| Project/Area Number |
17H04663
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Hygiene and public health
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Hirai Itaru 琉球大学, 医学部, 教授 (00359994)
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| Co-Investigator(Kenkyū-buntansha) |
宮城 和文 琉球大学, 医学部, 助教 (70372810)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Keywords | 薬剤耐性菌 / 健康保菌 / 感染症 / 抗生物質 |
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| Outline of Final Research Achievements |
In the Southeast Asian countries including Vietnam, it has been reported that detection rates of drug-resistant bacteria, such as ESBL-producing bacteria, were high and that more than half of healthy individuals carried those drug-resistant bacteria. This study was conducted in one area of Hanoi, Vietnam. Consequently, our interview suggested the distance between a health office and participants’ house and gender, i.e. female, might be associated the carriage rate of ESBL-producing bacteria. It has been suggested that there might be genetic relatedness among ESBL-producing isolates obtained from family member and from around toilet of their house. It implied that ESBL-producing bacteria may be transmitted among the family members through housework and toilets. It was suggested that these points could be targets for activity to contain distribution of drug-resistance bacteria in the community.
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| Academic Significance and Societal Importance of the Research Achievements |
ベトナムなど東南アジア諸国で多く観察されている健康な人の薬剤耐性菌保菌について、保菌している薬剤耐性菌の家庭内の伝播の可能性を示した。この点は、今後ベトナムで行われる可能性のある薬剤耐性菌の封じ込めを目的とした活動において一つの標的となる可能性があり、これまで制御が非常に難しかったコミュニティにおける薬剤耐性菌の感染制御に対して重要な知見となったものと考えられる。また、本研究で行われた薬剤耐性菌の分子性情解析において、副次的に確立された薬剤耐性遺伝子の解析法は、今後薬剤耐性菌分布の調査や伝播方向の解析に用いられる可能性もあり、学術的にも価値の高いものと推察される。
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