| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Outline of Final Research Achievements |
To investigate effects of perinatal dioxin exposure on circadian rhythm, clock gene RNA expression of buccal mucosa swaps was examined in 9-year-olds from Da Nang birth cohort recruited in 2007-8 living around former Da Nang U.S. airbase. A total 135 children were participated to the survey, BMAL1 RNA expression was detected in 17 boys and 15 girls. In girls with detected BMAL1, increased BMAL1 copy number was associated with increasing TCDD and TEQ-PCDD/Fs. Also, inverse correlations were found between BMAL1 copy number and sleep hours at night and total sleep hours including nap time in girls. Increased CLDQ language score in boys and hyperactivity impulsiveness score in girls were also significantly correlated with increased BMAL1 copy number.
When we performed similar analysis in 56 boys and 36 girls whose Per 1 RNA gene expression were detected and found that Per1 copy number decreased with increasing TEQ-PCDD/Fs and increased with increasing verbal aggression and hostility scores.
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