Analysis of the situation of antimicrobial residues and the transmission mechanism of antimicrobial resistant bacteria in rural Vietnam

Research Project

Project/Area Number	17H04647
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	海外学術
Research Field	Environmental and hygienic pharmacy
Research Institution	Osaka University
Principal Investigator	Hirata Kazumasa 大阪大学, 薬学研究科, 教授 (30199062)
Co-Investigator(Kenkyū-buntansha)	原田和生大阪大学, 医学系研究科, 特任准教授(常勤) (50397741) 松浦秀幸大阪大学, 薬学研究科, 助教 (10596232)
Project Period (FY)	2017-04-01 – 2020-03-31
Project Status	Completed (Fiscal Year 2019)
Budget Amount *help	¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000) Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords	衛生薬学 / 薬剤耐性菌 / 抗菌性物質
Outline of Final Research Achievements	The spread of drug-resistant bacteria has become a global problem, and particularly in Southeast Asian countries, the carrier rate of healthy people in the city is 50% or more, which is extremely serious. The purpose of this study was to analyze and follow up antimicrobial agents and drug resistance genes from environmental water and healthy people in rural areas near Hanoi, Vietnam. The detection rate and concentration range of antimicrobial agents have decreased compared to the research conducted by researchers. It might be due to suppression of inappropriate use by education and enlightenment activities on drug-resistant bacteria by local residents. However, ESBL-producing bacteria and drug resistance genes were detected at all sampling points.
Academic Significance and Societal Importance of the Research Achievements	本研究により周辺住民の薬剤耐性菌に関する教育、啓蒙活動によって、不適正使用を抑制し、環境中抗菌性物質残留濃度を低下させることが可能であることを示唆した。しかし、環境中の薬剤耐性菌については、環境中抗菌性物質残留濃度と高い相関は見られず、検出されなくなるまでには、相当の対策と時間を要することが示唆された。また、不適正使用の抑制により、周辺住民の経済活動にどのような影響が現れたかを今後評価する必要もある。