• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of brain mechanisms that enables flexible modulation of learning

Research Project

Project/Area Number 17H04789
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Experimental psychology
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology

Principal Investigator

Shibata Kazuhisa  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, 主幹研究員(任常) (20505979)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2018: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2017: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords視覚 / 学習 / 脳イメージング / 知覚 / 脳計測 / 非侵襲脳計測
Outline of Final Research Achievements

The brain need to stabilize learned contents while must be sufficiently plastic to allow the learned contents to be further enhanced according to behavioral demands. However, it has been unclear how these seemingly contradicting functions are implemented in the brain. In this study, we addressed this question by combining visual training paradigms and a non-invasive brain imaging method called magnetic resonance spectroscopy. We obtained the following findings. First, we found that an excitatory-inhibitory (E/I) balance, defined by the ratio of glutamate and GABA, in the early visual areas of the brain changed in association with stabilization, re-activation, and re-stabilization of visual learning. Second, we set about development of a new neurofeedback method that enables to modulate E/I balance in the brain and obtained some preliminary results. The development of the method has been merged into a new project based under the support of Grant-in-Aid for Scientific Research A.

Academic Significance and Societal Importance of the Research Achievements

本研究から得られた結果によって、学習や再学習といった場面において、すでに学んだ内容の保持とその内容の更新の両立が、脳においてどのように実現されているかが明らかになった。これらの成果は、学習に関わる脳機能、すなわち脳の可塑性メカニズムの解明に大きく寄与するとともに、今後より効率的な学習・訓練方法の開発に応用可能であり、学習障害や再就職者の再訓練などの社会的課題を解消するにあたり、大きな社会的意義を持つと考えられる。

Report

(3 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (6 results)

All 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] ブラウン大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ブラウン大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Toward a comprehensive understanding of the neural mechanisms of decoded neurofeedback2019

    • Author(s)
      Shibata Kazuhisa、Lisi Giuseppe、Cortese Aurelio、Watanabe Takeo、Sasaki Yuka、Kawato Mitsuo
    • Journal Title

      NeuroImage

      Volume: 188 Pages: 539-556

    • DOI

      10.1016/j.neuroimage.2018.12.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neural signals in amygdala predict implicit prejudice toward an ethnic outgroup2019

    • Author(s)
      Izuma Keise、Aoki Ryuta、Shibata Kazuhisa、Nakahara Kiyoshi
    • Journal Title

      NeuroImage

      Volume: 189 Pages: 341-352

    • DOI

      10.1016/j.neuroimage.2019.01.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Consolidation and reconsolidation share behavioural and neurochemical mechanisms2018

    • Author(s)
      Bang Ji Won、Shibata Kazuhisa、Frank Sebastian M.、Walsh Edward G.、Greenlee Mark W.、Watanabe Takeo、Sasaki Yuka
    • Journal Title

      Nature Human Behaviour

      Volume: 2 Issue: 7 Pages: 507-513

    • DOI

      10.1038/s41562-018-0366-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Extensive training with feedback reduces attentional demand in visual feature binding2019

    • Author(s)
      Yoko Higuchi, Naotsugu Tsuchiya, Ryota Kanai, & Kazuhisa Shibata
    • Organizer
      Vision Sciences Society Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi