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Multiple control and visualization of self-somatic- stem cells for atrophic jaw bone augmentation

Research Project

Project/Area Number 17H04394
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionKagoshima University

Principal Investigator

NISHIMURA Masahiro  鹿児島大学, 医歯学域歯学系, 教授 (00294570)

Co-Investigator(Kenkyū-buntansha) 石井 正和  鹿児島大学, 医歯学域歯学系, 助教 (00456683)
朝比奈 泉  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (30221039)
山田 和彦  鹿児島大学, 総合科学域総合研究学系, 教授 (40241103)
小戝 健一郎  鹿児島大学, 医歯学域医学系, 教授 (90258418)
佐原 寿史  鹿児島大学, 総合科学域総合研究学系, 准教授 (90452333)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2019: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords再生医療 / 間葉系幹細胞 / 骨再生 / 再生医学 / 骨増生
Outline of Final Research Achievements

Mesenchymal stem cells present in jaw bone marrow (MBMSCs) are a promising cell source for jaw bone regeneration. The function of MBMSCs is still unclear, and it is important to understand its characteristics accurately for successful bone regeneration therapy by MBMSCs.
For the characterization of MBMSCs, we compared the differentiation potential of MBMSCs and iliac bone marrow derived MSCs (IBMSCs). It was revealed that MBMSCs had a low adipose differentiation potential, although bone and cartilage differentiation potential were equivalent. It was revealed that there are many miRNAs with different expression patterns in MBMSC and IBMSC. It was found that VEGF-C has an effect of promoting MSC migration. In addition, spinach-derived glycolipids were shown to have an inhibitory effect on LPS-induced vascular inflammation. It is suggested that the application of these research results to the bone regeneration therapy by MBMSC may improve the therapeutic effect.

Academic Significance and Societal Importance of the Research Achievements

顎骨骨髄はインプラント手術の際に、新たな侵襲を加えずに簡便に採取ができ、ごく少量の骨髄液からでもMBMSCの培養が可能である。また、患者の年齢に関わらず細胞を得ることができる。この点が他の組織由来MSCよりも優位な点である。しかし、これまでMBMSC移植による骨増生効果にはバラツキが大きく、治療効果を一定にコントロールすることができなかった。本研究成果によって、MBMSCの機能を制御する分子が見出され、これらの分子の発現解析が新たな細胞評価基盤技術となる可能性がある。また、本研究成果は歯科領域のみならず、幅広い領域の細胞移植治療にも応用可能であると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (17 results)

All 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (14 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] Vascular Endothelial Growth Factor-C Promotes Human Mesenchymal Stem Cell Migration via an ERK-and FAK-dependent Mechanism.2018

    • Author(s)
      Ishii M, Takahashi M, Murakami J, Yanagisawa T, Nishimura M.
    • Journal Title

      Mol Cell Biochem.

      Volume: 455 Issue: 1-2 Pages: 185-193

    • DOI

      10.1007/s11010-018-3481-y

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] シリーズ/補綴医に贈る再生医療の話 第1回2018

    • Author(s)
      末廣史雄,西村正宏
    • Journal Title

      日本補綴歯科学会誌

      Volume: 10 Pages: 105-110

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycolipids from spinach suppress LPS-induced vascular inflammation through eNOS and NF-κB signaling2017

    • Author(s)
      Ishii M, Nakahara T, Araho D, Murakami J, Nishimura M
    • Journal Title

      Biomedicine & Pharmacotherapy

      Volume: 91 Pages: 111-120

    • DOI

      10.1016/j.biopha.2017.04.052

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] The efficacy of maxillary/mandibular bone marrow stromal cells for bone regeneration2019

    • Author(s)
      Suehiro F, Ishii M, Komabashiri N, Masuzaki T, Kawamoto S, Nishimura M
    • Organizer
      EAO 28th Annual Scientific Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The sodium glucose transporter 2 inhibitor effects bone formation around implants in diabetes rats2019

    • Author(s)
      Masuzaki T, Shimizu T, Komabashiri N, Suehiro F, Kawamoto S, Nishimura M
    • Organizer
      EAO 28th Annual Scientific Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗菌性ペプチドLL37のリンパ管新生促進効果の検討2019

    • Author(s)
      柳澤高大,石井正和,西村正宏
    • Organizer
      第1回南九州歯学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 顎骨骨髄由来間葉系幹細胞の特性解析2019

    • Author(s)
      宮田春香, 石井正和, 西村正宏
    • Organizer
      第1回南九州歯学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 抗菌性ペプチドLL-37によるリンパ管内皮細胞活性化効果の検討2019

    • Author(s)
      柳澤高大,西村正宏
    • Organizer
      令和元年度日本補綴歯科学会九州支部学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 骨再生に対する顎骨骨髄間質細胞の有効性2019

    • Author(s)
      駒走 尚大,末廣 史雄,益﨑 与泰,西村 正宏
    • Organizer
      令和元年度日本補綴歯科学会九州支部学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 企画講演 顎骨の造成・増生の未来2019

    • Author(s)
      西村正宏
    • Organizer
      第49回日本口腔インプラント学会学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 顎堤増生を目的とした顎骨骨髄由来間質細胞の採取成績2019

    • Author(s)
      末廣史雄,益崎与泰,田中謙光,駒走尚大,西村正宏
    • Organizer
      第36回日本口腔インプラント学会九州支部学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 顎骨骨髄由来間質細胞の骨形成能判定のためのマーカー探索2019

    • Author(s)
      駒走尚大,末廣史雄,石井正和,柳澤嵩大,原田佳枝,西村正宏
    • Organizer
      第18回日本再生医療学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] VEGF-Cによる骨髄間葉系幹細胞の遊走促進効果2019

    • Author(s)
      柳澤嵩大、石井正和、高橋まなみ、村上寿理、西村正宏
    • Organizer
      第18回日本再生医療学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 顎骨再生を目的とした顎骨骨髄間質細胞培養法の開発2017

    • Author(s)
      末廣史雄,藤島 慶,益﨑与泰,原田佳枝,柳澤嵩大,西村正宏
    • Organizer
      第126回日本補綴歯科学会(神奈川県横浜市)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 吸収性乳酸/グリコール酸共重合体(PLGA)膜と非吸収性高密度4フッ化エチレン樹脂(d-PTFE)膜を用いたGBRの比較検討2017

    • Author(s)
      末廣史雄,益﨑与泰,石畑清秀,村上寿理,中村利明,西村正宏
    • Organizer
      第47回日本口腔インプラント学会(仙台国際センター)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔インプラント治療と材料に関わる近年の動向2017

    • Author(s)
      西村正宏
    • Organizer
      H29年度鹿児島市歯科医師会・前期学会(鹿児島県歯科医師会館)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 欠損補綴における口腔インプラントの活用方法 -トラブルインプラントも味方に変える-2017

    • Author(s)
      西村正宏
    • Organizer
      H29年度鹿児島市歯科医師会・イブニングセミナー(鹿児島県歯科医師会館)
    • Related Report
      2017 Annual Research Report
    • Invited

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Published: 2017-04-28   Modified: 2021-02-19  

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