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Unified protocol of cognitive behavioral therapy for emotional disorders: Extention of clinical trial for the comprehensive examination

Research Project

Project/Area Number 17H04788
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Clinical psychology
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

Ito Masaya  国立研究開発法人国立精神・神経医療研究センター, 認知行動療法センター, 部長 (20510382)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2017: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywordsうつ病 / 不安症 / 感情 / 認知行動療法 / 診断横断 / 脳画像 / 治療機序 / 臨床試験 / 統一プロトコル / UP / うつ / 不安 / 感情障害 / 機序 / コーディネート / 症状評価
Outline of Final Research Achievements

The primary aim of this study was to test the efficacy of a unified protocol of transdiagnostic treatment for depressive and anxiety disorders (UP) by a randomized controlled trial. Other objectives were to examine the therapeutic mechanism, neural basis, and long-term effects of UP. The clinical trial achieved the enrollment of the target number of 104 patients. The data was fixed, statistically analyzed. Drafting the primary outcome paper has almost completed. In addition, we obtained the participants' brain image at before and after the intervention. Using the data from preliminary trial and observational studies, we published articles on the therapeutic mechanisms and processes of UP. Interventional materials and other materials prepared for clinical trials have been used extensively for education and training of UP.

Academic Significance and Societal Importance of the Research Achievements

本研究は、日本人の成人のうつ病や不安症に対する、汎用性の高い認知行動療法の有効性を、科学的に厳密な方法であるランダム化比較試験によって検証することを目的としていた。そのために、当初から目標としていた104名がこの臨床試験に参加した。加えて、この療法が作用するメカニズムや、関連する脳機能を明らかにするための研究を実施してきた。本研究によって、うつ病や不安症に対する新たな治療法の開発や、それが有効となるメカニズムを明らかにすることに貢献できた。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (28 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (5 results) Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (12 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Book (5 results) Remarks (2 results)

  • [Int'l Joint Research] Boston University(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] フリードリヒ・アレクサンダー大学エアランゲン=ニュルンベルク(ドイツ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] ボストン大学(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ボストン大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ボストン大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] The influence of emotion regulation on posttraumatic stress symptoms among Japanese people2020

    • Author(s)
      Fujisato Hiroko、Ito Masaya、Berking Matthias、Horikoshi Masaru
    • Journal Title

      Journal of Affective Disorders

      Volume: 277 Pages: 577-583

    • DOI

      10.1016/j.jad.2020.08.056

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Expressive suppression of emotion is a moderator of anxiety in a unified protocol for transdiagnostic treatment of anxiety and depressive disorders: A secondary analysis2020

    • Author(s)
      Hiroki Hosogoshi, Yoshitake Takebayashi, Masaya Ito, Hiroko Fujisato, Noriko Kato, Shun Nakajima, Yuki Oe, Mitsuhiro Miyamae, Ayako Kanie, Masaru Horikoshi
    • Journal Title

      Journal of Affective Disorders

      Volume: 277 Pages: 1-4

    • DOI

      10.1016/j.jad.2020.07.132

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of Trait Mindfulness in Behavioral Activation Mechanism for Patients With Major Depressive Disorder2020

    • Author(s)
      Takagaki K, Ito M, Takebayashi Y, Nakajima S and Horikoshi M
    • Journal Title

      Frontier in Psychology

      Volume: 11 Pages: 845-845

    • DOI

      10.3389/fpsyg.2020.00845

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] うつと不安に対する診断横断的な認知行動療法の最前線2018

    • Author(s)
      伊藤正哉・加藤典子・藤里紘子
    • Journal Title

      分子精神医学

      Volume: 19 Pages: 23-27

    • Related Report
      2018 Annual Research Report
  • [Presentation] Current status of research on the Unified Protocol for the transdiagnostic treatment of emotional disorders in Japan2019

    • Author(s)
      Masaya Ito
    • Organizer
      Association for Behavioral and Cognitive Therapies 53rd Annual Convention
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An artificial intelligence-aided approach to train cognitive behavioral therapists in the Unified Protocol for transdiagnostic treatment of emotional disorders in Japan(シンポジウム発表)2019

    • Author(s)
      Yuko Shigeeda
    • Organizer
      Asian Congress of Health Psychology (ACHP 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An artificial intelligence-aided approach to train cognitive behavioral therapists in the Unified Protocol for transdiagnostic treatment of emotional disorders in Japan(ポスター発表)2019

    • Author(s)
      Yuko Shigeeda
    • Organizer
      Asian Congress of Health Psychology (ACHP 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 臨床研究におけるスーパービジョンの方法2019

    • Author(s)
      伊藤正哉
    • Organizer
      日本健康心理学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 感情障害に対する診断を越えた治療のための統一プロトコル2019

    • Author(s)
      伊藤正哉
    • Organizer
      集団認知行動療法研究会 第10回学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 不安症に対する曝露療法の研究動向―トピックモデリングによる検討2019

    • Author(s)
      山口慶子・竹林由武・伊藤正哉・堀越勝
    • Organizer
      第11回日本不安症学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 児童の感情障害に対する統一プロトコルの実施可能性と有効性の検討2018

    • Author(s)
      藤里紘子・加藤典子・生田目光・野村朋子・二宮宗三・伊藤正哉・宇佐美政英・堀越勝
    • Organizer
      第18回日本認知療法・認知行動療法学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 臨床試験における独立評価者の訓練プログラムとその事例:うつ病と不安症への統一プロトコルのランダム化比較試験での実践2018

    • Author(s)
      山口慶子・大江悠樹・宮前光宏・駒沢あさみ・中山千秋・伊藤正哉・堀越 勝
    • Organizer
      第18回認知療法・認知行動療法学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 認知行動療法のランダム化比較試験における独立評価者マスキングのための臨床研究コーディネート -JUNP Studyでの工夫-2018

    • Author(s)
      豊田彩花,伊藤正哉,加藤典子,花田孝子,溝川英里子,駒沢あさみ,堀越勝
    • Organizer
      第18回日本認知療法・認知行動療法学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of the Japanese version of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children.2018

    • Author(s)
      Noriko Kato, HirokoFujisato, Hikari Namatame, Masaya Ito, Masaru Horikoshi
    • Organizer
      13th International Conference on Child and Adolescent Psychopathology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Progress report about the open-label feasibility trial of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders among the Japanese Children.2018

    • Author(s)
      HirokoFujisato, Noriko Kato, Hikari Namatame, Masahide Usami, Masaya Ito, Masaru Horikoshi
    • Organizer
      13th International Conference on Child and Adolescent Psychopathology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 臨床試験における独立評価班の運用:うつ病と不安症への統一プロトコルのランダム化比較試験での実2018

    • Author(s)
      宮前光宏・山口慶子・大江悠樹・駒沢あさみ・中山千秋・伊藤正哉・堀越勝
    • Organizer
      第18回日本認知療法・認知行動療法学会
    • Related Report
      2018 Annual Research Report
  • [Book] 不安とうつの統一プロトコル 診断を越えた認知行動療法 臨床応用編2020

    • Author(s)
      監修 伊藤正哉・堀越勝(著・バーロウ・ファーキオーニ)
    • Total Pages
      248
    • Publisher
      診断と治療社
    • ISBN
      9784787824547
    • Related Report
      2019 Annual Research Report
  • [Book] 公認心理師の基礎と実践 第8巻 感情・人格心理学 第4章 ポジティブ感情の効果2019

    • Author(s)
      伊藤正哉
    • Publisher
      遠見書房
    • Related Report
      2018 Annual Research Report
  • [Book] 精神科診療マニュアル V.不安に関連する疾患 3.全般不安症2019

    • Author(s)
      伊藤正哉、蟹江絢子、中嶋愛一郎、堀越勝
    • Publisher
      科学評論社
    • Related Report
      2018 Annual Research Report
  • [Book] 現代の臨床心理学 第4巻 臨床心理研究法 診断横断アプローチ2019

    • Author(s)
      伊藤正哉・藤里紘子・加藤典子
    • Publisher
      東京大学出版会
    • Related Report
      2018 Annual Research Report
  • [Book] Applications of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (Chapter 16, Cross-cultural Applications of the Unified Protocol: Examples from Japan and Colombia)2017

    • Author(s)
      David H. Barlow and Todd Farchione (Ed), Amantia Ametaj, Nina Wong Sarver, Obianujunwa Anakwenze, Masaya Ito, Michel Ratner and Ramya Potluri(Author of Chapter 16)
    • Total Pages
      376
    • Publisher
      Oxford University Press
    • Related Report
      2017 Annual Research Report
  • [Remarks] 不安とうつへの認知行動療法の統一プロトコル

    • URL

      https://www.ncnp.go.jp/cbt/research/archives/5

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] 不安とうつへの認知行動療法の統一プロトコル

    • URL

      http://cbt.ncnp.go.jp/research/archives/5

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2022-05-23  

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