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Study on the possibility of AIDS supressipm through oral care for children living with HIV

Research Project

Project/Area Number 17H04658
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene and public health
Research InstitutionKyushu University

Principal Investigator

Kikuchi Kimiyo  九州大学, 医学研究院, 講師 (40644737)

Co-Investigator(Kenkyū-buntansha) 安岡 潤子  東京農工大学, 農学部, 特任教授 (90451773)
大川 純代  地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 疫学統計部研究員 (50747673)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
KeywordsHIV / 口腔衛生 / 小児 / カンボジア / ランダム化比較試験 / 感染症 / 衛生
Outline of Final Research Achievements

This study examined the impact of oral health intervention on overall health in children living with HIV, by comparing HIV-positive intervention group, HIV-positive control group, and HIV-negative control group. A randomized controlled trial was conducted in Phnom Penh City with children living with HIV. They attended oral hygiene seminars together with their caregivers and performed daily oral care for approximately 2 years.
The intervention group showed a positive longitudinal association between number of caries in permanent teeth and viral load, also between salivary flow and quality of life. Results of the intervention suggest that improved oral hygiene may be associated with improved overall health status in children living with HIV.

Academic Significance and Societal Importance of the Research Achievements

これまでAIDS発症を抑制する方法はARTがメインであった。しかし口腔ケアがAIDS発症の抑制や全身の健康に関係があることを示すことができれば、服薬遵守が低くなりがちな小児においても、口腔ケアにより健康状態を改善する可能性を追究する重要な意義を有する。
また本研究では児の栄養状態や生活の質にも着目し、疾患が抑えられるだけでなく、口腔ケアがHIVに感染している児の質的な健康にも寄与するかを合わせて調査する。本研究は「HIVに感染している児の健康な成長」という、小児HIVの新たな研究エリアへの可能性に寄与する研究である。

Report

(5 results)
  • 2022 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (19 results)

All 2023 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (6 results) Journal Article (8 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (4 results) (of which Int'l Joint Research: 4 results) Remarks (1 results)

  • [Int'l Joint Research] KHANA Center for Population Health/National Pediatric Hospital(カンボジア)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] KHANA Ctr. Population Health Research/National Pediatric Hospital(カンボジア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] National University of Singapore/National University Health System(シンガポール)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Touro University(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] KHANA Ctr. Population Health Research(カンボジア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] KHANA/National Pediatric Hospital(カンボジア)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Impact of oral intervention on the oral and overall health of children living with HIV in Cambodia: a randomized controlled trial2023

    • Author(s)
      Kikuchi Kimiyo、Tuot Sovannary、Yasuoka Junko、Murayama Makoto、Okawa Sumiyo、Shibanuma Akira、Nanishi Keiko、Eng Sothearith、Huot Chantheany、Yi Siyan
    • Journal Title

      BMC Medicine

      Volume: 21 Issue: 1 Pages: 162-162

    • DOI

      10.1186/s12916-023-02862-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oral health among HIV-positive and HIV-negative children in Phnom Penh, Cambodia: a cross-sectional study2021

    • Author(s)
      Kikuchi Kimiyo、Yi Siyan、Yasuoka Junko、Tuot Sovannary、Okawa Sumiyo、Murayama Makoto、Yem Sokunthea、Chhoun Pheak、Eng Sothearith、Huot Chantheany、Morokuma Seiichi
    • Journal Title

      BMJ Paediatrics Open

      Volume: 5 Issue: 1 Pages: e000992-e000992

    • DOI

      10.1136/bmjpo-2020-000992

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Dental caries in association with viral load in children living with HIV in Phnom Penh, Cambodia: a cross‐sectional study2021

    • Author(s)
      Kikuchi Kimiyo、Yasuoka Junko、Tuot Sovannary、Okawa Sumiyo、Yem Sokunthea、Chhoun Pheak、Murayama Makoto、Huot Chantheany、Yi Siyan
    • Journal Title

      BMC Oral Health

      Volume: 21 Issue: 1 Pages: 159-159

    • DOI

      10.1186/s12903-021-01441-2

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Nutritional status and dietary diversity of school-age children living with HIV: a cross-sectional study in Phnom Penh, Cambodia2020

    • Author(s)
      Yasuoka Junko、Yi Siyan、Okawa Sumiyo、Tuot Sovannary、Murayama Makoto、Huot Chantheany、Chhoun Pheak、Yem Sokunthea、Yuzuriha Kazuki、Mizutani Tetsuya、Kikuchi Kimiyo
    • Journal Title

      BMC Public Health

      Volume: 20 Issue: 1

    • DOI

      10.1186/s12889-020-09238-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 母子健康保健に関する栄養調査|Nutrition survey for material and child health2020

    • Author(s)
      Kazuki Yuzuriha、Siyan Yi、Chantheanny Huot、Sovannary Tuot、Kimiyo Kikuchi
    • Journal Title

      決断科学

      Volume: 7 Pages: 64-67

    • Related Report
      2019 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] Association of oral health status with the CD4+ cell count in children living with HIV in Phnom Penh, Cambodia2019

    • Author(s)
      Kikuchi Kimiyo、Furukawa Yusuke、Tuot Sovannary、Pal Khuondyla、Huot Chantheany、Yi Siyan
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1

    • DOI

      10.1038/s41598-019-51077-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] “Who cares” is key: factors associated with oral health status in children living with HIV in Phnom Penh, Cambodia2019

    • Author(s)
      Kikuchi Kimiyo、Furukawa Yusuke、Tout Sovannary、Pal Khuondyla、Huot Chantheany、Yi Siyan
    • Journal Title

      AIDS Care

      Volume: 32 Issue: 4 Pages: 462-470

    • DOI

      10.1080/09540121.2019.1622634

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Improving overall health of children living with HIV through an oral health intervention in Cambodia: study protocol for a randomized controlled trial2018

    • Author(s)
      Kikuchi Kimiyo、Yasuoka Junko、Tuot Sovannary、Yem Sokunthea、Chhoun Pheak、Okawa Sumiyo、Murayama Makoto、Huot Chantheany、Yi Siyan
    • Journal Title

      Trials

      Volume: 19 Issue: 1 Pages: 673-673

    • DOI

      10.1186/s13063-018-3047-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Nutrition survey for Maternal and Child Health2019

    • Author(s)
      Yuzuriha K, Kikuchi K, Yi S, Huot C, Tuot S
    • Organizer
      Healthcare, SDGs, and Social Business International Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association between oral health status and CD4 counts among children living with HIV: A cross-sectional study in Cambodia2018

    • Author(s)
      Kimiyo Kikuchi
    • Organizer
      American Public Health Association Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oral health status in association with CD4 counts in children living with HIV in Phnom Penh2018

    • Author(s)
      Kimiyo Kikuchi
    • Organizer
      Asia-Pacific Academic Consortium for Public Health Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Caregivers’ biological status influences perinatally HIV-infected children’s oral health status2017

    • Author(s)
      Kimiyo Kikuchi
    • Organizer
      Asia-Pacific Academic Consortium for Public Health Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Remarks] ISRCTN registry

    • URL

      http://www.isrctn.com/ISRCTN15177479

    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2024-01-30  

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