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Development of novel real-time feedback system using electromyography

Research Project

Project/Area Number 17H04748
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Rehabilitation science/Welfare engineering
Research InstitutionShinshu University (2019-2020)
Nagoya University (2017-2018)

Principal Investigator

Nojima Ippei  信州大学, 医学部, 准教授(特定雇用) (20646286)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2017: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Keywords歩行 / コヒーレンス / 筋電図 / 経頭蓋直流電気刺激 / 歩行リハ / 筋電図コヒーレンス / 運動学習 / 脳波 / 電気刺激 / 学習 / コヒーレンス値 / リハビリテーション
Outline of Final Research Achievements

This study aimed to develop a novel gait rehabilitation intervention system through real-time feedback of EMG coherence combined with non-invasive brain stimulation in patients with Parkinson's disease. Although the COVID-19 pandemic was expanded in Japan and we could not conduct a clinical research activity in 2020, each system has been developed and measured the effectiveness of these systems for motor function in PD patients. In the clinical study, we executed gait rehabilitation combined with non-invasive brain stimulation adjusted by gait patterns in total 10 times, and we compared with the control group with sham stimulation. This intervention showed that real stimulation synchronized gait patterns reduced asymmetric gait patterns and improving the stepping parameters.

Academic Significance and Societal Importance of the Research Achievements

本研究では、歩行時の神経系の活動を調整する新しいリハビリテーション方法の開発を目指しました。具体的には、神経活動を非侵襲的に筋電図などで計測し、その情報を視覚的に表示することにより自身で自らの神経活動を調整するシステムを開発しました。また、歩行のリズムに合わせた脳への電気刺激を併用する方法の効果検証も行いました。そしてこれらのシステムをパーキンソン病患者を対象とした臨床研究で検証し、介入により歩行時の非対称性などを改善できる可能性を示すことができました。今後は、より安全・簡便な方法で神経系の活動を調整する方法の開発を行うことで、効果的なリハビリテーションの開発を進めていきたいと考えています。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (26 results)

All 2020 2019 2018 2017 Other

All Journal Article (15 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 15 results,  Open Access: 12 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Remarks (1 results)

  • [Journal Article] Smaller muscle mass is associated with increase in EMG-EMG coherence of the leg muscle during unipedal stance in elderly adults2020

    • Author(s)
      Ippei Nojima, Yuki Suwa, Hideshi Sugiura, Taiji Noguchi, ShigeovTanabe, Tatsuya Mima, Tatsunori Watanabe
    • Journal Title

      Human Movement Science

      Volume: 71 Pages: 1-9

    • DOI

      10.1016/j.humov.2020.102614

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of beta-band resting-state functional connectivity as a predictor of motor learning ability2020

    • Author(s)
      Sugata Hisato、Yagi Kazuhiro、Yazawa Shogo、Nagase Yasunori、Tsuruta Kazuhito、Ikeda Takashi、Nojima Ippei、Hara Masayuki、Matsushita Kojiro、Kawakami Kenji、Kawakami Keisuke
    • Journal Title

      NeuroImage

      Volume: 210 Pages: 116562-116562

    • DOI

      10.1016/j.neuroimage.2020.116562

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Navigated repetitive transcranial magnetic stimulation as preoperative assessment in patients with brain tumors2020

    • Author(s)
      Motomura Kazuya、Takeuchi Hiroki、Nojima Ippei、Aoki Kosuke、Chalise Lushun、Iijima Kentaro、Wakabayashi Toshihiko、Natsume Atsushi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 1-1

    • DOI

      10.1038/s41598-020-65944-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnification of visual feedback modulates corticomuscular and intermuscular coherences differently in young and elderly adults2020

    • Author(s)
      Watanabe Tatsunori、Nojima Ippei、Mima Tatsuya、Sugiura Hideshi、Kirimoto Hikari
    • Journal Title

      NeuroImage

      Volume: 220 Pages: 117089-117089

    • DOI

      10.1016/j.neuroimage.2020.117089

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcranial static magnetic stimulation over the primary motor cortex alters sequential implicit motor learning2019

    • Author(s)
      Nojima I, Watanabe T, Goyda T, Sugata H, Ikeda T, Mima T.
    • Journal Title

      Neurosci Lett

      Volume: 696 Pages: 33-37

    • DOI

      10.1016/j.neulet.2018.12.010

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcranial static magnetic stimulation from bench to bedside and beyond2019

    • Author(s)
      NOJIMA Ippei、OLIVIERO Antonio、MIMA Tatsuya
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 250-255

    • DOI

      10.1016/j.neures.2019.12.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impaired Motor Skill Acquisition Using Mirror Visual Feedback Improved by Transcranial Direct Current Stimulation (tDCS) in Patients With Parkinson's Disease2019

    • Author(s)
      Horiba M, Ueki Y, Nojima I, Shimizu Y, Sahashi K, Itamoto S, Suzuki A, Yamada G, Matsukawa N, Wada I
    • Journal Title

      Front Neurosci

      Volume: 13 Pages: 602-602

    • DOI

      10.3389/fnins.2019.00602

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Voluntary control of forward leaning posture relates to low-frequency neural inputs to the medial gastrocnemius muscle2018

    • Author(s)
      Watanabe T, Nojima I, Sugiura H, Yacoubi B, Christou EA
    • Journal Title

      Gait & Posture

      Volume: 68 Pages: 187-192

    • DOI

      10.1016/j.gaitpost.2018.11.026

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fatigue-induced decline in low-frequency common input to bilateral and unilateral plantar flexors during quiet standing2018

    • Author(s)
      Watanabe Tatsunori、Saito Kotaro、Ishida Kazuto、Tanabe Shigeo、Nojima Ippei
    • Journal Title

      Neuroscience Letters

      Volume: 686 Pages: 193-197

    • DOI

      10.1016/j.neulet.2018.09.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-Related Declines in the Ability to Modulate Common Input to Bilateral and Unilateral Plantar Flexors During Forward Postural Lean2018

    • Author(s)
      Watanabe T, Saito K, Ishida K, Tanabe S, Nojima I
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 12 Pages: 1-9

    • DOI

      10.3389/fnhum.2018.00254

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of auditory stimulus on executive function and execution time during cognitively demanding stepping task in patients with Parkinson's disease.2018

    • Author(s)
      Watanabe T, Saito K, Ishida K, Tanabe S, Horiba M, Itamoto S, Ueki Y, Wada I, Nojima I.
    • Journal Title

      Neurosci Lett

      Volume: 674 Pages: 101-105

    • DOI

      10.1016/j.neulet.2018.03.032

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of EMG-EMG Coherence in a Choice Stepping Task2018

    • Author(s)
      Nojima Ippei、Watanabe Tatsunori、Saito Kotaro、Tanabe Shigeo、Kanazawa Hoshinori
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 12 Pages: 111-111

    • DOI

      10.3389/fnhum.2018.00050

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transcranial Static Magnetic Field Stimulation over the Primary Motor Cortex Induces Plastic Changes in Cortical Nociceptive Processing2018

    • Author(s)
      Kirimoto Hikari、Tamaki Hiroyuki、Otsuru Naufumi、Yamashiro Koya、Onishi Hideaki、Nojima Ippei、Oliviero Antonio
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 12 Pages: 63-63

    • DOI

      10.3389/fnhum.2018.00063

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Coordination of plantar flexor muscles during bipedal and unipedal stances in young and elderly adults2018

    • Author(s)
      Watanabe Tatsunori、Saito Kotaro、Ishida Kazuto、Tanabe Shigeo、Nojima Ippei
    • Journal Title

      Experimental Brain Research

      Volume: - Issue: 5 Pages: 1229-1239

    • DOI

      10.1007/s00221-018-5217-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auditory stimulus has a larger effect on anticipatory postural adjustments in older than young adults during choice step reaction2017

    • Author(s)
      Watanabe Tatsunori、Saito Kotaro、Ishida Kazuto、Tanabe Shigeo、Nojima Ippei
    • Journal Title

      European Journal of Applied Physiology

      Volume: 117 Issue: 12 Pages: 2409-2423

    • DOI

      10.1007/s00421-017-3727-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ミラー療法による運動麻痺へのアプローチ2020

    • Author(s)
      野嶌一平
    • Organizer
      第50回日本臨床神経生理学会学術大会(シンポジウム)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 経皮的脊髄直流電流刺激による歩行機能調整2019

    • Author(s)
      野嶌一平、大鶴直史、大西秀明、美馬達哉
    • Organizer
      第27回日本物理療法学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 地域在住高齢者における社会的孤立、孤独感と認知機能との関連2019

    • Author(s)
      野口泰司、野嶌一平、井上倫恵、水澤純、濱部優、杉浦英志
    • Organizer
      第61回日本老年医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脳機能修飾技術のリハビリテーションへの応用2019

    • Author(s)
      野嶌一平
    • Organizer
      第56回日本リハビリテーション医学会学術集会教育講演
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 非侵襲脳刺激法による新しいリハビリテーション介入2019

    • Author(s)
      野嶌一平
    • Organizer
      第21回日本看護医療学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Transcranial static magnetic stimulation over human primary motor cortex can modulate implicit motor learning2018

    • Author(s)
      Nojima I, Watanabe T, Hirayama M, Sugata H, Ikeda T, Mima T.
    • Organizer
      Society for Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reconsolidation task performed with untrained limb enhances motor skill acquisition2018

    • Author(s)
      Gyoda T, Ishida K, Watanabe T, Nojima I
    • Organizer
      Society for Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 運動技能再取得に対する両側性転移効果の検討2018

    • Author(s)
      行田智哉、 石田和人、 渡邊龍憲 、 野嶌一平
    • Organizer
      Motor control研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 認知機能低下高齢者における歩行パラメータの変化2018

    • Author(s)
      野嶌一平、野口泰司、松下光次郎、齊藤浩太郎、菅田陽怜、杉浦英志
    • Organizer
      日本予防理学療法学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高齢者の立位ステップ課題における下肢筋電図コヒーレンス変化2017

    • Author(s)
      野嶌一平、渡辺龍憲、齊藤浩太郎、田辺茂雄、金沢星慶
    • Organizer
      第47回臨床神経生理学会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 野嶌研究室

    • URL

      https://www.shinshu-u.ac.jp/faculty/medicine/chair/i-undoseigyo/index.html

    • Related Report
      2020 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

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