| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
We previously reported that scaffold-free three-dimensional (3D) cell construct could be formed and its availability for fabricating the artificial dental pulp-like tissue in vitro. In this study, attempt to form a functionalized biomimetic tissue which enable to regenerate dental pulp within the pulpless teeth in a short period was performed by using 3D cell constructs. It was revealed that 3D cell constructs with vascular-like structure or nerve-like cells were successfully fabricated by utilizing the differentiation ability of dental pulp stem cells (DPSCs). In addition, vascularized DPSC constructs promoted dental pulp regeneration compared with the use of undifferentiated DPSC constructs. Functionalized dental pulp-like tissue based on the 3D DPSC construct could be applied as a transplant and this artificial tissue is a promising biomaterial for achieving the tailor-made dental pulp regenerative medicine.
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