Development of risk evaluation system of cerebral aneurysms based on the computational fluid dynamics

• Project/Area Number: 17H04745
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Medical systems
• Research Institution: Tohoku University
• Principal Investigator: NIIZUMA KUNIYASU 東北大学, 医工学研究科, 教授 (10643330)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000); Fiscal Year 2019: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2018: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000); Fiscal Year 2017: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
• Keywords: 数値流体力学 / 血流 / 磁気共鳴血管撮影 / 脳動脈瘤 / 脳血管障害 / 血行力学 / 数値流体力学解析 / 血流解析

Outline of Final Research Achievements

The purpose of this study is to establish a theoretical basis for diagnosis and treatment using computational fluid dynamics (CFD) for mainly cerebral aneurysms. Simultaneously, we constructed a case repository with hemorrhagic factors.
We analyzed numbers of cerebral aneurysms treated by coil embolization or flow diverter, and revealed the risk factors for the recurrence of the aneurysms.
We also investigated the complex hemodynamics of Moyamoya disease using CFD using large eddy simulation technique.

Academic Significance and Societal Importance of the Research Achievements

最新の治療であるフローダイバータにおいて、CFDを用いて治療後の不完全閉塞などと関連する所見を見出し、これは今後の治療法改善や危険因子探索において大きな社会的波及効果を生み出すと考えられた。
また、個人レベルで解析するのではなく、学会と連携して、他施設共同でデータを蓄積するとともに、各研究者には解析結果を提供するサービスを構築していった。これは、大きな規模のデータベース化とともに、CFD普及に貢献する取り組みであり、社会的意義も大きいと考える。

Research Products

• [Journal Article] What does computational fluid dynamics tell us about intracranial aneurysms? A meta-analysis and critical review (2020)
  • Author(s): Saqr Khalid M、Rashad Sherif、Tupin Simon、Niizuma Kuniyasu、Hassan Tamer、Tominaga Teiji、Ohta Makoto
  • Journal Title: Journal of Cerebral Blood Flow & Metabolism Volume: - Issue: 5 Pages: 1021-1039
  • DOI: 10.1177/0271678x19854640
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The hemodynamic complexities underlying transient ischemic attacks in early-stage Moyamoya disease: an exploratory CFD study (2020)
  • Author(s): Rashad Sherif、Saqr Khalid M.、Fujimura Miki、Niizuma Kuniyasu、Tominaga Teiji
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 3700-3700
  • DOI: 10.1038/s41598-020-60683-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Circumferential wall enhancement in evolving intracranial aneurysms on magnetic resonance vessel wall imaging (2019)
  • Author(s): Omodaka Shunsuke、Endo Hidenori、Niizuma Kuniyasu、Fujimura Miki、Inoue Takashi、Endo Toshiki、Sato Kenichi、Sugiyama Shin-ichiro、Tominaga Teiji
  • Journal Title: Journal of Neurosurgery Volume: 131 Issue: 4 Pages: 1262-1268
  • DOI: 10.3171/2018.5.jns18322
  • Peer Reviewed
• [Journal Article] Real-World Variability in the Prediction of Intracranial Aneurysm Wall Shear Stress: The 2015 International Aneurysm CFD Challenge (2018)
  • Author(s): Valen-Sendstad K, ..., Tsuji M, ..., Steinman DA
  • Journal Title: Cardiovasc Eng Technol Volume: 9 Issue: 4 Pages: 544-564
  • DOI: 10.1007/s13239-018-00374-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 脳動脈瘤に対する治療医シミュレーション・再発予測 (2020)
  • Author(s): 新妻邦泰
  • Organizer: 第43回脳神経CI学会
  • Invited