|Budget Amount *help
¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2020: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
|Outline of Final Research Achievements
Human studies have shown a correlational relationship between aggression and immune system, however its neurobiological mechanism is still unknown. This study aimed to understand the effect of cytokines on neural activity of the dorsal raphe nucleus, a brain area that has been linked to escalated aggression from our studies, which might produce individual difference of aggression in male mice. Our results showed that individual difference of aggression linked to the level of interleukin 1 beta (IL-1b) in the dorsal raphe nucleus (DRN). IL-1b inhibited neural activity of the serotonergic neurons in the DRN that caused suppression of aggressive behavior in male mice. We also showed that this individual difference of IL-1b level was produced by microglial cells in the DRN.