and short chain fatty acid on allergic rhinitis

Research Project

Project/Area Number 17H04344
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionUniversity of Fukui

Principal Investigator

Fujieda Shigeharu  福井大学, 学術研究院医学系部門, 教授 (30238539)

Co-Investigator(Kenkyū-buntansha) 加藤 幸宣  福井大学, 学術研究院医学系部門(附属病院部), 助教 (00748981)
野口 恵美子  筑波大学, 医学医療系, 教授 (40344882)
高林 哲司  福井大学, 学術研究院医学系部門(附属病院部), 講師 (70397272)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Keywords花粉症 / アレルギー性鼻炎 / マイクロバイオーム / 鼻腔内細菌叢 / 短鎖脂肪酸 / 酪酸 / スギ花粉症 / 血管内皮細胞 / 上皮系サイトカイン / 鼻科学 / アレルギー学 / CST-1 / シャルコットライデン結晶 / 臨床免疫学 / 炎症学 / 腸内細菌叢 / 線溶系 / 凝固系 / 免疫担当細胞 / アレルギー / 衛生 / 免疫学 / 微生物 / 細菌
Outline of Final Research Achievements

We analyzed microbiome in the nose for the Japanese-cedar (JC) pollinosis patients, people those who showed sensitization of JC but no nasal symptoms, and health people without sensitization of JC. There were significant differences of alpha and beta diversity between pollinosis patients and non-pollinosis people. One-specific bacteria were not found in the nose of JC pollinosis. This bacterium produces butyric acid. Butyric acid, one of short chain fatty acid, inhibited the production of epithelial-cytokine by the nasal epithelial cell line. Butyric acid also inhibited the expression of ICAM-1 and VCAM-1 in vascular endothelial cells. We succeeded the production of recombinant Bet v1 and birch-induced allergic rhinitis mice model. Intranasal administration of low dose of butyric acid for 5 days inhibited the frequency of nasal scratching number. This bacterium may be a critical for the onset of JC-pollinosis.

Academic Significance and Societal Importance of the Research Achievements

スギ花粉症を中心とするアレルギー性鼻炎は、増加の一途をたどってきた。その原因は不明であり、アレルギー性鼻炎を予防する手立ては皆無と言ってよい状態である。今回の研究で、どのような細菌叢が発症に関与しているのか同定できたことで、発症予防になる細菌叢や細菌が産生する物質による予防策が取れる可能性あり、国民病とも言えるスギ花粉症対策に貢献できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (18 results)

All 2020 2019 2018 2017 2016

All Journal Article (13 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 13 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Journal Article] High-Yield Production of the Major Birch Pollen Allergen Bet v 1 With Allergen Immunogenicity in Nicotiana benthamiana.2020

    • Author(s)
      Yamada Y, Kidoguchi M, Fujieda S, et al.
    • Journal Title

      Front Plant Sci.

      Volume: 11 Pages: 344-346

    • DOI

      10.3389/fpls.2020.00344

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epidemiological study of oral allergy syndrome in birch pollen dispersal-free regions2020

    • Author(s)
      Osawa Y, Ito Y, Fujieda S, et al.
    • Journal Title

      Allergology International

      Volume: 69 Issue: 2 Pages: 246-252

    • DOI

      10.1016/j.alit.2019.09.008

    • NAID

      130007832960

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety profile and immunological response of dual sublingual immunotherapy with house dust mite tablet and Japanese cedar pollen tablet2020

    • Author(s)
      Gotoh M, Okubo K, Fujieda S, et al
    • Journal Title

      Allergology International

      Volume: 69 Issue: 1 Pages: 104-110

    • DOI

      10.1016/j.alit.2019.07.007

    • NAID

      130007788693

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eotaxin-3 as a Plasma Biomarker for Mucosal Eosinophil Infiltration in Chronic Rhinosinusitis2019

    • Author(s)
      Yamada Takechiyo、Miyabe Yui、Ueki Shigeharu、Fujieda Shigeharu、Tokunaga Takahiro、Sakashita Masafumi、Kato Yukinori、Ninomiya Takahiro、Kawasaki Yohei、Suzuki Shinsuke、Saito Hidekazu
    • Journal Title

      Frontiers in Immunology

      Volume: 10 Pages: 74-74

    • DOI

      10.3389/fimmu.2019.00074

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eosinophilic Upper Airway Inflammation in a Murine Model Using an Adoptive Transfer System Induces Hyposmia and Epithelial Layer Injury with Convex Lesions.2019

    • Author(s)
      Kanda A, Fujieda S, et al.
    • Journal Title

      Med Sci (Basel).

      Volume: 7(2) Issue: 2 Pages: 22-22

    • DOI

      10.3390/medsci7020022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy of house dust mite sublingual tablet in the treatment of allergic rhinoconjunctivitis: A randomized trial in a pediatric population.2019

    • Author(s)
      Okamoto Y, Fujieda S, Okano M, Hida H, Kakudo S, Masuyama K.
    • Journal Title

      Pediatr Allergy Immunol.

      Volume: 30 Issue: 1 Pages: 66-73

    • DOI

      10.1111/pai.12984

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combination therapy with montelukast and loratadine alleviates pharyngolaryngeal symptoms related to seasonal allergic rhinitis.2019

    • Author(s)
      Imoto Y, Takabayashi T, Sakashita M, Tokunaga T, Morikawa T, Ninomiya T, Okamoto M, Narita N, Fujieda S.
    • Journal Title

      J Allergy Clin Immunol Pract.

      Volume: 7 Issue: 3 Pages: 1068-1070

    • DOI

      10.1016/j.jaip.2018.07.034

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human cystatin SN is an endogenous protease inhibitor that prevents allergic rhinitis2019

    • Author(s)
      Fukuoka Ayumi、Matsushita Kazufumi、Morikawa Taiyo、Adachi Takumi、Yasuda Koubun、Kiyonari Hiroshi、Fujieda Shigeharu、Yoshimoto Tomohiro
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 143 Issue: 3 Pages: 1153-1162

    • DOI

      10.1016/j.jaci.2018.06.035

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short-chain fatty acids induce tissue plasminogen activator in airway epithelial cells via GPR41&43.2018

    • Author(s)
      Imoto Y, Kato A, Takabayashi T, Sakashita M, Norton JE, Suh LA, Carter RG, Weibman AR, Hulse KE, Stevens W, Harris KE, Peters AT, Grammer LC, Tan BK, Welch K, Conley DB, Kern RC, Fujieda S, Schleimer RP.
    • Journal Title

      Clin Exp Allergy.

      Volume: 48 Issue: 5 Pages: 544-554

    • DOI

      10.1111/cea.13119

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association study of childhood food allergy with genome-wide association studies-discovered loci of atopic dermatitis and eosinophilic esophagitis.2017

    • Author(s)
      Hirota T, et al
    • Journal Title

      J Allergy Clin Immunol

      Volume: 140 Issue: 6 Pages: 1713-1716

    • DOI

      10.1016/j.jaci.2017.05.034

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of group 2 innate lymphoid cells exacerbates and confers corticosteroid resistance to mouse nasal type 2 inflammation2017

    • Author(s)
      Morikawa Taiyo、Fukuoka Ayumi、Matsushita Kazufumi、Yasuda Koubun、Iwasaki Naruhito、Akasaki Shoko、Fujieda Shigeharu、Yoshimoto Tomohiro
    • Journal Title

      International Immunology

      Volume: 29 Issue: 5 Pages: 221-233

    • DOI

      10.1093/intimm/dxx030

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japanese guidelines for allergic rhinitis 20172017

    • Author(s)
      Okubo K, Kurono Y, Ichimura K, Enomoto T, Okamoto Y, Kawauchi H, Suzaki H, Fujieda S, Masuyama K
    • Journal Title

      Allergology International

      Volume: 66 Issue: 2 Pages: 205-219

    • DOI

      10.1016/j.alit.2016.11.001

    • NAID

      130005628190

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Toll-like receptor ligands induce cytokine and chemokine production in human inner ear endolymphatic sac fibroblasts.2016

    • Author(s)
      Yamada T, Ogi K, Sakashita M, Kanno M, Kubo S, Ito Y, Imoto Y, Tokunaga T, Okamoto M, Narita N, Fujieda S.
    • Journal Title

      Auris Nasus Larynx

      Volume: 44(4) Issue: 4 Pages: 398-403

    • DOI

      10.1016/j.anl.2016.10.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] アレルギー性鼻炎の先制医療2019

    • Author(s)
      藤枝重治
    • Organizer
      第1回日本アレルギー学会中国・四国地方部会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] アレルギー性鼻炎の先制医療2019

    • Author(s)
      藤枝重治
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 日本耳鼻咽喉科免疫アレルギー学会の近未来 将来構想2019

    • Author(s)
      藤枝重治
    • Organizer
      第37回日本耳鼻咽喉科免疫アレルギー学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 耳鼻咽喉科疾患における治療薬最前線2018

    • Author(s)
      藤枝重治
    • Organizer
      第5回日本アレルギー学会・総合アレルギー講習会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Allergic rhinitis and asthma.2018

    • Author(s)
      Fujieda S
    • Organizer
      XXIV World Congress of Asthma
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2017-04-28   Modified: 2021-02-19  

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