| Budget Amount *help |
¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2019: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2017: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
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| Outline of Final Research Achievements |
One of the problems in the cell transplantation therapy is the lack of technologies to directly evaluate the therapeutic effect by the non-invasive detection of biological functions (survival, proliferation, differentiation, etc.) of transplanted cells for a long period. In this project, the detection technology of cellular biological function by the molecular beacon which enable to fluorescently detect the intracellular nucleic acid and the intracellular controlled release technology by biodegradable nanoparticles were combined to tackle the problem. The long-term detection of various biological functions expressed by the transplanted cells were successfully realized by performing this project.
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