| Budget Amount *help |
¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2018: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Outline of Final Research Achievements |
Aiming at the advanced utilization of first-row transition metals in organic synthesis, we developed highly active catalysts based on designing reaction fields that take advantage of the properties of solids and molecules. With heterogeneous nickel catalysts consisting of polystyrene-cross-linking bisphosphine PS-DPPBz that allowed selective metal monochelation, efficient molecular transformations such as cross-coupling of aryl chlorides with alkyl lithiums and decarboxylation of aryl carbamates for aniline synthesis were developed. Moreover, we designed and synthesized dumbbell-shaped bipyridine ligands that promotes nickel-catalyzed one-electron transfer coupling, and their utilities were demonstrated in cross-electrophilic coupling between aryl bromides and alkyl bromides.
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