| Budget Amount *help |
¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
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| Outline of Final Research Achievements |
The T-tubule membrane, a specialized membrane structure of cardiomyocytes, is critical for efficient contraction and relaxation of the cardiomyocytes. Since disruption of the T-tubule membrane structure triggers the onset of heart failure, this study aimed to elucidate the mechanisms underlying the support and disruption of the T-tubule membrane structure by analyzing the progression of heart failure in mice. We found that the abnormal localization of Junctophilin-2, a protein that bridges T-tubules and SR membranes, causes the disruption of the T-tubule membrane. We proposed the possibility that the T-tubule membrane structure can be maintained by controlling the factors that cause Junctophilin-2 mislocalization.
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