| Budget Amount *help |
¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2019: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2017: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
|
|---|
| Outline of Final Research Achievements |
Many polyketide-peptide hybrid molecules have been isolated as bioactive natural products. In this research, we aimed to establish a new method for ribosomal synthesis of peptides bearing unique polyketide-like moieties. To this end, we tested several different synthetic approaches, and eventually demonstrated that peptides with polyketide-like long backbone structures can be expressed by a combination of in vitro translation and posttranslational acyl transfer reaction. This synthetic method has indeed allowed for in vitro ribosomal synthesis of a model bioactive molecule.
|
