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Chemical analysis of secondary metabolites of Striga and maximum utilization of Striga

Research Project

Project/Area Number 17H04621
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Bioorganic chemistry
Research InstitutionKobe University

Principal Investigator

Kuse Masaki  神戸大学, 農学研究科, 准教授 (40335013)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords寄生植物 / 天然物化学 / フィールドワーク / 分析化学 / 生体成分 / フィールド調査 / 有機化学 / メタボローム解析 / 生理活性 / 植物 / 分析科学
Outline of Final Research Achievements

An exploratory research on useful substances in Striga was conducted with the aim of controlling the weed "Striga", which parasitizes sorghum, which is the main grain in the world, and causes great damage to the yield. As a result, we succeeded in determining the structure of flavonoid derivatives, and speculate that these are the reasons why Striga has been used as a medicinal plant since ancient times. We were able to establish a system to conduct on-site demonstration experiments of herbicidal effects. The transfer of analytical technology to Sudanese researchers was also promoted as planned.

Academic Significance and Societal Importance of the Research Achievements

ストライガのような寄生植物は穀物の収穫を低下させる原因であり、この防除は世界の食糧問題を解決する上で欠くことのできない重要なタスクである。本研究成果は、ストライガにおける市場価値のある天然物を見出し、除草にインセンティブを与えることで、除草による寄生植物の防除を目指す上で必須のものである。今後、除草したストライガを買いとるシステムを構築することで、除草による防除効果が大きく期待できることから、世界の食糧問題を解決する一つの手法を提供するものである。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (21 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (4 results) Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results) Presentation (9 results) (of which Int'l Joint Research: 4 results) Remarks (1 results)

  • [Int'l Joint Research] Medicinal&Aromatic Plant/Research Institute/National Center for Research(スーダン)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Medicinal&Aromatic Plant/Research Institute/National Center for Research(スーダン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Medicinal&Aromatic Plant/Research Institute/National Center for Research(スーダン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Medicinal and Aromatic Plant/Research Institute/National Center for Research(Sudan)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Expression of recombinant apopholasin using a baculovirus-silkworm multigene expression system and activation via dehydrocoelenterazine2020

    • Author(s)
      Maiko Moriguchi, RyoTakahashi, Bubwoong Kang, Masaki Kuse
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 30 Issue: 12 Pages: 127177-127177

    • DOI

      10.1016/j.bmcl.2020.127177

    • NAID

      120006864548

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ethyl Acetate Fraction of Solanum nigrum L.: Cytotoxicity, Induction of Apoptosis, Cell Cycle in Breast Cancer Cells, and Gas Chromatography-Mass Spectrometry Analysis2019

    • Author(s)
      Moglad, E.H.O, Alhassan, M.S., Abdalkareem, E.A., Abdalla, A.N., Kuse, M.
    • Journal Title

      Asian Journal of Pharmaceutics

      Volume: 13 Pages: 246-251

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enhanced elevations of hypo-osmotic shock-induced cytosolic and nucleic calcium concentrations in tobacco cells by pretreatment with dimethyl sulfoxide2019

    • Author(s)
      Nguyen HTH, Bouteau F, Mazars C, Kuse M, Kawano T
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 83 Issue: 2 Pages: 318-321

    • DOI

      10.1080/09168451.2018.1533801

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Natural Products Responsible for Bioluminescence: Synthesis of Coelenterazines and Dehydrocoelenterazines2018

    • Author(s)
      森口舞子, 井庭早耶香, 久世雅樹
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 76 Issue: 10 Pages: 1000-1009

    • DOI

      10.5059/yukigoseikyokaishi.76.1000

    • NAID

      130007496476

    • ISSN
      0037-9980, 1883-6526
    • Year and Date
      2018-10-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The involvement of calmodulin and protein kinases in the upstream of cytosolic and nucleic calcium signaling induced by hypoosmotic shock in tobacco cells2018

    • Author(s)
      Nguyen HTH, Bouteau F, Mazars C, Kuse M, Kawano T
    • Journal Title

      Plant Signaling & Behavior

      Volume: 13 Pages: 1-7

    • DOI

      10.1080/15592324.2018.1494467

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Total Synthesis of (±)-Ramariolides C and D2017

    • Author(s)
      Masaki Kuse; Maiko Moriguchi; Masashi Hachida; Hirosato Takikawa
    • Journal Title

      Chemistry Letters

      Volume: 46 Issue: 9 Pages: 1409-1411

    • DOI

      10.1246/cl.170631

    • NAID

      130006067985

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First synthesis of (S)-(+)-hymenoic acid, a DNA polymerase λ inhibitor isolated from Hymenochaetaceae sp2017

    • Author(s)
      Kensuke Takahashi; Miki Matsui; Masaki Kuse; Hirosato Takikawa
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 82 Issue: 1 Pages: 42-45

    • DOI

      10.1080/09168451.2017.1406302

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Pholasinの発現と活性化2021

    • Author(s)
      森口舞子、姜法雄、久世雅樹
    • Organizer
      日本農芸化学会 2021年度大会(仙台)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Isolation and identification of bioactive constituents of Striga hermonthica2019

    • Author(s)
      Hanaa HASSABOW and Masaki KUSE
    • Organizer
      JSBBA Kansai 6th Student Forum
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] デヒドロセレンテラジン(DCL)およびDCL 誘導体の化学合成2019

    • Author(s)
      森口舞子, 滝川浩郷, 久世雅樹
    • Organizer
      日本農芸化学会 2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 8-Methoxyvestitol の合成研究2019

    • Author(s)
      大江拓人, 滝川浩郷, 久世雅樹
    • Organizer
      日本農芸化学会 2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Towards Maximum Utilization of the Noxious Invasive Root Parasitic Weeds, Striga spp.2018

    • Author(s)
      Masaki Kuse
    • Organizer
      SATREPS SYmposium on Striga Managemnet
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アルキリデンブテノリド骨格の選択的な構築法によるramariolide類の合成2018

    • Author(s)
      森口 舞子; 久世 雅樹; 滝川 浩郷
    • Organizer
      日本農芸化学会2018年度大会「名古屋」
    • Related Report
      2017 Annual Research Report
  • [Presentation] キノリン骨格から誘導されるアライン中間体を利用した環化付加反応2018

    • Author(s)
      小玉 彩友美; 久世 雅樹; 滝川 浩郷
    • Organizer
      日本農芸化学会2018年度大会「名古屋」
    • Related Report
      2017 Annual Research Report
  • [Presentation] Design and Synthesis of Substrate Analogs for Pholasin Bioluminescence2017

    • Author(s)
      久世 雅樹; 大西 里佳; 松岡 絢香; 滝川 浩郷
    • Organizer
      18th Tetrahedron Symposium Asia Editon
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of Ramariolide A, C, and D2017

    • Author(s)
      森口 舞子; 八田 雅士; 滝川 浩郷; 久世 雅樹
    • Organizer
      18th Tetrahedron Symposium Asia Editon
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 神戸大学 大学院農学研究科 天然有機分子化学研究室

    • URL

      http://www.research.kobe-u.ac.jp/ans-nprd-chem/index.html

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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