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Is a deteriorate in oral health the risk factor for metabolic syndrome? The Suita study

Research Project

Project/Area Number 17H04388
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionNiigata University

Principal Investigator

Ono Takahiro  新潟大学, 医歯学系, 教授 (30204241)

Co-Investigator(Kenkyū-buntansha) 宮本 恵宏  国立研究開発法人国立循環器病研究センター, 病院, 部長 (10312224)
小久保 喜弘  国立研究開発法人国立循環器病研究センター, 病院, 医長 (20393217)
中井 陸運  国立研究開発法人国立循環器病研究センター, その他, 研究員 (50595147)
大川 純平  新潟大学, 医歯学総合研究科, 研究員 (10846041)
設樂 仁子  新潟大学, 医歯学総合病院, 医員 (10848261)
菊地 さつき  新潟大学, 医歯学総合病院, 医員 (20846076)
山鹿 義郎  新潟大学, 医歯学総合病院, 助教 (20736607)
金田 恒  新潟大学, 医歯学総合病院, 助教 (60322103)
尾形 宗士郎  国立研究開発法人国立循環器病研究センター, その他, 流動研究員 (00805012)
來田 百代  大阪大学, 歯学部附属病院, 医員 (10733082)
高阪 貴之  大阪大学, 歯学部附属病院, 医員 (40755360)
小飯塚 仁美  新潟大学, 医歯学総合病院, 医員 (80783349)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywordsメタボリックシンドローム / 生活習慣病 / 口腔健康 / 咀嚼能力 / 歯周病 / 咬合力 / 循環器疾患 / 前向きコホート研究 / 動脈硬化性疾患 / 咀嚼機能 / 歯学
Outline of Final Research Achievements

In cross-sectional analysis on 1780 data, compared to the highest quartile of masticatory performance, the 2nd quartile showed a 1.46-fold increase in the prevalence of MetS (trend P = 0.159). In addition, Analysis by age showed 1.67-, 1.90-and 1.74-fold increases in the prevalence of MetS in the 3rd, 2nd and 1st quartiles among individuals in their 70s, respectively (trend P = 0.094). However, individuals in their 50s and 60s showed no significant relationship between masticatory performance and MetS. In longitudinal analysis on 599 data (average observation period: 4.4 years), decline of masticatory performance was found as a risk factor for MetS after adjusting age, periodontal disease, smoking and drinking habits. Those results suggested that oral health promotion might be beneficial for preventing MetS and cardio- and cerebro-vascular diseases.

Academic Significance and Societal Importance of the Research Achievements

我が国において、動脈硬化性疾患(心疾患、脳血管疾患)は悪性腫瘍に次ぐ死亡原因であるだけでなく、要介護状態となる主原因の一つである。その予防は健康政策の重点課題とされ、平 成 20 年より 40 歳以上を対象とした特定健康診査・特定保健指導が開始され、いわゆる「メタボリックシンドローム(MetS)」の概念を中心としたヘルスプロモーションが行なわれているが、その効果はまだ十分とは言えない。 しかしながら、本研究の結果より、咀嚼能力の低下がすることがMetSのリスク因子の一つである可能性が示唆されたことから、医科歯科連携による新たなMetS予防の戦略が可能になると期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (30 results)

All 2020 2019 2018 2017

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (18 results) (of which Int'l Joint Research: 5 results,  Invited: 8 results) Book (2 results)

  • [Journal Article] Decreased masticatory performance is related to increased intima-media thickness in a general urban Japanese population: The Suita study2020

    • Author(s)
      Kida Momoyo、Ono Takahiro、Kokubo Yoshihiro、Yoshimuta Yoko、Kosaka Takayuki、Kikui Miki、Yamamoto Masa-aki、Ikebe Kazunori、Maeda Yoshinobu、Nokubi Takashi、Nishimura Kunihiro、Watanabe Makoto、Higashiyama Aya、Miyamoto Yoshihiro
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 64 Issue: 3 Pages: 346-353

    • DOI

      10.1016/j.jpor.2019.10.001

    • NAID

      130007885705

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Periodical utilization of dental services is an effective breakthrough for declining masticatory performance: the Suita study2020

    • Author(s)
      Fujii Katsunori, Kosaka Takayuki, Hasegawa Yoko, Kida Momoyo, Hashimoto Sakae, Fushida Shuri, Nokubi Takashi, Kokubo Yoshihiro, Watanabe Makoto, Higashiyama Aya, Miyamoto Yoshihiro, Ikebe Kazunori, Ono Takahiro
    • Journal Title

      Odontology

      Volume: ‐ Issue: 4 Pages: 1-7

    • DOI

      10.1007/s10266-020-00501-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 健康リスクとしての咀嚼障害と義歯治療の効果-超高齢社会の歯科的戦略-2019

    • Author(s)
      小野高裕
    • Journal Title

      群馬県歯科医学会雑誌

      Volume: 23 Pages: 1-6

    • NAID

      40021938927

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Factors influencing the changes in masticatory performance: the Suita study.2018

    • Author(s)
      Kosaka T, Kida M, Kikui M, Hashimoto S, Fujii K, Yamamoto M, Nokubi T, Maeda Y, Hasegawa Y, Kokubo Y, Watanabe M, Higashiyama A, Miyamoto Y, Ono T
    • Journal Title

      JDR Clinical & Translational Research

      Volume: 3(4) Issue: 4 Pages: 405-412

    • DOI

      10.1177/2380084418785863

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between the burden of major periodontal bacteria and serum lipid profile in a cross-sectional Japanese study2018

    • Author(s)
      Choi Youn-Hee、Kosaka Takayuki、Ojima Miki、Sekine Shinichi、Kokubo Yoshihiro、Watanabe Makoto、Miyamoto Yoshihiro、Ono Takahiro、Amano Atsuo
    • Journal Title

      BMC Oral Health

      Volume: 18 Issue: 1 Pages: 77-77

    • DOI

      10.1186/s12903-018-0536-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 咀嚼とメタボ予防2018

    • Author(s)
      小野高裕
    • Journal Title

      陽光

      Volume: 21 Pages: 4-5

    • Related Report
      2018 Annual Research Report
  • [Journal Article] こころとからだの健康を支える咀嚼を測ろう2018

    • Author(s)
      小野高裕
    • Journal Title

      栄養教諭

      Volume: 51 Pages: 44-49

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Relationship between Metabolic Syndrome Components and Periodontal Disease in a Japanese General Population: the Suita Study2017

    • Author(s)
      Miki Kikui, Yoshihiro Kokubo, Takahiro Ono, Momoyo Kida, Takayuki Kosaka, Masaaki Yamamoto, Makoto Watanabe, Yoshinobu Maeda, Yoshihiro Miyamoto.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 24 Issue: 5 Pages: 495-507

    • DOI

      10.5551/jat.33761

    • NAID

      130005631699

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Relationship between metabolic syndrome and objective masticatory performance in a Japanese general population: the Suita study.2017

    • Author(s)
      Miki Kikui, Takahiro Ono, Yoshihiro Kokubo, Momoyo Kida, Takayuki Kosaka, Masaaki Yamamoto, Takashi Nokubi, Makoto Watanabe, Yoshinobu Maeda, Yoshihiro Miyamoto.
    • Journal Title

      Journal of Dentistry

      Volume: 56 Pages: 53-57

    • DOI

      10.1016/j.jdent.2016.10.014

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 咀嚼能力の低下とメタボリックシンドロームの関連性 -よく噛めないとメタボになる?2017

    • Author(s)
      菊井美希,小野高裕
    • Journal Title

      臨床栄養

      Volume: 130 Pages: 554-556

    • Related Report
      2017 Annual Research Report
  • [Presentation] Can quality/quantity of mastication be a key to successful ageing?2019

    • Author(s)
      Ono T
    • Organizer
      97th General Session of International Association for Dental Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] “Masticatory Performance” as a novel biomarker of oral and general health2019

    • Author(s)
      Ono T
    • Organizer
      29th Annual Congress of the European College of Gerodontology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 咀嚼能力と咀嚼行動から”よく噛む”ことの意味を考える2019

    • Author(s)
      小野高裕
    • Organizer
      第33回日本口腔リハビリテーション学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 客観的に咀嚼機能を測る意義は何か?2019

    • Author(s)
      小野高裕
    • Organizer
      令和元年度日本補綴歯科学会東北・北海道支部学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] A prediction model of objective masticatory performance change in 50-70 years old Japanese: the Suita study2019

    • Author(s)
      Kosaka T, Ono T, Kida M, Hashimoto S, Fujii K, Fushida S, Nokubi T , Kokubo Y, Watanabe M, Higashiyama A, Miyamoto Y, Ikebe K
    • Organizer
      29th Annual Congress of the European Collage of Gerodontology
    • Related Report
      2019 Annual Research Report
  • [Presentation] 都市部一般住民における最大咬合力と循環器病発症との関連:吹田研究2019

    • Author(s)
      橋本 栄,小野高裕,來田百代,高阪貴之,菊井美希,池邉一典
    • Organizer
      日本補綴歯科学会第128回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 都市部一般住民における咀嚼能率低下はメタボリックシンドローム罹患のリスクとなる ー吹田研究ー2019

    • Author(s)
      伏田朱里,小野高裕,高阪貴之,來田百代, 橋本 栄,野首孝祠, 小久保喜弘,池邉一典
    • Organizer
      日本咀嚼学会第30回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of Masticatory Performance as a Novel Biomarker of General Health2019

    • Author(s)
      Ono T
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel Monitoring System for Mastication and Swallowing2018

    • Author(s)
      Ono T
    • Organizer
      Symposium for 10th Anniversary of Faculty of Dentistry, Maranatha Christian University, “Acceleration in Dental Technology”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 都市部一般住民における継続的な歯科定期受診と咀嚼能率との関係について 吹田研究2018

    • Author(s)
      藤井克則, 金田 恒, 長谷川陽子, 小野高裕
    • Organizer
      2018年度第2回新潟歯学会例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 都市部一般住民における咀嚼能率低下予測モデルの開発-吹田研究-2018

    • Author(s)
      高阪貴之,小野高裕,來田百代,菊井美希,橋本 栄,藤井克則, 伏田朱里,小久保喜弘,池邉一典,野首孝祠
    • Organizer
      日本咀嚼学会第29回学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] グミゼリー咀嚼時感応と口腔機能の変化について-吹田研究-2018

    • Author(s)
      橋本 栄,小野高裕,來田百代,高阪貴之,菊井美希,伏田朱里,山本雅章,小久保喜弘,野首孝祠
    • Organizer
      日本老年歯科医学会第29回学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 健康リスクとしての咀嚼障害と義歯治療の効果ー超高齢社会の歯科的戦略2017

    • Author(s)
      小野高裕
    • Organizer
      平成29年度群馬県歯科医学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 健康バイオマーカーとしての咀嚼能率の可能性2017

    • Author(s)
      小野高裕
    • Organizer
      第17回日本抗加齢医学会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Longitudinal change of masticatory performance in a Japanese general population - The Suita study2017

    • Author(s)
      Ono T, Kosaka T, Kida M, Kikui M, Hashimoto S, Fujii K, Kaneda K, Yamamoto M, Maeda Y
    • Organizer
      30th Store Kro Club Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 20歯以上保有者における咀嚼能率低値の原因は何か?-吹田研究-2017

    • Author(s)
      橋本 栄,小野高裕,來田百代,高阪貴之,菊井美希,藤井克則,伏田朱里,山本雅章,小久保喜弘,野首孝祠
    • Organizer
      第28回日本咀嚼学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 都市部一般住民における継続的な歯科定期受診と咀嚼能率との関係について ―吹田研究―2017

    • Author(s)
      藤井克則, 小野高裕, 來田百代, 高阪貴之, 菊井美希, 橋本 栄, 伏田朱里, 山本雅章, 金田 恒, 長谷川陽子, 小久保喜弘, 野首孝祠
    • Organizer
      第28回日本咀嚼学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 都市部一般住民における唾液中ストレスマーカーと咀嚼能率との関連-吹田研究-2017

    • Author(s)
      高阪貴之,小野高裕,來田百代,菊井美希,橋本 栄,藤井克則,伏田朱里,山本雅章,長谷川陽子,小久保喜弘,野首孝祠
    • Organizer
      第28回日本咀嚼学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Book] 咀嚼機能アップBOOK2018

    • Author(s)
      小野高裕,金田恒
    • Total Pages
      151
    • Publisher
      クインテッセンス出版
    • ISBN
      9784781206004
    • Related Report
      2017 Annual Research Report
  • [Book] 咀嚼の本2 -ライフステージから考える咀嚼・栄養・健康-2017

    • Author(s)
      小野高裕
    • Total Pages
      168
    • Publisher
      口腔保健協会
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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