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Label-free superresolution microscopy

Research Project

Project/Area Number 17H04852
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Atomic/Molecular/Quantum electronics
Research InstitutionThe University of Tokyo

Principal Investigator

Ideguchi Takuro  東京大学, 大学院理学系研究科(理学部), 講師 (30735999)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2018: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2017: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Keywords振動分光 / 分子振動 / ラベルフリー顕微鏡 / 超解像 / コヒーレントラマン顕微鏡 / フーリエ変換分光 / 赤外フォトサーマル顕微鏡 / 応用光学・量子光工学
Outline of Final Research Achievements

We developed two super-resolution techniques of label-free molecular vibrational microscopy. First, we proposed and demonstrated a super-resolution infrared microscope called mid-infrared photothermal phase-contrast microscope. The spatial resolution of this microscope is determined by the visible illumination light of the microscope which probes refractive index change due to the photothermal effect triggered by the infrared absorption of the molecules. Next, we studied chip-enhanced super-resolution coherent Raman microscopy. We developed an ultra-broadband coherent Raman microscope and started proof-of-concept demonstration of super-resolution imaging with the chip-enhancement.

Academic Significance and Societal Importance of the Research Achievements

開発に成功した赤外フォトサーマル位相差顕微鏡は、赤外吸収の高感度特性と可視光の高空間分解能特性を併せ持つ手法であり、また、低いフォトダメージ特性を持つ。数百ナノメートルの空間分解能を持つラベルフリー分子イメージングであるため、生命科学研究の新しいツールとなることが期待される。創薬分野における小分子薬剤の細胞内局在の可視化や、医療分野における組織の迅速病理診断などへの応用が想定される。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • Research Products

    (25 results)

All 2019 2018 2017 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (17 results) (of which Int'l Joint Research: 10 results,  Invited: 6 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Phase-controlled Fourier-transform spectroscopy2018

    • Author(s)
      Hashimoto Kazuki、Ideguchi Takuro
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 4448-4448

    • DOI

      10.1038/s41467-018-06956-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 創薬における超高速ラマン分光法の活用2018

    • Author(s)
      長島優、橋本和樹、大間知潤子、井手口拓郎
    • Journal Title

      光アライアンス

      Volume: 29 Pages: 2126-2126

    • Related Report
      2017 Annual Research Report
  • [Presentation] 高速広帯域CARS分光とその応用2019

    • Author(s)
      井手口拓郎
    • Organizer
      レーザー学会学術講演会第39回年次大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Molecular contrast added to phase-contrast microscope2019

    • Author(s)
      Keiichiro Toda, Miu Tamamitsu, Ryoichi Horisaki, Takuro Ideguchi
    • Organizer
      CIAiS International Symposium 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hyperspectral single-pixel imaging for remote gas sensing2019

    • Author(s)
      Akira Kawai, Yuki Yoshida, Kazuki Hashimoto, Takuro Ideguchi
    • Organizer
      CIAiS International Symposium 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 中赤外フォトサーマル位相差顕微鏡2019

    • Author(s)
      戸田圭一郎、玉光未侑、堀崎遼一、井手口拓郎
    • Organizer
      第66回応用物理学会春季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ナイキスト限界の高速広帯域フーリエ分光法2019

    • Author(s)
      橋本和樹、井手口拓郎
    • Organizer
      第66回応用物理学会春季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Nyquist-limited Efficient Fourier-transform Spectrosocpy2019

    • Author(s)
      Kazuki Hashimoto, Takuro Ideguchi
    • Organizer
      Conference on Lasers and Electro-Optics OSA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiphoton Microscope with a Rapid Broadband CARS Modality2019

    • Author(s)
      Faris Sinjab, Kazuki Hashimoto, Venkata Ramaiah Badarla, Yu Nagashima, and Takuro Ideguchi
    • Organizer
      CLEO/Europe-EQEC 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phase-contrast microscope with molecular contrast2019

    • Author(s)
      Keiichiro Toda, Miu Tamamitsu, Ryoichi Horisaki, and Takuro Ideguchi
    • Organizer
      CLEO/Europe-EQEC 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nyquist-limited Fourier-transform spectroscopy with phase-controlled delay line2019

    • Author(s)
      Takuro Ideguchi
    • Organizer
      OSA Light, Energy and the Environment Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 振動分光顕微イメージング2019

    • Author(s)
      井手口拓郎
    • Organizer
      第58回日本生体医工学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Quantitative phase microscopy with molecular vibrational sensitivity2019

    • Author(s)
      Miu Tamamitsu, Keiichiro Toda, Ryoichi Horisaki, Takuro Ideguchi
    • Organizer
      CLEO/Europe-EQEC 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High-speed ultra-broadband Fourier-transform CARS spanning over 3,000 cm-12018

    • Author(s)
      Junko Omachi, Kazuki Hashimoto, and Takuro Ideguchi
    • Organizer
      Conference on Lasers and Electro-Optics OSA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高速スキャン広帯域コヒーレントラマン分光2018

    • Author(s)
      井手口拓郎
    • Organizer
      分光学会シンポジウム「先端的振動分光法の新しい技術と応用」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ラピッドスキャン型フーリエ変換CARS分光による高速・超広帯域な分子振動分析2018

    • Author(s)
      大間知潤子、橋本和樹、井手口拓郎
    • Organizer
      第10回文部科学省「最先端の光の創成を目指したネットワーク研究拠点プログラム」シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ultrafast Broadband Fourier-transform CARS Spectroscopy2018

    • Author(s)
      Takuro Ideguchi
    • Organizer
      BIT's 6th Annual Conference of AnalytiX-2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 6-fsパルスレーザを用いた高速スキャン広帯域フーリエ変換CARS分光2018

    • Author(s)
      橋本 和樹、大間知 潤子、井手口 拓郎
    • Organizer
      第65回応用物理学会春季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ultrafast Fourier Transform Spectroscopy with Frequency Combs2017

    • Author(s)
      Takuro Ideguchi
    • Organizer
      BIT's 8th Annual Global Congress of Catalysis-2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] 光を巧みに操ることで新しい分子分光法の開発に成功 ~光の波形制御で分子の同定を高速・簡便化~

    • URL

      https://www.s.u-tokyo.ac.jp/ja/info/6100/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 光を巧みに操ることで新しい分子分光法の開発に成功 ~光の波形制御で分子の同定を高速・簡便化~

    • URL

      https://www.jst.go.jp/pr/announce/20181025/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 研究室の扉「新たなサイエンスを生み出す光の工夫」

    • URL

      https://www.youtube.com/watch?v=Q64hAx_RowM

    • Related Report
      2018 Annual Research Report
  • [Remarks] 学部生に伝える研究最前線「未来の科学を創る新規分光計測」

    • URL

      http://www.s.u-tokyo.ac.jp/ja/story/newsletter/page/6202/

    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 高速スキャンフーリエ変換分光装置及び分光方法2018

    • Inventor(s)
      井手口拓郎、橋本和樹
    • Industrial Property Rights Holder
      井手口拓郎、橋本和樹
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-129410
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 画像生成装置および画像生成方法2018

    • Inventor(s)
      1.井手口拓郎、戸田圭一郎、玉光未侑、橋本和樹、堀崎遼一
    • Industrial Property Rights Holder
      1.井手口拓郎、戸田圭一郎、玉光未侑、橋本和樹、堀崎遼一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-133711
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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