| Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2017: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
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| Outline of Final Research Achievements |
Photon upconversion from near-infrared (NIR) light to visible light has attracted much attention as an internal light source for biological applications. However, it has been difficult to upconvert NIR light to visible light with good efficiency, and the quenching of upconverted emission by dissolved oxygen molecules has been a severe issue. In this project, we employed metal complexes showing singlet-to-triplet direct transition (S-T absorption) as the triplet sensitizer, and developed supramolecular systems with good oxygen-barrier ability. We achieved NIR-to-blue upconversion in air-saturated water and applied this upconversion hydrogels to control the morphology of neurons. This demonstrates the first example of optogenetics by molecular TTA upconversion systems.
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