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High-throughput electron density mapping by a combination of X-ray laser and nanofabrication technology

Research Project

Project/Area Number 17H04819
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Quantum beam science
Research InstitutionHokkaido University

Principal Investigator

Suzuki Akihiro  北海道大学, 電子科学研究所, 助教 (20781850)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
KeywordsX線自由電子レーザー / コヒーレントX線イメージング / フォトリソグラフィ / X線イメージング / コヒーレントX線回折 / 位相回復計算 / バイオイメージング
Outline of Final Research Achievements

In this study, a liquid cell used for X-ray laser imaging was improved by utilizing photolithography technology. As a result, it allows us to control a single-particle hit rate, which is important for high-throughput electron density mapping. Furthermore, we designed and manufactured a newly designed liquid cell that can be measured even at high tilt angles towards three-dimensional imaging of unidirectionally-aligned particles in solution. Finally, we have demonstrated that the new liquid cell can be used for the X-ray laser measurement using SACLA. The research paper of the result was selected in the 2019 PCCP HOT articles of Physical Chemistry Chemical Physics.

Academic Significance and Societal Importance of the Research Achievements

液体ジェットインジェクターを利用した試料導入方法と比較し、試料環境のコントロールが容易な試料環境セルの高度化を進めることができた。将来的に、希少試料の測定や、温度やpHに応答したダイナミクス観察に繋がる。また、放射線損傷の影響を受けずに内部構造のスナップショット画像を復元できるX線レーザーイメージングは、電子顕微鏡や原子間力顕微鏡と相補的な技術であり、触媒材料の構造解析など産業分野でも活用されることが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (17 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (11 results) (of which Int'l Joint Research: 4 results,  Invited: 4 results)

  • [Int'l Joint Research] Academia Sinica(台湾)(その他の国・地域)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Academia Sinica(台湾)(その他の国・地域)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Academia Sinica(台湾)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Design of a liquid cell toward three-dimensional imaging of unidirectionally-aligned particles in solution using X-ray free-electron lasers2020

    • Author(s)
      Suzuki Akihiro、Kimura Takashi、Yang Ying、Niida Yoshiya、Nishioka Akiko、Tachibana Tatsuro、Takei Masashi、Tono Kensuke、Yabashi Makina、Ishikawa Tetsuya、Oshima Tairo、Bessho Yoshitaka、Joti Yasumasa、Nishino Yoshinori
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: 22 Issue: 5 Pages: 2622-2628

    • DOI

      10.1039/c9cp03658j

    • NAID

      120006957264

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] XFEL coherent diffraction imaging for weakly scattering particles using heterodyne interference2020

    • Author(s)
      Chi-Feng Huang, Wei-Hau Chang, Ting-Kuo Lee, Yasumasa Joti, Yoshinori Nishino, Takashi Kimura, Akihiro Suzuki, Tetsuya Ishikawa, Keng S. Liang et al.,
    • Journal Title

      AIP Advances (Accepted)

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SACLAを用いた環境制御ナノイメージング2017

    • Author(s)
      西野吉則、木村隆志、鈴木明大、城地保昌、別所義隆
    • Journal Title

      レーザー研究

      Volume: 45 Pages: 508-512

    • NAID

      130007957391

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] パルス状コヒーレントX線溶液散乱法の現状と高度化に向けた取り組み2020

    • Author(s)
      鈴木明大, 城地保昌, 別所義隆, 西野吉則
    • Organizer
      第33回日本放射光学会年会・放射光科学合同シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 1粒子XFELイメージングのための超低バックグラウンド溶液試料セル開発に向けて2020

    • Author(s)
      鈴木明大, 湯本博勝, 小山貴久, 城地保昌, 別所義隆, 登野健介, 矢橋牧名, 石川哲也, 大橋治彦, 西野吉則
    • Organizer
      第33回日本放射光学会年会・放射光科学合同シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] X線レーザー回折による溶液中試料イメージング -高度化に向けた最新の取り組み-2019

    • Author(s)
      鈴木明大
    • Organizer
      レーザー学会「レーザーバイオ医療」技術専門委員会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] X線レーザー回折による溶液試料のナノ構造分析2019

    • Author(s)
      鈴木明大
    • Organizer
      日本放射光学会 第11回若手研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Feasibility study on solution sample holding technique for XFEL based single-particle imaging2019

    • Author(s)
      Akihiro Suzuki
    • Organizer
      SACLA Users' Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Imaging thermoresponsive gold nanoparticles in solution by X-ray laser diffraction2018

    • Author(s)
      Akihiro Suzuki, Takashi Kimura, Ryo Iida, Hideyuki Mitomo, Yasumasa Joti, Yoshitaka Bessho, Ken-ichi Niikura, Kuniharu Ijiro, Yoshinori Nishino
    • Organizer
      International Conference on X-ray Optics and Applications 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recent Advances in XFEL-Based Coherent Diffractive Imaging at SACLA2018

    • Author(s)
      Akihiro Suzuki, Takashi Kimura, Yoshimasa Joti, Yoshitaka Bessho, Yoshinori Nishino
    • Organizer
      Coherence 2018: International Workshop on Phase Retrieval and Coherent Scattering
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] X線レーザー回折による温度応答性金ナノ粒子の溶液中イメージング2018

    • Author(s)
      鈴木明大、木村隆志、飯田良、三友秀之、城地保昌、別所義隆、新倉謙一、居城邦治、西野吉則
    • Organizer
      第31回日本放射光学会年会・放射光科学合同シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] New design of environmental cells as a first step toward 3D imaging in solution by X-ray laser diffraction2017

    • Author(s)
      Akihiro Suzuki, Tatsuro Tachibana, Naoya Tani, Yasumasa Joti, Yoshitaka Bessho, Takashi Kimura, Yoshinori Nishino
    • Organizer
      International Conference on X-ray Optics and Applications2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 外部刺激応答性ナノ粒子のX線レーザーイメージング2017

    • Author(s)
      鈴木明大
    • Organizer
      第14回X線結像光学シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] X-ray laser imaging of thermoresponsive gold nanoparticles in solution2017

    • Author(s)
      Akihiro Suzuki, Takashi Kimura, Ryo Iida, Hideyuki Mitomo, Yasumasa Joti, Yoshitaka Bessho, Ken-ichi Niikura, Kuniharu Ijiro, Yoshinori Nishino
    • Organizer
      The 18th RIES-HOKUDAI International Symposium
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2022-08-05  

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