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Development of a chemical biology tool for in vivo imaging of biomolecules

Research Project

Project/Area Number 17H04764
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Chemical biology
Research InstitutionThe University of Tokyo

Principal Investigator

Asanuma Daisuke  東京大学, 大学院医学系研究科(医学部), 助教 (10611204)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Keywordsケミカルタグ / 分子イメージング / 蛍光プローブ / ケミカルバイオロジー / 生体分子計測 / 分子タグ技術
Outline of Final Research Achievements

Small-molecular fluorescence probes have contributed to the understanding of cellular phenomena by visualizing the spatiotemporal dynamics of various biomolecules. However, their contribution to elucidation of molecular dynamics in living systems has not been sufficiently achieved. This research aimed at developing a near-infrared fluorescence probe technology, based on our recently constructed chemical tag system, for visualization of physiologically active molecules by eliminating the non-specific staining that has caused severe problems in conventional in vivo applications. The findings obtained in this research can be expected to be useful for future development of promising chemical biology tools.

Academic Significance and Societal Importance of the Research Achievements

ダイナミックな生命現象をありのままに理解するには、主要な役割を果たす生理活性分子の生体内での振る舞いを明らかにする必要がある。生理活性分子の時空間動態を可視化する蛍光プローブ技術の開発は、生命現象の分子レベルでのメカニズムの理解に始まり、疾病の理解、さらには創薬への架け橋となる大きな意義を有する。本研究で得られた成果は、ライフサイエンス研究の今後の発展に寄与していくと期待できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (7 results)

All 2020 2019 2018

All Presentation (7 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Presentation] 近赤外領域におけるカルシウム蛍光イメージングのための新規タグツールの開発2020

    • Author(s)
      磯野有希、浅沼大祐、大久保洋平、並木繁行、廣瀬謙造
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Fluorophore-quencher based chemical tag technology for biological imaging2019

    • Author(s)
      Daisuke Asanuma, Shigeyuki Namiki, and Kenzo Hirose
    • Organizer
      2019 International Conference for Leading and Young Medical Scientists
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高精細なバイオイメージングのためのケミカルタグ技術の開発2019

    • Author(s)
      浅沼大祐
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 近赤外蛍光in vivoイメージングのためのケミカルタグツールの開発2019

    • Author(s)
      浅沼大祐、小島佑介、岡本紘幸、並木繁行、廣瀬謙造
    • Organizer
      日本薬学会 第139年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of turn-on fluorescent tag system for live-cell imaging2019

    • Author(s)
      Sin Ying Yip, Shigeyuki Namiki, Daisuke Asanuma, Kenzo Hirose
    • Organizer
      第92回日本薬理学会年会(日本、大阪)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of a tag-probe based cell labeling technique for in vivo fluorescence imaging2018

    • Author(s)
      Hiroyuki Okamoto, Daisuke Asanuma, Shigeyuki Namiki, Kenzo Hirose
    • Organizer
      WCP2018(日本、京都)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development live cell superresolution microscopy based on a novel fluorescence switching technology2018

    • Author(s)
      Shigeyuki Namiki, Daisuke Asanuma, Kenzo Hirose
    • Organizer
      WCP2018(日本、京都)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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