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Establishment of international liaison between medical doctors and dentists for the purpose of reduction of stroke in Nigeria and Kenya

Research Project

Project/Area Number 17H04670
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Ihara Masafumi  国立研究開発法人国立循環器病研究センター, 病院, 部長 (00372590)

Co-Investigator(Kenkyū-buntansha) 仲野 和彦  大阪大学, 歯学研究科, 教授 (00379083)
田中 智貴  国立研究開発法人国立循環器病研究センター, 病院, 医師 (80726373)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords脳卒中 / アフリカ / 歯科衛生 / 口腔内細菌 / 齲蝕原性細菌 / 脳神経疾患 / 歯学 / 循環器・高血圧 / 細菌
Outline of Final Research Achievements

In order to understand the current status of stroke treatment in Ibadan (Nairobi) and Nairobi (Kenia), we visited Professor Ogeng'o, Vice President of the University of Nairobi and Professor of Pathology, and also dental clinic to investigate oral hygiene status and stroke frequency in Nairobi. The results were published in a peer-reviewed journal. An overseas academic research was developed by inviting a young stroke doctor (Dr. Ominde) from the University of Nairobi and conducting educational training to introduce Japanese stroke treatment to Nairobi. We co-authored a paper on the current state of stroke care in Africa.
As mentioned above, we have established an international medical-dental cooperation in Africa, and have established a system that allows us to examine the relationship between the differences in dental practice systems between Africa and Japan and the prognosis of stroke.

Academic Significance and Societal Importance of the Research Achievements

我が国とアフリカ(ケニア、ナイジェリア)の脳卒中医が相互交流を行い,日本の若手医師・研究者がアフリカの大学病院や歯科クリニックを訪問し,アフリカの若手医師が日本の脳卒中病院を訪問し、それぞれの診療を経験する機会を得た.さらにその成果を,英文誌と邦文誌に出版することが出来た.以上,アフリカの医科-歯科国際連携が構築でき,アフリカと日本の歯科診療体制の違いと脳卒中予後との関わりを検討できる体制を整えることが出来た.

Report

(4 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (42 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (6 results) Journal Article (23 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 22 results,  Open Access: 5 results) Presentation (10 results) (of which Int'l Joint Research: 10 results,  Invited: 10 results) Book (1 results) Remarks (2 results)

  • [Int'l Joint Research] ナイロビ大学(ケニア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] イバダン大学(ナイジェリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ナイロビ大学(ケニア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] イバダン大学(ナイジェリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Nairobi University(Kenya)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Ibadan University(Nigeria)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] アフリカでの脳卒中低減を目指した医科―歯科国際連携の試み.2020

    • Author(s)
      殿村 修一,井上 学,角田 良介,野村 良太,仲野 和彦,猪原 匡史
    • Journal Title

      脳卒中

      Volume: 42 Pages: 107-108

    • NAID

      130007815617

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualizing prolonged hyperperfusion in post-stroke epilepsy using postictal subtraction SPECT2020

    • Author(s)
      Kazuki Fukuma, Katsufumi Kajimoto, Tomotaka Tanaka, Shigetoshi Takaya, Katsuya Kobayashi, Akihiro Shimotake, Riki Matsumoto, Akio Ikeda, Kazunori Toyoda, Masfumi Ihara
    • Journal Title

      Journal of Cerebral Blood Flow and Metabolism

      Volume: - Issue: 1 Pages: 146-156

    • DOI

      10.1177/0271678x20902742

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset2020

    • Author(s)
      Koga Masatoshi、Yamamoto Haruko、Inoue Manabu、et al.
    • Journal Title

      Stroke

      Volume: 51 Issue: 5 Pages: 1530-1538

    • DOI

      10.1161/strokeaha.119.028127

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia2020

    • Author(s)
      Uemura Maiko T.、Maki Takakuni、Ihara Masafumi、Lee Virginia M. Y.、Trojanowski John Q.
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 12 Pages: 80-80

    • DOI

      10.3389/fnagi.2020.00080

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] D-dimer level and outcome of minor ischemic stroke with large vessel occlusion2020

    • Author(s)
      Sato Takeo、Sato Shoichiro、Yamagami Hiroshi、Komatsu Teppei、Mizoguchi Tadataka、Yoshimoto Takeshi、Takagi Masahito、Ihara Masafumi、Koga Masatoshi、Iwata Hiroyoshi、Matsushima Masato、Toyoda Kazunori、Iguchi Yasuyuki
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 413 Pages: 116814-116814

    • DOI

      10.1016/j.jns.2020.116814

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease2020

    • Author(s)
      Yamamoto Yumi、Kojima Katsutoshi、Taura Daisuke、Sone Masakatsu、Washida Kazuo、Egawa Naohiro、Kondo Takayuki、Minakawa Eiko N.、Tsukita Kayoko、Enami Takako、Tomimoto Hidekazu、Mizuno Toshiki、Kalaria Raj N.、Inagaki Nobuya、Takahashi Ryosuke、Harada-Shiba Mariko、Ihara Masafumi、Inoue Haruhisa
    • Journal Title

      Molecular Brain

      Volume: 13 Issue: 1 Pages: 38-38

    • DOI

      10.1186/s13041-020-00573-w

    • NAID

      120006818682

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Concentrations of dabigatran administered after acute ischemic stroke2020

    • Author(s)
      Wada Shinichi、Inoue Manabu、Matsuki Takayuki、Okata Takuya、Kumamoto Masaya、Tagawa Naoki、Yoshimura Sohei、Okamoto Akira、Miyata Toshiyuki、Ihara Masafumi、Toyoda Kazunori、Koga Masatoshi
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 411 Pages: 116704-116704

    • DOI

      10.1016/j.jns.2020.116704

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Late Neurological Deterioration after Acute Intracerebral Hemorrhage: A post hoc Analysis of the ATACH-2 Trial2020

    • Author(s)
      Okazaki Shuhei、Yamamoto Haruko、Foster Lydia、Fukuda-Doi Mayumi、Koga Masatoshi、Ihara Masafumi、Toyoda Kazunori、Palesch Yuko?Y.、Qureshi Adnan?I.
    • Journal Title

      Cerebrovascular Diseases

      Volume: 49 Issue: 1 Pages: 26-31

    • DOI

      10.1159/000506117

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Statin treatment can reduce incidence of early seizure in acute ischemic stroke: A propensity score analysis2020

    • Author(s)
      Matsubara Soichiro、Tanaka Tomotaka、Tomari Shinya、Fukuma Kazuki、Ishiyama Hiroyuki、Abe Soichiro、Arimizu Takuro、Yamaguchi Yoshitaka、Ogata Soshiro、Nishimura Kunihiro、Koga Masatoshi、Ando Yukio、Toyoda Kazunori、Ihara Masafumi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 1968-1968

    • DOI

      10.1038/s41598-020-58652-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of <i>CYP2C19</i> Polymorphisms With Clopidogrel Reactivity and Clinical Outcomes in Chronic Ischemic Stroke2019

    • Author(s)
      Tanaka Tomotaka、Yamagami Hiroshi、Ihara Masafumi、et al.
    • Journal Title

      Circulation Journal

      Volume: 83 Issue: 6 Pages: 1385-1393

    • DOI

      10.1253/circj.CJ-18-1386

    • NAID

      130007652780

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2019-05-24
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of Diffusion‐Weighted Imaging‐Alberta Stroke Program Early Computed Tomography Score (DWI‐ASPECTS) and Ischemic Core Volume to Determine the Malignant Profile in Acute Stroke2019

    • Author(s)
      Yoshimoto Takeshi、Inoue Manabu、Yamagami Hiroshi、Fujita Kyohei、Tanaka Kanta、Ando Daisuke、Sonoda Kazutaka、Kamogawa Naruhiko、Koga Masatoshi、Ihara Masafumi、Toyoda Kazunori
    • Journal Title

      Journal of the American Heart Association

      Volume: 8 Issue: 22

    • DOI

      10.1161/jaha.119.012558

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The rise and rise of cerebral small vessel disease: implications for vascular cognitive impairment and dementia2019

    • Author(s)
      Kalaria Raj N、Hase Yoshiki、Ihara Masafumi
    • Journal Title

      Future Neurology

      Volume: 14 Issue: 2

    • DOI

      10.2217/fnl-2019-0004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of fingolimod on oligodendrocyte maturation under prolonged cerebral hypoperfusion2019

    • Author(s)
      Yasuda Ken、Maki Takakuni、Saito Satoshi、Yamamoto Yumi、Kinoshita Hisanori、Choi Yoon Kyung、Arumugam Thiruma Valavan、Lim Yun-An、Chen Christopher Li Hsian、Wong Peter Tsun-Hon、Ihara Masafumi、Takahashi Ryosuke
    • Journal Title

      Brain Research

      Volume: 1720 Pages: 146294-146294

    • DOI

      10.1016/j.brainres.2019.06.013

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detrimental Effect of Chronic Hypertension on Leptomeningeal Collateral Flow in Acute Ischemic Stroke2019

    • Author(s)
      Fujita Kyohei、Tanaka Kanta、Yamagami Hiroshi、Ide Toshihiro、Ishiyama Hiroyuki、Sonoda Kazutaka、Satow Tetsu、Takahashi Jun C.、Ihara Masafumi、Koga Masatoshi、Yokota Takanori、Toyoda Kazunori
    • Journal Title

      Stroke

      Volume: 50 Issue: 7 Pages: 1751-1757

    • DOI

      10.1161/strokeaha.119.025142

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Stenosis Progression in Intracranial Vertebral Artery Dissection Using Carotid Ultrasonography2019

    • Author(s)
      Wada Shinichi、Koga Masatoshi、Makita Naoki、Nakamura Yuki、Miwa Kaori、Ide Toshihiro、Yi Kenichiro、Mizoguchi Tadataka、Yamaguchi Yoshitaka、Ihara Masafumi、Toyoda Kazunori
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 28 Issue: 8 Pages: 2201-2206

    • DOI

      10.1016/j.jstrokecerebrovasdis.2019.04.033

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Balloon-like Mobile Plaque in the Innominate Artery: Ultrasonographic and Pathological Perspectives of Repetitive Embolism2019

    • Author(s)
      Ikenouchi Hajime、Washida Kazuo、Yoshimoto Takeshi、Fukuma Kazuki、Saito Satoshi、Inoue Yosuke、Matsuda Hitoshi、Ihara Masafumi
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 28 Issue: 7 Pages: e95-e97

    • DOI

      10.1016/j.jstrokecerebrovasdis.2019.04.015

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of RNF213 p.R4810K Variant in Early-Onset Stroke With Intracranial Arterial Stenosis2019

    • Author(s)
      Kamimura Teppei、Okazaki Shuhei、Morimoto Takaaki、Kobayashi Hatasu、Harada Kouji、Tomita Tsutomu、Higashiyama Aya、Yoshimoto Takeshi、Takahashi Jun C.、Nakagawara Jyoji、Koga Masatoshi、Toyoda Kazunori、Maruyama Hirofumi、Koizumi Akio、Ihara Masafumi
    • Journal Title

      Stroke

      Volume: 50 Issue: 6 Pages: 1561-1563

    • DOI

      10.1161/strokeaha.118.024712

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Large aortic arch plaques correlate with CHADS2 and CHA2DS2-VASc scores in cryptogenic stroke2019

    • Author(s)
      Ueno Yuji、Tateishi Yohei、Doijiri Ryosuke、Kuriki Ayako、Shimizu Takahiro、Kikuno Muneaki、Shimada Yoshiaki、Takekawa Hidehiro、Yamaguchi Eriko、Koga Masatoshi、Kamiya Yuki、Ihara Masafumi、Tsujino Akira、Hirata Koichi、Toyoda Kazunori、Hasegawa Yasuhiro、Hattori Nobutaka、Urabe Takao
    • Journal Title

      Atherosclerosis

      Volume: 284 Pages: 181-186

    • DOI

      10.1016/j.atherosclerosis.2019.03.009

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and Radiological Characteristics of Intracranial Artery Dissection Using Recently Proposed Diagnostic Criteria2019

    • Author(s)
      Nakamura Y, Yamaguchi Y, Makita N, Morita Y, Ide T, Wada S, Mizoguchi T, Ikenouchi H, Miwa K, Yi K, Irie K, Shimohama S, Ihara M, Toyoda K, Koga M
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: Epub Issue: 6 Pages: 30063-1

    • DOI

      10.1016/j.jstrokecerebrovasdis.2019.02.019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa2019

    • Author(s)
      Akinyemi Rufus O.、Owolabi Mayowa O.、Ihara Masafumi、Damasceno Albertino、Ogunniyi Adesola、Dotchin Catherine、Paddick Stella-Maria、Ogeng’o Julius、Walker Richard、Kalaria Raj N.
    • Journal Title

      Brain Research Bulletin

      Volume: 145 Pages: 97-108

    • DOI

      10.1016/j.brainresbull.2018.05.018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] アフリカでの脳卒中低減を目指した医科―歯科国際連携の試み2019

    • Author(s)
      1.殿村 修一,井上 学,角田 良介,野村 良太,仲野 和彦,猪原 匡史
    • Journal Title

      脳卒中

      Volume: 印刷中

    • NAID

      130007815617

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collagen-binding Streptococcus mutans tied to cerebral microbleeds and intracerebral hemorrhage2018

    • Author(s)
      Ihara Masafumi、Tonomura Shuichi、Yamamoto Yumi、Saito Satoshi
    • Journal Title

      Future Neurology

      Volume: 13 Issue: 4 Pages: 219-224

    • DOI

      10.2217/fnl-2018-0016

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Medial temporal lobe atrophy is the norm in cerebrovascular dementias2017

    • Author(s)
      Kalaria R. N.、Ihara M.
    • Journal Title

      European Journal of Neurology

      Volume: 24 Issue: 4 Pages: 539-540

    • DOI

      10.1111/ene.13243

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Modeling mural cell pathology of CADASIL with disease-specific iPS cells.2020

    • Author(s)
      Masafumi Ihara
    • Organizer
      International Stroke Conference 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of induced pluripotent stem cell in CADASIL research2019

    • Author(s)
      Masafumi Ihara
    • Organizer
      CADASIL symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism and management of stroke-associated comorbidities, dementia and epilepsy2019

    • Author(s)
      Masafumi Ihara
    • Organizer
      Brain & Brain PET 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Update: treatment of small vessel disease.2019

    • Author(s)
      Masafumi Ihara
    • Organizer
      2019 Asia Stroke Joint Meeting (ASJM) and Stroke Treatment and Research Society-Taiwan (STARS-Taiwan) Spring Forum
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Medical management for small vessel disease.2019

    • Author(s)
      Masafumi Ihara
    • Organizer
      International Stroke Conference 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cerebral hypoperfusion.2018

    • Author(s)
      Masafumi Ihara
    • Organizer
      16th Asian Oceanian Congress of Neurology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pathogenesis of sporadic small vessel disease.2018

    • Author(s)
      Masafumi Ihara
    • Organizer
      2nd Asia-Pacific Aging Protection Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Bench to bedside: using mouse models to identify new treatment approaches for dementia.2018

    • Author(s)
      Masafumi Ihara
    • Organizer
      CINP2018 (31st The International College of Neuropsychopharmacology)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clinical trial on human lymphatic drainage system.2018

    • Author(s)
      Masafumi Ihara
    • Organizer
      XXI Symposium Neuroradiologicum (SNR2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dental microbes and stroke/dementia2017

    • Author(s)
      Masafumi Ihara
    • Organizer
      Brain Ageing and Dementia in LIMICS
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] Annual Review神経20192019

    • Author(s)
      殿村 修一,猪原 匡史
    • Total Pages
      326
    • Publisher
      中外学社
    • Related Report
      2018 Annual Research Report
  • [Remarks] 国立循環器病研究センター 脳神経内科

    • URL

      http://www.ncvc.go.jp/hospital/section/scd/cerebrovascular/b-group.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 国立循環器病研究センター病院・脳神経内科

    • URL

      http://www.ncvc.go.jp/hospital/section/scd/cerebrovascular/b-group.html

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

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