| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
We have studied the medicinal resources in Indonesia for a long time and discovered many new biologically active compounds from marine organisms, microorganisms and medicinal plants. In this study, we studied the medicinal resources in Thailand and isolated 307 endophytic fungi. We screened the biological activities of the fungal extracts. Now we perform the purification and structure elucidation of new metabolites produced through co-culture of two fungi, inhibitors of degradation of cellular proteins, and inhibitors of differentiation and cell fusion in the osteoclastgenesis.
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