Understanding the association of gait and cognitive dysfunction
| Project/Area Number |
17H04760
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
Sakurai Ryota 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (00749856)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2019: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2018: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2017: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 歩行機能 / 認知機能 / 高齢者 / 脳構造 / ApoE4 / 加齢 / 白質病変 / 認知症 / MCI / 縦断研究 / 2重課題 / APOE |
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| Outline of Final Research Achievements |
This research project demonstrated that the concurrent presence of at least one copy of apolipoprotein E polymorphism ε4 allele (ApoE4) and slow gait, and not one factor alone, results in cognitive impairment. Furthermore, among older adults with pathological cognitive impairment (e.g., Alzheimer’s disease patients), ApoE4 carriers with slow gait showed significantly higher burden of white matter hyperintensities compared with ApoE4 carriers without slow gait. This finding suggests that brain structural changes, attributable to Alzheimer’s pathology, may mediate the association between ApoE4 and slow gait among elderly individuals with pathological cognitive impairment.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、老年学の分野で関連が示唆されてきた歩行機能低下と認知機能低下について、その関連メカニズムについて検討を行った。得られた研究成果は、高齢期の健康づくりには歩行機能の維持が重要であり、たとえ認知症発症のリスクを高めるような遺伝子多型を有する者であっても歩行機能が維持されていれば認知機能の低下や、それに関連する脳構造の変化を防ぐことができる可能性が高いことが明らかとなった。以上の高齢期の健康づくりに資する知見が本研究の社会的意義を示すものである。
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Characteristics for Gait Parameters of Community-Dwelling Elderly Japanese with Lower Cognitive Function2019
Author(s)
Yu Taniguchi, Yutaka Watanabe, Yosuke Osuka, Akihiko Kitamura, Satoshi Seino, Hunkyun Kim, Hisashi Kawai, Ryota Sakurai, Hiroki Inagaki, Shuichi Awata, Shoji Shinkai.
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Journal Title
Plos One
Volume: 27
Issue: 3
Pages: 0-0
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Consensus on Shared Measures of Mobility and Cognition: From the Canadian Consortium on Neurodegeneration in Aging (CCNA).2019
Author(s)
Montero-Odasso M, Almeida QJ, Bherer L, Burhan AM, Camicioli R, Doyon J, Fraser S, Muir-Hunter S, Li KZH, Liu-Ambrose T, McIlroy W, Middleton L, Morais JA, Sakurai R, Speechley M, Vasudev A, Beauchet O, Hausdorff JM, Rosano C, Studenski S, Verghese J; Canadian Gait and Cognition Network.
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Journal Title
J Gerontol A Biol Sci Med Sci.
Volume: 印刷中
Issue: 6
Pages: 897-909
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The neural substrate of gait and executive function relationship in elderly women: a PET study.2017
Author(s)
Sakurai R, Ishii K, Yasunaga M, Takeuchi R, Murayama H, Sakuma N, Sakata M, Oda K, Ishibashi K, Ishiwata K, Fujiwara Y, Montero-Odasso M
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Journal Title
Geriatrics & Gerontology International
Volume: 印刷中
Issue: 11
Pages: 1873-1880
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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