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Analysis of present status and comprehensive molecular epidemiology of emerging drug-resistant bacteria in developing regions of Asia and Caribbean province

Research Project

Project/Area Number 17H04664
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene and public health
Research InstitutionSapporo Medical University

Principal Investigator

Kobayashi Nobumichi  札幌医科大学, 医学部, 教授 (80186759)

Co-Investigator(Kenkyū-buntansha) 鷲見 紋子  札幌医科大学, 医学部, 准教授 (10363699)
アウン メイジソウ  札幌医科大学, 医学部, 助教 (10749584)
川口谷 充代  札幌医科大学, 医学部, 助教 (70733062)
漆原 範子  札幌医科大学, 医学部, 准教授 (80396308)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords薬剤耐性菌 / メチシリン耐性黄色ブドウ球菌(MRSA) / 基質拡張型ベータラクタマーゼ(ESBL) / カルバペネマーゼ / バングラデシュ / ミャンマー / キューバ / 分子疫学 / 開発途上国 / メチシリン耐性黄色ブドウ球菌 / カルバペネム耐性腸内細菌
Outline of Final Research Achievements

In three countries in Asia and Caribbean regions (Bangladesh, Myanmar, and Cuba) where information on antimicrobial resistance (AMR) is insufficient, resistance rates to various antimicrobials, prevalence of genes associated with AMR and virulence, genetic characteristics of drug-resistant isolates were analyzed for major pathogenic bacterial species (Escherichia coli, Klebsiella pneumoniae, Acinetobacter, Staphylococccus aureus, Enterococcus). As a result, it was revealed that various beta-lactamase genes have been widely distributed to Gram-negative rods represented by E. coli, and virulence factor PVL (Panton-Valentine leukocidin) associated with increased pathogenicity has been prevalent at relatively high rate among methicillin-resistant S. aureus (MRSA).

Academic Significance and Societal Importance of the Research Achievements

感染性微生物の薬剤耐性は世界的な公衆衛生上の重要課題のひとつである。開発途上国では、抗菌薬使用に関する規制が遅れているため薬剤耐性が急速に進行していると予想されるが、その実態は良くわかっていない。本研究ではバングラデシュ、ミャンマー、キューバにおける感染症の主要な原因菌において、世界的に増加が懸念される各種の薬剤耐性遺伝子や病原遺伝子が比較的高率に分布していることを明らかにした。本研究の成果は、開発途上国において薬剤耐性の実態とその対策の重要性を示す科学的根拠として用いられることが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (24 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (6 results) Journal Article (10 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 10 results,  Open Access: 4 results) Presentation (7 results) (of which Int'l Joint Research: 3 results) Remarks (1 results)

  • [Int'l Joint Research] ヤンゴン第二医科大学(ミャンマー)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] マイメンシン医科大学(バングラデシュ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Pedro Kouri熱帯医学研究所(キューバ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Medicine (2), Yangon(Myanmar)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Mymensingh Medical College(Bangladesh)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] IPK Tropical Medicine Institute(Cuba)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Molecular Characterization of Methicillin-Susceptible and -Resistant Staphylococcus aureus Harboring Panton-Valentine Leukocidin-Encoding Bacteriophages in a Tertiary Care Hospital in Myanmar2020

    • Author(s)
      Aung MS, San T, Urushibara N, San N, Oo WM, Soe PE, Kyaw Y, Ko PM, Thu PP, Hlaing MS, Kawaguchiya M, Kobayashi N
    • Journal Title

      Microbial Drug Resistance

      Volume: 25 Issue: 4 Pages: 360-367

    • DOI

      10.1089/mdr.2019.0208

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] High Prevalence of CTX-M Type Extended-Spectrum Beta-Lactamase Genes and Detection of NDM-1 Carbapenemase Gene in Extraintestinal Pathogenic Escherichia coli in Cuba2020

    • Author(s)
      Quinones D, Aung MS, Carmona Y, Gonzalez MK, Pereda N, Hidalgo M, Rivero M, Zayas A, Del Campo R, Urushibara N, Kobayashi N
    • Journal Title

      Pathogens

      Volume: 9 Issue: 1 Pages: 65-65

    • DOI

      10.3390/pathogens9010065

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] First detection of the mcr-1 colistin resistance gene in Escherichia coli from a patient with urinary tract infection in Myanmar2019

    • Author(s)
      San N, Aung MS, Thu PP, Myint YY, Aung MT, San T, Mar TT, Lwin MM, Maw WW, Hlaing MS, Kobayashi N.
    • Journal Title

      New Microbes New Infect

      Volume: 30 Pages: 100550-100550

    • DOI

      10.1016/j.nmni.2019.100550

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic Diversity of CMY Beta-Lactamase Genes in Clinical Isolates of Escherichia coli in Myanmar: Identification of Three Novel Types and Updated Phylogenetic Classification of bla(CMY)2019

    • Author(s)
      San N, Aung MS, Urushibara N, San T, Maw WW, Lwin MM, Mar TT, Myint YY, Thu PP, Hlaing MS, Ganesh B, Kobayashi N
    • Journal Title

      Microb Drug Resist

      Volume: 印刷中 Issue: 5 Pages: 497-504

    • DOI

      10.1089/mdr.2019.0234

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular epidemiological characterization of methicillin-susceptible and -resistant Staphylococcus aureus isolated from skin and soft tissue infections in Bangladesh.2019

    • Author(s)
      Haque N, Aung MS, Paul SK, Bari MS, Ahmed S, Sarkar SR, Roy S, Nasreen SA, Mahmud MC, Hossain MA, Urushibara N, Kawaguchiya M, Sumi A, Kobayash N
    • Journal Title

      Microbial Drug Resistance

      Volume: 25 Issue: 2 Pages: 241-250

    • DOI

      10.1089/mdr.2018.0123

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular characterization of Staphylococcus argenteus in Myanmar: identification of novel genotypes/clusters in staphylocoagulase, protein A, alpha-haemolysin and other virulence factors.2019

    • Author(s)
      Aung MS, San T, San N, Oo WM, Ko PM, Thet KT, Urushibara N, Kawaguchiya M, Sumi A, Kobayashi N.
    • Journal Title

      Journal of Medical Microbiology

      Volume: 68 Issue: 1 Pages: 95-104

    • DOI

      10.1099/jmm.0.000869

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prevalence and molecular epidemiology of clinical isolates of Escherichia coli and Klebsiella pneumoniae harboring extended-spectrum beta-lactamase and carbapenemase genes in Bangladesh.2018

    • Author(s)
      Khan ER, Aung MS, Paul SK, Ahmed S, Haque N, Ahamed F, Sarkar SR, Roy S, Rahman MM, Mahmud MC, Hossain MA, Urushibara N, , Kawaguchiya M, Sumi A, Kobayashi N.
    • Journal Title

      MIcribial Drug Resistance

      Volume: 24 Issue: 10 Pages: 1568-1579

    • DOI

      10.1089/mdr.2018.0063

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetic characteristics of VanA-type vancomycin-resistant Enterococcus faecalis and Enterococcus faecium in Cuba.2018

    • Author(s)
      Quinones D, Aung MS, Sousa Martins JP, Urushibara N, Kobayashi N
    • Journal Title

      New Microbes New Infect

      Volume: 21 Pages: 125-127

    • DOI

      10.1016/j.nmni.2017.12.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevalence of Extended-Spectrum Beta-Lactamase and Carbapenemase Genes in Clinical Isolates of Escherichia coli in Myanmar: Dominance of blaNDM-5 and Emergence of blaOXA-181.2018

    • Author(s)
      Aung MS, San N, Maw WW, San T, Urushibara N, Kawaguchiya M, Sumi A, Kobayashi N
    • Journal Title

      Microbial Drug Resistance

      Volume: - Issue: 9 Pages: 1333-1344

    • DOI

      10.1089/mdr.2017.0387

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prevalence and Genetic Characteristics of Staphylococcus aureus and Staphylococcus argenteus Isolates Harboring Panton-Valentine Leukocidin, Enterotoxins, and TSST-1 Genes from Food Handlers in Myanmar.2017

    • Author(s)
      Aung MS, San T, Aye MM, Mya S, Maw WW, Zan KN, Htut WHW, Kawaguchiya M, Urushibara N, Kobayashi N
    • Journal Title

      Toxins

      Volume: 9 Issue: 8 Pages: 241-253

    • DOI

      10.3390/toxins9080241

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ミャンマーにおける黄色ブドウ球菌の分子疫学とPVL遺伝子の分布状況2020

    • Author(s)
      小林宣道、メイジソウアウン、漆原範子、川口谷充代、ニラサン、ヤミンチョウ、ピョマイコウ、ウィンマーウー、ティダサン
    • Organizer
      第90回日本衛生学会総会(誌上開催)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Molecular epidemiology and prevalence of extended-spectrum beta-lactamase and carbapenem genes of extraintestinal pathogenic Escherichia coli in Cuba2019

    • Author(s)
      Quinones D, Aung MS, Cartaya YC, Novales NP, Kobayashi N
    • Organizer
      29th European Congress of Clinical Microbiology & Infectious Diseases
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular epidemiological characterization of methicillin-susceptible and -resistant Staphylococcus aureus isolated from skin and soft tissue infections in Bangladesh2019

    • Author(s)
      Nazia Haque, Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Shyamal Kumar Paul, Nobumichi Kobayashi.
    • Organizer
      第64回日本ブドウ球菌研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Molecular characterization of Staphylococcus aureus and Staphylococcus argenteus from food handlers in Myanmar.2018

    • Author(s)
      Meiji Soe Aung、漆原範子、Thida San、川口谷充代、小林宣道
    • Organizer
      第63回日本ブドウ球菌研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ミャンマーの大腸菌臨床分離株におけるESBL・カルバペネマーゼ遺伝子の分布状況2018

    • Author(s)
      小林宣道、アウンメイジソウ、サン ニラ、モウ ウィンウィン、川口谷充代、漆原範子、鷲見紋子
    • Organizer
      第88回日本衛生学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Escherichia coli O25b-ST131: a pandemic, multi-resistant, community-associated strain isolated from puerperal infections in Bangladesh.2017

    • Author(s)
      Ahmed S, Paul SK, Nasreen SA, Haque N, Kawaguchiya M, Urushibara N, Hossain MA, Kobayashi N
    • Organizer
      15th International Congress of Bacteriology and Applied Microbiology (IUMS, 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular epidemiology, virulence and drug resistance profile of extended-spectrum β-lactamases- (ESBLs) producing extraintestinal pathogenic Escherichia coli (ExPEC) in Myanmar.2017

    • Author(s)
      Aung MS, San N, Kawaguchiya M, Urushibara N, Kobayashi N
    • Organizer
      30th International Congress of Chemotherapy and Infection 2017 (ICC, 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 札幌医科大学医学部衛生学講座ホームページ

    • URL

      http://web.sapmed.ac.jp/hygiene/index.html

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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