• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the mechanism leading to the initiation of transcription associated homologous recombination

Research Project

Project/Area Number 17H04713
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation and chemicals
Research InstitutionGunma University

Principal Investigator

Shibata Atsushi  群馬大学, 未来先端研究機構, 准教授 (30707633)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2020: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
KeywordsDNA修復 / NHEJ / HR / 転写共役型DNA修復 / DNA二本鎖切断 / DSB修復経路 / 放射線誘発DSB / 相同組換え修復 / 非相同末端連結 / 修復
Outline of Final Research Achievements

A DNA Double-strand break (DSB) caused by ionizing irradiation is one of the serious DNA damage that affects the cell fate; however, the molecular mechanism at transcriptionally active locus remains unclear. In this study, we demonstrated that transcription-associated homologous recombination (HR)is initiated by RAD52 / XPG in G2 phase cells. In contrast, in the G1 phase, we found that RAP80 protects R-loops during transcription-associated DSB repair (Cell Reports, 2022).

Academic Significance and Societal Importance of the Research Achievements

放射線照射によって生じるDNAの二本鎖切断(DSB)は、細胞の運命を左右する重篤なDNA損傷の一つであり。そのため、DSB修復の成否はがん化や老化、種々の疾病に繋がることから、その詳細な分子機構を解き明かす必要がある。今回、タンパク質をコードする遺伝子領域での修復機構を明らかにした。これらの分子機構が明らかになることで、放射線照射によって発症するがんを含めた種々の疾患に対する新たな予防法および治療法の開発が期待される。

Report

(5 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (82 results)

All 2022 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (11 results) Journal Article (28 results) (of which Int'l Joint Research: 27 results,  Peer Reviewed: 28 results,  Open Access: 24 results) Presentation (40 results) (of which Int'l Joint Research: 17 results,  Invited: 30 results) Remarks (3 results)

  • [Int'l Joint Research] サセックス大学(英国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] インドネシア大学(インドネシア)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] タタ記念病院(インド)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] サセックス大学(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] インドネシア大学(インドネシア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] タタ記念病院(インド)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Sussex(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Tata Memorial Hospital(インド)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Dr. Cipto National General Hospital(インドネシア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Sussex(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Massachusetts General Hospital(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair2022

    • Author(s)
      Yasuhara Takaaki、Kato Reona、Yamauchi Motohiro、Uchihara Yuki、Zou Lee、Miyagawa Kiyoshi、Shibata Atsushi
    • Journal Title

      Cell Reports

      Volume: 38 Issue: 5 Pages: 110335-110335

    • DOI

      10.1016/j.celrep.2022.110335

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expression of non-homologous end joining factor, Ku80, is negatively correlated with PD-L1 expression in cancer cells after X-ray irradiation2021

    • Author(s)
      Kumazawa Takuya、Mori Yasumasa、Sato Hiro、Permata Tiara、Uchihara Yuki、Noda Shin-Ei、Okada Kohei、Kakoti Sangeeta、Suzuki Keiji、Ikota Hayato、Yokoo Hideaki、Gondhowiardjo Soehartati、Nakano Takashi、Ohno Tatsuya、Shibata Atsushi
    • Journal Title

      Oncology Letters

      Volume: 23 Issue: 1 Pages: 29-29

    • DOI

      10.3892/ol.2021.13147

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 64Cu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity2021

    • Author(s)
      Nachankar Ankita、Oike Takahiro、Hanaoka Hirofumi、Kanai Ayaka、Sato Hiro、Yoshida Yukari、Obinata Hideru、Sakai Makoto、Osu Naoto、Hirota Yuka、Takahashi Akihisa、Shibata Atsushi、Ohno Tatsuya
    • Journal Title

      Cancers

      Volume: 13 Issue: 24 Pages: 6159-6159

    • DOI

      10.3390/cancers13246159

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genome Maintenance Mechanisms at the Chromatin Level2021

    • Author(s)
      Takatsuka Hirotomo、Shibata Atsushi、Umeda Masaaki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 19 Pages: 10384-10384

    • DOI

      10.3390/ijms221910384

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ATM’s Role in the Repair of DNA Double-Strand Breaks2021

    • Author(s)
      Shibata Atsushi、Jeggo Penny A.
    • Journal Title

      Genes

      Volume: 12 Issue: 9 Pages: 1370-1370

    • DOI

      10.3390/genes12091370

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mechanism of chromosome rearrangement arising from single-strand breaks2021

    • Author(s)
      Kot Palina、Yasuhara Takaaki、Shibata Atsushi、Hirakawa Miyako、Abe Yu、Yamauchi Motohiro、Matsuda Naoki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 572 Pages: 191-196

    • DOI

      10.1016/j.bbrc.2021.08.001

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells2021

    • Author(s)
      Permata Tiara Bunga Mayang、Sato Hiro、Gu Wenchao、Kakoti Sangeeta、Uchihara Yuki、Yoshimatsu Yukihiko、Sato Itaru、Kato Reona、Yamauchi Motohiro、Suzuki Keiji、Oike Takahiro、Tsushima Yoshito、Gondhowiardjo Soehartati、Ohno Tatsuya、Yasuhara Takaaki、Shibata Atsushi
    • Journal Title

      Journal of Radiation Research

      Volume: 62 Issue: 5 Pages: 773-781

    • DOI

      10.1093/jrr/rrab050

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modulation of immune responses by DNA damage signaling2021

    • Author(s)
      Uchihara Yuki、Permata Tiara Bunga Mayang、Sato Hiro、Shibata Atsushi
    • Journal Title

      DNA Repair

      Volume: 104 Pages: 103135-103135

    • DOI

      10.1016/j.dnarep.2021.103135

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analysis of radiotherapy induced alteration of CD8+ T cells and PD-L1 expression in patients with uterine cervical squamous cell carcinoma2021

    • Author(s)
      Mori Yasumasa、Sato Hiro、Kumazawa Takuya、Permata Tiara、Yoshimoto Yuya、Murata Kazutoshi、Noda Shin-Ei、Kaminuma Takuya、Ando Ken、Oike Takahiro、Okonogi Noriyuki、Okada Kohei、Kakoti Sangeeta、Suzuki Keiji、Ikota Hayato、Yokoo Hideaki、Nakano Takashi、Ohno Tatsuya、Shibata Atsushi
    • Journal Title

      Oncology Letters

      Volume: 21 Issue: 6 Pages: 446-446

    • DOI

      10.3892/ol.2021.12707

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantitative volumetric analysis of the Golgi apparatus following X-ray irradiation by super-resolution 3D-SIM microscopy2021

    • Author(s)
      Oike Takahiro、Uchihara Yuki、Permata Tiara Bunga Mayang、Gondhowiardjo Soehartati、Ohno Tatsuya、Shibata Atsushi
    • Journal Title

      Medical Molecular Morphology

      Volume: - Issue: 2 Pages: 166-172

    • DOI

      10.1007/s00795-020-00277-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks2020

    • Author(s)
      Akagawa Remi、Trinh Hai Thanh、Saha Liton Kumar、Tsuda Masataka、Hirota Kouji、Yamada Shintaro、Shibata Atsushi、Kanemaki Masato T.、Nakada Shinichiro、Takeda Shunichi、Sasanuma Hiroyuki
    • Journal Title

      iScience

      Volume: 23 Issue: 4 Pages: 101027-101027

    • DOI

      10.1016/j.isci.2020.101027

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells2020

    • Author(s)
      Nakajima Nakako Izumi、Yamauchi Motohiro、Kakoti Sangeeta、Cuihua Liu、Kato Reona、Permata Tiara Bunga Mayang、Iijima Moito、Yajima Hirohiko、Yasuhara Takaaki、Yamada Shigeru、Hasegawa Sumitaka、Shibata Atsushi
    • Journal Title

      DNA Repair

      Volume: 91-92 Pages: 102872-102872

    • DOI

      10.1016/j.dnarep.2020.102872

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Roles for 53BP1 in the repair of radiation-induced DNA double strand breaks2020

    • Author(s)
      Shibata Atsushi、Jeggo Penny A.
    • Journal Title

      DNA Repair

      Volume: 93 Pages: 102915-102915

    • DOI

      10.1016/j.dnarep.2020.102915

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] DNA Repair and Signaling in Immune-Related Cancer Therapy2020

    • Author(s)
      Kakoti Sangeeta、Sato Hiro、Laskar Siddhartha、Yasuhara Takaaki、Shibata Atsushi
    • Journal Title

      Frontiers in Molecular Biosciences

      Volume: 7 Pages: 205-205

    • DOI

      10.3389/fmolb.2020.00205

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Roles for the DNA-PK complex and 53BP1 in protecting ends from resection during DNA double-strand break repair2020

    • Author(s)
      Shibata Atsushi、Jeggo Penny A
    • Journal Title

      Journal of Radiation Research

      Volume: 61 Issue: 5 Pages: 718-726

    • DOI

      10.1093/jrr/rraa053

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Combination of Anti-Cancer Drugs with Molecular Chaperone Inhibitors2019

    • Author(s)
      Shevtsov Maxim、Multhoff Gabriele、Mikhaylova Elena、Shibata Atsushi、Guzhova Irina、Margulis Boris
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 21 Pages: 5284-5284

    • DOI

      10.3390/ijms20215284

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] p53 deficiency augments nucleolar instability after ionizing irradiation.2019

    • Author(s)
      Kakoti, S., Yamauchi, M., Gu, W., Kato, R., Yasuhara, T., Hagiwara, Y., Laskar, S., Oike, T., Sato, H., Held, KD., Nakano, T., and Shibata, A.
    • Journal Title

      Oncology Reports

      Volume: 42 Pages: 2293-2302

    • DOI

      10.3892/or.2019.7341

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulation of programmed death‐ligand 1 expression in response to DNA damage in cancer cells: Implications for precision medicine2019

    • Author(s)
      Sato Hiro、Jeggo Penny A.、Shibata Atsushi
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 11 Pages: 3415-3423

    • DOI

      10.1111/cas.14197

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] FGFR Signaling as a Candidate Therapeutic Target for Cancers Resistant to Carbon Ion Radiotherapy2019

    • Author(s)
      Darwis, N. D. M. Nachankar, A. Sasaki, Y. Matsui, T. Noda, S. E. Murata, K. Tamaki, T. Ando, K. Okonogi, N. Shiba, S. Irie, D. Kaminuma, T. Kumazawa, T. Anakura, M. Yamashita, S. Hirakawa, T. Kakoti, S. Hirota, Y. Tokino, T. Iwase, A. Ohno, T. Shibata, A. Oike, T. Nakano, T.
    • Journal Title

      Int J Mol Sci

      Volume: 20 Issue: 18 Pages: 4563-4563

    • DOI

      10.3390/ijms20184563

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Robustness of clonogenic assays as a biomarker for cancer cell radiosensitivity.2019

    • Author(s)
      Matsui T, Nuryadi E, Komatsu S, Hirota Y, Shibata A, Oike T, Nakano T.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 17 Pages: 4148-4148

    • DOI

      10.3390/ijms20174148

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deep learning-assisted literature mining for in vitro radiosensitivity data2019

    • Author(s)
      Komatsu Shuichiro、Oike Takahiro、Komatsu Yuka、Kubota Yoshiki、Sakai Makoto、Matsui Toshiaki、Nuryadi Endang、Permata Tiara Bunga Mayang、Sato Hiro、Kawamura Hidemasa、Okamoto Masahiko、Kaminuma Takuya、Murata Kazutoshi、Okano Naoko、Hirota Yuka、Ohno Tatsuya、Saitoh Jun-ichi、Shibata Atsushi、Nakano Takashi
    • Journal Title

      Radiotherapy and Oncology

      Volume: 139 Pages: 87-93

    • DOI

      10.1016/j.radonc.2019.07.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Radiosensitivity Differences between EGFR Mutant and Wild-Type Lung Cancer Cells are Larger at Lower Doses2019

    • Author(s)
      Anakura Mai、Nachankar Ankita、Kobayashi Daijiro、Amornwichet Napapat、Hirota Yuka、Shibata Atsushi、Oike Takahiro、Nakano Takashi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 15 Pages: 3635-3635

    • DOI

      10.3390/ijms20153635

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A historical reflection on our understanding of radiation-induced DNA double strand break repair in somatic mammalian cells; interfacing the past with the present2019

    • Author(s)
      Shibata Atsushi、Jeggo Penny
    • Journal Title

      International Journal of Radiation Biology

      Volume: - Issue: 7 Pages: 1-12

    • DOI

      10.1080/09553002.2018.1564083

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clustered DNA double-strand break formation and the repair pathway following heavy-ion irradiation2018

    • Author(s)
      Hagiwara Yoshihiko、Oike Takahiro、Niimi Atsuko、Yamauchi Motohiro、Sato Hiro、Limsirichaikul Siripan、Held Kathryn D、Nakano Takashi、Shibata Atsushi
    • Journal Title

      Journal of Radiation Research

      Volume: 60 Issue: 1 Pages: 69-79

    • DOI

      10.1093/jrr/rry096

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair2018

    • Author(s)
      Yasuhara Takaaki、Kato Reona、Hagiwara Yoshihiko、Shiotani Bunsyo、Yamauchi Motohiro、Nakada Shinichiro、Shibata Atsushi、Miyagawa Kiyoshi
    • Journal Title

      Cell

      Volume: 175 Issue: 2 Pages: 558-570

    • DOI

      10.1016/j.cell.2018.08.056

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analysis of programmed death-ligand 1 expression in primary normal human dermal fibroblasts after DNA damage2018

    • Author(s)
      Hagiwara Yoshihiko, Sato Hiro, Permata Tiara Bunga Mayang, Niimi Atsuko, Yamauchi Motohiro, Oike Takahiro, Nakano Takashi, Shibata Atsushi
    • Journal Title

      Human Immunology

      Volume: 79 Issue: 8 Pages: 627-631

    • DOI

      10.1016/j.humimm.2018.05.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation2017

    • Author(s)
      Hagiwara Yoshihiko、Niimi Atsuko、Isono Mayu、Yamauchi Motohiro、Yasuhara Takaaki、Limsirichaikul Siripan、Oike Takahiro、Sato Hiro、Held Kathryn D.、Nakano Takashi、Shibata Atsushi
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 65 Pages: 109370-109381

    • DOI

      10.18632/oncotarget.22679

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells2017

    • Author(s)
      Sato Hiro、Niimi Atsuko、Yasuhara Takaaki、Permata Tiara Bunga Mayang、Hagiwara Yoshihiko、Isono Mayu、Nuryadi Endang、Sekine Ryota、Oike Takahiro、Kakoti Sangeeta、Yoshimoto Yuya、Held Kathryn D.、Suzuki Yoshiyuki、Kono Koji、Miyagawa Kiyoshi、Nakano Takashi、Shibata Atsushi
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 1751-1751

    • DOI

      10.1038/s41467-017-01883-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Immune responses regulated by DNA damage signaling2022

    • Author(s)
      柴田 淳史
    • Organizer
      12th International Symposium Gunma University Initiative for Advanced Research (GIAR)、Hybrid conference
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 放射線の細胞への影響2022

    • Author(s)
      柴田 淳史
    • Organizer
      日本放射線腫瘍学会 第12回放射線生物学セミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Radiation-induced DNA damage and repair: a look into carbon-ion dependent Clustered DNA Double Strand Breaks2021

    • Author(s)
      柴田 淳史
    • Organizer
      International Training Course on Carbon Ion Radiotherapy 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 放射線照射が誘発する免疫応答の分子機構からみた放射線免疫治療併用の可能性2021

    • Author(s)
      柴田 淳史
    • Organizer
      第62回日本肺癌学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 修復:線量によって変化するDNA修復機構2021

    • Author(s)
      柴田 淳史
    • Organizer
      日本放射線腫瘍学会第34回学術大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 正確なDNA修復へと導くDNA二本鎖切断修復経路の決定メカニズム2021

    • Author(s)
      柴田 淳史
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 放射線治療時に生じるDNA損傷を起因とする腫瘍免疫活性化の分子メカニズム2021

    • Author(s)
      柴田 淳史
    • Organizer
      第59回日本癌治療学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 放射線分子生物学の知見をどのようにして私たちの健康に役立てるのか?2021

    • Author(s)
      柴田 淳史
    • Organizer
      日本放射線影響学会 第64回大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 放射線照射により惹起される免疫応答系リガンドの発現制御機構2021

    • Author(s)
      柴田 淳史
    • Organizer
      第49回放射線による制癌シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ゲノムの安定性維持機構の破綻による細胞影響から病態理解へ2020

    • Author(s)
      柴田 淳史
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 生命科学研究の最前線~生命の神秘を解き明かし、世界の医療発展に貢献する~2020

    • Author(s)
      柴田 淳史
    • Organizer
      群馬大学グローバルフロンティアリーダー(GFL)先端研究学際講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] G1期細胞におけるDNA二本鎖切断修復選択機構2020

    • Author(s)
      柴田 淳史
    • Organizer
      日本放射線影響学会第63回大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 転写活性領域におけるDNA二本鎖切断修復の経路選択機構2020

    • Author(s)
      柴田 淳史
    • Organizer
      第20回日本抗加齢医学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] RAP80 suppresses deleterious repair of double-strand break in transcribed genome2019

    • Author(s)
      柴田淳史
    • Organizer
      第10回 International Symposium on DNA Damage Response & Human Disease (isDDRHD)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DNA二本鎖切断修復経路の決定メカニズム2019

    • Author(s)
      柴田淳史
    • Organizer
      日本核酸医薬学会生物セッション第4回サテライトシンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Radiation-induced DNA damage and repair2019

    • Author(s)
      柴田淳史
    • Organizer
      IROS Annual Scientific Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of DSB repair pathway choice and its downstream signaling2019

    • Author(s)
      柴田淳史
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] DNA損傷応対により制御されるがん免疫治療標の分子動態解析2019

    • Author(s)
      柴田淳史
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 重粒子線特異的誘発されるクラスターDNA二本鎖切断の生成機構とその修復経路2019

    • Author(s)
      柴田淳史
    • Organizer
      日本放射線影響学会第62回大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Regulation of transcription-associated end-joining mediated by MRE11, BRCA1, Polθ and LIG1/3. Regulation of DNA damage signalling-dependent PD-L1 expression in cancer cells.2019

    • Author(s)
      柴田淳史
    • Organizer
      16th International Congress of Radiation Research 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 転写共役型DNA二本鎖切断修復経路の分子機構2019

    • Author(s)
      柴田淳史
    • Organizer
      第8回DNA損傷応答ワークショップ
    • Related Report
      2018 Annual Research Report
  • [Presentation] DNA二本鎖切断の相同組換え修復におけるスプライシング因子SART1とBRCAの協調的働き. DNA二本鎖切断の転写共役型未来結合修復におけるR-loop構造内一本鎖DNA領域の保護.2019

    • Author(s)
      柴田淳史
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Regulation of DNA damage signalling-dependent PD-L1 expression in cancer cells2019

    • Author(s)
      柴田淳史
    • Organizer
      16th International Congress of Radiation Research 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] がん治療時の免疫応答に関わる DNA損傷依存的PD-L1発現調節機構の研究2019

    • Author(s)
      柴田淳史
    • Organizer
      第21回がん治療増感シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] DNA損傷応答により誘導される PD-L1発現制御機構2019

    • Author(s)
      柴田淳史
    • Organizer
      AAA研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] RAP80 suppresses Artemis-dependent deleterious rejoining during transcription-associated DSB repair in the G1-phase2019

    • Author(s)
      柴田淳史
    • Organizer
      Keystone Symposia: DNA Replication and Genome Instability: From Mechanism to Disease
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elucidation of the molecular mechanism underlying PD-L1 expression after DNA damage for precision radioimmunotherapy2018

    • Author(s)
      柴田淳史
    • Organizer
      The 3rd FARO Meeting 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] RAP80 regulates transcription-associated DNA end resection in the G1-phase2018

    • Author(s)
      柴田淳史
    • Organizer
      Mechanisms of Recombination 2018 Abcam
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] RAP80 regulates transcription-associated DNA end resection in the G1-phase2018

    • Author(s)
      Takaaki Yasuhara, Reona Kato, Kiyoshi Miyagawa, and Atsushi Shibata
    • Organizer
      Gordon Research Conference Genomic Instability
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Super-resolution imaging reveals clustered DNA double strand break formation after high LET particle therapy2018

    • Author(s)
      柴田淳史
    • Organizer
      FARO MEETING 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Elucidation of PD-L1 expression in cancer cells after radiotherapy2018

    • Author(s)
      柴田淳史
    • Organizer
      International Particle Medicine Research Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 転写活性領域におけるDNA二本鎖切断修復とその修復経路選択機構2018

    • Author(s)
      柴田淳史
    • Organizer
      日本放射線腫瘍学会生物部会「第56回生物部会学術大会・第47回放射線による制癌シンポジウム」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] RAP800 regulates transcription-associated DNA end resection in the G1-phase2018

    • Author(s)
      Takaaki Yasuhara, Reona Kato, Kiyoshi Miyagawa and Atsushi Shibata
    • Organizer
      Abcam Conference: Mechanisms of Recombination
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells2018

    • Author(s)
      Hiro Sato, Takaaki Yasuhara, Tiara Bunga Mayang Permata, Takahiro Oike, Kathryn D. Held, kiyoshi Miyagawa, Takashi Nakano and Atsushi Shibata
    • Organizer
      Radiation Break-through: from DNA damage responses to precision cancer therapy
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DNA二本鎖切断修復経路による免疫チェックポイント標的分子PD-L1の発現制御機構2017

    • Author(s)
      柴田淳史
    • Organizer
      2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会・第90回日本生化学大会合同大会:ワークショップ・ゲノム恒常性維持機構の破綻と疾患発症の分子メカニズム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] DNA二本鎖切断修復経路による免疫チェックポイント標的分子PD-L1の発現制御機構2017

    • Author(s)
      柴田淳史
    • Organizer
      第24回DNA複製・組換え・修復ワークショップ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 放射線照射により誘導される免疫チェックポイント標的分子PD-L1の発現制御機構2017

    • Author(s)
      柴田淳史
    • Organizer
      日本放射線影響学会 第60回大会:シンポジウム・DNA修復研究の最前線:放射線生物応答の統合的理解へ向けて
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Regulation of DSB repair pathway choice after ionizing radiation2017

    • Author(s)
      柴田淳史
    • Organizer
      1st International Symposium on Radiation Therapeutics and Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Spatiotemporal regulation of DNA double strand break repair pathway choice in G2-phase2017

    • Author(s)
      柴田淳史
    • Organizer
      6th US-Japan DNA Repair Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] BRCA1 directs the repair pathway to homologous recombination by promoting 53BP1 dephosphorylation2017

    • Author(s)
      柴田淳史
    • Organizer
      Institute for Protein Research seminar on Chromosome Dynamic and genome stability in meiosis and mitosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] 柴田研究室HP

    • URL

      https://shibataxlab.com/

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] 柴田研究室

    • URL

      http://shibatalab.com/

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] SHIBATA LAB

    • URL

      http://shibatalab.com/english/

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi