| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
Orthodontic tooth movement (OTM) is achieved by the remodeling of the periodontal ligament (PDL) and alveolar bone in response to balanced mechanical loading. We investigated the regulatory dynamics of the SOST/Scl expression generated by orthodontic tooth movement (OTM) in vivo and in vitro. Our results provide evidence to support that factors secreted by the PDL, including SOST/Sclerostin, control alveolar bone remodeling through osteocytic SOST/Sclerostin in OTM. In addition, our findings suggest that augmented mechanical stress-mediated Ca2+ oscillations in PDL enhance the production and release of bone regulatory signals.
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