Elucidation of the mechanism leading to the initiation of transcription associated homologous recombination

• Project/Area Number: 17H04713
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Gunma University
• Principal Investigator: Shibata Atsushi 群馬大学, 未来先端研究機構, 准教授 (30707633)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000); Fiscal Year 2020: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: DNA修復 / NHEJ / HR / 転写共役型DNA修復 / DNA二本鎖切断 / DSB修復経路 / 放射線誘発DSB / 相同組換え修復 / 非相同末端連結 / 修復

Outline of Final Research Achievements

A DNA Double-strand break (DSB) caused by ionizing irradiation is one of the serious DNA damage that affects the cell fate; however, the molecular mechanism at transcriptionally active locus remains unclear. In this study, we demonstrated that transcription-associated homologous recombination (HR)is initiated by RAD52 / XPG in G2 phase cells. In contrast, in the G1 phase, we found that RAP80 protects R-loops during transcription-associated DSB repair (Cell Reports, 2022).

Academic Significance and Societal Importance of the Research Achievements

放射線照射によって生じるDNAの二本鎖切断（DSB)は、細胞の運命を左右する重篤なDNA損傷の一つであり。そのため、DSB修復の成否はがん化や老化、種々の疾病に繋がることから、その詳細な分子機構を解き明かす必要がある。今回、タンパク質をコードする遺伝子領域での修復機構を明らかにした。これらの分子機構が明らかになることで、放射線照射によって発症するがんを含めた種々の疾患に対する新たな予防法および治療法の開発が期待される。

Research Products

• [Int'l Joint Research] サセックス大学(英国)
• [Int'l Joint Research] インドネシア大学(インドネシア)
• [Int'l Joint Research] タタ記念病院(インド)
• [Int'l Joint Research] サセックス大学(英国)
• [Int'l Joint Research] インドネシア大学(インドネシア)
• [Int'l Joint Research] タタ記念病院(インド)
• [Int'l Joint Research] University of Sussex(英国)
• [Int'l Joint Research] Tata Memorial Hospital(インド)
• [Int'l Joint Research] Dr. Cipto National General Hospital(インドネシア)
• [Int'l Joint Research] University of Sussex(英国)
• [Int'l Joint Research] Massachusetts General Hospital(米国)
• [Journal Article] RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair (2022)
  • Author(s): Yasuhara Takaaki、Kato Reona、Yamauchi Motohiro、Uchihara Yuki、Zou Lee、Miyagawa Kiyoshi、Shibata Atsushi
  • Journal Title: Cell Reports Volume: 38 Issue: 5 Pages: 110335-110335
  • DOI: 10.1016/j.celrep.2022.110335
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression of non-homologous end joining factor, Ku80, is negatively correlated with PD-L1 expression in cancer cells after X-ray irradiation (2021)
  • Author(s): Kumazawa Takuya、Mori Yasumasa、Sato Hiro、Permata Tiara、Uchihara Yuki、Noda Shin-Ei、Okada Kohei、Kakoti Sangeeta、Suzuki Keiji、Ikota Hayato、Yokoo Hideaki、Gondhowiardjo Soehartati、Nakano Takashi、Ohno Tatsuya、Shibata Atsushi
  • Journal Title: Oncology Letters Volume: 23 Issue: 1 Pages: 29-29
  • DOI: 10.3892/ol.2021.13147
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 64Cu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity (2021)
  • Author(s): Nachankar Ankita、Oike Takahiro、Hanaoka Hirofumi、Kanai Ayaka、Sato Hiro、Yoshida Yukari、Obinata Hideru、Sakai Makoto、Osu Naoto、Hirota Yuka、Takahashi Akihisa、Shibata Atsushi、Ohno Tatsuya
  • Journal Title: Cancers Volume: 13 Issue: 24 Pages: 6159-6159
  • DOI: 10.3390/cancers13246159
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome Maintenance Mechanisms at the Chromatin Level (2021)
  • Author(s): Takatsuka Hirotomo、Shibata Atsushi、Umeda Masaaki
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Issue: 19 Pages: 10384-10384
  • DOI: 10.3390/ijms221910384
  • Peer Reviewed / Open Access
• [Journal Article] ATM’s Role in the Repair of DNA Double-Strand Breaks (2021)
  • Author(s): Shibata Atsushi、Jeggo Penny A.
  • Journal Title: Genes Volume: 12 Issue: 9 Pages: 1370-1370
  • DOI: 10.3390/genes12091370
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mechanism of chromosome rearrangement arising from single-strand breaks (2021)
  • Author(s): Kot Palina、Yasuhara Takaaki、Shibata Atsushi、Hirakawa Miyako、Abe Yu、Yamauchi Motohiro、Matsuda Naoki
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 572 Pages: 191-196
  • DOI: 10.1016/j.bbrc.2021.08.001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells (2021)
  • Author(s): Permata Tiara Bunga Mayang、Sato Hiro、Gu Wenchao、Kakoti Sangeeta、Uchihara Yuki、Yoshimatsu Yukihiko、Sato Itaru、Kato Reona、Yamauchi Motohiro、Suzuki Keiji、Oike Takahiro、Tsushima Yoshito、Gondhowiardjo Soehartati、Ohno Tatsuya、Yasuhara Takaaki、Shibata Atsushi
  • Journal Title: Journal of Radiation Research Volume: 62 Issue: 5 Pages: 773-781
  • DOI: 10.1093/jrr/rrab050
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Modulation of immune responses by DNA damage signaling (2021)
  • Author(s): Uchihara Yuki、Permata Tiara Bunga Mayang、Sato Hiro、Shibata Atsushi
  • Journal Title: DNA Repair Volume: 104 Pages: 103135-103135
  • DOI: 10.1016/j.dnarep.2021.103135
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of radiotherapy induced alteration of CD8+ T cells and PD-L1 expression in patients with uterine cervical squamous cell carcinoma (2021)
  • Author(s): Mori Yasumasa、Sato Hiro、Kumazawa Takuya、Permata Tiara、Yoshimoto Yuya、Murata Kazutoshi、Noda Shin-Ei、Kaminuma Takuya、Ando Ken、Oike Takahiro、Okonogi Noriyuki、Okada Kohei、Kakoti Sangeeta、Suzuki Keiji、Ikota Hayato、Yokoo Hideaki、Nakano Takashi、Ohno Tatsuya、Shibata Atsushi
  • Journal Title: Oncology Letters Volume: 21 Issue: 6 Pages: 446-446
  • DOI: 10.3892/ol.2021.12707
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantitative volumetric analysis of the Golgi apparatus following X-ray irradiation by super-resolution 3D-SIM microscopy (2021)
  • Author(s): Oike Takahiro、Uchihara Yuki、Permata Tiara Bunga Mayang、Gondhowiardjo Soehartati、Ohno Tatsuya、Shibata Atsushi
  • Journal Title: Medical Molecular Morphology Volume: - Issue: 2 Pages: 166-172
  • DOI: 10.1007/s00795-020-00277-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks (2020)
  • Author(s): Akagawa Remi、Trinh Hai Thanh、Saha Liton Kumar、Tsuda Masataka、Hirota Kouji、Yamada Shintaro、Shibata Atsushi、Kanemaki Masato T.、Nakada Shinichiro、Takeda Shunichi、Sasanuma Hiroyuki
  • Journal Title: iScience Volume: 23 Issue: 4 Pages: 101027-101027
  • DOI: 10.1016/j.isci.2020.101027
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells (2020)
  • Author(s): Nakajima Nakako Izumi、Yamauchi Motohiro、Kakoti Sangeeta、Cuihua Liu、Kato Reona、Permata Tiara Bunga Mayang、Iijima Moito、Yajima Hirohiko、Yasuhara Takaaki、Yamada Shigeru、Hasegawa Sumitaka、Shibata Atsushi
  • Journal Title: DNA Repair Volume: 91-92 Pages: 102872-102872
  • DOI: 10.1016/j.dnarep.2020.102872
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Roles for 53BP1 in the repair of radiation-induced DNA double strand breaks (2020)
  • Author(s): Shibata Atsushi、Jeggo Penny A.
  • Journal Title: DNA Repair Volume: 93 Pages: 102915-102915
  • DOI: 10.1016/j.dnarep.2020.102915
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] DNA Repair and Signaling in Immune-Related Cancer Therapy (2020)
  • Author(s): Kakoti Sangeeta、Sato Hiro、Laskar Siddhartha、Yasuhara Takaaki、Shibata Atsushi
  • Journal Title: Frontiers in Molecular Biosciences Volume: 7 Pages: 205-205
  • DOI: 10.3389/fmolb.2020.00205
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Roles for the DNA-PK complex and 53BP1 in protecting ends from resection during DNA double-strand break repair (2020)
  • Author(s): Shibata Atsushi、Jeggo Penny A
  • Journal Title: Journal of Radiation Research Volume: 61 Issue: 5 Pages: 718-726
  • DOI: 10.1093/jrr/rraa053
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Combination of Anti-Cancer Drugs with Molecular Chaperone Inhibitors (2019)
  • Author(s): Shevtsov Maxim、Multhoff Gabriele、Mikhaylova Elena、Shibata Atsushi、Guzhova Irina、Margulis Boris
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 21 Pages: 5284-5284
  • DOI: 10.3390/ijms20215284
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] p53 deficiency augments nucleolar instability after ionizing irradiation. (2019)
  • Author(s): Kakoti, S., Yamauchi, M., Gu, W., Kato, R., Yasuhara, T., Hagiwara, Y., Laskar, S., Oike, T., Sato, H., Held, KD., Nakano, T., and Shibata, A.
  • Journal Title: Oncology Reports Volume: 42 Pages: 2293-2302
  • DOI: 10.3892/or.2019.7341
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Regulation of programmed death‐ligand 1 expression in response to DNA damage in cancer cells: Implications for precision medicine (2019)
  • Author(s): Sato Hiro、Jeggo Penny A.、Shibata Atsushi
  • Journal Title: Cancer Science Volume: 110 Issue: 11 Pages: 3415-3423
  • DOI: 10.1111/cas.14197
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] FGFR Signaling as a Candidate Therapeutic Target for Cancers Resistant to Carbon Ion Radiotherapy (2019)
  • Author(s): Darwis, N. D. M. Nachankar, A. Sasaki, Y. Matsui, T. Noda, S. E. Murata, K. Tamaki, T. Ando, K. Okonogi, N. Shiba, S. Irie, D. Kaminuma, T. Kumazawa, T. Anakura, M. Yamashita, S. Hirakawa, T. Kakoti, S. Hirota, Y. Tokino, T. Iwase, A. Ohno, T. Shibata, A. Oike, T. Nakano, T.
  • Journal Title: Int J Mol Sci Volume: 20 Issue: 18 Pages: 4563-4563
  • DOI: 10.3390/ijms20184563
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Robustness of clonogenic assays as a biomarker for cancer cell radiosensitivity. (2019)
  • Author(s): Matsui T, Nuryadi E, Komatsu S, Hirota Y, Shibata A, Oike T, Nakano T.
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 17 Pages: 4148-4148
  • DOI: 10.3390/ijms20174148
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Deep learning-assisted literature mining for in vitro radiosensitivity data (2019)
  • Author(s): Komatsu Shuichiro、Oike Takahiro、Komatsu Yuka、Kubota Yoshiki、Sakai Makoto、Matsui Toshiaki、Nuryadi Endang、Permata Tiara Bunga Mayang、Sato Hiro、Kawamura Hidemasa、Okamoto Masahiko、Kaminuma Takuya、Murata Kazutoshi、Okano Naoko、Hirota Yuka、Ohno Tatsuya、Saitoh Jun-ichi、Shibata Atsushi、Nakano Takashi
  • Journal Title: Radiotherapy and Oncology Volume: 139 Pages: 87-93
  • DOI: 10.1016/j.radonc.2019.07.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Radiosensitivity Differences between EGFR Mutant and Wild-Type Lung Cancer Cells are Larger at Lower Doses (2019)
  • Author(s): Anakura Mai、Nachankar Ankita、Kobayashi Daijiro、Amornwichet Napapat、Hirota Yuka、Shibata Atsushi、Oike Takahiro、Nakano Takashi
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 15 Pages: 3635-3635
  • DOI: 10.3390/ijms20153635
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A historical reflection on our understanding of radiation-induced DNA double strand break repair in somatic mammalian cells; interfacing the past with the present (2019)
  • Author(s): Shibata Atsushi、Jeggo Penny
  • Journal Title: International Journal of Radiation Biology Volume: - Issue: 7 Pages: 1-12
  • DOI: 10.1080/09553002.2018.1564083
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clustered DNA double-strand break formation and the repair pathway following heavy-ion irradiation (2018)
  • Author(s): Hagiwara Yoshihiko、Oike Takahiro、Niimi Atsuko、Yamauchi Motohiro、Sato Hiro、Limsirichaikul Siripan、Held Kathryn D、Nakano Takashi、Shibata Atsushi
  • Journal Title: Journal of Radiation Research Volume: 60 Issue: 1 Pages: 69-79
  • DOI: 10.1093/jrr/rry096
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair (2018)
  • Author(s): Yasuhara Takaaki、Kato Reona、Hagiwara Yoshihiko、Shiotani Bunsyo、Yamauchi Motohiro、Nakada Shinichiro、Shibata Atsushi、Miyagawa Kiyoshi
  • Journal Title: Cell Volume: 175 Issue: 2 Pages: 558-570
  • DOI: 10.1016/j.cell.2018.08.056
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of programmed death-ligand 1 expression in primary normal human dermal fibroblasts after DNA damage (2018)
  • Author(s): Hagiwara Yoshihiko, Sato Hiro, Permata Tiara Bunga Mayang, Niimi Atsuko, Yamauchi Motohiro, Oike Takahiro, Nakano Takashi, Shibata Atsushi
  • Journal Title: Human Immunology Volume: 79 Issue: 8 Pages: 627-631
  • DOI: 10.1016/j.humimm.2018.05.008
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation (2017)
  • Author(s): Hagiwara Yoshihiko、Niimi Atsuko、Isono Mayu、Yamauchi Motohiro、Yasuhara Takaaki、Limsirichaikul Siripan、Oike Takahiro、Sato Hiro、Held Kathryn D.、Nakano Takashi、Shibata Atsushi
  • Journal Title: Oncotarget Volume: 8 Issue: 65 Pages: 109370-109381
  • DOI: 10.18632/oncotarget.22679
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells (2017)
  • Author(s): Sato Hiro、Niimi Atsuko、Yasuhara Takaaki、Permata Tiara Bunga Mayang、Hagiwara Yoshihiko、Isono Mayu、Nuryadi Endang、Sekine Ryota、Oike Takahiro、Kakoti Sangeeta、Yoshimoto Yuya、Held Kathryn D.、Suzuki Yoshiyuki、Kono Koji、Miyagawa Kiyoshi、Nakano Takashi、Shibata Atsushi
  • Journal Title: Nature Communications Volume: 8 Issue: 1 Pages: 1751-1751
  • DOI: 10.1038/s41467-017-01883-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Immune responses regulated by DNA damage signaling (2022)
  • Author(s): 柴田 淳史
  • Organizer: 12th International Symposium Gunma University Initiative for Advanced Research (GIAR)、Hybrid conference
  • Int'l Joint Research
• [Presentation] 放射線の細胞への影響 (2022)
  • Author(s): 柴田 淳史
  • Organizer: 日本放射線腫瘍学会 第12回放射線生物学セミナー
  • Invited
• [Presentation] Radiation-induced DNA damage and repair: a look into carbon-ion dependent Clustered DNA Double Strand Breaks (2021)
  • Author(s): 柴田 淳史
  • Organizer: International Training Course on Carbon Ion Radiotherapy 2021
  • Int'l Joint Research / Invited
• [Presentation] 放射線照射が誘発する免疫応答の分子機構からみた放射線免疫治療併用の可能性 (2021)
  • Author(s): 柴田 淳史
  • Organizer: 第62回日本肺癌学会学術集会
  • Invited
• [Presentation] 修復：線量によって変化するDNA修復機構 (2021)
  • Author(s): 柴田 淳史
  • Organizer: 日本放射線腫瘍学会第34回学術大会
  • Invited
• [Presentation] 正確なDNA修復へと導くDNA二本鎖切断修復経路の決定メカニズム (2021)
  • Author(s): 柴田 淳史
  • Organizer: 第94回日本生化学会大会
  • Invited
• [Presentation] 放射線治療時に生じるDNA損傷を起因とする腫瘍免疫活性化の分子メカニズム (2021)
  • Author(s): 柴田 淳史
  • Organizer: 第59回日本癌治療学会学術集会
  • Invited
• [Presentation] 放射線分子生物学の知見をどのようにして私たちの健康に役立てるのか？ (2021)
  • Author(s): 柴田 淳史
  • Organizer: 日本放射線影響学会 第64回大会
  • Invited
• [Presentation] 放射線照射により惹起される免疫応答系リガンドの発現制御機構 (2021)
  • Author(s): 柴田 淳史
  • Organizer: 第49回放射線による制癌シンポジウム
  • Invited
• [Presentation] ゲノムの安定性維持機構の破綻による細胞影響から病態理解へ (2020)
  • Author(s): 柴田 淳史
  • Organizer: 第43回日本分子生物学会年会
  • Invited
• [Presentation] 生命科学研究の最前線～生命の神秘を解き明かし、世界の医療発展に貢献する～ (2020)
  • Author(s): 柴田 淳史
  • Organizer: 群馬大学グローバルフロンティアリーダー（GFL）先端研究学際講演会
  • Invited
• [Presentation] G1期細胞におけるDNA二本鎖切断修復選択機構 (2020)
  • Author(s): 柴田 淳史
  • Organizer: 日本放射線影響学会第63回大会
  • Invited
• [Presentation] 転写活性領域におけるDNA二本鎖切断修復の経路選択機構 (2020)
  • Author(s): 柴田 淳史
  • Organizer: 第20回日本抗加齢医学会総会
  • Invited
• [Presentation] RAP80 suppresses deleterious repair of double-strand break in transcribed genome (2019)
  • Author(s): 柴田淳史
  • Organizer: 第10回 International Symposium on DNA Damage Response & Human Disease (isDDRHD)
  • Int'l Joint Research / Invited
• [Presentation] DNA二本鎖切断修復経路の決定メカニズム (2019)
  • Author(s): 柴田淳史
  • Organizer: 日本核酸医薬学会生物セッション第4回サテライトシンポジウム
  • Invited
• [Presentation] Radiation-induced DNA damage and repair (2019)
  • Author(s): 柴田淳史
  • Organizer: IROS Annual Scientific Meeting
  • Int'l Joint Research / Invited
• [Presentation] Regulation of DSB repair pathway choice and its downstream signaling (2019)
  • Author(s): 柴田淳史
  • Organizer: 第78回日本癌学会学術総会
  • Invited
• [Presentation] DNA損傷応対により制御されるがん免疫治療標の分子動態解析 (2019)
  • Author(s): 柴田淳史
  • Organizer: 第42回日本分子生物学会年会
  • Invited
• [Presentation] 重粒子線特異的誘発されるクラスターDNA二本鎖切断の生成機構とその修復経路 (2019)
  • Author(s): 柴田淳史
  • Organizer: 日本放射線影響学会第62回大会
  • Invited
• [Presentation] Regulation of transcription-associated end-joining mediated by MRE11, BRCA1, Polθ and LIG1/3. Regulation of DNA damage signalling-dependent PD-L1 expression in cancer cells. (2019)
  • Author(s): 柴田淳史
  • Organizer: 16th International Congress of Radiation Research 2019
  • Int'l Joint Research
• [Presentation] 転写共役型DNA二本鎖切断修復経路の分子機構 (2019)
  • Author(s): 柴田淳史
  • Organizer: 第８回DNA損傷応答ワークショップ
• [Presentation] DNA二本鎖切断の相同組換え修復におけるスプライシング因子SART1とBRCAの協調的働き. DNA二本鎖切断の転写共役型未来結合修復におけるR-loop構造内一本鎖DNA領域の保護. (2019)
  • Author(s): 柴田淳史
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] Regulation of DNA damage signalling-dependent PD-L1 expression in cancer cells (2019)
  • Author(s): 柴田淳史
  • Organizer: 16th International Congress of Radiation Research 2019
  • Int'l Joint Research
• [Presentation] がん治療時の免疫応答に関わる DNA損傷依存的PD-L1発現調節機構の研究 (2019)
  • Author(s): 柴田淳史
  • Organizer: 第21回がん治療増感シンポジウム
  • Invited
• [Presentation] DNA損傷応答により誘導される PD-L1発現制御機構 (2019)
  • Author(s): 柴田淳史
  • Organizer: AAA研究会
  • Invited
• [Presentation] RAP80 suppresses Artemis-dependent deleterious rejoining during transcription-associated DSB repair in the G1-phase (2019)
  • Author(s): 柴田淳史
  • Organizer: Keystone Symposia: DNA Replication and Genome Instability: From Mechanism to Disease
  • Int'l Joint Research
• [Presentation] Elucidation of the molecular mechanism underlying PD-L1 expression after DNA damage for precision radioimmunotherapy (2018)
  • Author(s): 柴田淳史
  • Organizer: The 3rd FARO Meeting 2018
  • Int'l Joint Research / Invited
• [Presentation] RAP80 regulates transcription-associated DNA end resection in the G1-phase (2018)
  • Author(s): 柴田淳史
  • Organizer: Mechanisms of Recombination 2018 Abcam
  • Int'l Joint Research
• [Presentation] RAP80 regulates transcription-associated DNA end resection in the G1-phase (2018)
  • Author(s): Takaaki Yasuhara, Reona Kato, Kiyoshi Miyagawa, and Atsushi Shibata
  • Organizer: Gordon Research Conference Genomic Instability
  • Int'l Joint Research
• [Presentation] Super-resolution imaging reveals clustered DNA double strand break formation after high LET particle therapy (2018)
  • Author(s): 柴田淳史
  • Organizer: FARO MEETING 2018
  • Int'l Joint Research / Invited
• [Presentation] Elucidation of PD-L1 expression in cancer cells after radiotherapy (2018)
  • Author(s): 柴田淳史
  • Organizer: International Particle Medicine Research Symposium
  • Int'l Joint Research / Invited
• [Presentation] 転写活性領域におけるDNA二本鎖切断修復とその修復経路選択機構 (2018)
  • Author(s): 柴田淳史
  • Organizer: 日本放射線腫瘍学会生物部会「第56回生物部会学術大会・第47回放射線による制癌シンポジウム」
  • Invited
• [Presentation] RAP800 regulates transcription-associated DNA end resection in the G1-phase (2018)
  • Author(s): Takaaki Yasuhara, Reona Kato, Kiyoshi Miyagawa and Atsushi Shibata
  • Organizer: Abcam Conference: Mechanisms of Recombination
  • Int'l Joint Research
• [Presentation] DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells (2018)
  • Author(s): Hiro Sato, Takaaki Yasuhara, Tiara Bunga Mayang Permata, Takahiro Oike, Kathryn D. Held, kiyoshi Miyagawa, Takashi Nakano and Atsushi Shibata
  • Organizer: Radiation Break-through: from DNA damage responses to precision cancer therapy
  • Int'l Joint Research
• [Presentation] DNA二本鎖切断修復経路による免疫チェックポイント標的分子PD-L1の発現制御機構 (2017)
  • Author(s): 柴田淳史
  • Organizer: 2017年度生命科学系学会合同年次大会（第40回日本分子生物学会年会・第90回日本生化学大会合同大会：ワークショップ・ゲノム恒常性維持機構の破綻と疾患発症の分子メカニズム
  • Invited
• [Presentation] DNA二本鎖切断修復経路による免疫チェックポイント標的分子PD-L1の発現制御機構 (2017)
  • Author(s): 柴田淳史
  • Organizer: 第24回DNA複製・組換え・修復ワークショップ
  • Invited
• [Presentation] 放射線照射により誘導される免疫チェックポイント標的分子PD-L1の発現制御機構 (2017)
  • Author(s): 柴田淳史
  • Organizer: 日本放射線影響学会 第60回大会：シンポジウム・DNA修復研究の最前線：放射線生物応答の統合的理解へ向けて
  • Invited
• [Presentation] Regulation of DSB repair pathway choice after ionizing radiation (2017)
  • Author(s): 柴田淳史
  • Organizer: 1st International Symposium on Radiation Therapeutics and Biology
  • Int'l Joint Research / Invited
• [Presentation] Spatiotemporal regulation of DNA double strand break repair pathway choice in G2-phase (2017)
  • Author(s): 柴田淳史
  • Organizer: 6th US-Japan DNA Repair Meeting
  • Int'l Joint Research / Invited
• [Presentation] BRCA1 directs the repair pathway to homologous recombination by promoting 53BP1 dephosphorylation (2017)
  • Author(s): 柴田淳史
  • Organizer: Institute for Protein Research seminar on Chromosome Dynamic and genome stability in meiosis and mitosis
  • Int'l Joint Research / Invited
• [Remarks] 柴田研究室HP
  • URL: https://shibataxlab.com/
• [Remarks] 柴田研究室
  • URL: http://shibatalab.com/
• [Remarks] SHIBATA LAB
  • URL: http://shibatalab.com/english/