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Study of AI-like drug delivery system for circulation and autonomic neural control system for clinical applications

Research Project

Project/Area Number 17H04365
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionOkayama University (2018-2019)
National Cardiovascular Center Research Institute (2017)

Principal Investigator

KAMIYA ATSUNORI  岡山大学, 医歯薬学総合研究科, 教授 (30324370)

Co-Investigator(Kenkyū-buntansha) 杉町 勝  国立研究開発法人国立循環器病研究センター, 研究所, 部長 (40250261)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords循環 / 自律神経 / 神経
Outline of Final Research Achievements

Circulation management of intensive care medicine is important to directly determine clinical outcome of patients. Circulation management in intensive care unit (ICU) needs expertise technique and rich experience in doctors, whereas their physical and psychological stress is great. In addition, medical error with overwork can occur particularly in area with few doctors. Accordingly, in the present study, we examined a possibility of AI-like automated drug delivery system for circulation and autonomic neural control system for clinical applications.

Academic Significance and Societal Importance of the Research Achievements

集中治療医学における循環管理を支援する自動循環管理システムは、動物実験では作動し、また、臨床医療現場で起こり得る様々なエラーや事故、急な病態変化等に対しても、多彩な安全装置やアラーム機能を搭載することによって、実現可能だと考えられました。また、神経系に介入して、神経の機能を調節することによる新しい医療は、様々な疾患について有望であると、考えられました。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (8 results)

All 2019 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results)

  • [Journal Article] Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression2019

    • Author(s)
      Kamiya Atsunori、Hayama Yohsuke、Kato Shigeki、Shimomura Akihiko、Shimomura Takushi、Irie Katsumasa、Kaneko Ryosuke、Yanagawa Yuchio、Kobayashi Kazuto、Ochiya Takahiro
    • Journal Title

      Nature Neuroscience

      Volume: 22 Issue: 8 Pages: 1289-1305

    • DOI

      10.1038/s41593-019-0430-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] State-space representation of extended Guyton's model.2017

    • Author(s)
      Kamiya A, Hayama Y, Shimizu S, Kawada T
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 313 Issue: 2 Pages: 320-322

    • DOI

      10.1152/ajpheart.00315.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 乳がんに分布する神経を操作してがんを抑制する、がん神経医療の開発2019

    • Author(s)
      神谷厚範
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] In vivo two-photon imaging of thermo-sensing at the skin of living rats2019

    • Author(s)
      Kamiya Atsunori
    • Organizer
      FAOPS 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2光子顕微イメージングによる自律神経-循環バイオロジー2018

    • Author(s)
      神谷厚範
    • Organizer
      第57回日本生体医工学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 生きた動物の2光子イメージングによる温度生物学研究2018

    • Author(s)
      神谷厚範
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] In vivo imaging of cellular dynamics in physiology2017

    • Author(s)
      Kamiya A
    • Organizer
      the 44th Annual Meeting, Fatal and Neonatal Physiological Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 臓器内部における末梢神経のメカノセンシング動態2017

    • Author(s)
      神谷厚範
    • Organizer
      第56回日本生物物理学
    • Related Report
      2017 Annual Research Report
    • Invited

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Published: 2017-04-28   Modified: 2021-02-19  

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