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Building the antimicrobials administration strategy by multi-agent model

Research Project

Project/Area Number 17H04731
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Social systems engineering/Safety system
Research InstitutionNagasaki University (2018-2021)
The University of Tokyo (2017)

Principal Investigator

ITO Hiromu  長崎大学, 熱帯医学研究所, 助教 (80780692)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2020: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords抗生剤 / 薬剤耐性菌 / AMR / 社会的ジレンマ / シミュレーション / 数理モデル / 進化 / 行動 / 薬剤耐性 / 公衆衛生 / 社会ネットワーク / 意思決定 / ゲーム理論 / 感染症 / シミュレーションモデル / リスクマネジメント / 数理モデリング / エージェントモデル
Outline of Final Research Achievements

I developed a multi-agent simulation model that demonstrate the use of antimicrobials and the evolution and spread of antimicrobial resistance (AMR). I also presented some of mathematical models of infectious diseases that introduced complex networks. In addition to this, I made a breakthrough in my research by recognizing the social dilemma behind the use of antimicrobials in our society. Therefore, I developed an international web-based survey covering a total of eight countries, and I verified the awareness rate of respondents in social dilemmas regarding antimicrobials use in each country, and I estimated strength of the social dilemma in the excess use of antimicrobials incurring antimicrobial resistance.

Academic Significance and Societal Importance of the Research Achievements

研究発足当初から薬剤耐性の問題は危惧されていたが、コロナ禍によってさらに注目度は集まっている。感染症問題そのものが世界全体の課題であることが広く認識された上に、薬剤耐性による死亡数がマラリアやHIV/AIDSに匹敵しているという報告も出てきた。このような時流の中で展開された本研究は、薬剤耐性の問題、特に社会的ジレンマに食い込むことで大きな成果を得た。特に一般市民が内包する抗生剤の使用に関する社会的ジレンマを明らかにする試みは、本研究以外には存在しない。社会的ジレンマと薬剤耐性の問題は今後ますます盛んに研究されていく科学的領域となるだろう。本研究はそのさきがけとしての役目を果たしたものと信ずる。

Report

(5 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (48 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (22 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 22 results,  Open Access: 22 results) Presentation (21 results) (of which Int'l Joint Research: 2 results,  Invited: 6 results) Remarks (3 results)

  • [Int'l Joint Research] University of Basel(スイス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of the Philippines Los Banos(フィリピン)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Unique hemoglobin dynamics in female Tibetan highlanders2021

    • Author(s)
      Arima Hiroaki、Nakano Masayuki、Koirala Sweta、Ito Hiromu、Pandey Basu Dev、Pandey Kishor、Wada Takayuki、Yamamoto Taro
    • Journal Title

      Tropical Medicine and Health

      Volume: 49 Issue: 1 Pages: 2-2

    • DOI

      10.1186/s41182-020-00289-6

    • NAID

      120006956200

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exaggerated evolution of male armaments via male?male competition2021

    • Author(s)
      Areja‐Gavina Maica Krizna D.、Torres Monica C.、Gamilla Gimelle B.、Sakaguchi Tomohiko、Ito Hiromu、Rabajante Jomar F.、Tubay Jerrold M.、Yoshimura Jin、Morita Satoru
    • Journal Title

      Ecology and Evolution

      Volume: 11 Issue: 11 Pages: 6977-6992

    • DOI

      10.1002/ece3.7546

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improving environment drives dynamical change in social game structure2021

    • Author(s)
      Chiba Erika、Cuaresma Diane Carmeliza N.、Rabajante Jomar F.、Tubay Jerrold M.、Areja Gavina Maica Krizna、Yamamoto Tatsuki、Yoshimura Jin、Morita Satoru、Ito Hiromu、Okabe Takuya
    • Journal Title

      Royal Society Open Science

      Volume: 8 Issue: 5 Pages: 1-7

    • DOI

      10.1098/rsos.201166

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analyzing Predictors of Control Measures and Psychosocial Problems Associated with COVID-19 Pandemic: Evidence from Eight Countries2021

    • Author(s)
      Jony Sheikh Saifur Rahman、Haque Ubydul、Webb Nathaniel J.、Spence Emily、Rahman Md. Siddikur、Aghamohammadi Nasrin、Lie Yongchan、Angulo-Molina Aracely、Ananth Sushmitha、Ren Xuelian、Kawachi Nobuyuki、Ito Hiromu、Ulvi Osman、Lubinda Jailos、Karamehic-Muratovic Ajlina、Maher Wasim、Ali Parveen、Rahman M. Sohel
    • Journal Title

      Behavioral Sciences

      Volume: 11 Issue: 8 Pages: 106-106

    • DOI

      10.3390/bs11080106

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The effect of men who have sex with men (MSM) on the spread of sexually transmitted infections2021

    • Author(s)
      Ito Hiromu、Yamamoto Taro、Morita Satoru
    • Journal Title

      Theoretical Biology and Medical Modelling

      Volume: 18 Issue: 1 Pages: 18-18

    • DOI

      10.1186/s12976-021-00148-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamic utility: the sixth reciprocity mechanism for the evolution of cooperation2020

    • Author(s)
      Ito, H., Tanimoto, J.
    • Journal Title

      Royal Society Open Science

      Volume: 7 Issue: 8 Pages: 200891-200891

    • DOI

      10.1098/rsos.200891

    • NAID

      120006988508

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Social efficiency deficit deciphers social dilemmas2020

    • Author(s)
      Arefin Md. Rajib、Kabir K. M. Ariful、Jusup Marko、Ito Hiromu、Tanimoto Jun
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 16092-16092

    • DOI

      10.1038/s41598-020-72971-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Energetic requirements of the transition from solitary to group living2020

    • Author(s)
      Sumaiya Rahila I.K.、Nii Momoka、Okabe Takuya、Ito Hiromu、Pulungan Muhammad Almaududi、Morita Satoru、Kobayashi Kazuya、Setou Mitsutoshi、Iwabuchi Kikuo、Matsuura Kenji、Yoshimura Jin
    • Journal Title

      Ecological Complexity

      Volume: 44, 100874 Pages: 1-5

    • DOI

      10.1016/j.ecocom.2020.100874

    • NAID

      120006980769

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mass killing by female soldier larvae is adaptive for the killed male larvae in a polyembryonic wasp2019

    • Author(s)
      Otsuki Takahiro、Uka Daisuke、Ito Hiromu、Ichinose Genki、Nii Momoka、Morita Satoru、Sakamoto Takuma、Nishiko Maaya、Tabunoki Hiroko、Kobayashi Kazuya、Matsuura Kenji、Iwabuchi Kikuo、Yoshimura Jin
    • Journal Title

      Scientific Reports

      Volume: 9 (7357) Issue: 1 Pages: 1-7

    • DOI

      10.1038/s41598-019-43643-3

    • NAID

      120006764368

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Grazing enhances species diversity in grassland communities2019

    • Author(s)
      Pulungan Muhammad Almaududi、Suzuki Shota、Gavina Maica Krizna Areja、Tubay Jerrold M.、Ito Hiromu、Nii Momoka、Ichinose Genki、Okabe Takuya、Ishida Atsushi、Shiyomi Masae、Togashi Tatsuya、Yoshimura Jin、Morita Satoru
    • Journal Title

      Scientific Reports

      Volume: 9 (11201) Issue: 1 Pages: 1-8

    • DOI

      10.1038/s41598-019-47635-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Is the network of heterosexual contact in Japan scale free?2019

    • Author(s)
      Ito Hiromu、Tamura Kazuhiro、Wada Takayuki、Yamamoto Taro、Morita Satoru
    • Journal Title

      PLOS ONE

      Volume: 14 (e0221520) Issue: 8 Pages: 1-12

    • DOI

      10.1371/journal.pone.0221520

    • NAID

      120006988420

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bankruptcy is an inevitable fate of repeated investments with leverage2019

    • Author(s)
      Nii Momoka、Okabe Takuya、Ito Hiromu、Morita Satoru、Yasuda Yosuke、Yoshimura Jin
    • Journal Title

      Scientific Reports

      Volume: 9 (13745) Issue: 1 Pages: 1-5

    • DOI

      10.1038/s41598-019-50237-6

    • NAID

      120006988398

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A single ‘weight-lifting’ game covers all kinds of games2019

    • Author(s)
      Yamamoto Tatsuki、Ito Hiromu、Nii Momoka、Okabe Takuya、Morita Satoru、Yoshimura Jin
    • Journal Title

      Royal Society Open Science

      Volume: 6 Issue: 11 Pages: 191602-191602

    • DOI

      10.1098/rsos.191602

    • NAID

      120006988349

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The type-reproduction number of sexually transmitted infections through heterosexual and vertical transmission2019

    • Author(s)
      Ito Hiromu、Yamamoto Taro、Morita Satoru
    • Journal Title

      Scientific Reports

      Volume: 9 (17408) Issue: 1 Pages: 1-13

    • DOI

      10.1038/s41598-019-53841-8

    • NAID

      120006988360

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Demography of sexually transmitted infections with vertical transmission2019

    • Author(s)
      Hiromu Ito, Taro Yamamoto, Satoru Morita
    • Journal Title

      Applied Mathematics and Computation

      Volume: 348 Pages: 363-370

    • DOI

      10.1016/j.amc.2018.12.002

    • NAID

      120006987869

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk sensitivity of a forager with limited energy reserves in stochastic environments2019

    • Author(s)
      Hiromu Ito
    • Journal Title

      Ecological Research

      Volume: 34 Issue: 1 Pages: 9-17

    • DOI

      10.1111/1440-1703.1058

    • NAID

      120006987844

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Density-dependent population model of effective release policy for Ayu fish2018

    • Author(s)
      Katsumata Yuki、Uehara Takashi、Ito Hiromu、Yoshimura Jin、Tainaka Kei-ichi、Ichinose Genki
    • Journal Title

      Ecological Modelling

      Volume: 388 Pages: 80-87

    • DOI

      10.1016/j.ecolmodel.2018.09.021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Scaling the phase- planes of social dilemma strengths shows game-class changes in the five rules governing the evolution of cooperation2018

    • Author(s)
      Ito, H., Tanimoto, J.
    • Journal Title

      Royal Society Open Science

      Volume: 2018 Issue: 10 Pages: 181085-181085

    • DOI

      10.1098/rsos.181085

    • NAID

      120006987890

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current health status and its risk factors of the Tsarang villagers living at high altitude in the Mustang district of Nepal2018

    • Author(s)
      Koirala Sweta、Nakano Masayuki、Arima Hiroaki、Takeuchi Shouhei、Ichikawa Tomo、Nishimura Takayuki、Ito Hiromu、Pandey Basu Dev、Pandey Kishor、Wada Takayuki、Yamamoto Taro
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 37 Issue: 1 Pages: 20-20

    • DOI

      10.1186/s40101-018-0181-y

    • NAID

      120006987944

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-term persistence of agricultural pest insects by risk-spreading dispersal2018

    • Author(s)
      Maica Krizna Areja Gavina, Kotaro Aoki, Genki Ichinose, Jomar Fajardo Rabajante, Hiromu Ito, Satoru Morita, Vincent A. A. Jansen, Jin Yoshimura
    • Journal Title

      Ecological Research

      Volume: 33 Issue: 5 Pages: 1031-1037

    • DOI

      10.1007/s11284-018-1615-z

    • NAID

      40021665058

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multi-species coexistence in Lotka-Volterra competitive systems with crowding effects2018

    • Author(s)
      Gavina Maica Krizna A.、Tahara Takeru、Tainaka Kei-ichi、Ito Hiromu、Morita Satoru、Ichinose Genki、Okabe Takuya、Togashi Tatsuya、Nagatani Takashi、Yoshimura Jin
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1-8

    • DOI

      10.1038/s41598-017-19044-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Territory holders and non-territory holders in Ayu fish coexist only in the population growth process due to territorial hysteresis2017

    • Author(s)
      Y. Katsumata, T. Uehara, H. Ito, J. Yoshimura, K. Tainaka and G. Ichinose
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 1-7

    • DOI

      10.1038/s41598-017-16859-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 数理モデルから考察する性感染症の存続性とヒト社会への適応2021

    • Author(s)
      伊東 啓
    • Organizer
      情報処理学会第16回ネットワーク生態学シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 数理モデルから考える性感染症の社会ネットワークへの適応2021

    • Author(s)
      伊東 啓
    • Organizer
      日本数理生物学会第31回大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] HTLV-1の蔓延リスク予測と最適な拡散防止戦略の構築2020

    • Author(s)
      伊東 啓
    • Organizer
      第27回ヘルスリサーチフォーラム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 性感染症の存続性と社会ネットワークへの適応2020

    • Author(s)
      伊東 啓
    • Organizer
      ネットワーク科学セミナー2020
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Why had periodical cicadas acquired periodicity and prime-numbered life cycles?2020

    • Author(s)
      Hiromu Ito
    • Organizer
      3rd International Workshop on Mathematical Biology 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Basic Reproduction Number of Sexually Transmitted Infections with Mother-to-Child Infection2020

    • Author(s)
      Satoru Morita, Hiromu Ito, Taro Yamamoto
    • Organizer
      NetSci X 2020: International School and Conference on Network Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 数理モデルから考察する性感染症の存続性2020

    • Author(s)
      伊東 啓
    • Organizer
      日本生態学会第67回全国大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cardiovascular Risk Factors among high altitude inhabitants of Nepal2019

    • Author(s)
      Koirala S, Nakano M, Arima H, Takeuchi S, Ichikawa T, Nishimura T, Ito H, Pandey BD, Pandey K, Wada T, Yamamoto T
    • Organizer
      Fifth National Summit of the Health and Population Scientists in Nepal
    • Related Report
      2019 Annual Research Report
  • [Presentation] 垂直感染を含む性感染伝播のネットワーク拡散モデル2019

    • Author(s)
      守田智, 伊東啓, 山本太郎
    • Organizer
      日本物理学会2019年秋季大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 母子感染を考慮した性感染ネットワーク拡散モデル2019

    • Author(s)
      守田智, 伊東啓, 山本太郎
    • Organizer
      日本数理生物学会第29回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 5つの互恵ルールが持つ社会的ジレンマ緩和機構の可視化2019

    • Author(s)
      伊東啓, 谷本潤
    • Organizer
      日本数理生物学会第29回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 社会ジレンマの存否とSocial Efficiency Deficit2019

    • Author(s)
      谷本潤, 伊東啓
    • Organizer
      日本数理生物学会第29回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 周期ゼミの数理モデリング2019

    • Author(s)
      伊東啓, 吉村仁
    • Organizer
      個体群生態学会第35回大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 母子感染と性ネットワークを考慮した性感染症拡散モデル2019

    • Author(s)
      伊東啓, 山本太郎, 守田智
    • Organizer
      個体群生態学会第35回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ゲノムインプリンティングによる真社会性の起源2019

    • Author(s)
      松浦健二, 伊東啓, 小林和也, 大崎遥, 吉村仁
    • Organizer
      個体群生態学会第35回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ゲーム理論におけるジレンマ強度の可視化と協力行動の進化~5つの互恵ルールを例に~2019

    • Author(s)
      伊東啓、谷本潤
    • Organizer
      日本生態学会第66回全国大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 縄張り競争の個体群動態モデルによるアユの効果的な放流方策の検討2018

    • Author(s)
      勝又雄基、上原隆司、伊東啓、吉村仁、泰中啓一、一ノ瀬元喜
    • Organizer
      第34回個体群生態学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 真社会性の作り方:ゲノムインプリンティング説の提唱2018

    • Author(s)
      松浦健二、伊東啓、吉村仁
    • Organizer
      第34回個体群生態学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ゲノムインプリンティングによる真社会性の起源2018

    • Author(s)
      松浦健二、伊東啓、吉村仁
    • Organizer
      日本動物行動学会第37回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 日本の人口移動を考慮したHTLV-1の拡散予測に向けて2018

    • Author(s)
      伊東啓、小林志穂美、守田智
    • Organizer
      第65回日本生態学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 日本における人口移動を考慮したHTLV-1の拡散モデル2017

    • Author(s)
      伊東啓、小林志穂美、守田智
    • Organizer
      第14回情報処理学会ネットワーク生態学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Remarks] 個人ホームページ

    • URL

      https://sites.google.com/view/h-ito/

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 国際保健学分野ホームページ

    • URL

      http://www.tm.nagasaki-u.ac.jp/newrect/index.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] researchmap

    • URL

      https://researchmap.jp/hiromu_ito/

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report

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Published: 2017-04-28   Modified: 2023-01-30  

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