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Neuroimmune interaction and escalated aggression

Research Project

Project/Area Number 17H04766
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Basic / Social brain science
Research InstitutionUniversity of Tsukuba

Principal Investigator

TAKAHASHI Aki  筑波大学, 人間系, 准教授 (30581764)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2020: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywords過剰な攻撃行動 / 免疫系 / 背側縫線核 / グルタミン酸 / インターロイキン1β / 雄マウス / 攻撃行動の個体差 / インターロイキン1β / 個体差 / 攻撃性 / サイトカイン / IL-1β / 腹側被蓋野
Outline of Final Research Achievements

Human studies have shown a correlational relationship between aggression and immune system, however its neurobiological mechanism is still unknown. This study aimed to understand the effect of cytokines on neural activity of the dorsal raphe nucleus, a brain area that has been linked to escalated aggression from our studies, which might produce individual difference of aggression in male mice. Our results showed that individual difference of aggression linked to the level of interleukin 1 beta (IL-1b) in the dorsal raphe nucleus (DRN). IL-1b inhibited neural activity of the serotonergic neurons in the DRN that caused suppression of aggressive behavior in male mice. We also showed that this individual difference of IL-1b level was produced by microglial cells in the DRN.

Academic Significance and Societal Importance of the Research Achievements

近年、様々な精神疾患において免疫系の働きが重要な役割を担うことが明らかとなっている。同時に、多くの精神疾患において易怒性や過剰な攻撃性が一部併発することが知られており、免疫系がこのような過剰な攻撃性の出現に関与している可能性が考えられるが、まだ相関的な関係しか明らかになっていない。本研究は、炎症性サイトカインが攻撃行動にかかわる神経回路にどのように影響するかを明らかにすることで、攻撃性と免疫系がつながるメカニズムを解明しようとしたものであり、実際にサイトカインがセロトニン神経系の神経活動に影響を与えることで攻撃行動の個体差が生ずることが明らかとなってきた。

Report

(5 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(65 results)

All 2022 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (16 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 14 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (41 results) (of which Int'l Joint Research: 14 results,  Invited: 3 results) Remarks (5 results)

  • [Int'l Joint Research] Icahn School of Medicine at Mount Sinai/The Rockefeller University/Weill Cornell Medical College(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Icahn School of Medicine at Mount Sinai/The Rockefeller University/Weill Cornell Medicine(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] マウントサイナイ医科大学/ロックフェラー大学/コーネル大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression.2021

    • Author(s)
      Takahashi A, Aleyasin H, Stavarache MA, Li, L, Cathomas F, Parise LF, Lin H, Burnett CJ, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, Sasaki T, Kaplitt MG, Ogawa S, McEwen BS, Russo SJ
    • Journal Title

      Molecular Psychiatry

      Volume: -

    • DOI

      10.1038/s41380-021-01110-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Social Stress and Aggression in Murine Models2021

    • Author(s)
      Takahashi A
    • Journal Title

      Curr Top Behav Neurosci

      Volume: -

    • DOI

      10.1007/7854_2021_243

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toward understanding the sex differences in the biological mechanism of social stress in mouse models2021

    • Author(s)
      Takahashi A
    • Journal Title

      Frontiers in Psychiatry

      Volume: 12 Pages: 644161-644161

    • DOI

      10.3389/fpsyt.2021.644161

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 過剰な攻撃行動の脳内メカニズム2020

    • Author(s)
      高橋阿貴
    • Journal Title

      Medical Science Digest

      Volume: 46 Pages: 50-51

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice2020

    • Author(s)
      Flanigan ME, Aleyasin H, Li L, Burnett CJ, Chan KL, LeClair KB, Lucas EK, Matikainen-Ankney B, Cuttoli RD, Takahashi A, Menard C, Pfau ML, Golden SA, Bouchard S, Calipari ES, Nestler EJ, DiLeone RJ, Yamanaka A, Huntley GW, Clem RL, Russo SJ
    • Journal Title

      Nat Neurosci

      Volume: - Pages: 638-650

    • DOI

      10.1038/s41593-020-0617-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cell-Type-Specific Role of FosB in Nucleus Accumbens In Modulating Intermale Aggression.2018

    • Author(s)
      Aleyasin H, Flanigan ME, Golden SA, Takahashi A, Menard C, Pfau ML, Multer J, Pina J, McCabe KA, Bhatti N, Hodes GE, Heshmati M, Neve RL, Nestler EJ, Heller EA, Russo SJ
    • Journal Title

      The Journal of Neuroscience

      Volume: 38 Pages: 5913-5924

    • DOI

      10.1523/jneurosci.0296-18.2018

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aggression, social stress and the immune system in humans and animal models.2018

    • Author(s)
      Takahashi A, Flanigan ME, McEwen BS, Russo SJ
    • Journal Title

      Frontiers in Behavioral Neuroscience.

      Volume: 12 Pages: 56-56

    • DOI

      10.3389/fnbeh.2018.00056

    • NAID

      120007134291

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cell-type specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility.2018

    • Author(s)
      Heshmati M, Aleyasin H, Menard C, Christoffel DJ, Flanigan ME, Pfau ML, Goff PH, Hodes GE, Lepack A, Bicks L, Takahashi A, Chandra R, Turecki G, Lobo MK, Maze I, Golden SA, Russo SJ
    • Journal Title

      Proceedings of the National Academy of Sciences U S A.

      Volume: 115 Pages: 1111-1116

    • DOI

      10.1073/pnas.1719014115

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Combinatorial Psycho-Pharmacological Approaches for the Treatment of Abnormal Aggression2018

    • Author(s)
      Golden SA, Takahashi A.
    • Journal Title

      Neuropsychopharmacology

      Volume: 43 Pages: 233-234

    • DOI

      10.1038/npp.2017.174

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Social stress induces neurovascular pathology promoting depression.2017

    • Author(s)
      Menard C, Pfau ML, Hodes GE, Kana V, Wang VX, Bouchard S, Takahashi A, Flanigan ME, Aleyasin H, LeClair KB, Janssen WG, Labonte B, Parise EM, Lorsch ZS, Golden SA, Heshmati M, Tamminga C, Turecki G, Campbell M, Fayad ZA, Tang CY, Merad M, Russo SJ.
    • Journal Title

      Nature Neuroscience.

      Volume: 20 Pages: 1752-1760

    • DOI

      10.1038/s41593-017-0010-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Establishment of a repeated social defeat stress model in female mice.2017

    • Author(s)
      Takahashi A, Chung J, Zhang S, Zhang H, Grossman Y, Aleyasin H, Flanigan ME, Pfau ML, Menard C, Dumitriu D, Hodes GE, McEwen BS, Nestler EJ, Han MH, Russo SJ
    • Journal Title

      Scientific Reports.

      Volume: 7 Pages: 12838-12838

    • DOI

      10.1038/s41598-017-12811-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice.2017

    • Author(s)
      Horii Y, Nagasawa T, Sakakibara H, Takahashi A, Tanave A, Matsumoto Y, Nagayama H, Yoshimi K, Yasuda MT, Shimoi K, Koide T.
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 6991-6991

    • DOI

      10.1038/s41598-017-07233-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An emerging role for the lateral habenula in aggressive behavior.2017

    • Author(s)
      Flanigan M, Aleyasin H, Takahashi A, Golden SA, Russo SJ.
    • Journal Title

      Pharmacology Biochemistry and Behavior

      Volume: 162 Pages: 79-86

    • DOI

      10.1016/j.pbb.2017.05.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Automated Estimation of Mouse Social Behaviors Based on a Hidden Markov Model.2017

    • Author(s)
      Arakawa T, Tanave A, Takahashi A, Kakihara S, Koide T, Tsuchiya T.
    • Journal Title

      Methods in Molecular Biology.

      Volume: 1552 Pages: 185-197

    • DOI

      10.1007/978-1-4939-6753-7_14

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 過剰な攻撃行動の神経生物学―動物行動神経科学の視点から2017

    • Author(s)
      高橋阿貴
    • Journal Title

      臨床精神医学

      Volume: 46 Pages: 1077-1082

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice2017

    • Author(s)
      Okabe, S., Tsuneoka, Y., Takahashi, A., Ooyama, R., Watarai, A., Maeda, S., Honda, Y., Nagasawa, M., Mogi, K., Nishimori, K., Kuroda, M., Koide, T., Kikusui, T.
    • Journal Title

      Psychoneuroendocrinology.

      Volume: 79 Pages: 20-30

    • DOI

      10.1016/j.psyneuen.2017.01.036

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 社会的ストレスと過剰攻撃行動の因果関係と神経メカニズムの解明2022

    • Author(s)
      高橋阿貴
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Neuromodulatory effect of cytokine on individual difference of aggression.2021

    • Author(s)
      Aki Takahashi
    • Organizer
      11th Annual Meeting of the Brazilian Institute of Neuropsychology and Behavior & 1st National Forum of Academic Leagues of Neuroscience
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Involvement the lateral habenula-dorsal raphe nucleus-ventral tegmental area projection in social instigation-heightened aggression in male mice2021

    • Author(s)
      Aki Takahashi, Meghan E Flanigan, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Michael Lazarus, Kenji F Tanaka, Akihiro Yamanaka, Sonoko Ogawa, Scott J Russo
    • Organizer
      Neuroscience 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of voluntary running wheel activity on spontaneous activity and aggressive behavior in male mice.2021

    • Author(s)
      Mayu Mogi, Hanna Miura, Tomomi Noda, Akari Shinohara, Koshiro Mitsui, Sonoko Ogawa, Aki Takahashi
    • Organizer
      第81回日本動物心理学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Optogenetic activation of the lateral hypothalamic neurons that project to the dorsal raphe nucleus increases intraspecific and predatory aggression as well as feeding behavior.2021

    • Author(s)
      Koshiro Mitsui, Sonoko Ogawa, Aki Takahashi
    • Organizer
      第81回日本動物心理学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Lateral septum estrogen receptor β is involved in the regulation of aggressive behavior and social anxiety in male mice.2021

    • Author(s)
      Kansuke Hasunuma, Kazuhiro Sano, Aki Takahashi, Sonoko Ogawa
    • Organizer
      第80回日本動物心理学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Glutamatergic projection from the lateral habenula to the dorsal raphe nucleus escalates aggressive behavior of male mice.2021

    • Author(s)
      Aki Takahashi, Meghan E Flanigan, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Michael Lazarus, Kenji F Tanaka, Akihiro Yamanaka, Sonoko Ogawa, Scott J Russo
    • Organizer
      第44回日本神経科学大会/CJK第1回国際会議
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Distribution and neuronal projection patterns of estrogen receptor a and b expressing cells in the lateral septum in male mice.2021

    • Author(s)
      Kansuke Hasunuma, Kazuhiro Sano, Aki Takahashi, Sonoko Ogawa
    • Organizer
      第44回日本神経科学大会/CJK第1回国際会議
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウスにおける腸内細菌叢と攻撃行動の関係の探索2021

    • Author(s)
      岡本昂大、三井鴻志郎、小川園子、高橋阿貴
    • Organizer
      JSBN2021
    • Related Report
      2020 Annual Research Report
  • [Presentation] 雄マウスの攻撃行動の個体差と脳内免疫細胞の関係2021

    • Author(s)
      Takahashi A, Aleyasin H, Stavarache MA, Li L, Cathomas F, Parise LF, Lin H, Burnett J, Aubry A, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, Ogawa S, McEwen BS and Russo SJ
    • Organizer
      2021年度遺伝研行動遺伝学研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 攻撃性の個体差に免疫系が及ぼす影響2021

    • Author(s)
      高橋阿貴
    • Organizer
      2021年度生理学研究所研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Neurobiology of escalated aggression in mice2021

    • Author(s)
      Aki Takahashi
    • Organizer
      East/South East Asia Social Brain Symposium
    • Related Report
      2020 Annual Research Report
  • [Presentation] 過剰な攻撃行動に関わる融合社会脳研究2020

    • Author(s)
      高橋阿貴
    • Organizer
      日本心理学会第84回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Neural mechanism of social frustration and escalation of aggressive behavior.2020

    • Author(s)
      Aki Takahashi
    • Organizer
      The 43rd Annual meeting of the Japan Neuroscience Society
    • Related Report
      2020 Annual Research Report
  • [Presentation] Adolescent social isolation causes heightened aggressive behaviors by social instigation in male mice2020

    • Author(s)
      Mitsui K, Brian H, Ogawa S, Takahashi A
    • Organizer
      第80回日本動物心理学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Identification of a factor that induces instigation-heightened aggression: Olfaction vs visual information.2020

    • Author(s)
      Brian Hu, 小川園子、高橋阿貴
    • Organizer
      JSBN2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] Glutamatergic input into the dorsal raphe nucleus and aggressive arousal.2020

    • Author(s)
      Takahashi A
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 雄マウスの攻撃行動を過剰にするメカニズムとしての背側縫線核の興奮性入力2019

    • Author(s)
      高橋阿貴
    • Organizer
      第31回日本行動内分泌研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Interplay between immune system and aggressive behavior.2019

    • Author(s)
      Takahashi A
    • Organizer
      The 42nd Annual Meeting of the Japan Neuroscience Society (Neuro2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Individual differences in aggression mediated by temporal changes in cytokine signaling in the dorsal raphe nucleus2019

    • Author(s)
      Takahashi A, Aleyasin H, Stavarache MA, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, Ogawa S, McEwen BS and Russo SJ
    • Organizer
      SfN2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differences of aggressive behavior of ICR mouse strain between breeders and peripheral immune cell profile.2019

    • Author(s)
      Takahashi A, Mimura N, Ogawa S
    • Organizer
      第79回日本動物心理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Phasic increase of interleukin 1 in the dorsal raphe nucleus affects inter-male aggressive behavior2019

    • Author(s)
      Takahashi A, Aleyasin H, Stavarache MA, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, Ogawa S, McEwen BS and Russo SJ
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies (FAOPS)
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウスモデルから探る過剰な攻撃性に関わる神経メカニズム2018

    • Author(s)
      高橋阿貴
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Invited
  • [Presentation] Prefrontal and subcortical neural mechanisms regulating escalated aggression in mice2018

    • Author(s)
      Takahashi A
    • Organizer
      30th APS Annual Convention
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Individual difference of aggressive behavior and interleukin 1 beta in the dorsal raphe nucleus2018

    • Author(s)
      Takahashi A, Aleyasin H, Stavarache MA, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, Ogawa S, McEwen BS and Russo SJ
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Orexin inputs to GABAergic lateral habenula neurons control aggression valence2018

    • Author(s)
      Flanigan M, Aleyasin H, Leclair L, Lucas EK, Matikainen-Ankney BA, Takahashi A, Menard C, Bouchard S, Pfau ML, Golden SA, Calipari ES, Nestler EJ, Dileone RJ, Yamanaka A, Huntley GW, Clem RL, Russo SJ
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modulation of dorsal raphe neuron activity by interleukin 1 beta and inter-male aggression in male mice2018

    • Author(s)
      Takahashi A, Aleyasin H, Stavarache MA, Ogawa S, Russo SJ
    • Organizer
      第78回日本動物心理学会大会
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Presentation] 視床下部内側視索前野に局在するエストロゲン受容体発現細胞集団は、 発現するエストロゲン受容体のサブタイプによって異なる遠心性投射パターンを示すのか?2018

    • Author(s)
      村川友哲, 佐越祥子, 高橋阿貴, 小川園子
    • Organizer
      第29回日本行動神経内分泌研究会
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Presentation] The role of interleukin 1β in the brain on individual difference of inter-male aggression in the mouse.2018

    • Author(s)
      Takahashi A, Aleyasin H, Stavarache MA, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, Ogawa S, McEwen BS, Russo SJ
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Presentation] Developmental changes and sex differences of ultrasonic vocalization in mice during social interactions2018

    • Author(s)
      Sano K, Saito K, Takahashi A, Ogawa S
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Presentation] Projections from the dorsal raphe nucleus that is involved in escalation of aggression.2017

    • Author(s)
      Takahashi A
    • Organizer
      The 40th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Neuromodulatory effect of cytokine in the dorsal raphe nucleus and individual difference of aggression.2017

    • Author(s)
      Takahashi A, Aleyasin H, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, McEwen BS and Russo SJ
    • Organizer
      The International Behavioral Neuroscience Society (IBNS) 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウスの雄間攻撃行動の個体差おける免疫系の関与2017

    • Author(s)
      Takahashi A, Aleyasin H, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, McEwen BS and Russo SJ
    • Organizer
      行動2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 視床下部腹内側核エストロゲン受容体 α 陽性神経細胞への特異的な操作が雌マウスの自発的活動量に及ぼす効果2017

    • Author(s)
      佐越祥子・武縄聡・高橋阿貴・小川園子
    • Organizer
      行動2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of optogenetic manipulation on dorsal raphe serotonergic neuronal activity increases pup-caring behavior in virgin female mice.2017

    • Author(s)
      Takenawa S, Nakamura S, Takahashi A, Tanaka K, Yamanaka A, Ogawa S
    • Organizer
      行動2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 社会的探索行動場面での雄マウスの内側扁桃体エストロゲン受容体アルファ陽性細胞の神経活動の解析2017

    • Author(s)
      宮坂藍・武縄聡・西野明日香・高橋阿貴・小川園子
    • Organizer
      行動2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Transcription factor deltaFosB regulates aggressive behavior in male mice in a cell-specific manner.2017

    • Author(s)
      Aleyasin H, Flanigan M, Golden SA, Takahashi A, Pina J, Menard C, Pfau ML, Hodes G, Heshmati M, Heller E, Russo SJ
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel lateral habenula microcircuit mediating appetitive aggression.2017

    • Author(s)
      Flanigan M, Aleyasin H, Matikainen-Ankney BA, Takahashi A, Calipari ES, Golden SA, Menard C, Pfau ML, Hodes GE, Russo S
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modulation of neuroligin-2 in the nucleus accumbens alters stress and dominance behaviors.2017

    • Author(s)
      Heshimati M, Aleyasin H, Menard C, Christoffel DJ, Flanigan M, Pfau ML, Goff PH, Hodes GE, Takahashi A, Lepack A, Bicks L, Chandra R, Lobo M, Maze I, Golden SA, Russo SJ
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of a repeated social defeat stress model in female mice.2017

    • Author(s)
      Chung JR, Takahashi A, Zhang S, Zhang H, Grossman Y, Aleyasin H, Flanigan M, Pfau M, Menard C, Dumitriu D, Hodes G, McEwen B, Nestler E, Han MH, Russo SJ
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Social stress induces neurovascular pathology promoting depression.2017

    • Author(s)
      Menard C, Pfau ML, Hodes GE, KANA V, Wang VX, Bouchard S, Takahashi A, Flanigan M, Aleyasin H, Leclair K, Janssen WG, Labonte B, Parise EM, Lorsch ZS, Golden SA, Heshmati M, Tamminga CA, Turecki G, Campbell M, Fayad Z, Tang CY, Menard M, Russo SJ
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 筑波大学研究者総覧TRIOS 高橋阿貴

    • URL

      https://trios.tsukuba.ac.jp/ja/researchers/0000003646

    • Related Report
      2020 Annual Research Report
  • [Remarks] 高橋阿貴 Research

    • URL

      https://sites.google.com/view/akitakahashi-tsukuba/home

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] 筑波大学研究者総覧TRIOS 高橋阿貴

    • URL

      https://trios.tsukuba.ac.jp/researcher/0000003646

    • Related Report
      2019 Annual Research Report
  • [Remarks] TSUKUBA FUTURE #097:マウスの行動に魅せられて

    • URL

      https://www.tsukuba.ac.jp/notes/097/index.html

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 雌マウスの社会的敗北ストレスモデルの確立 女性のストレス関連疾患を生物学的に研究するために

    • URL

      https://academist-cf.com/journal/?p=6398

    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2023-01-30  

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