Investigation of role of serotonergic neurons in regulation of masseter muscle activity using optogenetics

• Project/Area Number: 17H04373
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Showa University
• Principal Investigator: Inoue Tomio 昭和大学, 歯学部, 教授 (70184760)
• Co-Investigator(Kenkyū-buntansha): 中山 希世美 昭和大学, 歯学部, 講師 (00433798) ; 望月 文子 昭和大学, 歯学部, 講師 (10453648) ; 田中 謙二 慶應義塾大学, 医学部(信濃町), 准教授 (30329700) ; 中村 史朗 昭和大学, 歯学部, 准教授 (60384187)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2017: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: セロトニン / 咀嚼 / 光遺伝学 / 三叉神経運動ニューロン / 樹状突起 / 5-HT2A受容体 / GluN2Aサブユニット / 5-HT1B受容体 / プレモーターニューロン / 除脳ラット動脈灌流標本 / 顎舌骨筋神経 / 舌下神経 / セロトニン神経系 / ブラキシズム / Srcキナーゼ / 除脳動物動脈灌流標本

Outline of Final Research Achievements

Various motor behaviors are modulated by serotonin (5-HT). While it is known that both the trigeminal motor nucleus and mesencephalic trigeminal nucleus (MesV) receive serotonergic inputs, it remains unclear how 5-HT affects jaw movement. We examined the effects of 5-HT on masseter (jaw-closing) motoneurons (MMNs) in Wistar rat brainstem slice preparations using a whole-cell recording technique. Activation of 5-HT2A receptors enhanced the function of NMDARs in MMN dendrites and presynaptic 5-HT1B receptors were shown to be involved in inhibition of excitatory synaptic inputs from MesV afferents to MMNs. Our results indicate that optogenetic activation of serotonergic neurons during mastication may promote masticatory movements.

Academic Significance and Societal Importance of the Research Achievements

本研究の特色は、セロトニンが神経細胞に対してどのような役割があるのかを解析したうえで、セロトニン神経特異的に活動を制御することができる光操作技術を、私たちが開発した独自の実験モデルに適用することで、セロトニンの役割を細胞レベルから個体レベルまで解析する点にある。本研究結果から、セロトニン神経系による咀嚼筋活動調節の詳細が明らかになり、さらには、セロトニン神経系の活動を特異的に操作することで、咀嚼の機能低下の治療やブラキシズムの治療につながれば、社会的意義は非常に大きいと考えられる。

Research Products

• [Int'l Joint Research] Dept Oral Anatomy and Neurobiology/School of Dentistry/Kyungpook National University(韓国)
• [Journal Article] Involvement of the basal nucleus of Meynert on regional cerebral cortical vasodilation associated with masticatory muscle activity in rats. (2019)
  • Author(s): Hotta H, Suzuki H, Inoue T, Stewart M.
  • Journal Title: J Cereb Blood Flow Metab Volume: in press Issue: 12 Pages: 2416-2428
  • DOI: 10.1177/0271678x19895244
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 5-HT2A receptor activation enhances NMDA receptor-mediated glutamate responses therough Src kinase in the dendrites of rat jaw-closing motoneurons. (2019)
  • Author(s): Dantsuji M, Nakamura S, Nakayam, K, Mochizuki A, Park SK, Bae YC, Ozeki M, Inoue T.
  • Journal Title: J. Physiol. Volume: 印刷中 Issue: 9 Pages: 2565-2589
  • DOI: 10.1113/jp275440
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serotonin1B receptor-mediated presynaptic inhibition of proprioceptive sensory inputs to jaw-closing motoneurons. (2019)
  • Author(s): Nagata A, Nakayama K, Nakamura S, Mochizuki A, Gemba C, Aoki R, Dantsuji M, Maki K, Inoue T.
  • Journal Title: Brain Res Bull. Volume: 149 Pages: 260-267
  • DOI: 10.1016/j.brainresbull.2019.05.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] High molecular weight amyloid β1‐42 oligomers induce neurotoxicity via plasma membrane damage (2019)
  • Author(s): Yasumoto Taro、Takamura Yusaku、Tsuji Mayumi、Watanabe‐Nakayama Takahiro、Imamura Keiko、Inoue Haruhisa、Nakamura Shiro、Inoue Tomio、Kimura Atsushi、Yano Satoshi、Nishijo Hisao、Kiuchi Yuji、Teplow David B.、Ono Kenjiro
  • Journal Title: The FASEB Journal Volume: 33 Issue: 8 Pages: 9220-9234
  • DOI: 10.1096/fj.201900604r
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Enhancement of swallowing motor activity by the ACE inhibitor imidapril in an arterially perfused rat preparation. (2019)
  • Author(s): Moriya T, Nakayama K, Nakamura S, Mochizuki A, Ofuji T, Shirota T, Inoue T.
  • Journal Title: Eur J Pharmacol. Volume: 861 Pages: 172601-172601
  • DOI: 10.1016/j.ejphar.2019.172601
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nanomechanical characterization of time-dependent deformation/recovery on human dentin caused by radiation-induced glycation (2019)
  • Author(s): Tobe T, Shibata Y, Mochizuki A, Shimomura N, Zhou J, Wurihan, Tanaka R, Ikeda S, Zhang Z, Li Q, Inoue T, Miyazaki T
  • Journal Title: J Mech Behav Biomed Mater Volume: 90 Pages: 248-255
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Involvement of orexin in lipid accumulation in the liver (2018)
  • Author(s): Mochizuki A, Nakayama K, Nakamura S, Dantsuji M, Kamijo R, Shioda S, Sakurai T, Ozeki M, Inoue T
  • Journal Title: J Oral Biosci Volume: 60(3) Pages: 76-82
  • Peer Reviewed
• [Journal Article] Experimental Study on Involvement of the Central Nervous System in Inferior Alveolar Nerve Damage-Associated Hyperalgesia of the Mental Region (2018)
  • Author(s): Kiyomoto Masaaki、Shirota Tatsuo、Moriya Takashi、Sato Hitoshi、Nakamura Shiro、Inoue Tomio
  • Journal Title: Journal of Oral and Maxillofacial Surgery Volume: 76 Issue: 10 Pages: 2089.e1-2089.e8
  • DOI: 10.1016/j.joms.2018.06.021
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Generation of orthotopically functional salivary gland from embryonic stem cells (2018)
  • Author(s): Tanaka Junichi、Ogawa Miho、Hojo Hironori、Kawashima Yusuke、Mabuchi Yo、Hata Kenji、Nakamura Shiro、Yasuhara Rika、Takamatsu Koki、Irie Tarou、Fukada Toshiyuki、Sakai Takayoshi、Inoue Tomio、Nishimura Riko、Ohara Osamu、Saito Ichiro、Ohba Shinsuke、Tsuji Takashi、Mishima Kenji
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 4216-4216
  • DOI: 10.1038/s41467-018-06469-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 咀嚼制御の神経メカニズム (2018)
  • Author(s): 井上富雄
  • Journal Title: 日本咀嚼学会誌 Volume: 28(2) Pages: 64-71
  • Peer Reviewed
• [Journal Article] Confocal calcium imaging analysis of respiratory-related burst activity in the parafacial region. (2018)
  • Author(s): Onimaru H, Nakamura S, Ikeda K, Kawakami K, Inoue T.
  • Journal Title: Brain Res Bull. Volume: 139 Pages: 16-20
  • DOI: 10.1016/j.brainresbull.2018.01.013
  • Peer Reviewed
• [Journal Article] Premotoneuronal inputs to early developing trigeminal motoneurons (2017)
  • Author(s): Matsuda K, Nakamura S, Nonaka M, Mochizuki A, Nakayama K, Iijima T, Yokoyama A, Funahashi M, Inoue T
  • Journal Title: J Oral Biosci Volume: 59(2) Pages: 96-103
  • Peer Reviewed
• [Journal Article] Distinctive features of Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus (2017)
  • Author(s): Nagoya K, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Nakayama K, Mochizuki A, Kiyomoto M, Satoh F, Kawakami H, Takahashi K, Inoue T.
  • Journal Title: Neuroscience Volume: 358 Pages: 211-226
  • DOI: 10.1016/j.neuroscience.2017.06.035
  • Peer Reviewed
• [Journal Article] 咀嚼の運動制御機構；網様体 ―古くて新しいシステム (2017)
  • Author(s): 井上富雄，中山希世美，中村史朗
  • Journal Title: Clinical Neuroscience Volume: 35(6) Pages: 689-691
• [Journal Article] Coordinated control of the tongue during suckling-like activity and respiration (2017)
  • Author(s): Inoue T, Nakayama K, Ihara Y, Tachikawa S, Nakamura S, Mochizuki A, Takahashi K, Iijima T
  • Journal Title: Journal of Oral Science Volume: 59 Issue: 2 Pages: 183-188
  • DOI: 10.2334/josnusd.16-0850
  • NAID: 130006882397
  • ISSN: 1343-4934, 1880-4926
  • Peer Reviewed
• [Journal Article] Central neural mechanisms involved in the control of jaw movement during postnatal development (2017)
  • Author(s): Nakamura S, Nagata S, Nonaka M, Nishimura A, Nagoya K, Dantsuji M, Nakayama K, Mochizuki A, Iijima T, Ozeki M, Yamamoto M, Inoue T
  • Journal Title: Showa Univ J Med Sci Volume: 29(3) Pages: 221-229
  • NAID: 130006219349
  • Peer Reviewed
• [Presentation] 除脳ラット動脈灌流標本を用いた咀嚼様リズム神経活動の誘発. (2019)
  • Author(s): 大藤拓生, 中山希世美, 中村史朗, 望月文子, 壇辻昌典, 井上富雄.
  • Organizer: 日本顎口腔機能学会第63回学術大会
• [Presentation] Serotonin1b receptor mediated presynaptic inhibition of jaw closing motoneurons. (2019)
  • Author(s): Nakayama K, Nagata A, Nakamura S, Mochizuki A, Dantsuji M, Maki K, Inoue T.
  • Organizer: Society for Neuroscience 49th annual meeting
  • Int'l Joint Research
• [Presentation] Orexin modulates electrophysiological properties of Phox2b neurons located around trigeminal motor nucleus. (2019)
  • Author(s): Nagoya K, Nakamura S, Tsujimura T, Inoue M, Inoue T.
  • Organizer: Society for Neuroscience 49th annual meeting
  • Int'l Joint Research
• [Presentation] Phox2b-expressing neurons located around trigeminal motor nucleus have specific properties for jaw-movements. (2019)
  • Author(s): Nagoya K, Nakamura S, Tsujimura T, Inoue M, Inoue T.
  • Organizer: Society for Neuroscience 49th annual meeting
  • Int'l Joint Research
• [Presentation] マウス咬筋の筋活動に対するSSRIの影響． (2019)
  • Author(s): 望月文子，池田美菜子，中村史朗，中山希世美，壇辻昌典，加藤隆史，馬場一美，井上富雄．
  • Organizer: 第61回歯科基礎医学会学術大会
• [Presentation] 嚥下関連筋支配神経の活動に対するイミダプリルの効果． (2019)
  • Author(s): 守谷崇, 中山希世美, 中村史朗, 望月文子, 壇辻昌典, 井上富雄.
  • Organizer: 第61回歯科基礎医学会学術大会
• [Presentation] Serotonin1B receptors are involved in presynaptic inhibition of proprioceptive afferent transmission to jaw-closing motoneurons. (2019)
  • Author(s): Inoue T, Nagata A, Nakayama K, Dantsuji M, Nakamura S, Mochizuki A, Maki K.
  • Organizer: IBRO2019 (The 10th IBRO World Congress of Neuroscience)
  • Int'l Joint Research
• [Presentation] Presynaptic Activation of 5-HT1B Receptors Inhibits Proprioceptive Sensory Inputs to Jaw-Closing Motoneurons. (2019)
  • Author(s): Inoue T, Nagata A, Nakayama K, Dantsuji M, Nakamura S, Mochizuki A, Maki K.
  • Organizer: FENS Regional Meeting 2019
  • Int'l Joint Research
• [Presentation] Electrophysiological recordings of neurons derived from sleep bruxism patient-specific iPSCs. (2019)
  • Author(s): Nakai K, Shiga T, Abe Y, Hoashi Y, Nakamura S, Yasuhara R, Matsumoto T, Avijite KS, Kotani K, Mishima K, Inoue T, Akamatsu W, Baba K.
  • Organizer: ISSCR Annual Meeting
  • Int'l Joint Research
• [Presentation] Patch-clamp recordings of neurons induced from sleep bruxism patient specific iPSCs. (2019)
  • Author(s): Nakai K, Hoashi Y, Abe Y, Nakamura S, Siga T, Avijite KS, Yasuhara R, Matsumoto T, Kotani K, Inoue T, Mishima K, Akamatsu W, Baba K.
  • Organizer: 97th general session & exhibition of the IADR
  • Int'l Joint Research
• [Presentation] 睡眠時ブラキシズム特異的iPS細胞由来GABA作動性神経細胞の電気生理学的評価 (2019)
  • Author(s): 中井健人，小溪啓介，帆足有理恵，松本貴志，安部友佳，安原理佳，美島健二，中村史朗，井上富雄，志賀孝宏，赤 松和士，馬場一美
  • Organizer: 日本補綴歯科学会128回学術大会
• [Presentation] 嚥下関連筋支配神経への嚥下改善薬の効果． (2019)
  • Author(s): 守谷崇, 中山希世美, 中村史朗, 望月文子, 壇辻昌典, 代田達夫, 井上富雄
  • Organizer: 日本顎口腔機能学会第62回学術大会
• [Presentation] Effects of optogenetic inhibition of 5-HT neurons in the dorsal raphe nucleus on respiratory control. (2019)
  • Author(s): Kanamaru M, Tsukada M, Yoshikawa A, Onimaru H, Mochizuki A,Sunagawa M, Inoue T,Izumizaki M.
  • Organizer: The 9th Federation of the Asian and Oceanian Physiological Societies Congress in conjunction with the 96th Annual Meeting of the Physiological Society of Japan
  • Int'l Joint Research
• [Presentation] Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus. (2019)
  • Author(s): Nakamura S, Nagoya K, Ikeda K, Onimaru H, Kawakami K, Nakayama K, Mochizuki A, Dantsuji M, Inoue T.
  • Organizer: The 9th Federation of the Asian and Oceanian Physiological Societies Congress in conjunction with the 96th Annual Meeting of the Physiological Society of Japan
  • Int'l Joint Research
• [Presentation] Properties of Phox2b-expressing premotor neurons targeting jaw-muscle motoneurons. (2019)
  • Author(s): Inoue T.
  • Organizer: The 9th Federation of the Asian and Oceanian Physiological Societies Congress in conjunction with the 96th Annual Meeting of the Physiological Society of Japan
  • Int'l Joint Research / Invited
• [Presentation] 嚥下改善薬の投与による嚥下への影響. (2018)
  • Author(s): 守谷崇, 中山希世美, 望月文子，中村史朗，代田達夫, 井上富雄.
  • Organizer: 第65回昭和大学学士会総会
• [Presentation] Activation of 5-HT2A receptor enhances function of GluN2A-containing NMDA receptor via Src kinase in dendrites of rat jaw-closing motoneurons. (2018)
  • Author(s): Dantsuji M, Nakamura S, Mochizuki A, Nakayama K, Kiyomoto M, S. K. Park, Y. J. Bae, Ozeki M, Inoue T.
  • Organizer: Society for Neuroscience 48th annual meeting
  • Int'l Joint Research
• [Presentation] Effects of pharmacological agents administered for swallowing disorders on swallowing motor activity in nerves innervating infrahyoid and laryngeal muscles. (2018)
  • Author(s): Moriya T, Nakayama K, Nakamura S, Mochizuki A, Shirota T, Inoue T
  • Organizer: Society for Neuroscience 48th annual meeting
  • Int'l Joint Research
• [Presentation] 閉口筋および開口筋運動ニューロンへの興奮性シナプス伝達の生後発達様式の比較 (2018)
  • Author(s): 中村史朗，中山希世美，望月文子，壇辻昌典，井上富雄
  • Organizer: 日本顎口腔機能学会第 61 回学術大会
• [Presentation] マウスの脂質代謝におけるオレキシンの影響 (2018)
  • Author(s): 望月文子，中村史朗，中山希世美，壇辻昌典，井上富雄
  • Organizer: 第60回歯科基礎医学会学術大会
• [Presentation] 発達期における閉口筋および開口筋運動ニューロンのグルタミン酸入力比較 (2018)
  • Author(s): 中村史朗，中山希世美，望月文子，壇辻昌典，井上富雄
  • Organizer: 第60回歯科基礎医学会学術大会
• [Presentation] マウスの睡眠覚醒ステージにおける咬筋活動に対するSSRIの影響 (2018)
  • Author(s): 池田美菜子，望月文子，中村史朗，中山希世美，馬場一美，井上富雄
  • Organizer: 第60回歯科基礎医学会学術大会
• [Presentation] 咬筋運動ニューロン樹状突起のグルタミン酸応答に対するセロトニンの効果 (2018)
  • Author(s): 壇辻昌典，中村史朗，望月文子，中山希世美，尾関雅彦，井上富雄
  • Organizer: 第60回歯科基礎医学会学術大会
• [Presentation] 5-HT2A receptor mediates enhancement of NMDA receptor function via Src pathway in dendrites of jaw-closing motoneurons in rats (2018)
  • Author(s): Dantsuji M, Nakamura S, Mochizuki A, Nakayama K, Kiyomoto M, S. K. Park, Y. J. Bae, Ozeki M, Inoue T
  • Organizer: 11th Forum of Neuroscience Berlin
  • Int'l Joint Research
• [Presentation] マウスの睡眠覚醒ステージにおける咬筋活動に対するSSRIの影響 (2018)
  • Author(s): 池田美菜子，望月文子，中村史朗，中山希世美，馬場一美，井上富雄
  • Organizer: 日本顎口腔機能学会第60回学術大会
• [Presentation] Postnatal change of glutamatergic synaptic transmission in the jaw-closing and jaw-opening motoneurons (2018)
  • Author(s): Shimono S, Teshima R, Nakamura S, Nakayama K, Mochizuki A, Ikeda M, Inoue T
  • Organizer: 第95回日本生理学会大会
• [Presentation] Effects of Imidapril on swallowing activity in in situ rat preparations (2018)
  • Author(s): Moriya T, Nakayama K, Nakamura S, Mochizuki A, Shirota T, Inoue T.
  • Organizer: 第95回日本生理学会大会
• [Presentation] 転写因子Phox2bを発現する三叉神経運動核背側網様体ニューロンの生理学的および形態学的解析 (2017)
  • Author(s): 那小屋公太，中村史朗，中山希世美，望月文子，吉田 篤，井上 誠，井上富雄
  • Organizer: 日本顎口腔機能学会第58回学術大会
• [Presentation] ラット三叉神経運動核の背側網様体に存在するPhox2b陽性ニューロンの電気生理学的および形態学的特性は Phox2b陰性ニューロンと異なる (2017)
  • Author(s): 那小屋公太，中村史朗，中山希世美，望月文子，佐藤文彦，吉田 篤，井上 誠，井上富雄
  • Organizer: 第59回歯科基礎医学会学術大会
• [Presentation] 三叉神経運動核背側網様体 Phox2b ニューロンの生理学的・形態学的解析 (2017)
  • Author(s): 井上富雄
  • Organizer: 日本咀嚼学会第28回学術大会
• [Presentation] Glutamatergic synaptic currents of rat jaw-closing motoneurons during transition period from sucking to chewing (2017)
  • Author(s): Nakamura S, Nakayama K, Mochizuki A, Inoue T
  • Organizer: Society for Neuroscience 47th annual meeting
  • Int'l Joint Research
• [Presentation] Distinctive properties of Phox2b neurons located in the rat reticular formation dorsal to the trigeminal motor nucleus (2017)
  • Author(s): Nagoya K, Nakamura S, Ikeda K, Onimaru H, Nakayama K, Mochizuki A, Sato F, Yoshida A, Kawakami K, Inoue M, Inoue T.
  • Organizer: Society for Neuroscience 47th annual meeting
  • Int'l Joint Research
• [Presentation] Postnatal changes of glutamatergic inputs to rat jaw-closing and jaw-opening motoneurons (2017)
  • Author(s): Teshima R, Shimono S, Nakamura S, Nakayama K, Mochizuki A, Ikeda M, Inoue T.
  • Organizer: The 65th Annual Meeting of Japanese Association for Dental Research (JADR)
• [Presentation] The effect of citalopram administration on the occurrence of vigilance states in the mouse model of depression (2017)
  • Author(s): Mochizuki A, Ikeda M, Nakamura S, Nakayama K, Inoue T
  • Organizer: The 65th Annual Meeting of Japanese Association for Dental Research (JADR)
• [Presentation] 咬筋運動ニューロン樹状突起における興奮性シナプス入力のセロトニンによる増幅機構 (2017)
  • Author(s): 壇辻昌典，中村史朗，望月文子，中山希世美，尾関雅彦，井上富雄
  • Organizer: 日本顎口腔機能学会第59回学術大会
• [Presentation] 自己組織化技術を用いたマウスES細胞由来3次元唾液腺組織の誘導 (2017)
  • Author(s): 田中準一，中村史朗，安原理佳，井上富雄，美島健二
  • Organizer: 第62回日本唾液腺学会総会・学術大会
• [Presentation] 咬筋運動ニューロンへのシナプス入力に対するセロトニンの影響 (2017)
  • Author(s): 永田愛，中山希世美，中村史朗，望月文子，槇宏太郎，井上富雄
  • Organizer: 第64回昭和大学学士会総会
• [Presentation] マウス咬筋に対するシタロプラムの影響 (2017)
  • Author(s): 望月文子、池田美菜子、中村史朗、中山希世美、井上富雄
  • Organizer: 第11回三叉神経領域の感覚‐運動統合機構研究会
• [Presentation] The effects of Citalopram on the masseter muscle activity during non-REM sleep in mice (2017)
  • Author(s): Mochizuki A, Ikawa Y, Kato T, Ikeda M, Nakamura S, Nakayama K, Baba K, Inoue T
  • Organizer: The 6th Annual International Institute for Integrative Sleep Medicine (IIIS) Symposium
  • Int'l Joint Research
• [Presentation] マウスES細胞を用いた3次元唾液腺組織の分化誘導 (2017)
  • Author(s): 田中準一，小川美帆，北條宏徳，中村史朗，波多賢二，馬渕洋，安原理佳，西村理行，井上富雄，大庭伸介，斎藤一 郎，辻 孝，美島健二
  • Organizer: 第17回再生医療学会
• [Presentation] Coordinated movement of the tongue in oral motor functions. (2017)
  • Author(s): Nakayama K, Tachikawa S, Ihara Y, Nakamura S, Mochizuki A, Iijima T, Takahashi K, Inoue T.
  • Organizer: Oral Neuroscience 2017 in Osaka Univ,
  • Int'l Joint Research / Invited
• [Presentation] 咀嚼機能 ―その制御機構― (2017)
  • Author(s): 井上富雄
  • Organizer: 日本顎口腔機能学会 第10回 顎口腔機能セミナー
  • Invited
• [Presentation] 咀嚼の神経メカニズム (2017)
  • Author(s): 井上富雄
  • Organizer: 日本咀嚼学会第28回大会
  • Invited
• [Book] 口腔生理学総論；基礎歯科生理学 第７版 (2019)
  • Author(s): 井上富雄
  • Total Pages: 475
  • Publisher: 医歯薬出版
  • ISBN: 9784263458464
• [Book] 咀嚼；基礎歯科生理学 第７版 (2019)
  • Author(s): 井上富雄、中村史朗
  • Total Pages: 475
  • Publisher: 医歯薬出版
  • ISBN: 9784263458464
• [Book] 歯周組織の生理学；ザ・ペリオドントロジー 第３版（沼部幸博、梅田誠、齋藤淳、山本松男編） (2019)
  • Author(s): 井上富雄
  • Total Pages: 297
  • Publisher: 永末書店
• [Book] 顎口腔系の機能；新編 顎関節症 改訂版（日本顎関節学会編） (2018)
  • Author(s): 井上富雄
  • Total Pages: 197
  • Publisher: 永末書店
• [Book] 日本顎関節学会学術用語集 (2017)
  • Author(s): 一般社団法人日本顎関節学会
  • Total Pages: 128
  • Publisher: クインテッセンス出版
  • ISBN: 9784781205663
• [Remarks] 昭和大学歯学部 口腔生理学講座 研究業績
  • URL: http://www10.showa-u.ac.jp/~oralphys/gyoseki.html