| Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
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| Outline of Final Research Achievements |
This study supports Oparin's coacervate hypothesis: peptide-based droplets were formed on the primitive Earth and that the first organisms were born from these droplets. Initially, we planned to construct a primitive cell using nucleic acids and a rigid lipid membrane. However, the interaction between the membrane and nucleic acids was stronger than expected. Therefore it was difficult to transfer information from the nucleic acids to the membrane. Here, we adopted the concept of the composome (individual composition is information), and were able to construct a primitive cell model from simple materials that are more similar to primitive cells. In this model, spontaneous formation of droplets of about 20 micrometer in size was observed by addition of molecules with a thioester skeleton to water at room temperature and 1 atm. When the synthesized molecule was added, the droplets repeatedly grew and divided ,that is, proliferated.
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