| Budget Amount *help |
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2017: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
The purpose of this study is to unravel the mechanism of abnormal behavior induced by valproate, focusing on microglial activation. VPA enlarged microglial cell body and up-regulated CD68 expression in hippocampal CA1 region at the age of P10 but not 6 weeks-old. The excitation-inhibition balance at the hippocampus was shifted toward to excitation especially in CA1 region by VPA treatment. Minocycline administration clearly suppressed microglial activation and the shift of excitation-inhibition balance by VPA. Taken together, activated microglia by prenatal VPA exposure can induce excitation-inhibition imbalances in hippocampus during developmental period.
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