| Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2019: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2018: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2017: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Outline of Final Research Achievements |
It is essential to deliver drugs not only crossing the blood-brain barrier (BBB) but also only to target cells in the brain parenchyma to effectively treat central nervous system diseases, such as Alzheimer's disease (AD). In this study, we developed polymeric self-assembly (PM) that selectively delivers nucleic acid drugs to neurons in the brain, using polymers that are safe in vivo as building blocks. In vivo experiments using AD model mice showed that the expression level of the target protein was significantly suppressed, and the ability related to spatial reference and long-term memory was successfully improved in behavioral tests.
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