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Mitochondrial complex II assembly in skeletal muscle abnormalities: novel therapeutic target

Research Project

Project/Area Number 17H04758
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Applied health science
Research InstitutionHokusho University (2019-2020)
Hokkaido University (2017-2018)

Principal Investigator

Takada Shingo  北翔大学, 生涯スポーツ学部, 講師 (60722329)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Keywords骨格筋 / マイオカイン / 心不全 / 運動能力 / ミトコンドリア / 加齢・老化 / 筋萎縮 / 酸化ストレス / 骨格筋異常 / ミトコンドリア複合体II / TCAサイクル / 筋力 / ミトコンドリア複合体会合因子 / complex II
Outline of Final Research Achievements

Mitochondrial oxidative phosphorylation underlies sustained ATP production, which has been implicated in the pathogenesis of cardiovascular disease such as heart failure (HF) after myocardial infarction (Circulation 2018; Cell Commun Signal 2019; Eur J Pharmacol 2020; Front Cardiovasc Med 2020; Circ Heart Fail 2021; Commun Biol 2021; Cardiovasc Res 2021). Mitochondrial complex I have been intensively investigated for their roles in inducing impaired mitochondrial respiration in HF. In this study, we showed the latest data on the pathobiology of complex assembly in mediating mitochondrial dysfunction processes, focusing on the central role of mitochondrial complex II (Cell Commun Signal 2019; Biochem Biophys Rep 2020). An improved understanding of these mechanisms might facilitate the development of novel therapeutic agents or diets targeting mitochondrial complex assembly, which could be effective in the prevention and treatment of skeletal muscle abnormalities in HF.

Academic Significance and Societal Importance of the Research Achievements

疾患における骨格筋異常の克服を目指し、心不全を中心とした心疾患における運動療法の代替となる “予防”や“治療”法の可能性を示唆し、今後の臨床応用が期待される。我々は今、単に薬物や医療介入に依存するのではなく、心不全の骨格筋異常を予防および治療するための、より「自然な」方法を開発するフェーズにある。人体の基本的な設計と分子メカニズム、特に身体運動と骨格筋および心筋の完全性と機能的可塑性との密接な関連性を証明するための更なる分析が必要である。今後の心不全治療に関して、エビデンスのみならずサイエンスに基づく安全かつ効果的な運動、栄養、薬物療法を推奨・開発することが期待される。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (81 results)

All 2020 2019 2018 2017 Other

All Journal Article (30 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 30 results,  Open Access: 18 results) Presentation (34 results) (of which Int'l Joint Research: 2 results,  Invited: 22 results) Book (6 results) Remarks (10 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Serum Brain-Derived Neurotrophic Factor Levels Are Associated with Skeletal Muscle Function but Not with Muscle Mass in Patients with Heart Failure2020

    • Author(s)
      Nakano Ippei、Kinugawa Shintaro、Hori Hiroaki、Fukushima Arata、Yokota Takashi、Takada Shingo、Kakutani Naoya、Obata Yoshikuni、Yamanashi Katsuma、Anzai Toshihisa
    • Journal Title

      International Heart Journal

      Volume: 61 Issue: 1 Pages: 96-102

    • DOI

      10.1536/ihj.19-400

    • NAID

      130007792874

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2020-01-31
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure2020

    • Author(s)
      Nambu Hideo、Takada Shingo、Fukushima Arata、Matsumoto Junichi、Kakutani Naoya、Maekawa Satoshi、Shirakawa Ryosuke、Nakano Ippei、Furihata Takaaki、Katayama Takashi、Yamanashi Katsuma、Obata Yoshikuni、Saito Akimichi、Yokota Takashi、Kinugawa Shintaro
    • Journal Title

      European Journal of Pharmacology

      Volume: 866 Pages: 172810-172810

    • DOI

      10.1016/j.ejphar.2019.172810

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial respiration of complex II is not lower than that of complex I in mouse skeletal muscle2020

    • Author(s)
      Maekawa Satoshi、Takada Shingo、Furihata Takaaki、Fukushima Arata、Yokota Takashi、Kinugawa Shintaro
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 21 Pages: 100717-100717

    • DOI

      10.1016/j.bbrep.2019.100717

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of invariant natural killer T cells by alpha-galactosylceramide ameliorates doxorubicin-induced cardiotoxicity in mice2020

    • Author(s)
      Obata Yoshikuni、Ishimori Naoki、Saito Akimichi、Kinugawa Shintaro、Yokota Takashi、Takada Shingo、Nakano Ippei、Kakutani Naoya、Yamanashi Katsuma、Anzai Toshihisa
    • Journal Title

      European Journal of Preventive Cardiology

      Volume: - Issue: 19 Pages: 2358-2361

    • DOI

      10.1177/2047487319901208

    • NAID

      120006940624

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The disruption of invariant natural killer T cells exacerbates cardiac hypertrophy and failure caused by pressure overload in mice2020

    • Author(s)
      Takahashi Masashige、Kinugawa Shintaro、Takada Shingo、Kakutani Naoya、Furihata Takaaki、Sobirin Mochamad Ali、Fukushima Arata、Obata Yoshikuni、Saito Akimichi、Ishimori Naoki、Iwabuchi Kazuya、Tsutsui Hiroyuki
    • Journal Title

      Experimental Physiology

      Volume: 105 Issue: 3 Pages: 489-501

    • DOI

      10.1113/ep087652

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Branched-chain amino acid supplementation ameliorates angiotensin II-induced skeletal muscle atrophy.2020

    • Author(s)
      Yamanashi K, Kinugawa S, Fukushima A, Kakutani N, Takada S, Obata Y, Nakano I, Yokota T, Kitaura Y, Shimomura Y, Anzai T.
    • Journal Title

      Life Sciences

      Volume: 250 Pages: 117593-117595

    • DOI

      10.1016/j.lfs.2020.117593

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between increased atrial expression of genes related to fatty acid metabolism and autophagy in patients with chronic atrial fibrillation2020

    • Author(s)
      Shingu Yasushige、Takada Shingo、Yokota Takashi、Shirakawa Ryosuke、Yamada Akira、Ooka Tomonori、Katoh Hiroki、Kubota Suguru、Matsui Yoshiro
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 4 Pages: e0224713-e0224713

    • DOI

      10.1371/journal.pone.0224713

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin-converting-enzyme inhibitor prevents skeletal muscle fibrosis in myocardial infarction mice2020

    • Author(s)
      Kakutani Naoya、Takada Shingo、Nambu Hideo、Matsumoto Junichi、Furihata Takaaki、Yokota Takashi、Fukushima Arata、Kinugawa Shintaro
    • Journal Title

      Skeletal Muscle

      Volume: 10 Issue: 1 Pages: 11-11

    • DOI

      10.1186/s13395-020-00230-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loop diuretic use is associated with skeletal muscle wasting in patients with heart failure2020

    • Author(s)
      Nakano Ippei、Tsuda Masaya、Kinugawa Shintaro、Fukushima Arata、Kakutani Naoya、Takada Shingo、Yokota Takashi
    • Journal Title

      Journal of Cardiology

      Volume: 76 Issue: 1 Pages: 109-114

    • DOI

      10.1016/j.jjcc.2020.01.003

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Work volume is an important variable in determining the degree of inhibitory control improvements following resistance exercise2020

    • Author(s)
      Tomoo Keigo、Suga Tadashi、Sugimoto Takeshi、Tanaka Daichi、Shimoho Kento、Dora Kento、Mok Ernest、Matsumoto Shawn、Tsukamoto Hayato、Takada Shingo、Hashimoto Takeshi、Isaka Tadao
    • Journal Title

      Physiological Reports

      Volume: 8 Issue: 15

    • DOI

      10.14814/phy2.14527

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative effects of blood flow restriction on perceptual responses to walking in healthy young adults: A pilot study2020

    • Author(s)
      Mok Ernest、Suga Tadashi、Sugimoto Takeshi、Tomoo Keigo、Dora Kento、Takada Shingo、Hashimoto Takeshi、Isaka Tadao
    • Journal Title

      Heliyon

      Volume: 6 Issue: 8 Pages: e04745-e04745

    • DOI

      10.1016/j.heliyon.2020.e04745

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type 2 diabetes is an independent predictor of lowered peak aerobic capacity in heart failure patients with non-reduced or reduced left ventricular ejection fraction2020

    • Author(s)
      Abe Takahiro、Yokota Takashi、Fukushima Arata、Kakutani Naoya、Katayama Takashi、Shirakawa Ryosuke、Maekawa Satoshi、Nambu Hideo、Obata Yoshikuni、Yamanashi Katsuma、Nakano Ippei、Takada Shingo、Yokota Isao、Okita Koichi、Kinugawa Shintaro、Anzai Toshihisa
    • Journal Title

      Cardiovascular Diabetology

      Volume: 19 Issue: 1 Pages: 142-142

    • DOI

      10.1186/s12933-020-01114-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormalities of Skeletal Muscle, Adipocyte Tissue, and Lipid Metabolism in Heart Failure: Practical Therapeutic Targets2020

    • Author(s)
      Takada Shingo、Sabe Hisataka、Kinugawa Shintaro
    • Journal Title

      Frontiers in Cardiovascular Medicine

      Volume: 7 Pages: 79-79

    • DOI

      10.3389/fcvm.2020.00079

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Impact and Associated Factors of Delayed Ambulation in Patients With Acute Heart Failure2019

    • Author(s)
      Ishikawa Koji、Fukushima Arata、Yokota Takashi、Takada Shingo、Furihata Takaaki、Kakutani Naoya、Yamanashi Katsuma、Obata Yoshikuni、Nakano Ippei、Abe Takahiro、Kinugawa Shintaro、Anzai Toshihisa
    • Journal Title

      Circulation Reports

      Volume: 1 Issue: 4 Pages: 179-186

    • DOI

      10.1253/circrep.CR-18-0022

    • NAID

      130007630368

    • ISSN
      2434-0790
    • Year and Date
      2019-04-10
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced Echo Intensity of Skeletal Muscle Is Associated With Exercise Intolerance in Patients With Heart Failure2019

    • Author(s)
      Nakano Ippei、Hori Hiroaki、Fukushima Arata、Yokota Takashi、Kinugawa Shintaro、Takada Shingo、Yamanashi Katsuma、Obata Yoshikuni、Kitaura Yasuyuki、Kakutani Naoya、Abe Takahiro、Anzai Toshihisa
    • Journal Title

      Journal of Cardiac Failure

      Volume: - Issue: 8 Pages: 30416-30419

    • DOI

      10.1016/j.cardfail.2019.09.001

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resistance training with interval blood flow restriction effectively enhances intramuscular metabolic stress with less ischemic duration and discomfort.2019

    • Author(s)
      Okita K, Takada S, Morita N, Takahashi M, Hirabayashi K, Yokota T, Kinugawa S.
    • Journal Title

      Appl Physiol Nutr Metab

      Volume: in press Issue: 7 Pages: 759-764

    • DOI

      10.1139/apnm-2018-0321

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis.2019

    • Author(s)
      Nakajima T, Yokota T, Shingu Y, Yamada A, Iba Y, Ujihira K, Wakasa S, Ooka T, Takada S, Shirakawa R, Katayama T, Furihata T, Fukushima A, Matsuoka R, Nishihara H, Dela F, Nakanishi K, Matsui Y, Kinugawa S.
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 3535-3535

    • DOI

      10.1038/s41598-019-40419-7

    • NAID

      120006603703

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells2019

    • Author(s)
      Katayama Takashi、Kinugawa Shintaro、Takada Shingo、Furihata Takaaki、Fukushima Arata、Yokota Takashi、Anzai Toshihisa、Hibino Mitsue、Harashima Hideyoshi、Yamada Yuma
    • Journal Title

      Mitochondrion

      Volume: 49 Pages: 66-72

    • DOI

      10.1016/j.mito.2019.07.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients2019

    • Author(s)
      Shirakawa Ryosuke、Yokota Takashi、Nakajima Takayuki、Takada Shingo、Yamane Miwako、Furihata Takaaki、Maekawa Satoshi、Nambu Hideo、Katayama Takashi、Fukushima Arata、Saito Akimichi、Ishimori Naoki、Dela Flemming、Kinugawa Shintaro、Anzai Toshihisa
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 14709-14709

    • DOI

      10.1038/s41598-019-51298-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure2019

    • Author(s)
      Maekawa Satoshi、Takada Shingo、Nambu Hideo、Furihata Takaaki、Kakutani Naoya、Setoyama Daiki、Ueyanagi Yasushi、Kang Dongchon、Sabe Hisataka、Kinugawa Shintaro
    • Journal Title

      Cell Communication and Signaling

      Volume: 17 Issue: 1 Pages: 128-128

    • DOI

      10.1186/s12964-019-0445-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitofusin 2 is involved in chemotaxis of neutrophil-like differentiated HL-60 cells2019

    • Author(s)
      Mazaki Yuichi、Takada Shingo、Nio-Kobayashi Junko、Maekawa Satoshi、Higashi Tsunehito、Onodera Yasuhito、Sabe Hisataka
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 513 Issue: 3 Pages: 708-713

    • DOI

      10.1016/j.bbrc.2019.04.037

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Arrhythmogenic β-adrenergic signaling in cardiac hypertrophy: The role of small-conductance calcium-activated potassium channels via activation of CaMKII2019

    • Author(s)
      Kamada Rui、Yokoshiki Hisashi、Mitsuyama Hirofumi、Watanabe Masaya、Mizukami Kazuya、Tenma Taro、Takahashi Masayuki、Takada Shingo、Anzai Toshihisa
    • Journal Title

      European Journal of Pharmacology

      Volume: 844 Pages: 110-117

    • DOI

      10.1016/j.ejphar.2018.12.011

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of High Respiratory Exchange Ratio During Submaximal Exercise on Adverse Clinical Outcome in Heart Failure2018

    • Author(s)
      Kakutani N, Fukushima A, Yokota T, Katayama T, Nambu H, Shirakawa R, Maekawa S, Abe T, Takada S, Furihata T, Ono K, Okita K, Kinugawa S, Anzai T.
    • Journal Title

      Circulation Journal

      Volume: 82 Issue: 11 Pages: 2753-2760

    • DOI

      10.1253/circj.CJ-18-0103

    • NAID

      40021697208

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2018-10-25
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deletion of NAD(P)H Oxidase 2 Prevents Angiotensin II-Induced Skeletal Muscle Atrophy2018

    • Author(s)
      Kadoguchi Tomoyasu、Takada Shingo、Yokota Takashi、Furihata Takaaki、Matsumoto Junichi、Tsuda Masaya、Mizushima Wataru、Fukushima Arata、Okita Koichi、Kinugawa Shintaro
    • Journal Title

      BioMed Research International

      Volume: 2018 Pages: 1-10

    • DOI

      10.1155/2018/3194917

    • NAID

      120006406686

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure2018

    • Author(s)
      Tsuda Masaya、Fukushima Arata、Matsumoto Junichi、Takada Shingo、Kakutani Naoya、Nambu Hideo、Yamanashi Katsuma、Furihata Takaaki、Yokota Takashi、Okita Koichi、Kinugawa Shintaro、Anzai Toshihisa
    • Journal Title

      Journal of Cachexia, Sarcopenia and Muscle

      Volume: 9 Issue: 5 Pages: 844-859

    • DOI

      10.1002/jcsm.12322

    • NAID

      120006626588

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Brain-Derived Neurotrophic Factor Improves Limited Exercise Capacity in Mice With Heart Failure2018

    • Author(s)
      Matsumoto Junichi、et al. Hatakeyama Shigetsugu、Matsumoto Masaki、Nakayama Keiichi I.、Otsuka Yutaro、Sabe Hisataka、Tsutsui Hiroyuki、Anzai Toshihisa
    • Journal Title

      Circulation

      Volume: 138 Issue: 18 Pages: 2064-2066

    • DOI

      10.1161/circulationaha.118.035212

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Small-conductance Ca2+-activated K+ channel activation deteriorates hypoxic ventricular arrhythmias via CaMKII in cardiac hypertrophy2018

    • Author(s)
      Tenma Taro、Mitsuyama Hirofumi、Watanabe Masaya、Kakutani Naoya、Otsuka Yutaro、Mizukami Kazuya、Kamada Rui、Takahashi Masayuki、Takada Shingo、Sabe Hisataka、Tsutsui Hiroyuki、Yokoshiki Hisashi
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: 315 Issue: 2 Pages: H262-H272

    • DOI

      10.1152/ajpheart.00636.2017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Decreased gene expression of fatty acid binding protein 3 in the atrium of patients with new onset of atrial fibrillation in cardiac perioperative phase.2018

    • Author(s)
      Shingu Y, Yokota T, Takada S, Niwano H, Ooka T, Katoh H, Tachibana T, Kubota S, Matsui Y.
    • Journal Title

      J Cardiol

      Volume: 71 Issue: 1 Pages: 65-70

    • DOI

      10.1016/j.jjcc.2017.07.003

    • NAID

      120006546752

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inverse Relationship between Sleep Duration and Cardio-Ankle Vascular Index in Children2017

    • Author(s)
      Morita N, Kambayashi I, Okuda T, Oda S, Takada S, Nakajima T, Shide N, Shinkaiya H, Okita K.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 24 Issue: 8 Pages: 819-826

    • DOI

      10.5551/jat.36517

    • NAID

      130005876106

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pioglitazone improves whole-body aerobic capacity and skeletal muscle energy metabolism in patients with metabolic syndrome2017

    • Author(s)
      Yokota T, Kinugawa S, Hirabayashi K, Suga T, Takada S, Omokawa M, Kadoguchi T, Takahashi M, Fukushima A, Matsushima S, Yamato M, Okita K, Tsutsui H
    • Journal Title

      J Diabetes Investig

      Volume: 印刷中 Issue: 4 Pages: 1-6

    • DOI

      10.1111/jdi.12606

    • NAID

      120006337767

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] シンポジウム「他臓器における理解と治療法」「不全心筋における栄養療法」2020

    • Author(s)
      髙田真吾、絹川真太郎
    • Organizer
      第75回日本体力医学会大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] シンポジウム「病態を癒す.運動のサイエンス~基礎研究から臨床研究まで~」「骨格筋線維化における予防とその意義」2020

    • Author(s)
      髙田真吾、角谷尚哉、絹川真太郎
    • Organizer
      第39回日本臨床運動療法学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] シンポジウム:「骨格筋をターゲットとした治療法の開発」「脳由来神経栄養因子による心不全骨格筋治療」2020

    • Author(s)
      髙田真吾
    • Organizer
      第26回日本心臓リハビリテーション学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 「心筋ミトコンドリア複合体II機能は複合体I機能と同等である」2020

    • Author(s)
      中村圭孝、髙田真吾、皆田崇照、前川 聡、絹川真太郎.
    • Organizer
      第75回日本体力医学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 「心不全の骨格筋におけるミトコンドリア複合体II」2020

    • Author(s)
      皆田崇照、髙田真吾、中村圭孝、前川 聡、絹川真太郎.
    • Organizer
      第75回日本体力医学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 「心筋ミトコンドリア複合体II機能は複合体I機能に匹敵する」2020

    • Author(s)
      中村圭孝、髙田真吾、皆田崇照、前川 聡、絹川真太郎.
    • Organizer
      第39回日本臨床運動療法学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 「心不全における骨格筋ミトコンドリア複合体IIの役割」2020

    • Author(s)
      皆田崇照、髙田真吾、中村圭孝、前川 聡、絹川真太郎.
    • Organizer
      第39回日本臨床運動療法学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 心不全患者における骨格筋輝度は運動耐容能と関連する2019

    • Author(s)
      髙田真吾、福島 新、仲野一平、角谷尚哉、横田 卓、沖田孝一、絹川真太郎.
    • Organizer
      第38回日本臨床運動療法学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 虚血プレコンディショニングが連続跳躍運動へ与える影響2019

    • Author(s)
      皆田崇照、髙田真吾、森田憲輝、石原 暢、苫米地伸泰、沖田孝一
    • Organizer
      第38回日本臨床運動療法学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 心不全の骨格筋異常発症におけるキサンチンオキダーゼの役割2019

    • Author(s)
      髙田真吾、南部秀雄、前川 聡、松本純一、角谷尚哉、絹川真太郎
    • Organizer
      第25回日本心臓リハビリテーション学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] セッションテーマ:1S03m「ファンクショナルプロテオミクスの最前線 ~分子メカニズムの包括的解明から創薬へ~」「心不全における骨格筋由来分泌因子(マイオカイン)の役割-運動療法代替治療法の開発-」2019

    • Author(s)
      髙田真吾
    • Organizer
      第92回日本生化学学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「未来の骨格筋治療の可能性に迫る」「心不全の骨格筋異常における治療法の開発」2019

    • Author(s)
      髙田真吾、角谷尚哉、絹川真太郎
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in murine heart failure.2019

    • Author(s)
      Hideo Nambu, Shingo Takada, Arata Fukushima, Naoya Kakutani, Satoshi Maekawa, Ryosuke Shirakawa, Takaaki Furihata, Akimichi Saito, Takashi Yokota, Shintaro Kinugawa
    • Organizer
      The 92nd Scientific Session of American Heart Association
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Linoleic acid improves assembly of the complex II subunit and complex III/IV complex of the mitochondrial oxidative phosphorylation system in heart failure2019

    • Author(s)
      Satoshi Maekawa, Shingo Takada, Hideo Nambu, Takaaki Furihata, Hisataka Sabe, Shintaro Kinugawa
    • Organizer
      The 92nd Scientific Session of American Heart Association
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ジュニア期のスポーツ医学2019

    • Author(s)
      髙田真吾
    • Organizer
      Hokkaido Junior Sports Club Association Coacher’s Seminar 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 食事・運動と抗老化・心不全予防(human biologyから見えてくること)2019

    • Author(s)
      髙田真吾
    • Organizer
      一般社団法人日本がんと炎症・代謝研究会セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 代謝制御による不全心筋ミトコンドリア機能における治療法の開発2019

    • Author(s)
      髙田真吾
    • Organizer
      北海道大学医学研究院連携研究センター 研究成果発表会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 運動効果におけるマイオカインのエビデンス構築に向けた基盤研究2019

    • Author(s)
      髙田真吾、菅 唯志、棗 寿喜、橋本 亨、植田幸嗣
    • Organizer
      北海道大学COI拠点サイトビジット
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 代謝制御による不全心筋ミトコンドリア治療法の開発2019

    • Author(s)
      髙田真吾
    • Organizer
      令和元年度 Vascular Biology Innovationに関する研究助成(VBIC)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] mitoNEETにおけるミトコンドリア鉄制御による心不全発症・進展機序の解明2019

    • Author(s)
      髙田真吾
    • Organizer
      公益信託循環器学研究振興基金報告会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ジュニア期のスポーツ医学2018

    • Author(s)
      髙田真吾
    • Organizer
      平成29年度北海道スポーツ少年団 指導者研修会(北海道釧路)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ジュニア期のスポーツ医学2018

    • Author(s)
      髙田真吾
    • Organizer
      平成29年度北海道スポーツ少年団 指導者研修会(北海道留萌)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 身心に効く! 筋肉から分泌されるホルモンたち~マイオカインによる健康寿命の延伸~2018

    • Author(s)
      髙田真吾
    • Organizer
      TREASURE DATA “PLAZMA” 2018 in Digital Belt.(東京都)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 骨格筋・心筋におけるミトコンドリア機能の新規制御機構2018

    • Author(s)
      髙田真吾
    • Organizer
      九州大学医学研究科臨床検査教室セミナー(福岡県)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 心不全の骨格筋異常におけるミトコンドリアアセチル化の役割.2017

    • Author(s)
      髙田真吾, 津田正哉,福島 新,角谷尚哉,横田 卓,沖田孝一,絹川真太郎.
    • Organizer
      第72回日本体力医学会大会(愛媛県)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨格筋・心筋ミトコンドリア治療2017

    • Author(s)
      髙田真吾
    • Organizer
      日本女子大学セミナー(東京都)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Exercise is medicine ―ミトコンドリア治療―2017

    • Author(s)
      髙田真吾
    • Organizer
      一般社団法人 身体開発研究機構 フィットネスデザイン交流会(北海道)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] mitoNEETによるミトコンドリア鉄制御機構の解明2017

    • Author(s)
      髙田真吾,降旗高明,前川 聡,絹川真太郎.
    • Organizer
      第12回Vascular Biology Innovationに関する研究助成(VBIC)(東京都)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 末梢血単核球ミトコンドリア機能制御による心筋炎症制御機構解明2017

    • Author(s)
      髙田真吾
    • Organizer
      ノーステック財団 研究開発助成事業 第10回若手研究者交流会(北海道)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 在宅でのICTを活用した心不全患者向けセルフケア強化システムの開発・検証2017

    • Author(s)
      髙田真吾
    • Organizer
      公益財団法人 福田記念医療技術振興財団 研究助成者記念品贈呈式及び講演会(東京都)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 究極のセルフヘルスケア2017

    • Author(s)
      髙田真吾,横田 卓,角谷尚哉,福島 新,藤野剛雄,加来秀隆,菅 唯志,吉野 正則.
    • Organizer
      COI2021第2回ワークショップ(東京都)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 身心に効く筋肉から分泌されるホルモンたち ーマイオカインによる健康寿命の延伸ー2017

    • Author(s)
      髙田真吾,横田 卓,角谷尚哉,福島 新,藤野剛雄,加来秀隆,菅 唯志,吉野 正則.
    • Organizer
      第3回COI2021会議(東京都)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 健康と時間2017

    • Author(s)
      髙田真吾
    • Organizer
      平成29年度北翔大学・北海道大学・未来講義(福島県南相馬市)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 認知機能における身体活動とその効果2017

    • Author(s)
      髙田真吾
    • Organizer
      相馬の里 特別出張講義(福島県南相馬市)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Book] 「心不全のミトコンドリア複合体会合不全を標的とした必須脂肪酸の有効性」2020

    • Author(s)
      髙田真吾
    • Publisher
      地域ケアリング
    • Related Report
      2020 Annual Research Report
  • [Book] 「心不全における骨格筋異常と治療法」2020

    • Author(s)
      髙田真吾
    • Publisher
      細胞
    • Related Report
      2020 Annual Research Report
  • [Book] 「心不全におけるミトコンドリア複合体の会合不全を標的としたΩ6脂肪酸による治療」2020

    • Author(s)
      髙田真吾
    • Publisher
      BIO Clinica
    • Related Report
      2020 Annual Research Report
  • [Book] 「不全心筋におけるミトコンドリア複合体会合不全を標的としたΩ6脂肪酸による治療」2020

    • Author(s)
      髙田真吾
    • Publisher
      アグリバイオ
    • Related Report
      2020 Annual Research Report
  • [Book] 「心不全のミトコンドリア複合体における会合不全を標的としたΩ脂肪酸による治療」2020

    • Author(s)
      髙田真吾
    • Total Pages
      46
    • Publisher
      Medical Science Digest
    • Related Report
      2020 Annual Research Report
  • [Book] 「慢性腎臓病における身体活動と運動耐容能」2020

    • Author(s)
      髙田真吾
    • Publisher
      腎と透析
    • Related Report
      2020 Annual Research Report
  • [Remarks] スポーツ教育学科講師髙田真吾らによる原著論文が「Eur J Pharmacol.」に掲載されました。

    • URL

      https://www.hokusho-u.ac.jp/info/?i=2496&cat=20

    • Related Report
      2020 Annual Research Report
  • [Remarks] スポーツ教育学科講師 髙田真吾らによる原著論文が、「J Card Fail.」に掲載されました。

    • URL

      https://www.hokusho-u.ac.jp/info/?i=2498&cat=20

    • Related Report
      2020 Annual Research Report
  • [Remarks] スポーツ教育学科講師 髙田真吾らによる原著論文が、「J Cardiol.」に掲載されました。

    • URL

      https://www.hokusho-u.ac.jp/info/?i=2499&cat=20

    • Related Report
      2020 Annual Research Report
  • [Remarks] 「Mol Ther Nucleic Acids.」に髙田真吾らによる原著論文が掲載されました。

    • URL

      https://www.hokusho-u.ac.jp/info/?i=2501&cat=20

    • Related Report
      2020 Annual Research Report
  • [Remarks] スポーツ教育学科講師髙田真吾らによる原著論文が、「Eur J Prev Cardiol.」に掲載

    • URL

      https://www.hokusho-u.ac.jp/info/?i=2500&cat=20

    • Related Report
      2020 Annual Research Report
  • [Remarks] 「Cell communication and signaling」に髙田真吾講師らの研究が原著論文

    • URL

      https://www.hokusho-u.ac.jp/info/?i=2158&cat=5

    • Related Report
      2019 Annual Research Report
  • [Remarks] 「第74回日本体力医学会大会」で発表と受賞の報告

    • URL

      https://www.hokusho-u.ac.jp/info/?i=2140&cat=5

    • Related Report
      2019 Annual Research Report
  • [Remarks] 髙田真吾講師らの研究が「European Journal of Pharmacology」に原著論文

    • URL

      https://www.hokusho-u.ac.jp/info/?i=2138&cat=5

    • Related Report
      2019 Annual Research Report
  • [Remarks] 「第92回日本生化学学会大会」で髙田真吾講師がシンポジストとして発表しました!

    • URL

      https://www.hokusho-u.ac.jp/info/?i=2121&cat=5

    • Related Report
      2019 Annual Research Report
  • [Remarks] 髙田真吾講師らの研究が「Scientific Reports」に原著論文として掲載されました!

    • URL

      https://www.hokusho-u.ac.jp/info/?i=2072&cat=5

    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 心不全の病態の評価法2019

    • Inventor(s)
      髙田真吾、前川 聡、佐邊壽孝、横田 卓、白川亮介
    • Industrial Property Rights Holder
      髙田真吾、前川 聡、佐邊壽孝、横田 卓、白川亮介
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
    • Overseas

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

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