Participation of innate-immune inflammation and coagulofibrinolytic responses to the organ dysfunction in post cardiac arrest syndrome

• Project/Area Number: 17H04361
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Hokkaido University
• Principal Investigator: Gando Satoshi 北海道大学, 医学研究院, 名誉教授 (30125306)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2017: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
• Keywords: 心停止 / 蘇生 / 臓器不全 / 予後 / 自然免疫炎症反応 / 凝固 / 線溶 / 凝固線溶反応

Outline of Final Research Achievements

Participation of innate-immune inflammation and coagulofibrinolytic responses to the organ dysfunction in post cardiac arrest syndrome has been studied.
We showed that innate-immune inflammation due to histones and disseminated intravascular coagulation (DIC) are deeply involved in the development of organ dysfunction in post cardiac arrest syndrome, leading to poor prognosis of the patients. The results of the studies were published as two original and one review articles.

Academic Significance and Societal Importance of the Research Achievements

心停止蘇生後には中枢神経を主体とした多臓器不全が発症し（心停止後症候群、post cardiac arrest syndrome, PCAS）、蘇生したにも関わらず遷延性意識障害等で症例の予後が不良となる事が多い。
従来論じられて来た心停止・蘇生時間（虚血・低酸素持続時間）に加えて、病的自然免疫（DAMPs/ヒストン）・凝固線溶反応（DIC）が蘇生後臓器不全発症に深く関わり、症例の予後を規定する事を解明した事に本研究の学術的意義があり、ヒストンおよびDICを標的とした治療方法の開発は大きな社会的利益をもたらすであろう。

Research Products

• [Journal Article] Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts (2021)
  • Author(s): Oami T、Karasawa S、Shimada T、Nakada T、Abe T、Ogura H、Shiraishi A、Kushimoto S、Saitoh D、Fujishima S、Mayumi T、Shiino Y、Tarui T、Hifumi T、Otomo Y、Okamoto K、Umemura Y、Kotani J、Sakamoto Y、Sasaki J、Shiraishi S、Takuma K、Tsuruta R、Hagiwara A、Yamakawa K、Masuno T、Takeyama N、et al
  • Journal Title: Scientific Reports Volume: 11 Pages: 343-351
  • DOI: 10.1016/j.ijid.2020.11.168
  • Peer Reviewed / Open Access
• [Journal Article] ISTH interim guidance on recognition and management of coagulopathy in COVID‐19 (2020)
  • Author(s): Thachil Jecko、Tang Ning、Gando Satoshi、Falanga Anna、Cattaneo Marco、Levi Marcel、Clark Cary、Iba Toshiaki
  • Journal Title: Journal of Thrombosis and Haemostasis Volume: 18 Issue: 5 Pages: 1023-1026
  • DOI: 10.1111/jth.14810
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Type and dose of heparin in Covid‐19: Reply (2020)
  • Author(s): Thachil Jecko、Tang Ning、Gando Satoshi、Falanga Anna、Levi Marcel、Clark Cary、Iba Toshiaki、Cattaneo Marco
  • Journal Title: Journal of Thrombosis and Haemostasis Volume: 18 Issue: 8 Pages: 2063-2064
  • DOI: 10.1111/jth.14870
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Laboratory haemostasis monitoring in COVID‐19 (2020)
  • Author(s): Thachil Jecko、Tang Ning、Gando Satoshi、Falanga Anna、Levi Marcel、Clark Cary、Iba Toshiaki
  • Journal Title: Journal of Thrombosis and Haemostasis Volume: 18 Issue: 8 Pages: 2058-2060
  • DOI: 10.1111/jth.14866
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] DOACs and “newer” hemophilia therapies in COVID‐19: Reply (2020)
  • Author(s): Thachil Jecko、Tang Ning、Gando Satoshi、Falanga Anna、Cattaneo Marco、Levi Marcel、Clark Cary、Iba Toshiaki
  • Journal Title: Journal of Thrombosis and Haemostasis Volume: 18 Issue: 7 Pages: 1795-1796
  • DOI: 10.1111/jth.14841
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Defining trauma‐induced coagulopathy with respect to future implications for patient management: Communication from the SSC of the ISTH (2020)
  • Author(s): Moore HB, Gando Satoshi、Iba Toshiaki、Kim Paul Y.、Yeh Calvin H.、Brohi Karim、Hunt Beverley J.、Levy Jerrold H.、Draxler Dominik F.、Stanworth Simon、G?rlinger Klaus、Neal Matthew D.、Schreiber Martin A.、Barrett Christopher D.、Medcalf Robert L.、Moore Ernest E.、Mutch Nicola J.、Thachil Jecko
  • Journal Title: Journal of Thrombosis and Haemostasis Volume: 18 Issue: 3 Pages: 740-747
  • DOI: 10.1111/jth.14690
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Significance of body temperature in elderly patients with sepsis (2020)
  • Author(s): Shimazui Takashi、Nakada TA、Walley KR、 Okamoto Kohji、Umemura Yutaka、Kotani Joji、Sakamoto Yuichiro、Sasaki Junichi、Shiraishi Shin-ichiro、Takuma Kiyotsugu、Gando Satoshi
  • Journal Title: Critical Care Volume: 24 Issue: 1 Pages: 387-387
  • DOI: 10.1186/s13054-020-02976-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The SIRS criteria have better performance for predicting infection than qSOFA scores in the emergency department (2020)
  • Author(s): Gando Satoshi、The Japanese Association for Acute Medicine (JAAM) Sepsis Prognostication in Intensive Care Unit and Emergency Room (SPICE) (JAAM SPICE) Study Group、Shiraishi Atsushi、Abe Toshikazu、Kushimoto Shigeki
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 8095-8095
  • DOI: 10.1038/s41598-020-64314-8
  • Peer Reviewed / Open Access
• [Journal Article] Characteristics and outcomes of bacteremia among ICU-admitted patients with severe sepsis (2020)
  • Author(s): Komori Akira、JAAM FORECAST group、Abe Toshikazu、Kushimoto Shigeki、Ogura Hiroshi、Shiraishi Atsushi、Saitoh Daizoh、Fujishima Seitaro、Mayumi Toshihiko、Naito Toshio、Hifumi Toru、Shiino Yasukazu、Gando Satoshi
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 2983-2983
  • DOI: 10.1038/s41598-020-59830-6
  • Peer Reviewed / Open Access
• [Journal Article] A multicenter prospective validation study on disseminated intravascular coagulation in trauma‐induced coagulopathy (2020)
  • Author(s): Gando Satoshi、Shiraishi Atsushi、Wada Takeshi、Yamakawa Kazuma、Fujishima Seitaro、Saitoh Daizoh、Kushimoto Shigeki、Ogura Hiroshi、Abe Toshikazu、Otomo Yasuhiro
  • Journal Title: Journal of Thrombosis and Haemostasis Volume: 18 Issue: 9 Pages: 2232-2244
  • DOI: 10.1111/jth.14931
  • Peer Reviewed / Open Access
• [Journal Article] Risk modifiers of acute respiratory distress syndrome in patients with non-pulmonary sepsis: a retrospective analysis of the FORECAST study (2020)
  • Author(s): Iriyama Hiroki、on behalf of JAAM FORECAST group、Abe Toshikazu、Kushimoto Shigeki、Fujishima Seitaro、Ogura Hiroshi、Shiraishi Atsushi、Saitoh Daizoh、Mayumi Toshihiko、Naito Toshio、Komori Akira、Hifumi Toru、Shiino Yasukazu、Nakada Taka-aki、Tarui Takehiko、Otomo Yasuhiro、Okamoto Kohji、Gando Satoshi
  • Journal Title: Journal of Intensive Care Volume: 8 Issue: 1 Pages: 7-7
  • DOI: 10.1186/s40560-020-0426-9
  • Peer Reviewed / Open Access
• [Journal Article] History of diabetes may delay antibiotic administration in patients with severe sepsis presenting to emergency departments (2020)
  • Author(s): Abe Toshikazu、Suzuki Tomoharu、Kushimoto Shigeki、Fujishima Seitaro、Sugiyama Takehiro、Iwagami Masao、Ogura Hiroshi、Shiraishi Atsushi、Saitoh Daizoh、Mayumi Toshihiko、Iriyama Hiroki、Gando Satoshi
  • Journal Title: Medicine Volume: 99 Issue: 11 Pages: e19446-e19446
  • DOI: 10.1097/md.0000000000019446
  • Peer Reviewed / Open Access
• [Journal Article] The significance of disseminated intravascular coagulation on multiple organ dysfunction during the early stage of acute respiratory distress syndrome (2020)
  • Author(s): Gando Satoshi、Fujishima Seitaro、Saitoh Daizoh、Shiraishi Atsushi、Yamakawa Kazuma、Kushimoto Shigeki、Ogura Hiroshi
  • Journal Title: Thrombosis Research Volume: 191 Pages: 15-21
  • DOI: 10.1016/j.thromres.2020.03.023
  • Peer Reviewed / Open Access
• [Journal Article] Underlying disorders of disseminated intravascular coagulation: Communication from the ISTH SSC Subcommittees on Disseminated Intravascular Coagulation and Perioperative and Critical Care Thrombosis and Hemostasis (2020)
  • Author(s): Squizzato Alessandro、Gallo Andrea、Levi Marcel、Iba Toshiaki、Levy Jerrold H.、Erez Offer、ten Cate Hugo、Solh Ziad、Gando Satoshi、Vicente Vicente、Di Nisio Marcello
  • Journal Title: Journal of Thrombosis and Haemostasis Volume: 18 Issue: 9 Pages: 2400-2407
  • DOI: 10.1111/jth.14946
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identifying Septic Shock Populations Benefitting from Polymyxin B Hemoperfusion (2020)
  • Author(s): Nakata Hidekazu、Yamakawa Kazuma、Kabata Daijiro、et al.
  • Journal Title: SHOCK Volume: in press Issue: 5 Pages: 667-674
  • DOI: 10.1097/shk.0000000000001533
  • Peer Reviewed / Open Access
• [Journal Article] Clinical characteristics of patients with severe sepsis and septic shock in relation to bacterial virulence of beta‐hemolytic Streptococcus and Streptococcus pneumoniae (2020)
  • Author(s): Hifumi Toru、Fujishima Seitaro、Ubukata Kimiko、Hagiwara Akiyoshi、Abe Toshikazu、Ogura Hiroshi、Shiraishi Atsushi、Kushimoto Shigeki、Saitoh Daizoh、Mayumi Toshihiko、Ikeda Hiroto、Ueyama Masashi、Otomo Yasuhiro、Okamoto Kohji、Umemura Yutaka、Gando Satoshi、the JAAM FORECAST group
  • Journal Title: Acute Medicine & Surgery Volume: 7 Issue: 1 Pages: 513-513
  • DOI: 10.1002/ams2.513
  • Peer Reviewed / Open Access
• [Journal Article] Characteristics and outcomes of frail patients with suspected infection in intensive care units: a descriptive analysis from a multicenter cohort study (2020)
  • Author(s): Komori Akira、for the JAAM SPICE Study Group、Abe Toshikazu、Yamakawa Kazuma、Ogura Hiroshi、Gando Satoshi
  • Journal Title: BMC Geriatrics Volume: 20 Issue: 1 Pages: 485-485
  • DOI: 10.1186/s12877-020-01893-1
  • Peer Reviewed / Open Access
• [Journal Article] Epidemiology of sepsis and septic shock in intensive care units between sepsis-2 and sepsis-3 populations: sepsis prognostication in intensive care unit and emergency room (SPICE-ICU) (2020)
  • Author(s): Abe Toshikazu、for the JAAM SPICE Study Group、Yamakawa Kazuma、Ogura Hiroshi、Kushimoto Shigeki、Saitoh Daizoh、Fujishima Seitaro、Otomo Yasuhiro、Kotani Joji、Gando Satoshi
  • Journal Title: Journal of Intensive Care Volume: 8 Issue: 1 Pages: 44-44
  • DOI: 10.1186/s40560-020-00465-0
  • Peer Reviewed / Open Access
• [Journal Article] COVID-19と凝固線溶系異常(第1回) 新型コロナウイルス感染症と凝固線溶系 (2020)
  • Author(s): 丸藤, 哲
  • Journal Title: Thrombosis Medicine Volume: 10 Pages: 314-319
  • NAID: 40022463328
  • Peer Reviewed / Open Access
• [Journal Article] 外国人救急医療の集約化には中国語通訳の準備と整形外科と消化器科のバックアップ体制が必要である (2020)
  • Author(s): 増井 伸高、丸藤 哲, 松田 知倫
  • Journal Title: 日本救急医学会雑誌 Volume: 31 Pages: 2168-2168
  • Peer Reviewed / Open Access
• [Journal Article] Demographics, Treatments, and Outcomes of Acute Respiratory Distress Syndrome (2019)
  • Author(s): Fujishima Seitaro、Gando Satoshi、Takeyama Naoshi、Yamashita Norio、Shiraishi Shin-ichiro、Ikeda Hiroto、Shiino Yasukazu、Tarui Takehiko、Nakada Taka-aki、Hifumi Toru、Otomo Yasuhiro、Okamoto Kohji、Sakamoto Yuichiro、Hagiwara Akiyoshi、Masuno Tomohiko、Ueyama Masashi、Fujimi Satoshi、Yamakawa Kazuma、Umemura Yutaka
  • Journal Title: SHOCK Volume: - Issue: 5 Pages: 1-1
  • DOI: 10.1097/shk.0000000000001416
  • Peer Reviewed / Open Access
• [Journal Article] Implementation of earlier antibiotic administration in patients with severe sepsis and septic shock in Japan: a descriptive analysis of a prospective observational study (2019)
  • Author(s): Abe T, Kushimoto S, Tokuda Y, Phillips GS, Rhodes A, Sugiyama T, et al.
  • Journal Title: Critical Care Volume: 23 Issue: 1 Pages: 360-360
  • DOI: 10.1186/s13054-019-2644-x
  • Peer Reviewed / Open Access
• [Journal Article] In-hospital mortality associated with the misdiagnosis or unidentified site of infection at admission (2019)
  • Author(s): Abe T, Tokuda Y, Shiraishi A, Fujishima S, Mayumi T, Sugiyama T, et al.
  • Journal Title: Critical Care Volume: 23 Issue: 1 Pages: 202-202
  • DOI: 10.1186/s13054-019-2475-9
  • NAID: 120006649618
  • Peer Reviewed / Open Access
• [Journal Article] Variations in infection sites and mortality rates among patients in intensive care units with severe sepsis and septic shock in Japan (2019)
  • Author(s): Abe T, Ogura H, Kushimoto S, Shiraishi A, Sugiyama T, Deshpande GA, et al.
  • Journal Title: Journal of Intensive Care Volume: 7 Issue: 1 Pages: 28-28
  • DOI: 10.1186/s40560-019-0383-3
  • NAID: 120006631021
  • Peer Reviewed / Open Access
• [Journal Article] Trends in sepsis care in Japan: comparison of two sepsis cohort studies conducted by the Japanese Association for Acute Medicine (2019)
  • Author(s): Fujishima Seitaro、Gando Satoshi、Nakada Taka‐aki、Hifumi Toru、Otomo Yasuhiro、Okamoto Kohji、Sakamoto Yuichiro、Hagiwara Akiyoshi、Masuno Tomohiko、Ueyama Masashi、Fujimi Satoshi、Yamakawa Kazuma、Umemura Yutaka
  • Journal Title: Acute Medicine & Surgery Volume: 6 Issue: 4 Pages: 425-427
  • DOI: 10.1002/ams2.449
  • Peer Reviewed / Open Access
• [Journal Article] Disseminated intravascular coagulation in cardiac arrest and resuscitation (2019)
  • Author(s): Gando Satoshi、Wada Takeshi
  • Journal Title: Journal of Thrombosis and Haemostasis Volume: 17 Issue: 8 Pages: 1205-1216
  • DOI: 10.1111/jth.14480
  • Peer Reviewed / Open Access
• [Journal Article] Role of disseminated intravascular coagulation in severe sepsis (2019)
  • Author(s): Yamashita Norio、Ikeda Hiroto、Mizushima Yasuaki、Gando Satoshi
  • Journal Title: Thrombosis Research Volume: 178 Pages: 182-188
  • DOI: 10.1016/j.thromres.2019.04.025
  • Peer Reviewed / Open Access
• [Journal Article] Trauma‐induced coagulopathy: The past, present, and future: A comment (2019)
  • Author(s): Gando Satoshi、Otomo Yasuhiro
  • Journal Title: Journal of Thrombosis and Haemostasis Volume: 17 Issue: 9 Pages: 1567-1569
  • DOI: 10.1111/jth.14520
  • Peer Reviewed / Open Access
• [Journal Article] Clinical features of patients with candidemia in sepsis (2019)
  • Author(s): Komori A, Abe T, Kushimoto S, Ogura H, Shiraishi A, Deshpande A. G, et al.
  • Journal Title: J Gen Fam Med Volume: 4 Issue: 4 Pages: 161-163
  • DOI: 10.1002/jgf2.250
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Body Temperature Abnormalities on the Implementation of Sepsis Bundles and Outcomes in Patients With Severe Sepsis: A Retrospective Sub-Analysis of the Focused Outcome Research on Emergency Care for Acute Respiratory Distress Syndrome, Sepsis and Trauma Study. (2019)
  • Author(s): Kushimoto S, Abe T, Ogura H, et al
  • Journal Title: Crit Care Med Volume: 47 Issue: 5 Pages: 691-699
  • DOI: 10.1097/ccm.0000000000003688
  • Peer Reviewed / Open Access
• [Journal Article] Significance of plasma fibrinogen level and antithrombin activity in sepsis: A multicenter cohort study using a cubic spline model (2019)
  • Author(s): Matsubara Tsunehiro、Yamakawa Kazuma、Umemura Yutaka、Gando Satoshi、Ogura Hiroshi、Shiraishi Atsushi、Kushimoto Shigeki、Abe Toshikazu、Tarui Takehiko、Hagiwara Akiyoshi、Otomo Yasuhiro、Fujimi Satoshi
  • Journal Title: Thrombosis Research Volume: 181 Pages: 17-23
  • DOI: 10.1016/j.thromres.2019.07.002
  • Peer Reviewed / Open Access
• [Journal Article] Nighttime and non-business days are not associated with increased risk of in-hospital mortality in patients with severe sepsis in intensive care units in Japan: The JAAM FORECAST study (2019)
  • Author(s): Masuno Tomohiko、Takeyama Naoshi、Yamashita Norio、Ikeda Hiroto、Ueyama Masashi、Fujimi Satoshi、Gando Satoshi
  • Journal Title: Journal of Critical Care Volume: 52 Pages: 97-102
  • DOI: 10.1016/j.jcrc.2019.04.021
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Accuracy of Quick SOFA is different according to the severity of illness in infectious patients (2019)
  • Author(s): Gando Satoshi、Otomo Yasuhiro、Okamoto Kohji、Kotani Joji、Sakamoto Yuichiro、Sasaki Junichi、Shiraishi Shin-ichiro、Takuma Kiyotsugu、Tsuruta Ryosuke、Hagiwara Akiyoshi、Masuno Tomohiko、Takeyama Naoshi、Yamashita Norio、Ikeda Hiroto、Ueyama Masashi、Yamakawa Kazuma
  • Journal Title: Journal of Infection and Chemotherapy Volume: 25 Issue: 12 Pages: 943-949
  • DOI: 10.1016/j.jiac.2019.05.010
  • Peer Reviewed / Open Access
• [Journal Article] Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy (2019)
  • Author(s): Gando Satoshi、Gorelick Kenneth J.、Opal Steven M.、Russell James A.、Saito Hidehiko、for the SCARLET Trial Group
  • Journal Title: JAMA Volume: 321 Issue: 20 Pages: 1993-2002
  • DOI: 10.1001/jama.2019.5358
  • Peer Reviewed / Open Access
• [Journal Article] Identifying Sepsis Populations Benefitting from Anticoagulant Therapy: A Prospective Cohort Study Incorporating a Restricted Cubic Spline Regression Model (2019)
  • Author(s): Yamakawa Kazuma、Gando Satoshi、Ogura Hiroshi、et al.
  • Journal Title: Thrombosis and Haemostasis Volume: 119 Issue: 11 Pages: 1740-1751
  • DOI: 10.1055/s-0039-1693740
  • Peer Reviewed / Open Access
• [Journal Article] 【呼吸療法における終末期医療の問題点】人生の最終段階における医療・ケアの決定プロセスを考える (2019)
  • Author(s): 丸藤 哲
  • Journal Title: 人工呼吸 Volume: 36 Pages: 130-139
  • Peer Reviewed / Open Access
• [Journal Article] 線溶亢進型DIC(第1回) 線溶亢進型DICとはなにか (2019)
  • Author(s): 丸藤 哲
  • Journal Title: Thrombosis Volume: 9 Pages: 235-240
  • NAID: 40022023562
  • Peer Reviewed / Open Access
• [Journal Article] 方針決定が困難な症例にどのように対応していくか? (2019)
  • Author(s): 澤村 匡史, 則末 泰博, 美馬 裕之, 植田 育也, 立野 淳子, 橋本 圭司, 吉里 孝子, 木下 浩作, 藤野 裕士, 丸藤 哲, 氏家 良人
  • Journal Title: 日本集中治療医学会雑誌 Volume: 26 Pages: 205-216
  • Peer Reviewed / Open Access
• [Journal Article] 肺炎球菌性肺炎に化膿性心外膜炎および膿胸を併発した一例 (2019)
  • Author(s): 本間 慶憲，吉田 知由，本間 多恵子，柳田 雄一郎，上垣 慎二，早川 峰司，澤村 淳，丸藤 哲
  • Journal Title: 日本集中治療医学会雑誌 Volume: 26 Pages: 189-190
  • NAID: 130007641283
  • Peer Reviewed / Open Access
• [Journal Article] Disseminated intravascular coagulation with increased fibrinolysis during the early phase of isolated traumatic brain injury. (2017)
  • Author(s): Wada T, Gando S, Maekawa K, Katabami K, Sageshima H, Hayakawa M, Sawamura A
  • Journal Title: Crit Care Volume: 21 Issue: 1 Pages: 219-219
  • DOI: 10.1186/s13054-017-1808-9
  • Peer Reviewed / Open Access
• [Presentation] 教育講演 生体侵襲とDIC-敗血症、外傷、心停止 (2020)
  • Author(s): 丸藤 哲
  • Organizer: 第14回日本血栓止血学会学術標準化委員会
  • Invited
• [Presentation] A multicenter prospective validation study and disseminated intravascular coagulation in trauma-induced coagulopathy (2020)
  • Author(s): 丸藤 哲
  • Organizer: ISTH 2020 Virtual Congress
  • Int'l Joint Research
• [Presentation] Invited speaker, Activation of the coagulation system during COVID-19 - insight in the pathophysiology (2020)
  • Author(s): 丸藤 哲
  • Organizer: Euroanesthesia
  • Int'l Joint Research / Invited
• [Presentation] 集中治療領域における理学療法の効果の検証 (2019)
  • Author(s): 中橋 奨、丸藤 哲、和田 剛志、今井 寛
  • Organizer: 第４６回日本集中治療医学会学術集会
• [Presentation] 「臨床研究①」O-004日本における重症敗血症および敗血症性ショック患者に対する積極的な抗生物質投与の現状 (2019)
  • Author(s): 阿部 智一、久志本, 成樹、徳田 安春、杉山 雄大、小倉 裕司、藤島 清太郎、白石 淳、斎藤 大蔵、真弓 俊彦、小森 大輝、入山 大希、戒能 多佳子、内藤 俊夫、阪本 雄一郎、丸藤 哲
  • Organizer: 第19回日本病院総合診療医学会学術総会
• [Presentation] 「症例報告【血液】」O-015非呼吸器感染症による敗血症性ARDSのrisk modifierの検討 (2019)
  • Author(s): 入山 大希、阿部 智一、内藤 俊夫、小倉 裕司、白石 淳、久志本 成樹、斎藤 大蔵、藤島 清太郎、真弓 俊彦、小森 大輝、戒能 多佳子、阪本 雄一郎、丸藤 哲
  • Organizer: 第19回日本病院総合診療医学会学術総会
• [Presentation] 「臨床研修③」O-090重症敗血症および敗血症性ショック患者における菌血症の有無による臨床的特徴と予後の比較 (2019)
  • Author(s): 小森 大輝、阿部 智一、入山 大希、戒能 多佳子、内藤 俊夫、小倉 裕司、白石 淳、久志本 成樹、斎藤 大蔵、藤島 清太郎、真弓 俊彦、阪本 雄一郎、丸藤 哲
  • Organizer: 第19回日本病院総合診療医学会学術総会
• [Presentation] Trauma-induced coagulopathy and disseminated intravascular coagulation. (2017)
  • Author(s): Gando S
  • Organizer: The 26th International Society on Thrombosis and Hemostasis 2017 Congress
  • Int'l Joint Research / Invited
• [Presentation] Disseminated intravascular coagulation during early phase of isolated traumatic brain injury. (2017)
  • Author(s): Gando S
  • Organizer: The 26th International Society on Thrombosis and Hemostasis 2017 Congress
  • Int'l Joint Research / Invited
• [Presentation] DIC in Sepsis. (2017)
  • Author(s): Gando S
  • Organizer: Chinese Critical Care Congress 2017, September 2017
  • Int'l Joint Research / Invited
• [Presentation] Trauma induced coagulopathy. (2017)
  • Author(s): Gando S
  • Organizer: Chinese Critical Care Congress 2017, September 2017
  • Int'l Joint Research / Invited
• [Book] Trauma Induced Coagulopathy (2021)
  • Author(s): Gando S, Wada T
  • Total Pages: 802
  • Publisher: Springer International Publishing