Development of Functional Molecules Constructing Dynamic Multidimensional Media
Project/Area Number |
17H04885
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Bio-related chemistry
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Research Institution | Tokyo University of Agriculture and Technology |
Principal Investigator |
Muraoka Takahiro 東京農工大学, 工学(系)研究科(研究院), 准教授 (70509132)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2017: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
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Keywords | ポリエチレングリコール / ベシクル / 結晶 / 両親媒性分子 / 生体関連化学 / 刺激応答性 |
Outline of Final Research Achievements |
Polyethylene glycol (PEG) is known to change the conformation in response to the temperature changes. Using this thermal response of PEG, we developed PEG-containing molecules functioning in 2D and 3D media. Membrane-embedded molecules containing PEG chains allowed for membrane deformation upon heating. Crystals made of cyclic molecules containing PEG chains showed polymorphic phase transition upon temperature changes to switch various physical properties. On the basis of amphiphilic molecules containing short PEG chains, we successfully developed functional molecules that enable membrane deformation of 2D assemblies and polymorphic phase transition of 3D assemblies.
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Academic Significance and Societal Importance of the Research Achievements |
ポリエチレングリコール(PEG)は、多くの低分子・高分子材料に広く使われる分子骨格である。一般的に、PEGは水溶性骨格として利用されるが、本研究成果により、脂質二重膜や結晶などの多次元場を機能化する上で有用であることが示された。このことは、機能性物質を開発する新たな設計指針としての学術的意義を有する。ベシクルや結晶は、様々な材料の基盤構造であり、その機能化を可能にする新たな分子を提示した点に、産業面などに資する社会的意義がある。
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Report
(3 results)
Research Products
(44 results)
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[Journal Article] Mechano-Sensitive Synthetic Ion Channels2017
Author(s)
Takahiro Muraoka, Kaori Umetsu, Kazuhito V. Tabata, Tsutomu Hamada, Hiroyuki Noji, Takashi Yamashita, and Kazushi Kinbara
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Journal Title
J. Am. Chem. Soc.
Volume: 139
Issue: 49
Pages: 18016-18023
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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