| Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
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| Outline of Final Research Achievements |
Small-molecular fluorescence probes have contributed to the understanding of cellular phenomena by visualizing the spatiotemporal dynamics of various biomolecules. However, their contribution to elucidation of molecular dynamics in living systems has not been sufficiently achieved. This research aimed at developing a near-infrared fluorescence probe technology, based on our recently constructed chemical tag system, for visualization of physiologically active molecules by eliminating the non-specific staining that has caused severe problems in conventional in vivo applications. The findings obtained in this research can be expected to be useful for future development of promising chemical biology tools.
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