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A new system of rehabilitation via immunometabolism

Research Project

Project/Area Number 17H04747
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKobe University

Principal Investigator

Maeshige Noriaki  神戸大学, 保健学研究科, 助教 (90617838)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Keywords骨格筋 / マクロファージ / 物理療法 / 免疫代謝 / 培養筋繊維 / エクソソーム / グルコース制限 / 筋管細胞 / イムノメタボリズム / 代謝産物 / メタボロミクス / 超音波刺激
Outline of Final Research Achievements

The effect of muscle-derived exosomes on innate immunity was investigated by the experimental system treating bone marrow-derived macrophages with the supernatant of cultured myotubes or extracted exosomes from the media.
M1 polarity (pro-inflammatory) of macrophages was downregulated by the addition of myotube supernatant or muscle exosomes. Ultrasound irradiation to myotubes doubled the release of muscle exosomes, and the ultrasound stimulation of the myotube enhanced the inhibitory effect of myotube supernatant on M1 polarity of macrophages. In addition, the effect of ultrasound was canceled by depleting exosomes from the culture supernatant.
This study suggested that the anti-inflammatory effect of skeletal muscle was exerted via exosomes.

Academic Significance and Societal Importance of the Research Achievements

本研究では、骨格筋から分泌されるエクソソームがマクロファージによる過剰炎症反応を制御することを見出した。このことは、生体内に存在する器官を疾病治療的に活用する基盤を構築した。さらに、骨格筋に対する物理刺激によって、筋障害なく筋エクソソームの効果を高めることとが確認され、具体的な治療戦略を打ち出すことができた。特に病原性微生物による感染では、過剰な炎症反応が呼吸器等の生命維持に必要な臓器の機能を顕著に低下させ、持続する炎症が損傷臓器の修復反応を遅延化させるため、重篤な後遺症をもたらし、ときには生命を脅かす。本研究では、それらを予防、あるいは重症化させない保存的手段の開発基盤を構築した。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (52 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (4 results) Journal Article (19 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 19 results,  Open Access: 4 results) Presentation (18 results) (of which Int'l Joint Research: 8 results) Book (9 results) Remarks (2 results)

  • [Int'l Joint Research] ハーバード大学医学大学院/ハーバード大学公衆衛生大学院(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] ハーバード大学医学大学院/ハーバード大学公衆衛生大学院(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ハーバード大学公衆衛生大学院(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ハーバード大学公衆衛生大学院(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] High-intensity ultrasound irradiation promotes the release of extracellular vesicles from C2C12 myotubes2021

    • Author(s)
      Maeshige Noriaki、Langston P. Kent、Yuan Zhi-Min、Kondo Hiroyo、Fujino Hidemi
    • Journal Title

      Ultrasonics

      Volume: 110 Pages: 106243-106243

    • DOI

      10.1016/j.ultras.2020.106243

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reduced metabolic capacity in fast and slow skeletal muscle via oxidative stress and the energy‐sensing of AMPK/SIRT1 in malnutrition2021

    • Author(s)
      Hirabayashi Takumi、Nakanishi Ryosuke、Tanaka Minoru、Nisa Badur un、Maeshige Noriaki、Kondo Hiroyo、Fujino Hidemi
    • Journal Title

      Physiological Reports

      Volume: 9 Issue: 5 Pages: 1-11

    • DOI

      10.14814/phy2.14763

    • NAID

      120007115801

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Can ultrasound irradiation be a therapeutic option for prostate cancer?2020

    • Author(s)
      Maeshige N, Kitagawa K, Yamasaki S, Ishii A, Shirakawa T, Yang YM, Sung SY, Chen KC, Yuan ZM, Shigemura K, Fujisawa M.
    • Journal Title

      Prostate

      Volume: 80 Issue: 12 Pages: 986

    • DOI

      10.1002/pros.24030

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Preventive effects of medium-chain triglycerides supplementation on the oxidative capacity in skeletal muscle under cachectic condition2020

    • Author(s)
      HIRABAYASHI Takumi、TANAKA Minoru、MATSUMOTO Tomohiro、MAESHIGE Noriaki、KONDO Hiroyo、FUJINO Hidemi
    • Journal Title

      Biomedical Research

      Volume: 41 Issue: 4 Pages: 179-186

    • DOI

      10.2220/biomedres.41.179

    • NAID

      130007887497

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 悪液質由来の骨格筋萎縮に対するパルス超音波療法の予防効果2020

    • Author(s)
      中西 亮介, 平山 佑介, 上野 瑞季, 前重 伯壮, 藤野 英己
    • Journal Title

      物理療法科学

      Volume: 27 Pages: 41-47

    • NAID

      40022368174

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心不全に伴う骨格筋の速筋化とミトコンドリア機能障害に対するパルス磁気刺激の効果2020

    • Author(s)
      平林 卓己, 中西 亮介, 前重 伯壮, 藤野 英己
    • Journal Title

      物理療法科学

      Volume: 27 Pages: 48-55

    • NAID

      40022368176

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of combined treatment with blood flow restriction and low current electrical stimulation on muscle hypertrophy in rats.2020

    • Author(s)
      Yoshikawa M, Morifuji T, Matsumoto T, Maeshige N, Tanaka M, Fujino H.
    • Journal Title

      J Appl Physiol

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Can ultrasound irradiation be a therapeutic option for prostate cancer?2020

    • Author(s)
      N.Maeshige, K.Kitagawa, S.Yamasaki, A.Ishii, S.Y.Sung, Z.M.Yuan, K.Shigemura, M.Fujisawa.
    • Journal Title

      The Prostate

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Transcutaneous carbon dioxide attenuates impaired oxidative capacity in skeletal muscle in hyperglycemia model.2019

    • Author(s)
      Matsumoto T, Tanaka M, Nakanish R, Takuwa M, Hirabayashi T, Ono K, Ikeji T, Maeshige N, Sakai Y, Akisue T, Kondo H, Ishihara A, Fujino H.
    • Journal Title

      Gen Physiol Biophys

      Volume: 38 Pages: 237-244

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of astaxanthin supplementation and electrical stimulation on muscle atrophy and decreased oxidative capacity in soleus muscle during hindlimb unloading in rats.2019

    • Author(s)
      Kanazashi M, Tanaka M, Nakanishi R, Maeshige N, Fujino H.
    • Journal Title

      J Physiol Sci

      Volume: 69 Pages: 757-767

    • NAID

      40022006466

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcutaneous carbon dioxide attenuates impaired oxidative capacity in skeletal muscle in hyperglycemia.2019

    • Author(s)
      Matsumoto T, Tanaka M, Nakanishi R, Takuwa M, Hirabayashi T, Ono K, Ikeji T, Maeshige N, Sakai Y, Akisue T, Kondo H, Ishihara A, Fujino H
    • Journal Title

      General Physiology and Biophysics

      Volume: in press

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of transcutaneous carbon dioxide improves capillary regression of skeletal muscle in hyperglycemia2019

    • Author(s)
      Matsumoto T, Tanaka M, Ikeji T, Maeshige N, Sakai Y, Akisue T, Kondo H, Ishihara A, Fujino H
    • Journal Title

      J Physiol Sci

      Volume: 69 Issue: 2 Pages: 223-233

    • DOI

      10.1007/s12576-018-0648-y

    • NAID

      40021819003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory Effects of Short-Chain Fatty Acids and ω-3 Polyunsaturated Fatty Acids on Profibrotic Factors in Dermal Fibroblasts.2019

    • Author(s)
      Maeshige N, Torii K, Tabuchi H, Imai M, Koga Y, Uemura M, Aoyama-Ishikawa M, Miyoshi M, Fujino H, Terashi H, Usami M
    • Journal Title

      Eplasty

      Volume: 19

    • NAID

      120006873027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective effects of Brazilian propolis supplementation on capillary regression in the soleus muscle of hindlimb-unloaded rats2018

    • Author(s)
      Tanaka Masayuki、Kanazashi Miho、Maeshige Noriaki、Kondo Hiroyo、Ishihara Akihiko、Fujino Hidemi
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 69 Issue: 2 Pages: 223-233

    • DOI

      10.1007/s12576-018-0639-z

    • NAID

      40021818923

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] モノクロタリン誘発性肺高血圧症ラットのヒラメ筋におけるミトコンドリア機能障害と毛細血管退行に対する中周波電気刺激の介入効果2018

    • Author(s)
      田中雅侑、前重伯壮、金指美帆、中西亮介、藤野英己.
    • Journal Title

      物理療法科学

      Volume: 25 Pages: 42-49

    • NAID

      40021724120

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心不全による骨格筋の毛細血管対抗退行に対するレーザー照射の治療効果.2018

    • Author(s)
      上野瑞季、田中雅侑、平山佑介、金指美帆、松本智博、前重伯壮、藤野英己.
    • Journal Title

      物理療法科学

      Volume: 25 Pages: 50-56

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 廃用性筋萎縮に対する神経筋電気刺激とパルス磁気刺激の比較検証.2018

    • Author(s)
      中西亮介,平山佑介,田中稔,小野紘平,池治 拓也, 前重伯壮,藤野英己
    • Journal Title

      物理療法科学

      Volume: 25 Pages: 57-62

    • NAID

      40021724178

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of plantar pressure and gastrocnemius activity during gait using electrical stimulation of the tibialis anterior in healthy adults.2018

    • Author(s)
      Moriguchi M, Maeshige N, Ueno M, Yoshikawa Y, Terashi H, Fujino H.
    • Journal Title

      PLoS One.

      Volume: 13(5) Issue: 5 Pages: e0195309-e0195309

    • DOI

      10.1371/journal.pone.0195309

    • NAID

      120006471066

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Weight-bearing stretching of the triceps surae muscle increases the range of motion on ankle dorsiflexion in diabetic patients: an approach to reduce the risk of diabetic foot ulcer development.2018

    • Author(s)
      Maeshige N, Hirasawa Y, Moriguchi M, Yoshikawa Y, Maruo K, Noguchi M, Terashi H, Fujino H.
    • Journal Title

      Journal of Japanese Society of Wound, Ostomy and Continence Management

      Volume: 22 Pages: 281-286

    • NAID

      130008032042

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effects of high-intensity ultrasound irradiation on exosomes release from cultured myotubes2021

    • Author(s)
      Hikari Noguchi, Noriaki Maeshige, P Kent Langston, Atomu Yamaguchi, Mikiko Uemura, Ryosuke Nakanishi, Hiroyo Kondo, Hidemi Fujino
    • Organizer
      EXPERIMENTAL BIOLOGY 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Conditioned Media from Ultrasound-treated C2C12 Myotubes Regulate Macrophage Inflammatory Responses2021

    • Author(s)
      Atomu Yamaguchi, Noriaki Maeshige, P Kent Langston, Hikari Noguchi, Xiaoqi Ma, Yusuke Ichikawa, Mikiko Uemura, Hiroyo Kondo, Hidemi Fujino
    • Organizer
      EXPERIMENTAL BIOLOGY 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高強度パルスモード超音波は培養筋繊維からの細胞外小胞の放出を促進させる2021

    • Author(s)
      前重伯壮, P Kent Langston, Zhi-Min Yuan, 近藤浩代, 藤野英己
    • Organizer
      第1回物理療法部門研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Beneficial effects of mild hyperbaric oxygen exposure on microcirculation in peripheral tissues and resting metabolic rate in healthy human subjects (末梢組織の微小循環と代謝に対する軽度高酸素暴露の効果)2020

    • Author(s)
      Badur Un Nisa(バドウル ウンニサ),中山 慧美,野口 ひかり,林 浩,平林 卓己, 植村 弥希子,中西 亮介,田中 稔,近藤 浩代,前重 伯壮,藤野 英己
    • Organizer
      第110回理学療法科学学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] レモンマートル抽出物がマイクロRNA発現抑制を介した筋衛星細胞の増殖に与える効果2020

    • Author(s)
      中山 慧美,山本 愛弓,本田 真一,野口 ひかり,林 浩,Badur Un Nisa Safder, 平林 卓己,植村 弥希子,中西 亮介,田中 稔,近藤 浩代,前重 伯壮,藤野 英己
    • Organizer
      第110回理学療法科学学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高強度超音波照射が培養筋管由来の細胞外小胞放出に与える効果2020

    • Author(s)
      野口 ひかり,中山 慧美,林 浩,Badur Un Nisa Safder,平林 卓己,植村 弥希子, 中西 亮介,田中 稔,近藤 浩代,前重 伯壮,藤野 英己
    • Organizer
      第110回理学療法科学学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 金属アレルギー患者に対する管理栄養士による栄養食事指導の効果 ランダム化比較試験2019

    • Author(s)
      三ヶ尻 礼子, 福永 淳, 三好 真琴, 前重 伯壮, 鷲尾 健, 正木 太郎, 田渕 聡子, 脇田 久美子, 山西 美沙, 中谷 早希, 菅 里沙子, 齋藤 沙緒理, 河村 弘美, 山本 育子, 高橋 路子, 木戸 良明, 錦織 千佳子, 宇佐美 眞
    • Organizer
      第23回日本病態栄養学会年次学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 心不全の骨格筋における速筋化とミトコンドリア機能障害に対するパルス磁気刺激の効果2019

    • Author(s)
      平林 卓己, 中西 亮介, 前重 伯壮, 藤野 英己
    • Organizer
      第27回日本物理療法学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高脂質食誘導性肥満の骨格筋における筋損傷治癒遅延に対するパルスモード超音波の効果2018

    • Author(s)
      松本 智博、田中 雅侑、池冶 拓也、前重 伯壮、藤野 英己
    • Organizer
      第26回日本物理療法学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effects of Transcutaneous Carbon Dioxide (CO2) on Hyperglycemia-induced Capillary Regression in Skeletal Muscle.2018

    • Author(s)
      T. Matsumoto, M. Takuwa, T. Hirabayashi, T. Ikeji, K. Ono, N. Maeshige, H. Kondo, H. Fujino.
    • Organizer
      Experimental Biology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Comparison of Protective Effects Between Electrical and Pulsed-Magnetic Stimulation in the Deep Layer of Skeletal Muscles Under Disuse Condition.2018

    • Author(s)
      K. Ono, R. Nakanishi, T. Matsumoto, M. Takuwa, T. Hirabayashi, T. Ikeji, M. Tanaka, N. Maeshige, H. Kondo, H. Fujino
    • Organizer
      Experimental Biology2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preventive Effects of Medium-Chain Triglycerides Supplementation on the Dysfunction of Mitochondrial Oxidative Phosphorylation in Skeletal Mucle Under Cachectic Condition.2018

    • Author(s)
      T. Hirabayashi, M. Tanaka, T. Matsumoto, T. Ikeji, K. Ono, M. Takuwa, N. Maeshige, H. Kondo, H. Fujino.
    • Organizer
      Experimental Biology2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高血糖に伴う骨格筋の酸化的リン酸化能低下や毛細血管退行に対する経皮的炭酸ガス吸収法の効果2018

    • Author(s)
      松本智博,宅和美穂,平林卓己,池治拓也,小野紘平,前重伯壮,近藤浩代,藤野英己.
    • Organizer
      第73回日本体力医学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 経皮的炭酸ガス吸収法が糖尿病の骨格筋代謝における代謝能低下や毛細血管退行に及ぼす効果2018

    • Author(s)
      松本智博,宅和美穂,平林卓己,池治拓也,前重伯壮,近藤浩代,藤野英己
    • Organizer
      第23回日本基礎理学療法学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Responses of Muscle Satellite Cells to Lemon Myrtle Supplementation Combined with Electrical Stimulation in Disuse-induced Skeletal Muscle Atrophy2018

    • Author(s)
      Takuwa M, Matsumoto T, Hirabayashi T, Ikeji T, Ono K, Honda S, Yamamoto A, Maeshige N, Kondo H, Fujino H.
    • Organizer
      Experimental Biology2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protective effects of Enterococcus faecium strain R30 on transformation of slow to fast fiber under inactive condition.2018

    • Author(s)
      Ikeji T, Hirayama Y, Matsumoto T, Ono K, Takuwa M, Hirabayashi T, Takegaki A, Maeshige N, Kondo H, Fujino H
    • Organizer
      Experimental Biology2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A comparison of protective effects between electrical and pulsed-magnetic stimulation in the deep layer of skeletal muscles under disuse condition2018

    • Author(s)
      Kohei Ono, Ryosuke Nakanishi, Tomohiro Matsumoto, Miho Takuwa, Takumi Hirabayashi, Takuya Ikeji, Minoru Tanaka, Noriaki Maeshige, Hiroyo Kondo, Hidemi Fujino
    • Organizer
      Experimental Biology 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 悪液質に伴う筋萎縮に対するパルス超音波が炎症性サイトカイン発現及びMAPキナーゼに与える効果2017

    • Author(s)
      上野瑞季、平山佑介、前重伯壮、藤野英己
    • Organizer
      第52回日本理学療法学術大会
    • Related Report
      2017 Annual Research Report
  • [Book] 「教育管理」 15レクチャーシリーズ理学療法テキスト 理学療法管理学2020

    • Author(s)
      前重伯壮 編集 石川朗 長野聖
    • Total Pages
      10
    • Publisher
      中山書店
    • ISBN
      9784521748139
    • Related Report
      2020 Annual Research Report
  • [Book] 「温熱療法の定義・分類」 標準理学療法学 専門分野 物理療法学 第5版2020

    • Author(s)
      前重伯壮 編集 網本和 菅原憲一 松田雅弘
    • Total Pages
      351
    • Publisher
      医学書院
    • Related Report
      2019 Annual Research Report
  • [Book] 「温熱療法の基礎と生理学的作用」 標準理学療法学 専門分野 物理療法学 第5版2020

    • Author(s)
      前重伯壮 編集 網本和 菅原憲一 松田雅弘
    • Total Pages
      351
    • Publisher
      医学書院
    • Related Report
      2019 Annual Research Report
  • [Book] 「温熱療法の実際①ホットパック」 標準理学療法学 専門分野 物理療法学 第5版2020

    • Author(s)
      前重伯壮 編集 網本和 菅原憲一 松田雅弘
    • Total Pages
      351
    • Publisher
      医学書院
    • Related Report
      2019 Annual Research Report
  • [Book] 「温熱療法の実際②パラフィン」 標準理学療法学 専門分野 物理療法学 第5版2020

    • Author(s)
      前重伯壮 編集 網本和 菅原憲一 松田雅弘
    • Total Pages
      351
    • Publisher
      医学書院
    • Related Report
      2019 Annual Research Report
  • [Book] 「温熱療法の実際③超短波療法・極超短波療法」 標準理学療法学 専門分野 物理療法学 第5版2020

    • Author(s)
      前重伯壮 編集 網本和 菅原憲一 松田雅弘
    • Total Pages
      351
    • Publisher
      医学書院
    • Related Report
      2019 Annual Research Report
  • [Book] 「温熱療法の実際④超音波療法」 標準理学療法学 専門分野 物理療法学 第5版2020

    • Author(s)
      前重伯壮 編集 網本和 菅原憲一 松田雅弘
    • Total Pages
      351
    • Publisher
      医学書院
    • Related Report
      2019 Annual Research Report
  • [Book] 「教育管理」 15レクチャーシリーズ理学療法テキスト 理学療法管理学2020

    • Author(s)
      前重伯壮 編集 石川朗
    • Total Pages
      180
    • Publisher
      中山書店
    • Related Report
      2019 Annual Research Report
  • [Book] <理学療法MOOK> 22 急性期の脳卒中理学療法 急性期における合併症予防③―褥瘡2018

    • Author(s)
      前重 伯壮
    • Total Pages
      5
    • Publisher
      三輪書店
    • Related Report
      2018 Annual Research Report
  • [Remarks]

    • URL

      https://researchmap.jp/7000012471

    • Related Report
      2020 Annual Research Report
  • [Remarks]

    • URL

      http://www.research.kobe-u.ac.jp/fhs-fujino/

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2022-06-07  

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