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Analysis of immune system in periodontal disease controlled by intestinal flora

Research Project

Project/Area Number 17H04371
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionFukuoka Dental College

Principal Investigator

Tanaka Yoshihiko  福岡歯科大学, 口腔歯学部, 教授 (00398083)

Co-Investigator(Kenkyū-buntansha) 永尾 潤一  福岡歯科大学, 口腔歯学部, 講師 (30509047)
成田 由香  福岡歯科大学, 口腔歯学部, 助教 (50758050)
長 環  福岡歯科大学, 口腔歯学部, 客員教授 (90131870)
有田 健一  福岡歯科大学, 口腔歯学部, 助教 (90780205)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywords歯周病 / 口腔細菌 / 免疫応答 / リンパ球 / 口腔感染 / 口腔細菌学
Outline of Final Research Achievements

Periodontal disease is one of the increasing diseases affecting many people in Japan. It is known that periodontal disease is a persistent chronic infection caused by bacteria in the oral cavity and immunity is involved in this disease. It has been noted that periodontal disease is not only a disease closely related to general health, but also a disease related to intestinal flora. We have found that the intestinal flora may be associated with periodontal disease in this study.

Academic Significance and Societal Importance of the Research Achievements

腸内フローラがダメージを受けると歯周病が悪化する可能性があることがマウスの研究で示されました。歯周病の原因となる細菌に対する免疫や腸内フローラを整えることで病気を改善できるかもしれません。歯周病原細菌に着目した新しい実験モデルを構築する手がかりを得ました。本研究をさらに進めることで、歯周病に関する知られていない原因や新しい診断法、予防法や治療法の開発に発展することが期待されます。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (27 results)

All 2020 2019 2018 2017 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (14 results) (of which Invited: 1 results) Book (1 results) Remarks (6 results)

  • [Journal Article] Bacterial-induced maternal interleukin-17A pathway promotes autistic-like behaviors in mouse offspring2020

    • Author(s)
      Yasumatsu K, Nagao J, Arita-Morioka K, Narita Y, Tasaki S, Toyoda K, Ito S, Kido H, Tanaka Y.
    • Journal Title

      Experimental Animals

      Volume: 69 Issue: 2 Pages: 250-260

    • DOI

      10.1538/expanim.19-0156

    • NAID

      130007835083

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 口腔細菌がもたらす全身とのクロストーク2019

    • Author(s)
      田中芳彦
    • Journal Title

      炎症と感染

      Volume: 27 Pages: 447-451

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Mild heat stress affects on the cell wall structure in Candida albicans biofilm.2019

    • Author(s)
      Ikezaki, S., Cho, T., Nagao, J., Tasaki, S., Yamaguchi, M., Arita-Morioka, K., Yasumatsu, K., Chibana, H., Ikebe, T. and Tanaka, Y.
    • Journal Title

      Med. Mycol. J.

      Volume: 60 Pages: 29-37

    • NAID

      130007656633

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibitory effects of Myricetin derivatives on curli-dependent biofilm formation in Escherichia coli.2018

    • Author(s)
      Arita-Morioka, K., Yamanaka, K., Mizunoe, Y., Tanaka, Y., Ogura, T. and Sugimoto, S.
    • Journal Title

      Sci. Rep.

      Volume: 8 Issue: 1 Pages: 8432-8432

    • DOI

      10.1038/s41598-018-26748-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis.2018

    • Author(s)
      Tasaki S, Cho T, Nagao JI, Ikezaki S, Narita Y, Arita-Morioka KI, Yasumatsu K, Toyoda K, Kojima H, Tanaka Y.
    • Journal Title

      FEMS Yeast Res.2018 May 1;18(3).

      Volume: 18 Issue: 3 Pages: 1-10

    • DOI

      10.1093/femsyr/foy018

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The AP-1 transcription factor JunB is required for Th17 cell differentiation2017

    • Author(s)
      Yamazaki Soh、Tanaka Yoshihiko、Araki Hiromitsu、Kohda Akira、Sanematsu Fumiyuki、Arasaki Tomoko、Duan Xuefeng、Miura Fumihito、Katagiri Takaharu、Shindo Ryodai、Nakano Hiroyasu、Ito Takashi、Fukui Yoshinori、Endo Shogo、Sumimoto Hideki
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 17402-17402

    • DOI

      10.1038/s41598-017-17597-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Investigation of pathological mechanism of periodontal disease via T-cell mediated immune response.2019

    • Author(s)
      Nagao, J., Narita, Y., Arita-Morioka, K, Yasumatsu, K., Tasaki, S., Cho, T., Tanaka Y.
    • Organizer
      The 49th Annual Meeting of The Japanese Society for Immunology
    • Related Report
      2019 Annual Research Report
  • [Presentation] AIを利用した歯周病画像判定システムの開発と実施調査2019

    • Author(s)
      吉永泰周, 米田雅裕, 廣松亮, 田中芳彦, 廣藤卓雄 , 小山昭則, 坂上竜資
    • Organizer
      第62回秋季日本歯周病学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 宿主免疫応答による歯周病の病態形成機構の解明2019

    • Author(s)
      永尾潤一、成田由香、有田(森岡)健一、安松香奈江、田崎園子、長環、田中芳彦
    • Organizer
      第61回歯科基礎医学会学術大会・総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 歯周炎を誘発するT細胞抗原エピトープの同定2019

    • Author(s)
      成田由香、永尾潤一、有田(森岡)健一、田﨑園子、安松香奈江、長環、田中芳彦
    • Organizer
      第61回歯科基礎医学会学術大会・総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 歯周病原細菌の増殖を抑制する口腔内細菌の同定と抗菌因子の解析2019

    • Author(s)
      池本梨央南、中村麻衣、永尾潤一、有田(森岡)健一、田中芳彦
    • Organizer
      第61回歯科基礎医学会学術大会・総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 歯周病の病態形成におけるプロバイオティクスの機能2019

    • Author(s)
      梁 尚陽、 永尾潤一、成田由香、有田(森岡)健一、安松香奈江、田﨑園子、長 環、田中芳彦
    • Organizer
      第61回歯科基礎医学会学術大会・総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A novel alternatively spliced SWAP-70-like adapter of T cells in differentiated Th2 cells.2018

    • Author(s)
      Tanaka, Y.
    • Organizer
      The 91th Annual Meeting of the Japanese Biochemical Society
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] う蝕および歯周病を標的とした口腔内細菌由来抗菌因子の探索2018

    • Author(s)
      池本梨央南、疊屋有希、永尾潤一、田中芳彦
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 歯周病発症に関わるT細胞免疫応答の制御機構の解明2018

    • Author(s)
      永尾潤一、成田由香、豊田馨太、有田(森岡)健一、安松香奈江、池崎晶二郎、田崎園子、長環、田中芳彦
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Myricetin類縁体を用いた細胞外アミロイド線維依存的なバイオフィルム形成の制御法2018

    • Author(s)
      有田(森岡)健一、永尾潤一、成田由香、池崎晶二郎、安松香奈江、豊田馨太、田﨑園子、長 環、田中芳彦
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 歯周病原細菌に対するT細胞応答に関与する抗原タンパク質の同定2018

    • Author(s)
      豊田馨太、成田由香、永尾潤一、有田(森岡)健一、安松香奈江、池崎晶二郎、田﨑園子、長環、城戸寛史、田中芳彦
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 歯周病病態形成における免疫制御機構の解明2017

    • Author(s)
      永尾潤一、成田由香、有田(森岡)健一、安松香奈江、田崎園子、池崎晶二郎、長環、田中芳彦.
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 実験的歯周炎モデルマウスを用いた病態を惹起する菌体成分の同定2017

    • Author(s)
      成田由香、永尾潤一、有田(森岡)健一、池崎晶二郎、田崎園子、安松香奈江、長環、田中芳彦.
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] インプラント細菌汚染モデルを用いた除染効果の検討2017

    • Author(s)
      安松香奈江,成田由香,長環,永尾潤一,有田(森岡)健一,田崎園子,池崎晶二郎,城戸寛史,田中芳彦.
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Book] 口腔微生物学 第6版2018

    • Author(s)
      石原和幸、今井健一、小川知彦、落合邦康、落合智子、葛城啓彰、上西秀則、清浦有祐、古西清司、田中芳彦、中澤 太、浜田信城、前田伸子、高尾亞由子、玉井利代子、長 環、宮川博史
    • Total Pages
      433
    • Publisher
      学建書院
    • ISBN
      9784762456541
    • Related Report
      2017 Annual Research Report
  • [Remarks] 研究者HP

    • URL

      https://www.fdcnet.ac.jp/col/info/teacher/teacher_info_tanaka

    • Related Report
      2019 Annual Research Report
  • [Remarks] 所属研究機関研究分野HP

    • URL

      https://www.fdcnet.ac.jp/col/department_graduate_school/div_info/div_info_kinou#sec02

    • Related Report
      2019 Annual Research Report
  • [Remarks] 研究者HP

    • URL

      http://www.fdcnet.ac.jp/col/info/teacher/teacher_info_tanaka

    • Related Report
      2018 Annual Research Report
  • [Remarks] 所属研究機関研究分野HP

    • URL

      http://www.fdcnet.ac.jp/col/department_graduate_school/div_info/div_info_kinou

    • Related Report
      2018 Annual Research Report
  • [Remarks] 研究者HP

    • URL

      http://www.fdcnet.ac.jp/col/info/teacher/10_2_1.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 所属研究機関研究分野HP

    • URL

      http://www.fdcnet.ac.jp/col/info/teacher/kouza/kinou.html#kansen

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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