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A study on adaptation mechanisms among people living in a high altitude--- obesity, diabetes and microbiota

Research Project

Project/Area Number 17H04659
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene and public health
Research InstitutionNagasaki University

Principal Investigator

YAMAMOTO Taro  長崎大学, 熱帯医学研究所, 教授 (70304970)

Co-Investigator(Kenkyū-buntansha) 植田 信太郎  東京大学, 大学院理学系研究科(理学部), 名誉教授 (20143357)
水野 文月  東邦大学, 医学部, 助教 (50735496)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords環境適応 / 間接リウマチ / 低酸素 / 糖尿病 / 関節リウマチ / 高地 / 適応 / 適応破綻 / 疾病 / 環境適応とNCD / 肥満 / 腸内細菌叢 / フィールド医学 / 高地と糖尿病 / 社会医学 / 医療人類学
Outline of Final Research Achievements

We have evaluated the actual conditions of hypoxic adaptation and the health status of Tibetan highlanders living in Mustang, which is located at an altitude of 3000 m or more in the northwestern part of Nepal.
From our study, it was suggested that there are many pre-diabetes residents, and that aging and hypoxemia may increase the risk of diabetes. In addition, a unique kinetics of increasing hemoglobin concentration with aging was observed in women. We also conducted a survey specifically for rheumatoid arthritis and found a higher estimated prevalence than in lowlanders. We will continue to investigate and analyze the relationship between the physiological characteristics and gender differences in these Tibetan highlanders and the intestinal flora.

Academic Significance and Societal Importance of the Research Achievements

我々は高地という特異な環境で代々生活をしてきたチベット高地民族を対象として健康調査や低酸素適応の実態を探ってきた。調査したムスタンは長い間外部との制限を交流していた旧ムスタン王国に位置しており、チベット高地民族が獲得してきた低酸素適応遺伝子の変異型を集団として強く受け継いでいると考えられている。近代化が進む中、2017年、2019年に調査を実施できたことは、失われゆく人類の形質を残せたという意味で意義があった。また、関節リウマチと低酸素環境との関連を探ったことは、貴重な成果が広く人類にもたらされたと考えられる。

Report

(5 results)
  • 2022 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (17 results)

All 2022 2019 2018 2017 Other

All Int'l Joint Research (4 results) Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (9 results) Book (1 results)

  • [Int'l Joint Research] ヒマラヤ医学研究所(ネパール)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ハルツーム大学医学部/スーダン教育省中央研究所(スーダン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ヒマラヤ医学研究所(ネパール)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ハルツーム大学医学部(スーダン)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] High prevalence of rheumatoid arthritis and its risk factors among Tibetan highlanders living in Tsarang, Mustang district of Nepal2022

    • Author(s)
      Arima Hiroaki、Koirala Sweta、Nema Kotaro、Nakano Masayuki、Ito Hiromu、Poudel Kapil Madi、Pandey Kishor、Pandey Basu Dev、Yamamoto Taro
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 41 Issue: 1 Pages: 12-12

    • DOI

      10.1186/s40101-022-00283-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Individual variations and sex differences in hemodynamics and percutaneous arterial oxygen saturation (SpO2) in Tibetan highlanders of Tsarang in the Mustang district of Nepal2022

    • Author(s)
      Nishimura Takayuki、Arima Hiroaki、Koirala Sweta、Ito Hiromu、Yamamoto Taro
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 41 Issue: 1 Pages: 9-9

    • DOI

      10.1186/s40101-022-00282-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Current health status and its risk factors of the Tsarang villagers living at high altitude in the Mustang district of Nepal2018

    • Author(s)
      Koirala Sweta、Nakano Masayuki、Arima Hiroaki、Takeuchi Shouhei、Ichikawa Tomo、Nishimura Takayuki、Ito Hiromu、Pandey Basu Dev、Pandey Kishor、Wada Takayuki、Yamamoto Taro
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 37 Issue: 1 Pages: 20-20

    • DOI

      10.1186/s40101-018-0181-y

    • NAID

      120006987944

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] チベット高地民における関節リウマチの有病率及びリスク因子の推定2022

    • Author(s)
      根間恒太朗,有馬弘晃,猪股晋作,山本太郎
    • Organizer
      第42回日本登山医学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] チベット高地民の女性における特異的なヘモグロビン動態2022

    • Author(s)
      有馬弘晃,根間恒太朗,猪股晋作,山本太郎
    • Organizer
      第42回日本登山医学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Cardiovascular Risk Factors among high altitude inhabitants of Nepal.2019

    • Author(s)
      Sweta Koirala, Masayuki Nakano, Hiroaki Arima, Shouhei Takeuchi, Tomo Ichikawa, Takayuki Nishimura, Hiromu Ito, Basu Dev Pandey, Kishor Pandey, Takayuki Wada, Taro Yamamoto.
    • Organizer
      Fifth National Summit of the Health and Population Scientists in Nepal.
    • Related Report
      2019 Annual Research Report
  • [Presentation] ネパール国高地住民における健康リスクと遺伝的背景の関係性について.2019

    • Author(s)
      中野政之、有馬弘晃、山本太郎
    • Organizer
      第78回日本公衆衛生学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ネパール国・高地住民における健康リスク因子の探索.2019

    • Author(s)
      中野政之、有馬弘晃、山本太郎
    • Organizer
      第84回日本健康学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ネパール高地民におけるテロメア長を用いた健康リスク評価.2018

    • Author(s)
      有馬弘晃, 中野政之, 山本太郎.
    • Organizer
      第59回日本熱帯医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Current health status and its risk factors of the Tsarang villagers living at high altitude in the Mustang district of Nepal.2018

    • Author(s)
      Koirala Sweta, 中野政之, 有馬弘晃, 山本太郎.
    • Organizer
      第59回日本熱帯医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ネパール国ムスタン地方住民における健康リスク因子の探索.2018

    • Author(s)
      中野政之, 有馬弘晃, 山本太郎.
    • Organizer
      第77回日本公衆衛生学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ネパール高地民におけるテロメア長を用いた健康リスク評価.2018

    • Author(s)
      有馬弘晃, 中野政之, 山本太郎.
    • Organizer
      第77回日本公衆衛生学会総会
    • Related Report
      2018 Annual Research Report
  • [Book] 抗生物質と人間2017

    • Author(s)
      山本太郎
    • Total Pages
      170
    • Publisher
      岩波書店
    • ISBN
      9784004316794
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2024-01-30  

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