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Search for RNA in body fluids that can evaluate the exposure dose of children and develop novel diagnostic methods

Research Project

Project/Area Number 17H04761
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Childhood science (childhood environment science)
Research InstitutionHirosaki University

Principal Investigator

Chiba Mitsuru  弘前大学, 保健学研究科, 准教授 (20583735)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2020: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords被ばくバイオマーカー / 血清中miRNA / 放射線被ばく / バイオマーカー / 血中RNA / エクソソーム / 急性放射線症候群 / 細胞外小胞 / 子ども期 / 血清中放射線応答性RNA / エキソソーム / microRNA / 子ども / 細胞外小胞/エキソソーム/エクソソーム / 体液中RNA
Outline of Final Research Achievements

In this study, it was revealed that the radiosensitivity of leukocytes in childhood and adult mice differs depending on age and post-exposure time. In addition, it was clarified that changes in the type and amount of serum miRNA differed between childhood and adulthood, suggesting that radiosensitivity also differs depending on the radiation dose and time of irradiation. These results suggest that biomarkers for estimating radiation damage should be used according to the dose and elapsed time after irradiation.

Academic Significance and Societal Importance of the Research Achievements

本研究では子ども期と大人期では白血球の放射線感受性に違いが生じることや、血清中miRNAの種類や量の変化が生じじることを明らかにした。この成果は、放射線被ばくバイオマーカー開発には年齢や被ばく後時間を考慮しなければいけないことを示唆した。日本は原子力災害を複数回経験した国であり、学校・地域住民への安全対策や緊急被ばく医療体制の整備は国家的責務である。今後世界中で起こりうる核テロや原子力災害への対応医療の備えとして、新たな子どもの被ばく診断技術の開発は不可欠な命題であり、本分野に貢献する研究は、日本が果たすべき世界からの信頼回復や大きな国際貢献につながる。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (70 results)

All 2020 2019 2018 2017

All Journal Article (22 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 21 results,  Open Access: 15 results,  Acknowledgement Compliant: 1 results) Presentation (48 results) (of which Int'l Joint Research: 13 results)

  • [Journal Article] HER2-positive breast cancer that resists therapeutic drugs and ionizing radiation releases sphingomyelin-based molecules to circulating blood serum.2020

    • Author(s)
      Monzen S, Tatara Y, Mariya Y, Chiba M, Wojcik A, Lundholm L
    • Journal Title

      Mol Clin Oncol.

      Volume: 13(6) Issue: 6 Pages: 70-70

    • DOI

      10.3892/mco.2020.2140

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Changes in miRNA expressions in the injured small intestine of mice following high-dose radiation exposure.2020

    • Author(s)
      Chiba M, Uehara H, Niiyama I, Kuwata H, Monzen S.
    • Journal Title

      Mol Med Rep.

      Volume: 21 Pages: 2452-2458

    • DOI

      10.3892/mmr.2020.11054

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic value of quantitative FDGFPET in the prediction of survival and local recurrence for patients with advanced oral cancer treated with superselective intra‑arterial chemoradiotherapy2020

    • Author(s)
      TOMOYUKI OYAMA, YOICHIRO HOSOKAWA, KAZUKI ABE, KAZUKI HASEGAWA, ROMAN FUKUI, MASAHIKO AOKI and WATARU KOBAYASHI
    • Journal Title

      ONCOLOGY LETTERS

      Volume: 19 Pages: 3775-3780

    • DOI

      10.3892/ol.2020.11370

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of voluntary and forced exercises on motor function recovery in intracerebral hemorrhage rats2020

    • Author(s)
      Chihiro Sato, Kunikazu Tanji, Shuji Shimoyama, Mitsuru Chiba, Misaki Mikami, Shuhei Koeda, Koshi Sumigawa,Kazuki Akahira, Junko Yamada
    • Journal Title

      Neuroreport

      Volume: 31 Issue: 2 Pages: 189-195

    • DOI

      10.1097/wnr.0000000000001396

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Injured pancreatic β cells enhance the release of miR?375?3p into the extracellular space2019

    • Author(s)
      Chiba Mitsuru、Niiyama Ikumi、Uehara Haruka、Kuwata Haruka
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 17 Pages: 2815-2820

    • DOI

      10.3892/etm.2019.7276

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Malondialdehyde: a urinary toxic biomarker for unexpected exposure to high-dose ionizing radiation2019

    • Author(s)
      Satoru Monzen, Mitsuru Chiba, Yasushi Mariya
    • Journal Title

      Rinsho Byori

      Volume: 67 Pages: 212-215

    • NAID

      40021862154

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell-to-cell communication via extracellular vesicles among human pancreatic cancer cells derived from the same patient2018

    • Author(s)
      Chiba Mitsuru、Kubota Shiori、Sakai Ayaka、Monzen Satoru
    • Journal Title

      Molecular Medicine Reports

      Volume: 18 Pages: 3989-3996

    • DOI

      10.3892/mmr.2018.9376

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The expressions of Caveolin-2 mRNAs, natural antisense transcripts and proteins in mouse liver development2018

    • Author(s)
      Chiba Mitsuru
    • Journal Title

      Biomedical Research

      Volume: 29 Issue: 12 Pages: 2659-2662

    • DOI

      10.4066/biomedicalresearch.29-18-626

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum miR-375-3p increase in mice exposed to a high dose of ionizing radiation2018

    • Author(s)
      Chiba Mitsuru、Monzen Satoru、Iwaya Chihiro、Kashiwagi Yuri、Yamada Sunao、Hosokawa Yoichiro、Mariya Yasushi、Nakamura Toshiya、Wojcik Andrzej
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1302-1302

    • DOI

      10.1038/s41598-018-19763-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression2018

    • Author(s)
      Monzen Satoru、Chiba Mitsuru、Ueno Tatsuya、Morino Yuki、Terada Kenji、Yamaya Hiroki、Hosokawa Yoichiro
    • Journal Title

      Oncology Letters

      Volume: 15(5) Pages: 6709-6714

    • DOI

      10.3892/ol.2018.8099

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] がん放射線療法における線量最適化のためのバイオマーカー探索2018

    • Author(s)
      上野 達也, 門前 暁, 千葉 満, 森野 友貴, 細川 洋一郎
    • Journal Title

      日本放射線技術学雑誌

      Volume: 74

    • NAID

      130006742922

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exosomal natural antisense transcripts in culture supernatants released from colorectal cancer SW480 cells2018

    • Author(s)
      Mitsuru Chiba
    • Journal Title

      Biomedical Research

      Volume: 29

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 緊急時放射線被ばく線量推定のための尿中バイオマーカー8-Hydroxy-2'-Deoxyguanosineの検討2018

    • Author(s)
      門前暁、多和田侑介、千葉満、高坂望美、森野友貴、山屋大樹、上野達也、Andrzej Wojcik
    • Journal Title

      Cytometry Research

      Volume: 28

    • NAID

      130007378932

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 細胞外小胞の細胞内への取り込み機構2018

    • Author(s)
      千葉 満、久保田 栞、門前 暁
    • Journal Title

      細胞

      Volume: 50

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 疾患バイオマーカーとしての体液中マイクロRNAの探索研究2018

    • Author(s)
      千葉 満
    • Journal Title

      臨床化学

      Volume: 47

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 膵β細胞障害は細胞外miR-375-3pを増加させる2018

    • Author(s)
      新井山 育未,上原 悠花,桑田 遥,千葉 満
    • Journal Title

      Journal of Health Sciences Research

      Volume: 8

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 生物学的評価による放射線治療線量の最適化のための基礎的検討2018

    • Author(s)
      上野達也、門前暁、千葉満、細川洋一郎
    • Journal Title

      Cytometry Research

      Volume: 28

    • NAID

      130007378939

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血液検体による放射線応答性マイクロRNAの探索2018

    • Author(s)
      千葉 満、門前 暁
    • Journal Title

      Cytometry Research

      Volume: 28

    • NAID

      130007378938

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-tumor and anti-invasion effects of a combination of 4-methylumbelliferone and ionizing radiation in human fibrosarcoma cells.2017

    • Author(s)
      Saga R, Monzen S, Chiba M, Yoshino H, Nakamura T, Hosokawa Y.
    • Journal Title

      Oncol Lett.

      Volume: 13(1) Issue: 1 Pages: 410-416

    • DOI

      10.3892/ol.2016.5385

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Anthocyanin-rich blackcurrant extract inhibits proliferation of the MCF10A healthy human breast epithelial cell line through induction of G0/G1 arrest and apoptosis2017

    • Author(s)
      Nanashima Naoki、Horie Kayo、Chiba Mitsuru、Nakano Manabu、Maeda Hayato、Nakamura Toshiya
    • Journal Title

      Molecular Medicine Reports

      Volume: 16 Issue: 5 Pages: 6134-6141

    • DOI

      10.3892/mmr.2017.7391

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antisense RNA transcripts in the blood may be novel diagnostic markers for colorectal cancer2017

    • Author(s)
      Tomohiro Kurokawa, Keisuke Kohno, Kentaro Nagai, Mitsuru Chiba, Sugiru Pak, Soichiro Murata, Kiyoshi Fukunaga, Hiroshi Yasue, Nobuhiro Ohkohchi
    • Journal Title

      Oncology Letters

      Volume: 14 Issue: 3 Pages: 3487-3493

    • DOI

      10.3892/ol.2017.6572

    • NAID

      120007134844

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] がん細胞由来エキソソームの間質細胞への影響2017

    • Author(s)
      千葉満、門前暁
    • Journal Title

      細胞

      Volume: 49 Pages: 40-43

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 大腸がんの放射線治療時における照射線量制御バイオマーカーの探索2020

    • Author(s)
      門前暁, 真里谷靖, 千葉満
    • Organizer
      第67回日本臨床検査医学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 肝細胞癌体幹部定位放射線療法におけるradiation-induced liver disease2020

    • Author(s)
      真里谷靖, 門前暁, 千葉満
    • Organizer
      第67回日本臨床検査医学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 放射線被ばくした子ども期と大人期のマウスにおける血算成分と血清中microRNAの変化2020

    • Author(s)
      千葉満, 松本佳菜, 門前暁, 真里谷靖
    • Organizer
      第67回日本臨床検査医学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Serum miR-375-3p increase in mice exposed to a high dose of ionizing radiation2019

    • Author(s)
      Mitsuru Chiba, Satoru Monzen, Yoichiro Hosokawa, Yashushi Mariya, Toshiya Nakamura, Andrzej Wojcik
    • Organizer
      International Congress of Radiation Research (ICRR2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Outcome of combined external beam radiotherapy and Ra-223 radionuclide treatment for castration resistant prostatic cancer with multiple bone metastases2019

    • Author(s)
      Yasushi Mariya, Kazuaki Yoshikawa, Satoru Monzen, Mitsuru Chiba, Andrzej Wojcik
    • Organizer
      International Congress of Radiation Research (ICRR2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of multi-potent progenitor cells in bone marrow damage induced by ionising radiation2019

    • Author(s)
      Monzen S, Morino Y, Wojcik A, Mariya Y, Chiba M, Nakamura T
    • Organizer
      International Congress of Radiation Research (ICRR2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SERUM MIR-375-3P INCREASE IN MICE EXPOSED TO A HIGH DOSE OF IONIZING RADIATION2019

    • Author(s)
      Mitsuru Chiba, Satoru Monzen, Yoichiro Hosokawa, Yasushi Mariya, Toshiya Nakamura, Andrzej Wojcik
    • Organizer
      European Radiation Protection Week 2019 (ERPW2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of multi-potent progenitor cells in bone marrow damage induced by high dose rate ionizing radiation2019

    • Author(s)
      Monzen S, Morino Y, Wojcik A, Lundholm L, Chiba M, Mariya Y
    • Organizer
      European Radiation Protection Week 2019 (ERPW2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HER-2 positive breast cancer that resists therapeutic drug and ionizing radiation releases sphingomyelin families to circulating blood2019

    • Author(s)
      門前暁, 多田羅洋太, 千葉満, 真里谷靖
    • Organizer
      日本放射線腫瘍学会第32回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 去勢抵抗性前立腺癌多発性骨転移に対する外照射併用Ra-223内用療法の治療成績2019

    • Author(s)
      真里谷靖, 吉川和暁, 門前暁, 千葉満
    • Organizer
      日本放射線腫瘍学会第32回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 放射線抵抗性を示すHER2陽性乳癌患者の血清中Sphingomyelin関連代謝物の濃度変化の特徴2019

    • Author(s)
      門前暁、多田羅洋太、千葉満、真里谷靖
    • Organizer
      第66回日本臨床検査医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Extracellular miRNAs in serum and feces of mice exposed to high-dose radiation2019

    • Author(s)
      千葉満、門前暁、真里谷靖
    • Organizer
      第66回日本臨床検査医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 少数個転移性肝腫瘍に対する体幹部定位放射線療法に伴うradiation-induced liver diseaseの検討2019

    • Author(s)
      真里谷靖、山田恭吾、門前暁、千葉満
    • Organizer
      第66回日本臨床検査医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Investigation of Urinary Metabolic Molecules for Radiation Biodosimetry and Its Functional Analysis2018

    • Author(s)
      Kenji Terada,Yusuke Tawata,Mitsuru Chiba, Yasushi Mariya,Satoru Monzen
    • Organizer
      第74回日本放射線技術学会総会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] URINARY BIOMARKERS OF LETHAL/SUBLETHAL IONIZING RADIATION DOSES2018

    • Author(s)
      Kenji Terada, Satoru Monzen, Mitsuru Chiba, Andrzej Wojcik, Yasushi Mariya
    • Organizer
      The 33rd World Congress of the International Federation of Biomedical Laboratory Science (IFBLS2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膵β細胞傷害は細胞外miR-375-3pを増加させる2018

    • Author(s)
      千葉 満
    • Organizer
      第58回日本臨床化学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] SERUM MIR-375-3P INCREASE IN MICE EXPOSED TO A HIGH DOSE OF IONIZING RADIATION2018

    • Author(s)
      Mitsuru Chiba, Satoru Monzen
    • Organizer
      The 33rd World Congress of the International Federation of Biomedical Laboratory Science (IFBLS2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 放射線被ばく時の急性骨髄障害における治療法の検討2018

    • Author(s)
      門前 暁、千葉 満、真里谷 靖
    • Organizer
      第65回日本臨床検査医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高線量率被ばくマウスの骨髄中造血前駆細胞の損傷の特徴2018

    • Author(s)
      森野友貴、寺田賢司、佐藤孝徳、千葉満、WOJCIK Andrzej、門前暁
    • Organizer
      日本放射線影響学会第61回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 放射線治療における生物学的な情報を含めた線量の最適化のための基礎的検討2017

    • Author(s)
      上野達也、門前暁、千葉満、細川洋一郎
    • Organizer
      第73回日本放射線技術学会総会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 致死線量放射線被ばくバイオマーカーとしての血中循環microRNA2017

    • Author(s)
      千葉満、門前暁
    • Organizer
      第27回日本サイトメトリー学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 放射線被ばく線量推定のための尿中バイオマーカーの探索2017

    • Author(s)
      門前暁、多和田侑介、千葉満、高坂望美、森野友貴、山屋大樹、上野達也、Andrzej Wojcik
    • Organizer
      第27回日本サイトメトリー学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生物学的評価による放射線治療線量の最適化のための基礎的検討2017

    • Author(s)
      上野達也、門前暁、千葉満、細川洋一郎
    • Organizer
      第27回日本サイトメトリー学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 放射線被ばくバイオマーカーとしての尿中8-OHdGの検討2017

    • Author(s)
      千葉満
    • Organizer
      第66回日本医学検査学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 子ども期の低線量放射線被ばくによる血中成分変化2017

    • Author(s)
      桑田 遥、上原 悠花、新井山 育未、千葉 満
    • Organizer
      第12回日本臨床検査学教育学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 急性被ばく腸管障害を予測できる血液・糞便中microRNAバイオマーカーの探索2017

    • Author(s)
      上原 悠花、桑田 遥、新井山 育未、千葉 満
    • Organizer
      第12回日本臨床検査学教育学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Serum microRNAs for early diagnosis of acute radiation syndrome2017

    • Author(s)
      Mitsuru Chiba, Satoru Monzen
    • Organizer
      第9回日本RNAi研究会・第4回日本細胞外小胞学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 膵β細胞障害は細胞外miR-375-3pを増加させる2017

    • Author(s)
      新井山 育未、上原 悠花、桑田 遥、千葉 満
    • Organizer
      第4回保健科学研究発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 放射線被ばくバイオマーカーとしての核酸代謝物の検討2017

    • Author(s)
      千葉 満
    • Organizer
      日本臨床検査自動化学会第49回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Serum microRNAs for early diagnosis of acute radiation syndrome2017

    • Author(s)
      Mitsuru Chiba, Satoru Monzen, Chihiro Iwaya, Yuri Kashiwagi, Sunao Yamada, Yoichiro Hosokawa, Yasushi Mariya, Toshiya Nakamura, and Andrzej Wojcik
    • Organizer
      4th Educational Symposium on RADIATION AND HEALTH by young scientists (ESRAH2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Radiosensitivity regulation in fibrosarcoma cells by anti-inflammatory agents2017

    • Author(s)
      Ryo Saga, Kosho Murata, Mitsuru Chiba, Natsu Shibata, Toshiya Nakamura, Yoichiro Hosokawa
    • Organizer
      4th Educational Symposium on RADIATION AND HEALTH by young scientists (ESRAH2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optimization of radiotherapy using extracellular microRNA expression2017

    • Author(s)
      Tatsuya Ueno, Satoru Monzen, Mitsuru Chiba, Yoichiro Hosokawa
    • Organizer
      4th Educational Symposium on RADIATION AND HEALTH by young scientists (ESRAH2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of urinary metabolic molecules for radiation biodosimetry2017

    • Author(s)
      Kenji Terada, Yusuke Tawada, Mitsuru Chiba, Yasushi Mariya, Satoru Monzen
    • Organizer
      4th Educational Symposium on RADIATION AND HEALTH by young scientists (ESRAH2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serum miR-375-3p as potential biomarkers of acute radiation syndrome in mice exposed to lethal dose2017

    • Author(s)
      Mitsuru Chiba
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Serum miR-375-3p as potential biomarkers of acute radiation syndrome in mice exposed to lethal dose2017

    • Author(s)
      千葉 満
    • Organizer
      第57回日本臨床化学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 子ども期の低線量放射線被ばくによる血中成分変化2017

    • Author(s)
      桑田 遥、上原 悠花、新井山 育未、千葉 満
    • Organizer
      第6回日臨技北日本支部医学検査学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 膵β細胞障害は細胞外miR-375-3pを増加させる2017

    • Author(s)
      新井山 育未、上原 悠花、桑田 遥、千葉 満
    • Organizer
      第6回日臨技北日本支部医学検査学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 急性被ばく腸管障害を予測できる血液・糞便中microRNAバイオマーカーの探索2017

    • Author(s)
      上原 悠花、桑田 遥、新井山 育未、千葉 満
    • Organizer
      第6回日臨技北日本支部医学検査学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Serum miR-375-3p as potential biomarkers of acute radiation syndrome in mice exposed to lethal dose2017

    • Author(s)
      千葉 満、門前 暁
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 尿中代謝産物に着目した放射線被ばくマーカーの探索2017

    • Author(s)
      寺田 賢司、多和田 侑介、千葉 満、真里谷 靖、門前 暁
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 放射線治療の線量最適化のための細胞外microRNA発現の利用検討2017

    • Author(s)
      上野達也、門前 暁、千葉 満、細川洋一郎
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A biomarker of acute radiation syndrome: miR-375-3p increases in mouse serum by exposure to lethal/sublethal dose2017

    • Author(s)
      Mitsuru Chiba, Satoru Monzen, Yasushi Mariya
    • Organizer
      第29回世界病理臨床検査医学会連合会議(WASPaLM2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Urinary biomarkers of lethal/sublethal ionizing radiation doses2017

    • Author(s)
      Satoru Monzen, Mitsuru Chiba, Yasushi Mariya
    • Organizer
      第29回世界病理臨床検査医学会連合会議(WASPaLM2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 去勢抵抗性前立腺癌骨転移患者に対するRa-223内照射と腫瘍・骨代謝・酸化ストレスマーカーの経時的推移2017

    • Author(s)
      真里谷 靖、門前 暁、千葉 満
    • Organizer
      第64回日本臨床検査医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 尿中代謝産物をバイオマーカーとした放射線被ばく影響の評価2017

    • Author(s)
      門前 暁、千葉 満、真里谷 靖
    • Organizer
      第64回日本臨床検査医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 被ばくバイオマーカーとしての血中循環microRNAの検討2017

    • Author(s)
      千葉 満、門前 暁、真里谷 靖
    • Organizer
      第64回日本臨床検査医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 尿中代謝物に着目した放射線被ばくの線量評価マーカーの探索2017

    • Author(s)
      門前 暁、寺田 賢司、多和田 侑介、真里谷 靖、千葉 満、Andrzej Wojcik
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 急性放射線症候群の初期診断のための血清中マイクロRNA2017

    • Author(s)
      Mitsuru Chiba
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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